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  1. Article ; Online: Non-zero-sum game of transfusions: EOL in leukemia.

    Medeiros, Bruno C

    Blood

    2018  Volume 132, Issue 7, Page(s) 676–678

    MeSH term(s) Hospices ; Humans ; Leukemia ; Platelet Transfusion ; Terminal Care
    Language English
    Publishing date 2018-08-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-06-856336
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  2. Article ; Online: Chemotherapy based combinations in AML: Time to take a step back?

    Medeiros, Bruno C

    Leukemia research

    2018  Volume 73, Page(s) 39–40

    MeSH term(s) Anthracyclines ; Drug Therapy, Combination ; Humans ; Leukemia, Myeloid, Acute ; Vidarabine/analogs & derivatives
    Chemical Substances Anthracyclines ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2018-08-31
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2018.08.018
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    Zs.A 1321: Show issues Location:
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  3. Article ; Online: Interpretation of clinical endpoints in trials of acute myeloid leukemia.

    Medeiros, Bruno C

    Leukemia research

    2018  Volume 68, Page(s) 32–39

    Abstract: Treatment regimens for acute myeloid leukemia (AML) have remained largely unchanged until recently. Molecular advances have opened the door to targeted therapies, many of which are in late-phase clinical trials. As new therapeutic opportunities arise, it ...

    Abstract Treatment regimens for acute myeloid leukemia (AML) have remained largely unchanged until recently. Molecular advances have opened the door to targeted therapies, many of which are in late-phase clinical trials. As new therapeutic opportunities arise, it is appropriate to review key aspects of clinical trial design, statistical interpretation of outcomes, and methods of data reporting. Complete remission and overall survival (OS) are common primary endpoints in early-phase AML clinical trials. OS and event-free survival are frequent primary endpoints in phase 3 trials. Clinical trials are designed to address the primary endpoint using prespecified α and power levels. Interpretation of additional endpoints (eg, secondary endpoints and subgroup analyses) must be viewed in light of a trial's statistical design. Furthermore, variations in reporting of endpoints must be considered in order to understand trial outcomes. Time-to-event endpoints are typically reported using Kaplan-Meier curves, which are visually informative. Statistical data derived from these curves can be complex, and a variety of factors may impact interpretation. The purpose of this review is to discuss the nuances of common AML trial endpoints and their data presentation to better inform evaluation and understanding of clinical trial data.
    MeSH term(s) Clinical Trials as Topic ; Data Interpretation, Statistical ; Endpoint Determination ; Humans ; Kaplan-Meier Estimate ; Leukemia, Myeloid, Acute/drug therapy ; Remission Induction ; Treatment Outcome
    Language English
    Publishing date 2018-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2018.02.002
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    Zs.A 1321: Show issues Location:
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  4. Article ; Online: Is there a standard of care for relapsed AML?

    Medeiros, Bruno C

    Best practice & research. Clinical haematology

    2018  Volume 31, Issue 4, Page(s) 384–386

    Abstract: Despite advances in treatment for acute myeloid leukemia (AML), the prognosis for patients with relapsed disease is extremely poor. The median overall survival for patients with relapsed AML ranges from 4-6 months and long-term survival from the time of ... ...

    Abstract Despite advances in treatment for acute myeloid leukemia (AML), the prognosis for patients with relapsed disease is extremely poor. The median overall survival for patients with relapsed AML ranges from 4-6 months and long-term survival from the time of relapse ranges from 5%-20%. Much of the difficulty in establishing a standard of care for relapsed AML is that the disease is clinically and genomically diverse. Nevertheless, significant progress has been made over the past 12 months with the approval of several agents, and the expectation is that additional therapies will be available soon. A brief review follows on the progress made in establishing a standard of care for relapsed AML.
    MeSH term(s) Disease-Free Survival ; Humans ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy ; Recurrence ; Survival Rate
    Language English
    Publishing date 2018-09-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2018.09.006
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  5. Article ; Online: Long non-coding RNAs: another brick in the wall of normal karyotype acute myeloid leukemia?

