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  1. Article ; Online: Intermediate Care in Italy: Addressing the Challenges and Opportunities for Person-Tailored Care.

    Boccardi, Virginia / Mecocci, Patrizia

    Geriatrics (Basel, Switzerland)

    2023  Volume 8, Issue 3

    Abstract: The concept of intermediate care is gaining increasing recognition in Italy as a critical strategy for improving quality of care and promoting the integration of healthcare services across different settings. This is driven by demographic changes and the ...

    Abstract The concept of intermediate care is gaining increasing recognition in Italy as a critical strategy for improving quality of care and promoting the integration of healthcare services across different settings. This is driven by demographic changes and the growing prevalence of chronic conditions. One of the key challenges in delivering intermediate care in Italy is ensuring that care is person-tailored, which requires a shift towards a more holistic approach that prioritizes individual preferences and values. This requires greater collaboration and communication across different healthcare settings and a coordinated approach to the delivery of care that promotes innovation and the use of technology to support remote monitoring and care delivery. Despite these challenges, intermediate care offers significant opportunities with which to enhance the quality of care, reduce healthcare costs, and promote social cohesion as well as community engagement. Overall, a coordinated and comprehensive approach is required to address the challenges and opportunities associated with intermediate care and to deliver person-tailored care that improves health outcomes as well as sustainability in Italy.
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Editorial
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics8030059
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  2. Article ; Online: Water intake, hydration and Parkinson's disease.

    Boccardi, Virginia / Mecocci, Patrizia

    Aging clinical and experimental research

    2022  Volume 34, Issue 12, Page(s) 3163

    MeSH term(s) Humans ; Drinking ; Parkinson Disease ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-11-08
    Publishing country Germany
    Document type Letter
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02285-8
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    Zs.A 3343: Show issues Location:
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  3. Article ; Online: Modeling the dynamics of energy imbalance: The free radical theory of aging and frailty revisited.

    Polidori, Maria Cristina / Mecocci, Patrizia

    Free radical biology & medicine

    2022  Volume 181, Page(s) 235–240

    Abstract: The role of oxidative stress in aging and the newly conceptualized vision of frailty is of great interest for the possibility to define a framework able to explain the several modifications observed in all biological molecules along with age. In this ... ...

    Abstract The role of oxidative stress in aging and the newly conceptualized vision of frailty is of great interest for the possibility to define a framework able to explain the several modifications observed in all biological molecules along with age. In this review, the impact of oxidative stress is considered in aging processes as well as in frailty, the geriatric concept of declined capacity to cope with any stressor, leading to a status of reduced ability to maintain the homeostatic balance. Although some pharmacological and behavioral approaches have been proposed, we are still lacking efficacious management able to prevent and avoid frailty. This represents a fundamental challenge for future research in this field.
    MeSH term(s) Adaptation, Psychological ; Aged ; Aging ; Frailty ; Free Radicals ; Humans ; Oxidative Stress
    Chemical Substances Free Radicals
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2022.02.009
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    Zs.A 2109: Show issues Location:
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  4. Article ; Online: Senotherapeutics: Targeting senescent cells for the main age-related diseases.

    Boccardi, Virginia / Mecocci, Patrizia

    Mechanisms of ageing and development

    2021  Volume 197, Page(s) 111526

    Abstract: The review aims to summarize and discuss the current knowledge on targeting senescent cells to reduce the risk of age-related diseases in animal models and human studies. The role of cellular senescence in aging and the major age-related diseases - ... ...

    Abstract The review aims to summarize and discuss the current knowledge on targeting senescent cells to reduce the risk of age-related diseases in animal models and human studies. The role of cellular senescence in aging and the major age-related diseases -including Alzheimer's disease, atherosclerosis, and type 2 diabetes- as well as the use of senotherapeutic strategies in both experimental and preclinical studies, will be described. A large number of molecules, including synthetic agents and natural compounds, have been proposed for anti-senescence activities. Research on senotherapeutics, which includes senolytic and senomorphic, has a growing interest, and their safety and reliability as anti-aging drugs have been tested in clinical trials. Initial findings suggest that the senotherapeutic approach may be translatable to humans. Due to the lack of evidence, caution must be used against senolytic agents due to their potential side-effects. In this context, natural senolytic compounds should have the advantage of low toxicity and potentially more useful in humans, although the mechanisms of action need to be defined.
    MeSH term(s) Aging/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Cellular Senescence ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Senotherapeutics/therapeutic use
    Chemical Substances Senotherapeutics
    Language English
    Publishing date 2021-06-21
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2021.111526
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    Zs.A 1012: Show issues Location:
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  5. Article ; Online: Focus on senescence: Clinical significance and practical applications.

