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Article ; Online: The Role of Zinc in Cardiovascular Disease.

Begum, Farhana / Me, Hay Me / Christov, Marta

2022 Volume 30, Issue 2, Page(s) 100–108

Abstract: Zinc is an essential trace element due to its role as a key part of human enzymatic activity. As a cofactor in metalloenzymes and metalloproteins, zinc participates in diverse biological functions, including gene transcription, translation, and ... ...

Abstract	Zinc is an essential trace element due to its role as a key part of human enzymatic activity. As a cofactor in metalloenzymes and metalloproteins, zinc participates in diverse biological functions, including gene transcription, translation, and replication, phagocytosis, and immunoglobulin and cytokine production. In this review, we will focus on the role of zinc in the cardiovascular system, including heart failure, vascular calcification, and myocardial infarction. We will further highlight the role of zinc in cardiovascular pathology in individuals with chronic kidney disease, and type II diabetes mellitus, groups uniquely at risk for cardiovascular morbidity and mortality.
MeSH term(s)	Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Humans ; Metalloproteins ; Renal Insufficiency, Chronic ; Zinc
Chemical Substances	Metalloproteins ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1294965-6
ISSN	1538-4683 ; 1061-5377
ISSN (online)	1538-4683
ISSN	1061-5377
DOI	10.1097/CRD.0000000000000382
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Zs.A 4491: Show issues

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Article: Impact of Early Rejection Treatment on Infection Development in Kidney Transplant Recipients: A Propensity Analysis.

Gupta, Simran / Gea-Banacloche, Juan / Heilman, Raymond L / Yaman, Reena N / Me, Hay Me / Zhang, Nan / Vikram, Holenarasipur R / Kodali, Lavanya

Journal of transplantation

2024 Volume 2024, Page(s) 6663086

Abstract: Introduction: The impact of renal allograft rejection treatment on infection development has not been formally defined in the literature.: Methods: We conducted a retrospective cohort study of 185 rejection (case) and 185 nonrejection (control) ... ...

Abstract	Introduction: The impact of renal allograft rejection treatment on infection development has not been formally defined in the literature. Methods: We conducted a retrospective cohort study of 185 rejection (case) and 185 nonrejection (control) kidney transplant patients treated at our institution from 2014 to 2020 to understand the impact of rejection on infection development. Propensity scoring was used to match cohorts. We collected data for infections within 6 months of rejection for the cases and 18 months posttransplant for controls. Results: In 370 patients, we identified 466 infections, 297 in the controls, and 169 in the cases. Urinary tract infections (38.9%) and cytomegalovirus viremia (13.7%) were most common. Cumulative incidence of infection between the case and controls was 2.17 (CI 1.54-3.05); Conclusions: As previously understood, rejection treatment is a risk factor for subsequent infection development. Our data have defined this relationship more clearly. This study is unique, however, in that we found that infections, but not rejection, negatively impacted both overall patient survival and allograft survival, likely due to our institution's robust post-rejection protocols. Clinicians should monitor patients closely for infections in the post-rejection period and have a low threshold to treat these infections while also restarting appropriate prophylaxis.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2503421-2
ISSN	2090-0015 ; 2090-0007
ISSN (online)	2090-0015
ISSN	2090-0007
DOI	10.1155/2024/6663086
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Article ; Online: Outcomes with transplanting kidneys offered through expedited allocation.

Jadlowiec, Caroline C / Ohara, Stephanie Y / Punukollu, Rachana / Wagler, Josiah / Ruch, Brianna / Kumm, Kayla / Budhiraja, Pooja / Me, Hay Me / Mathur, Amit K / Reddy, Kunam S / Khamash, Hasan / Heilman, Raymond

Clinical transplantation

2023 Volume 37, Issue 11, Page(s) e15094

Abstract: Introduction: Expedited out-of-sequence deceased donor kidney allocation is a strategy to avoid discards after early placement attempts have been unsuccessful. Our study aimed to assess outcomes and characteristics of these transplanted kidneys.: ... ...