    Medeiros, Bruno C

    Haematologica

    2017  Volume 102, Issue 8, Page(s) 1301–1303

    MeSH term(s) Humans ; Karyotype ; Karyotyping ; Leukemia, Myeloid, Acute ; Prognosis ; RNA, Long Noncoding
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2017
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2017.171744
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  6. Article: Management of invasive Aspergillosis in acute myelogenous leukemia.

    Medeiros, Bruno C

    Clinical advances in hematology & oncology : H&O

    2016  Volume 14, Issue 7, Page(s) 502–504

    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Aspergillosis/etiology ; Aspergillosis/prevention & control ; Azoles/pharmacology ; Azoles/therapeutic use ; Disease Management ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/mortality ; Prognosis ; Risk Assessment ; Treatment Outcome
    Chemical Substances Antifungal Agents ; Azoles
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
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    Zs.A 6505: Show issues Location:
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  7. Article: Management considerations in older patients with AML: a 2014 perspective.

    Medeiros, Bruno C

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2014  Volume 55, Issue 10, Page(s) 1803–1807

    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Induction Chemotherapy ; Leukemia, Myeloid, Acute/therapy ; Middle Aged ; Predictive Value of Tests ; Quality of Life ; Remission Induction ; Stem Cell Transplantation ; Treatment Outcome
    Language Japanese
    Publishing date 2014
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
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    Zs.MO 535: Show issues

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  8. Article ; Online: Facts about FCE (fludarabine, cytarabine, etoposide) in acute myeloid leukemia.

    Medeiros, Bruno C

    Acta haematologica

    2014  Volume 131, Issue 4, Page(s) 200–201

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cytarabine/therapeutic use ; Drug Resistance, Neoplasm ; Etoposide/therapeutic use ; Female ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Male ; Salvage Therapy ; Vidarabine/analogs & derivatives ; Vidarabine/therapeutic use
    Chemical Substances Cytarabine (04079A1RDZ) ; Etoposide (6PLQ3CP4P3) ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000355134
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    Ud II Zs.145: Show issues Location:
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  9. Article ; Online: CD11b expression and MK+ AML: a sign of impending doom?

    Medeiros, Bruno C

    Leukemia research

    2013  Volume 37, Issue 2, Page(s) 121

    MeSH term(s) CD11b Antigen/metabolism ; Female ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Male ; Monosomy
    Chemical Substances CD11b Antigen
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2012.10.013
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    Zs.A 1321: Show issues Location:
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  10. Article ; Online: Epidemiology of invasive fungal diseases in adults with newly diagnosed acute myeloid leukemia.

    Miranti, Eugenia / Ho, Dora Y / Enriquez, Kyle / Subramanian, Aruna K / Medeiros, Bruno C / Epstein, David J

    Leukemia & lymphoma

    2022  Volume 63, Issue 9, Page(s) 2206–2212

    Abstract: Invasive fungal diseases (IFDs) are common in patients with acute myeloid leukemia (AML), but no recent data on incidence without antifungal prophylaxis are available. We evaluated the incidence of IFDs in patients with AML undergoing induction ... ...

    Abstract Invasive fungal diseases (IFDs) are common in patients with acute myeloid leukemia (AML), but no recent data on incidence without antifungal prophylaxis are available. We evaluated the incidence of IFDs in patients with AML undergoing induction chemotherapy at Stanford University Hospital from 2012 to 2017, for up to 12 weeks after induction. We also analyzed factors associated with IFD development. Thirty-six of 240 patients (13%) developed at least one proven or probable IFD. Seventy-eight percent of the proven or probable IFDs were due to Candida or Aspergillus species. Infection due to Fusarium and Mucorales was uncommon. Absolute neutrophil count (ANC) of <500 µL/L at the start of induction was associated with an increased risk of IFD. One hundred and eighty-seven patients (78%) were started on systemic antifungal drugs, even without microbiologic evidence of an IFD. IFDs remain frequent in AML patients undergoing induction chemotherapy without antifungal prophylaxis.
    MeSH term(s) Adult ; Antifungal Agents/therapeutic use ; Humans ; Incidence ; Induction Chemotherapy ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/epidemiology ; Invasive Fungal Infections/etiology ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/epidemiology ; Retrospective Studies
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2060504
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