    Boccardi, Virginia / Orr, Miranda Ethel / Polidori, M Cristina / Ruggiero, Carmelinda / Mecocci, Patrizia

    Journal of internal medicine

    2024  Volume 295, Issue 5, Page(s) 599–619

    Abstract: The older population is increasing worldwide, and life expectancy is continuously rising, predominantly thanks to medical and technological progress. Healthspan refers to the number of years an individual can live in good health. From a gerontological ... ...

    Abstract The older population is increasing worldwide, and life expectancy is continuously rising, predominantly thanks to medical and technological progress. Healthspan refers to the number of years an individual can live in good health. From a gerontological viewpoint, the mission is to extend the life spent in good health, promoting well-being and minimizing the impact of aging-related diseases to slow the aging process. Biologically, aging is a malleable process characterized by an intra- and inter-individual heterogeneous and dynamic balance between accumulating damage and repair mechanisms. Cellular senescence is a key component of this process, with senescent cells accumulating in different tissues and organs, leading to aging and age-related disease susceptibility over time. Removing senescent cells from the body or slowing down the burden rate has been proposed as an efficient way to reduce age-dependent deterioration. In animal models, senotherapeutic molecules can extend life expectancy and lifespan by either senolytic or senomorphic activity. Much research shows that dietary and physical activity-driven lifestyle interventions protect against senescence. This narrative review aims to summarize the current knowledge on targeting senescent cells to reduce the risk of age-related disease in animal models and their translational potential for humans. We focused on studies that have examined the potential role of senotherapeutics in slowing the aging process and modifying age-related disease burdens. The review concludes with a general discussion of the mechanisms underlying this unique trajectory and its implications for future research.
    MeSH term(s) Animals ; Humans ; Clinical Relevance ; Aging ; Longevity ; Life Expectancy ; Cellular Senescence
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13775
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  6. Article ; Online: The Potential of Fasting-Mimicking Diet as a Preventive and Curative Strategy for Alzheimer's Disease.

    Boccardi, Virginia / Pigliautile, Martina / Guazzarini, Anna Giulia / Mecocci, Patrizia

    Biomolecules

    2023  Volume 13, Issue 7

    Abstract: This review examines the potential of fasting-mimicking diets (FMDs) in preventing and treating Alzheimer's disease (AD). FMDs are low-calorie diets that mimic the physiological and metabolic effects of fasting, including the activation of cellular ... ...

    Abstract This review examines the potential of fasting-mimicking diets (FMDs) in preventing and treating Alzheimer's disease (AD). FMDs are low-calorie diets that mimic the physiological and metabolic effects of fasting, including the activation of cellular stress response pathways and autophagy. Recent studies have shown that FMDs can reduce amyloid-beta accumulation, tau phosphorylation, and inflammation, as well as improve cognitive function in animal models of AD. Human studies have also reported improvements in AD biomarkers, cognitive functions, and subjective well-being measures following FMDs. However, the optimal duration and frequency of FMDs and their long-term safety and efficacy remain to be determined. Despite these uncertainties, FMDs hold promise as a non-pharmacological approach to AD prevention and treatment, and further research in this area is warranted.
    MeSH term(s) Animals ; Humans ; Alzheimer Disease/prevention & control ; Alzheimer Disease/metabolism ; Fasting/physiology ; Diet ; Amyloid beta-Peptides/metabolism ; Caloric Restriction ; tau Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13071133
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  7. Article ; Online: A blast from the past: To tame time with metformin.

