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  1. Book ; Online ; Thesis: Eine explorative Studie zur Untersuchung von Defiziten kortikaler Plastizität mittels transkranieller Magnetstimulation bei Patienten mit amnestischer leichter kognitiver Beeinträchtigung und Patienten mit Demenz vom Alzheimer-Typ im Vergleich zu gesunden Probanden

    Meder, Adam [Verfasser] / Ziemann, Ulf [Akademischer Betreuer]

    2022  

    Author's details Adam Meder ; Betreuer: Ulf Ziemann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Motor cortical excitability and paired-associative stimulation-induced plasticity in amnestic mild cognitive impairment and Alzheimer's disease.

    Meder, Adam / Liepelt-Scarfone, Inga / Sulzer, Patricia / Berg, Daniela / Laske, Christoph / Preische, Oliver / Desideri, Debora / Zipser, Carl M / Salvadore, Giacomo / Tatikola, Kanaka / Timmers, Maarten / Ziemann, Ulf

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Volume 132, Issue 9, Page(s) 2264–2273

    Abstract: Objective: Synaptopathy including alterations of synaptic plasticity (long-term potentiation, LTP) may precede neurodegeneration in Alzheimer's disease (AD). We studied LTP-like corticospinal plasticity induced by paired-associative stimulation (PAS: ... ...

    Abstract Objective: Synaptopathy including alterations of synaptic plasticity (long-term potentiation, LTP) may precede neurodegeneration in Alzheimer's disease (AD). We studied LTP-like corticospinal plasticity induced by paired-associative stimulation (PAS
    Methods: 15 AD and 15 aMCI patients, and 23 demographically matched healthy controls (HC) were included. Resting motor threshold (RMT) and stimulus intensity needed to evoke motor evoked potentials (MEP) of 1 mV (SI1mV) were obtained as single-pulse transcranial magnetic stimulation (TMS) measures of corticospinal excitability in a hand muscle at baseline, followed by PAS
    Results: SI1mV were lower in aMCI compared to HC, while there was no difference between AD and HC. RMT and SI1mV showed excellent test-retest reliability in all groups. PAS
    Conclusions: aMCI shows corticospinal hyperexcitability, consistent with glutamatergic excitotoxicity in early-stage AD. Possible abnormalities of LTP-like plasticity could not be reliably tested with the standard PAS
    Significance: Findings indicate corticospinal hyperexcitability in prodromal AD, and reliability of single-pulse TMS measures for identifying such abnormality. In contrast, the standard PAS
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/physiopathology ; Cognitive Dysfunction/physiopathology ; Evoked Potentials, Motor ; Female ; Humans ; Long-Term Potentiation ; Male ; Middle Aged ; Motor Cortex/physiopathology ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2021-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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