Abstract	Introduction: Expedited out-of-sequence deceased donor kidney allocation is a strategy to avoid discards after early placement attempts have been unsuccessful. Our study aimed to assess outcomes and characteristics of these transplanted kidneys. Methods: KDPI matching was performed between expedited allocation (EA) and standard allocation (SA) deceased donor kidney transplants performed at our center. Results: Between 2018 and 2021, there were 225 EA offers, and 189 (84%) were transplanted. EA recipients were older (p = .007) and had shorter dialysis vintage (p < .0001). EA kidneys were likely to be nationally allocated (p < .001), have AKI (p < .0001) and longer CIT (p < .0001). There were no differences in EA and SA time-zero kidney biopsies (ci, p = .07; ct, p = .89; cv, p = .95; ah, p = .79). EA kidneys had more DGF (p = .0006), but there were no differences in DGF duration (p = .83), hospital length of stay (p = .43), 1- and 2-year eGFR (p = .16, p = .99), patient (p = .34), or death-censored graft (p = .66) survival. Conclusion: During this study period, our center transplanted 189 kidneys through EA following local-regional declines. These kidneys often came from AKI donors and had more DGF but had similar outcomes to KDPI-matched SA kidneys. Although it has been suggested that EA has the potential to worsen transplant disparities, transplant center level decisions on organ acceptance contribute to these variations.
MeSH term(s)	Humans ; Tissue and Organ Procurement ; Kidney Transplantation ; Graft Survival ; Kidney ; Tissue Donors ; Acute Kidney Injury
Language	English
Publishing date	2023-08-10
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15094
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Zs.A 2204: Show issues

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Article ; Online: Utilizing kidneys from a donor with bile-cast nephropathy.

Me, Hay Me / Budhiraja, Pooja / Nair, Sumi / Kodali, Lavanya / Ryan, Margaret / Khamash, Hasan / Heilman, Raymond / Wagler, Josiah / Ruch, Brianna / Jadlowiec, Caroline C / Moss, Adyr / Reddy, Kunam S

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2023 Volume 24, Issue 1, Page(s) 141–144

Abstract: Here we discuss the successful utilization of a pair of deceased donor kidneys with bile-cast nephropathy. The donor had a kidney donor profile index of 48% and an acute kidney injury requiring continuous renal replacement therapy. Peak donor bilirubin ... ...

Abstract	Here we discuss the successful utilization of a pair of deceased donor kidneys with bile-cast nephropathy. The donor had a kidney donor profile index of 48% and an acute kidney injury requiring continuous renal replacement therapy. Peak donor bilirubin was 40.5 mg/dL, and renal wedge biopsies showed bile-cast nephropathy. Both recipients had delayed graft function lasting up to 4 weeks. The 4-month biopsies showed mild interstitial fibrosis, tubular atrophy, and a resolution of bile casts. These kidney allografts showed the reversible course of cholemic nephropathy and the potential for increasing the utilization of previously discarded kidneys.
MeSH term(s)	Humans ; Bile ; Kidney/pathology ; Kidney Transplantation/adverse effects ; Acute Kidney Injury/etiology ; Transplantation, Homologous ; Tissue Donors ; Biopsy ; Graft Survival
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1016/j.ajt.2023.08.018
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Zs.A 5542: Show issues

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Article ; Online: Outcomes of asymptomatic histologic pyelonephritis of kidney transplant.

Budhiraja, Pooja / Butterfield, Richard / Gea-Banacloche, Juan / Swaminathan, Sundararaman / Smith, Maxwell L / Khamash, Hassan A / Me, Hay Me / Kodali, Lavanya / Mour, Girish K / Nair, Sumi / Misra, Suman / Heilman, Raymond L

Clinical transplantation

2023 Volume 37, Issue 12, Page(s) e15125

Abstract: Background: Urinary Tract Infections are the most common post-transplant infection and can have varied presentations. This study aimed to describe the outcomes of kidney transplant recipients with asymptomatic histologic pyelonephritis on allograft ... ...

