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Article: Coronary sinus angioplasty to enable optimal left ventricular lead placement for resynchronization.

Medeiros, Paulo / Lousinha, Ana / Oliveira, Mário Martins

2023 Volume 9, Issue 6, Page(s) e16090

Language	English
Publishing date	2023-05-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Intrapericardial Cisplatin Instillation for Malignant Pericardial Effusion: A Single-center Experience.

Medeiros, Paulo / Rodrigues, Jorge / Gaspar, António

Arquivos brasileiros de cardiologia

2023 Volume 120, Issue 10, Page(s) e20220912

Title translation	Instilação Intrapericárdica de Cisplatina para Derrame Pericárdico Maligno: Uma Experiência em um Único Centro.
MeSH term(s)	Humans ; Cisplatin/therapeutic use ; Pericardial Effusion/drug therapy ; Lung Neoplasms/drug therapy ; Cardiac Tamponade ; Heart Neoplasms ; Antineoplastic Agents/therapeutic use
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents
Language	Portuguese
Publishing date	2023-09-26
Publishing country	Brazil
Document type	Letter
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20220912
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Article: The Effect of Sacubitril-Valsartan on Ventricular Arrhythmia Burden in Patients With Heart Failure With Reduced Ejection Fraction.

Medeiros, Paulo / Coelho, Cláudia / Costa-Oliveira, Cátia / Rocha, Sérgia

Cureus

2023 Volume 15, Issue 2, Page(s) e34508

Abstract: Introduction Heart failure with reduced ejection fraction (HFrEF) patients are prone to developing ventricular arrhythmias. In the PARADIGM-HF trial, sacubitril-valsartan (SV) showed a reduction in the composite endpoint of death and HF hospitalization ... ...

Abstract	Introduction Heart failure with reduced ejection fraction (HFrEF) patients are prone to developing ventricular arrhythmias. In the PARADIGM-HF trial, sacubitril-valsartan (SV) showed a reduction in the composite endpoint of death and HF hospitalization in HFrEF patients; subgroup analysis of this trial revealed a reduction in both sudden death and deaths from worsening HF. The mechanism by which SV may affect the incidence of ventricular arrhythmias is currently under debate, and the literature provides conflicting results. The aim of our study was to evaluate the potential antiarrhythmic effect of this drug in patients with HFrEF carrying an implantable cardiac defibrillator (ICD) or a cardiac resynchronization therapy with a defibrillator (CRT-D). Methods This was a single-center, observational and retrospective study. Inclusion criteria were implantation of an ICD or CRT-D device between 2009 and 2019, age ≥18 years, left ventricle ejection fraction (LVEF) ≤40%, New York Heart Association (NYHA) functional class ≥II, and treatment with an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker for at least 12 months, followed by replacement with SV. Exclusion criteria were NYHA class IV, frequent alterations in chronic medication for HFrEF, and implantation of an ICD or CRT-D after the introduction of SV. The primary outcome was the occurrence of ventricular arrhythmias in the form of appropriate device shocks, ventricular fibrillation, or ventricular tachycardia. The comparisons were performed between two periods of time (12 months before and 12 months after SV) in the same group of patients. Results Fifty-four patients met the inclusion criteria. The mean age was 69.5 ± 1.65 years, and 74.1% of patients were male. The number of patients experiencing appropriate shocks was significantly lower after SV initiation (2% vs. 18%; p=0.016). The percentage of VT (13 vs. 20%; p=0.549) and VF episodes (4% vs. 13% for VF; p=0.289) were also lower, but these differences were not statistically significant. There were no significant differences in the value of NT-proBNP (1128 vs. 775 pg/mL; p=0.858), LVEF (28.4 vs. 29.6%; p=0.315), and left ventricular end-diastolic diameter (65.0 vs. 66.0 mm; p=0.5492). Conclusion SV seems to reduce the risk of arrhythmic events requiring appropriate shock therapy.
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34508
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Article: The Impact of Left Ventricle Ejection Fraction Reduction and Transient Ischemic Dilation in Patients With Normal Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging.

Medeiros, Paulo / Pereira, Bárbara / Rodrigues, Jorge

Cureus

2022 Volume 14, Issue 12, Page(s) e32950

Abstract: Introduction: Coronary artery disease (CAD) is a leading cause of death in developed countries. Non-invasive functional imaging modalities are currently recommended as initial diagnostic tests in patients with an intermediate-high pretest probability of ...

