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  1. Article ; Online: Correction: Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital.

    Medetov, Yerkin / Babi, Aisha / Makhambetov, Yerbol / Menlibayeva, Karashash / Bex, Torekhan / Kaliyev, Assylbek / Akshulakov, Serik

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 374

    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02901-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary.

    Medetov, Yerkin / Babi, Aisha / Makhambetov, Yerbol / Menlibayeva, Karashash / Bex, Torekhan / Kaliyev, Assylbek / Akshulakov, Serik

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 357

    Abstract: Background: Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to ...

    Abstract Background: Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to establish the risk factors of RIA in the Kazakh population.  METHODS: Retrospective analysis of 762 patients with single IAs, who attended the neurosurgical center from 2008 until 2018, was conducted. Demographic characteristics, such as age, sex, smoking status, and hypertension were considered. Descriptive and bivariate analyses were performed. A multivariable logistic regression model was built to identify factors correlated with RIA.
    Results: The mean age of participants was 48.49 ± 0.44 years old. The majority (68.37%) of IAs have ruptured. Of the ruptured aneurysms, 43.76% were < 6 mm, and 38.39% were located on the anterior cerebral and anterior communicating arteries (ACA). Logistic regression model indicates younger age group (16-40 years), smoking, having stage 3 hypertension, smaller IA size and its location on ACA increase the odds of rupture.
    Conclusions: This study has revealed that younger, smoking patients with stage 3 arterial hypertension are at higher risk for RIA. Small aneurysms (< 6 mm) and location on ACA had increased odds of rupture, while larger aneurysms on internal carotid arteries had lower odds.
    MeSH term(s) Adolescent ; Adult ; Aneurysm, Ruptured/epidemiology ; Aneurysm, Ruptured/surgery ; China ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Intracranial Aneurysm/epidemiology ; Intracranial Aneurysm/surgery ; Middle Aged ; Retrospective Studies ; Risk Factors ; Young Adult
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02892-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of giant internal carotid aneurysm by extracranial-intracranial bypass and flow diverter stent.

    Kaliyev, Assylbek / Makhambetov, Yerbol / Medetov, Yerkin / Kulmirzayev, Marat / Dusembayev, Serik / Nurimanov, Chingiz / Kunakbayev, Baurzhan / Akshulakov, Serik

    British journal of neurosurgery

    2021  Volume 37, Issue 6, Page(s) 1893–1897

    Abstract: Flow diverter stents have become the standard approach to managing intracranial aneurysms; however, in some cases of complex, wide-necked aneurysms, poor outcomes due to stent occlusion have been reported. We report the case of a giant internal carotid ... ...

    Abstract Flow diverter stents have become the standard approach to managing intracranial aneurysms; however, in some cases of complex, wide-necked aneurysms, poor outcomes due to stent occlusion have been reported. We report the case of a giant internal carotid artery aneurysm treated by high-flow extracranial-intracranial (EC-IC) bypass with flow diverter deployment. Seven months post-operatively, radiographic imaging demonstrated occlusion of the stent and parent artery, with further ischemic events prevented by collateral flow from the high flow bypass. This case demonstrates the continued utility of EC-IC bypass in the endovascular era, especially as a rescue tool in cases of delayed stent occlusion.
    MeSH term(s) Humans ; Carotid Artery, Internal/diagnostic imaging ; Carotid Artery, Internal/surgery ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/surgery ; Neurosurgical Procedures/methods ; Stents ; Treatment Outcome
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2021.1947974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Activated leukocyte cell adhesion molecule/cluster of differentiation 166 rs10933819 (G>A) variant is associated with familial intracranial aneurysms.

    Aitkulova, Akbota / Mukhtarova, Kymbat / Zholdybayeva, Elena / Medetov, Yerkin / Dzhamantayeva, Botagoz / Kassymbek, Kuat / Utupov, Talgat / Akhmetollayev, Ilyas / Akshulakov, Serik / Kulmambetova, Gulmira / Ramankulov, Yerlan

    Biomedical reports

    2022  Volume 17, Issue 2, Page(s) 65

    Abstract: Rupture of intracranial aneurysms (IAs) is the most common cause of subarachnoid hemorrhage (SAH). Currently, there is sufficient evidence to indicate that inflammatory responses contribute to aneurysm rupture. Moreover, the familial occurrence of SAH ... ...

    Abstract Rupture of intracranial aneurysms (IAs) is the most common cause of subarachnoid hemorrhage (SAH). Currently, there is sufficient evidence to indicate that inflammatory responses contribute to aneurysm rupture. Moreover, the familial occurrence of SAH suggests that genetic factors may be involved in disease susceptibility. In the present study, a clinically proven case of IA in a patient who is a heterozygous mutation carrier of the activated leukocyte cell adhesion molecule (
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2022.1548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Early and midterm results of treatment of giant internal carotid artery paraclinoid aneurysms with trapping and flow diverters.

