Article ; Online: NAADP-Evoked Ca
International journal of molecular sciences
2023 Volume 24, Issue 6
Abstract: Huntington's disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N- ... ...
| Abstract | Huntington's disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N-terminal region of the huntingtin, which form abnormal conformations and aggregates. Alterations in Ca |
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| MeSH term(s) | Mice ; Animals ; Calcium Channels/metabolism ; Astrocytes/metabolism ; Neurodegenerative Diseases/metabolism ; NADP/metabolism ; Lysosomes/metabolism ; Autophagy ; Calcium/metabolism ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism |
| Chemical Substances | Calcium Channels ; NAADP (5502-96-5) ; NADP (53-59-8) ; Calcium (SY7Q814VUP) ; Huntingtin Protein |
| Language | English |
| Publishing date | 2023-03-15 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms24065593 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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