Abstract	Introduction: Coronary artery disease (CAD) is a leading cause of death in developed countries. Non-invasive functional imaging modalities are currently recommended as initial diagnostic tests in patients with an intermediate-high pretest probability of CAD. Single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) creates images of regional myocardial tracer uptake, reflecting relative myocardial blood flow. However, there are other non-perfusion predictors of CAD, such as transient ischemic dilatation (TID) and reduced post-stress left ventricle ejection fraction (LVEF). Available data regarding these parameters is controversial. The aim of our study was to evaluate the incidence of significant CAD in patients with non-perfusion high-risk markers of ischemia despite a normal SPECT-MPI. Methods: Single-center, observational, retrospective, and longitudinal study. Inclusion criteria were age ≥18 years, normal SPECT-MPI, and availability of gated study for LVEF and volume analysis. Exclusion criteria were any known cardiomyopathy or congenital heart disease and known CAD. Non-perfusion high-risk markers: LVEF reduction ≥5% on post-stress images; TID (defined as a stress/rest left ventricle volume ratio ≥ 1.15), including end-systolic, end-diastolic, and mean volumes. The primary endpoint was the identification of significant CAD (stenosis >70% on an epicardial coronary artery or >50% on the left main artery) on invasive coronary angiography. Results: A total of 197 patients met the inclusion criteria. Mean age was 64 ± 12.6 years and 59.4% (n = 117) of patients were male. Overall, 26% of patients had LVEF reduction ≥5% on stress study; 24.9% had a stress/rest end-systolic volume ratio ≥ 1.15; 7.1% had a stress/rest mean volume ratio ≥ 1.15; 7.1% had a stress/rest end-diastolic volume ratio ≥ 1.15. Time-to-primary endpoint was significantly lower in patients with LVEF reduction ≥5% on stress study (67.99 (95% CI 60.49-75.49) vs. 77.56 months (95% CI 75.14-79.99); p = 0.003) and in patients with stress/rest end-systolic volume ratio ≥ 1.15 (68.39 (95% CI 60.69-76.10) vs. 77.31 months (95% ICCI 74.68-79.76); p = 0.013). Conclusion: In patients with normal perfusion on SPECT-MPI, the incidence of significant CAD was significantly higher in those with LVEF reduction ≥ 5% on stress study and in those with a stress/rest end-systolic volume ratio ≥ 1.15, during a follow-up period of five years.
Language	English
Publishing date	2022-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.32950
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Article ; Online: Right heart dilatation: role of cardiac magnetic resonance and computed tomography in the differential diagnosis.

Medeiros, Paulo Duarte Araújo Leite / Vieira, Catarina / Pereira, Vítor

The international journal of cardiovascular imaging

2022 Volume 38, Issue 10, Page(s) 2217–2218

MeSH term(s)	Humans ; Diagnosis, Differential ; Dilatation ; Predictive Value of Tests ; Cardiomegaly ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-022-02702-z
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Article ; Online: A Rare Subtype of a Rare Tumor.

Medeiros, Paulo / Coelho, Ana Rita / Magalhães, João / Salomé, Nuno / Pereira, Vítor

Arquivos brasileiros de cardiologia

2023 Volume 120, Issue 2, Page(s) e20220486

Title translation	Um Subtipo Raro de um Tumor Raro.
Language	Portuguese
Publishing date	2023-02-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20220486
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Article ; Online: Implantable cardioverter-defibrillator in patients with inherited arrhythmia syndromes: A systematic review.

Medeiros, Paulo / Santos, Maria / Arantes, Carina / Pereira, Vitor Hugo / Rocha, Sérgia

Heart & lung : the journal of critical care

2023 Volume 60, Page(s) 1–7

Abstract: Background: The potential benefit of implantable cardioverter-defibrillator (ICD) therapy in individuals with inherited arrhythmia syndromes is well known. However, it is not deprived of morbidity, in the form of inappropriate therapies and other ICD- ... ...

Abstract	Background: The potential benefit of implantable cardioverter-defibrillator (ICD) therapy in individuals with inherited arrhythmia syndromes is well known. However, it is not deprived of morbidity, in the form of inappropriate therapies and other ICD-related complications. Objective: The aim of this systematic review is to estimate the rate of appropriate and inappropriate therapy, as well as other ICD-related complications, in individuals with inherited arrhythmia syndromes. Methods: A systematic review was performed, regarding appropriate and inappropriate therapy, and other ICD-related complications, in individuals with inherited arrhythmia syndromes (Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Early Repolarization Syndrome, Long QT Syndrome and Short QT syndrome). Studies were identified by searching published papers in PubMed and Embase up to August 23rd, 2022. Results: From data gathered of 36 studies, with a total of 2750 individuals, during a mean follow-up time of 69 months, appropriate therapies occurred in 21% of the individuals and inappropriate therapies in 20% of the individuals. Concerning the other ICD-related complications, 456 complications were observed, amongst 2084 individuals (22%), with the most frequent being lead malfunction (46%), followed by infectious complications (13%). Conclusions: ICD-related complications are not uncommon, especially when one considers the exposure time of young individuals. The incidence of inappropriate therapies was 20%, although lower rates were reported in recent publications. S-ICD is an effective alternative to transvenous ICD for sudden death prevention. The decision to implant an ICD should be individualized, taking into account the risk profile of each patient, as well as the possibility of complications.
MeSH term(s)	Humans ; Defibrillators, Implantable/adverse effects ; Electrocardiography ; Arrhythmias, Cardiac/therapy ; Tachycardia, Ventricular ; Long QT Syndrome/therapy ; Death, Sudden, Cardiac/epidemiology ; Treatment Outcome
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2023.02.012
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Article ; Online: Infective endocarditis by a rare and fastidious agent:

Mosca, Ana Margarida / Mané, Fenando / Marques Pires, Carla / Medeiros, Paulo

BMJ case reports

2021 Volume 14, Issue 6

Abstract: Abiotrophia ... ...