Abstract	Background: Urinary Tract Infections are the most common post-transplant infection and can have varied presentations. This study aimed to describe the outcomes of kidney transplant recipients with asymptomatic histologic pyelonephritis on allograft biopsy. Histologic Pyelonephritis was defined as neutrophil cast or neutrophilic tubulitis, interstitial infiltrates with predominant neutrophils, and no evidence of rejection or glomerulonephritis on biopsy. Methods: The study included 123 kidney transplant recipients, of whom 95 underwent protocol biopsies, and 28 had biopsies for elevated creatinine within the first 2 years of a kidney transplant. Results: The mean age of the cohort was 55.3 years, with 52% females and 78% deceased donor transplants. The risk factors for asymptomatic histologic pyelonephritis were recipient female sex (OR 1.89, 1.3-2.7, diabetes mellitus (OR 2.479, 1.687-3.645), and deceased donation (OR 1.69, 1.098-2.63). The incidence of asymptomatic pyelonephritis on protocol biopsy was 1.7%, with 52% having positive urine cultures and Escherichia coli being the most common bacteria. Subjects with asymptomatic pyelonephritis had inferior graft survival compared to the matched cohort HR 1.88 (1.06-3.35), p = .0281. In addition, of these 123 subjects, 68 (55%) subsequently developed pyelonephritis, and 34 subjects had pyelonephritis within 6 months after this episode. Subjects with recurrent infections exhibited lower survival HR 2.86 (1.36-6.02) and a trend toward higher rejection risk. Conclusion: Asymptomatic histologic pyelonephritis can occur in kidney transplant recipients and is associated with inferior graft survival.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Kidney Transplantation/adverse effects ; Pyelonephritis/etiology ; Pyelonephritis/pathology ; Urinary Tract Infections/etiology ; Transplantation, Homologous ; Bacteria ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Rejection/epidemiology ; Graft Survival ; Kidney/pathology
Language	English
Publishing date	2023-09-13
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15125
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Zs.A 2204: Show issues

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Article: Favorable Outcomes in Older Recipients Receiving Simultaneous Pancreas Kidney Transplantation.

Budhiraja, Pooja / Heilman, Raymond L / Reddy, Kunam S / Jadlowiec, Caroline C / Khamash, Hassan A / Ninan, Jacob / Reddy, Swetha / Me, Hay Me / Misra, Suman / Katariya, Nitin / Chakkera, Harini A

Transplantation direct

2022 Volume 8, Issue 12, Page(s) e1413

Abstract: The objective of this study was to compare the long-term outcomes of older (50-65 y) type 1 diabetics with body mass index <35 kg/m: Methods: This is a retrospective single-center study from July 2003 to March 2021 with a median follow-up of 7.5 y.: ...

Abstract	The objective of this study was to compare the long-term outcomes of older (50-65 y) type 1 diabetics with body mass index <35 kg/m Methods: This is a retrospective single-center study from July 2003 to March 2021 with a median follow-up of 7.5 y. Results: There were 104 recipients in the SPKT and 80 in the LDKT group. The mean age was 56 y in SPKT and 58 y in LDKT. There were 55% male recipients in the SPKT group versus 75% in LDKT. The duration of diabetes was 32 y in SPKT versus 25 y in LDKT. The number of preemptive transplants and length of dialysis were similar. However, the wait time was shorter for LDKT (269 versus 460 d). Forty-nine percent of the LDKT recipients received the organ within 6 mo of being waitlisted compared with 28% of SPKT recipients ( Conclusions: SPKT in selected recipients aged 50 and above can have excellent outcomes similar to LDKT recipients.
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001413
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Article ; Online: Direct Correlation of Soluble HLA and HLA-Containing Exosomes and Inverse Correlation of Tolerance Marker-Containing Exosomes With Antibody-Mediated Rejection After Simultaneous Liver-Kidney Transplantation: A Case Study.

Me, Hay Me / Ravichandran, Ranjithkumar / Khamash, Hasan A / Nair, Sumi S / Hacke, Katrin / Ramon, Daniel S / Mohanakumar, T / Heilman, Raymond L / Jaramillo, Andrés

Transplantation proceedings

2022

Abstract: There is a lower incidence of antibody-mediated rejection (AMR) after simultaneous liver-kidney transplantation (SLKT) than after kidney-only transplantation. It has been suggested that soluble human leukocyte antigen (sHLA) produced by the liver ... ...