    Xenos, Dionysios / Mecocci, Patrizia / Boccardi, Virginia

    Mechanisms of ageing and development

    2022  Volume 208, Page(s) 111743

    Abstract: The strong evidence of metformin use in subjects affected by type 2 diabetes (T2DM) on health outcomes, together with data from pre-clinical studies, has led the gerontological research to study the therapeutic potential of such a drug as a slow-aging ... ...

    Abstract The strong evidence of metformin use in subjects affected by type 2 diabetes (T2DM) on health outcomes, together with data from pre-clinical studies, has led the gerontological research to study the therapeutic potential of such a drug as a slow-aging strategy. However, despite clinical use for over fifty years as an anti-diabetic drug, the mechanisms of action beyond glycemic control remain unclear. In this review, we have deeply examined the literature, doing a narrative review from the metformin story, through mechanisms of action to slow down aging potential, from lower organisms to humans. Based on the available evidence, we conclude that metformin, as shown in lower organisms and mice, may be effective in humans' longevity. A complete analysis and follow-up of ongoing clinical trials may provide more definitive answers as to whether metformin should be promoted beyond its use to treat T2DM as a drug that enhances both healthspan and lifespan.
    MeSH term(s) Humans ; Mice ; Animals ; Metformin/pharmacology ; Metformin/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Longevity ; Aging ; Geriatrics ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Metformin (9100L32L2N) ; Hypoglycemic Agents
    Language English
    Publishing date 2022-10-22
    Publishing country Ireland
    Document type Review ; Journal Article
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111743
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    Zs.A 1012: Show issues Location:
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  8. Article ; Online: The impact of aging in dementia: It is time to refocus attention on the main risk factor of dementia.

    Mecocci, Patrizia / Boccardi, Virginia

    Ageing research reviews

    2020  Volume 65, Page(s) 101210

    Abstract: Alzheimer's disease (AD) represents the most common form of dementia among old age subjects, and despite decades of studies, the underlying etiopathogenetic mechanisms remain unsolved, and no cure is available. The amyloid hypothesis has been recently ... ...

    Abstract Alzheimer's disease (AD) represents the most common form of dementia among old age subjects, and despite decades of studies, the underlying etiopathogenetic mechanisms remain unsolved, and no cure is available. The amyloid hypothesis has been recently questioned due to the failure of amyloid-centered treatments. The fact that cognitively normal old age subjects have substantial amyloid deposition in the brain comparable to the levels observed in AD patients suggests that amyloid accumulation may enter into the normal process of aging and what really triggers neuronal death and clinical manifestation is the loss of function due to an energetic failure. With this viewpoint article, we aim to challenge the traditional view of amyloid as the leading cause of AD. Conversely, we propose the core feature of aging, that is the progressive brain energy decline, as the main risk factor for dementia in older persons. Thus, a bioenergetic deficit secondary to mitochondrial dysfunction may lead to progressive neuronal death and clinical expression of dementia. The optimization of brain energetics should become a key component in future strategies for preventing and treating dementia.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/epidemiology ; Alzheimer Disease/etiology ; Amyloid beta-Peptides/metabolism ; Attention ; Brain/metabolism ; Humans ; Risk Factors
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2020.101210
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    Zs.A 5579: Show issues Location:
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  9. Article ; Online: Editorial for the Special Issue "Molecular Bases of Senescence".

    Fanò-Illic, Giorgio / Fulle, Stefania / Mecocci, Patrizia

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: The increasing life expectancy of populations worldwide represents the most evident success of the last century thanks to varying interacting social and medical achievements [ ... ]. ...

    Abstract The increasing life expectancy of populations worldwide represents the most evident success of the last century thanks to varying interacting social and medical achievements [...].
    MeSH term(s) Cellular Senescence ; Humans ; Life Expectancy
    Language English
    Publishing date 2021-11-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222111873
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  10. Article ; Online: DPP-4 inhibitors: meeting the needs of the very old population.

    Boccardi, Virginia / Mecocci, Patrizia

    Acta diabetologica

    2019  Volume 56, Issue 7, Page(s) 819

    MeSH term(s) Diabetes Mellitus, Type 2 ; Dipeptidyl-Peptidase IV Inhibitors ; Humans
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2019-03-28
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-019-01329-2
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    Zs.A 611: Show issues Location:
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