Abstract	Abiotrophia defectiva
MeSH term(s)	Abiotrophia ; Adult ; Endocarditis ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Female ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/drug therapy ; Humans
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-241964
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Article ; Online: Validation of surgical care quality indicators in the Brazilian Unified Health System.

Caldas, Anna Cláudia Sales Gomes / Araújo, Rafael Santiago de / Medeiros, Paulo José / Freitas, Marise Reis de / Aledo, Victoriano Soria / Gama, Zenewton André da Silva

Revista de saude publica

2023 Volume 57, Page(s) 27

Abstract: Objective: To validate a set of indicators for monitoring the quality of surgical procedures in the Brazilian Unified Health System (SUS).: Methods: Validation study developed in 5 stages: 1) literature review; 2) prioritization of indicators; 3) ... ...

Abstract	Objective: To validate a set of indicators for monitoring the quality of surgical procedures in the Brazilian Unified Health System (SUS). Methods: Validation study developed in 5 stages: 1) literature review; 2) prioritization of indicators; 3) content validation of indicators by RAND/UCLA consensus method; 4) pilot study for reliability analysis; and 5) development of instruction for tabulation of outcome indicators for monitoring via official information systems. Results: From the literature review, 217 indicators of surgical quality were identified. The excluded indicators were: those based on scientific evidence lower than 1A, similar, specific, which corresponded to sentinel events; and those that did not apply to the SUS context. Twenty-six indicators with a high level of scientific evidence were submitted to expert consensus. Twenty-two indicators were validated, of which 14 process indicators and 8 outcome indicators with content validation index ≥80%. Of the validated process indicators, 6 were considered substantially reliable (Kappa coefficient between 0.6 and 0.8; p < 0.05) and 2 had almost perfect reliability (Kappa coefficient > 0.8, p < 0.05), when the inter-rater agreement was analyzed. One could measure and establish tabulation mechanism for TabWin for 7 outcome indicators. Conclusion: The study contributes to the development of a set of potentially effective surgical indicators for monitoring the quality of care and patient safety in SUS hospital services.
MeSH term(s)	Humans ; Brazil ; Pilot Projects ; Quality Indicators, Health Care ; Quality of Health Care ; Reproducibility of Results
Language	Portuguese
Publishing date	2023-04-28
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/s1518-8787.2023057004723
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Article ; Online: Negative self-perception of hearing and depression in older adults: a population-based study.

Paiva, Karina Mary de / Samelli, Alessandra Giannella / Oliveira, Pamela Lopes de / Hillesheim, Danúbia / Haas, Patrícia / Medeiros, Paulo Adão de / d'Orsi, Eleonora

Revista de saude publica

2023 Volume 57, Page(s) 15

Abstract: Objective: To estimate the association between negative self-perception of hearing and depression in older adults in Southern Brazil.: Methods: This is a cross-sectional study conducted with data from the third wave of the EpiFloripa Idoso 2017/19 ... ...

Abstract	Objective: To estimate the association between negative self-perception of hearing and depression in older adults in Southern Brazil. Methods: This is a cross-sectional study conducted with data from the third wave of the EpiFloripa Idoso 2017/19 study, a population-based cohort of older adults (60+). A total of 1,335 older adults participated in this wave. The dependent variable was self-reported depression, and the main exposure was self-perception of hearing (negative; positive). For both the crude (bivariate) and adjusted analysis, the odds ratio (OR) was used as a measure of association and estimated by means of binary logistic regression analysis. The exposure variable was adjusted by sociodemographic and health covariates. A p value < 0.05 was adopted as statistically significant. Results: The prevalence of negative self-perception of hearing and depression was 26.0% and 21.8%, respectively. In the adjusted analysis, the older adults with negative self-perception of hearing were 1.96 times more likely to report depression when compared to the ones with positive self-perception of hearing (p = 0.002). Conclusion: The association between negative self-perception of hearing and depression reflects the importance of reviewing health care actions for older adults, incorporating hearing-related issues, to ensure comprehensive care for this growing segment of the population.
MeSH term(s)	Humans ; Aged ; Hearing Loss/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Brazil/epidemiology ; Hearing ; Self Concept
Language	Portuguese
Publishing date	2023-04-14
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/s1518-8787.2023057004675
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