Abstract	There is a lower incidence of antibody-mediated rejection (AMR) after simultaneous liver-kidney transplantation (SLKT) than after kidney-only transplantation. It has been suggested that soluble human leukocyte antigen (sHLA) produced by the liver protects the kidney from AMR. However, this hypothesis has not been tested after SLKT. We present a case of SLKT with 2 donor-specific antibodies (DSAs) (DR53, 12,364 mean fluorescence intensity [MFI]; DQ7, 1253 MFI) that displayed a decrease by day 7 (DR53, 2747 MFI; DQ7, 107 MFI). On day 351, the patient was diagnosed with kidney AMR associated with high levels of DSA (DR53, 18,542 MFI; DQ7, 22,007 MFI) that persisted until day 531. High levels of sHLA-DR/DQ and HLA-DR/DQ-containing exosomes were also detected on day 398. Consequently, the patient underwent treatment with plasmapheresis, intravenous immunoglobulin, prednisone, and rituximab. On day 752, biopsy results were negative for AMR. Moderate levels of DSA (DR53, 9798 MFI; DQ7, 1271 MFI), and baseline levels of sHLA-DR/DQ and HLA-DR/DQ-containing exosomes were observed. Increases in CD4
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.10.025
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Zs.A 835: Show issues

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Article ; Online: Infections following rejection therapies in kidney and liver transplant recipients.

Gupta, Simran / Gea-Banacloche, Juan / Me, Hay-Me / Chascsa, David M H / Heilman, Raymond L / Budhiraja, Pooja / Yaman, Reena N / Vikram, Holenarasipur R / Zhang, Nan / Joseph, Anna M / Kodali, Lavanya

Transplant infectious disease : an official journal of the Transplantation Society

2022 , Page(s) e13981

Abstract: Introduction: Infections are known complications of solid-organ transplant. Treatment for rejection may increase risk of infection. We aimed to study frequency of infection and identify the risk factors for infections in solid organ transplant (SOT) ( ... ...

Abstract	Introduction: Infections are known complications of solid-organ transplant. Treatment for rejection may increase risk of infection. We aimed to study frequency of infection and identify the risk factors for infections in solid organ transplant (SOT) (liver and kidney) recipients treated for rejection. Methods: This is a retrospective chart review of all liver and kidney transplant recipients treated for rejection at our institution from 2014 to 2020. We collected information on episodes of acute rejection in the first year of transplant and infections within 6 months following rejection treatment. Results: We identified 257 transplant patients treated for rejection. One hundred twelve (43.6%) developed infections, with a total of 226 infections. Urinary tracts infections were the most common, 72 (31.9%), followed by cytomegalovirus viremia in 37 (16.4%), bacteremia in 24 (10.6%), and BK virus in 14 (6.2%). Female sex (p = .047), elevated neutrophil count at rejection (p = .002), and increased number of rejection episodes (p = .022) were predictors of infection in kidney and simultaneous liver-kidney recipients. No specific type of induction or rejection therapy was identified as a risk factor for infection, likely due to the prophylaxis protocols at our institution. Infection post rejection treatment was associated with higher graft loss (p = .021) and mortality (p = .031) in kidney transplant recipients. Conclusions: Infections are common complications after treatment of SOT rejection. Female gender, higher neutrophil at time of rejection, and increased numbers of rejection episodes were predictors of infections after rejection in simultaneous liver-kidney and kidney transplant patients. Infections were predictors of graft loss at 6 months and mortality at any point in follow-up in kidney transplant patients.
Language	English
Publishing date	2022-10-27
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13981
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Zs.A 5100: Show issues

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Article: Community acquired

Lee, Bianca / Yeroushalmi, Kevin / Me, Hay Me / Sojitra, Paresh / Jilani, Usman / Iqbal, Syed / Ahmed, Shadab / Verley, Janice / Akella, Jagadish

Germs

2018 Volume 8, Issue 2, Page(s) 92–95

Abstract: Introduction: Klebsiella pneumoniae: Case report: We report a clinical case of adult community acquired : Conclusion: Our case highlights the importance of ... ...

Abstract	Introduction: Klebsiella pneumoniae Case report: We report a clinical case of adult community acquired Conclusion: Our case highlights the importance of suspecting
Language	English
Publishing date	2018-06-04
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2649305-6
ISSN	2248-2997
ISSN	2248-2997
DOI	10.18683/germs.2018.1136
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