    Makhambetov, Yerbol / Kaliyev, Assylbek / Kikuta, Ken-Ichiro / Smagulov, Faizulla / Medetov, Yerkin / Kulmirzayev, Marat / Kerimbayev, Talgat / Kissamedenov, Nurlan / Tursynkhan, Aigerim / Doskaliyev, Aidos / Akshulakov, Serik

    Acta neurochirurgica

    2019  Volume 161, Issue 9, Page(s) 1755–1761

    Abstract: Background: Flow diverter devices (FDD) carry risks of postoperative complications when treating aneurysms with wide necks, stenosis, and severe tortuosity of the parent vessel. In this study, we evaluated early and midterm results for the treatment of ... ...

    Abstract Background: Flow diverter devices (FDD) carry risks of postoperative complications when treating aneurysms with wide necks, stenosis, and severe tortuosity of the parent vessel. In this study, we evaluated early and midterm results for the treatment of giant paraclinoid aneurysms managed by trapping and endovascular deployment of FDD.
    Methods: Medical records were analyzed for patients with giant paraclinoid aneurysms treated between July 2008 and December 2017 at National Centre for Neurosurgery with either a flow diverter or by trapping the aneurysm with or without extracranial-intracranial (EC-IC) bypass surgery. We recorded age, sex, clinical presentation, treatment modality, morbidity, and mortality. Clinical outcomes were assessed using a modified Rankin scale (mRS).
    Results: Among 29 consecutive patients, 13 were treated with FDD, and 16 patients were managed by trapping the aneurysm, where 7/16 cases had preliminary EC-IC bypass. Of 16 trapping patients, six were trapped endovascularly and ten were trapped surgically. During the follow-up period (mean 33 months, range 6-96), total exclusion of the aneurysm from the circulation was observed 100% of aneurysms in the trapping group and 84.6% in the FDD group (P = 0.192). Early postoperative morbidity was observed in three (23%) cases in the FDD group, and four (25%) in trapping group (P = 0.525). The FDD group had one (7.7%) fatal complication due to stent occlusion and severe ischemic stroke after three months postoperatively, despite appropriate antiplatelet therapy. There were no mortalities in the trapping group (P = 0.149). The rate of mRS 0-2 did not differ significantly across groups at discharge (81.3% vs. 69.2%; P = 0.667), and all patients had mRS 0-2 at follow-up (P = 1.000).
    Conclusions: FDD deployment for giant paraclinoid aneurysms results in comparable angiographic and clinical outcomes to aneurysm trapping. Despite implementation of modern endovascular treatment methods, aneurysm trapping remains a valuable treatment option in carefully selected patients with giant paraclinoid aneurysms.
    MeSH term(s) Adult ; Aged ; Carotid Artery, Internal/surgery ; Cerebral Revascularization/adverse effects ; Cerebral Revascularization/instrumentation ; Cerebral Revascularization/methods ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Endovascular Procedures/methods ; Female ; Humans ; Intracranial Aneurysm/surgery ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Stents/adverse effects
    Language English
    Publishing date 2019-07-15
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-019-04002-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population.

    Zholdybayeva, Elena V / Medetov, Yerkin Z / Aitkulova, Akbota M / Makhambetov, Yerbol T / Akshulakov, Serik K / Kaliyev, Assylbek B / Talzhanov, Yerkebulan A / Kulmambetova, Gulmira N / Iskakova, Aisha N / Ramankulov, Yerlan M

    Journal of molecular neuroscience : MN

    2018  Volume 66, Issue 1, Page(s) 135–145

    Abstract: An intracranial aneurysm (IA) is a weak or thin area on a blood vessel in the brain that balloons as it fills with blood. Genetic factors can influence the risk of developing an aneurism. The purpose of this study was to explore the relationship between ... ...

    Abstract An intracranial aneurysm (IA) is a weak or thin area on a blood vessel in the brain that balloons as it fills with blood. Genetic factors can influence the risk of developing an aneurism. The purpose of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) and IA in Kazakh population. The patients were genotyped for 60 single nucleotide polymorphisms. Genotyping was performed on the QuantStudio 12K Flex (Life Technologies). A linear regression analysis found 13 SNPs' significant association with development and rupture of IA: the rs1800956 polymorphism of the ENG gene, rs1756 46 polymorphism of the JDP2 gene, variant rs1800255 of the COL3A1, rs4667622 of the UBR3, rs2374513 of the c12orf75, rs3742321 polymorphism of the StAR, the rs3782356 polymorphism of MLL2 gene, rs3932338 to 214 kilobases downstream of PRDM9, rs7550260 polymorphism of the ARHGEF, rs1504749 polymorphism of the SOX17, the rs173686 polymorphism of CSPG2 gene, rs6460071 located on LIMK1 gene, and the rs4934 polymorphism of SERPINA3. A total of 13 SNPs were identified as potential genetic markers for the development and risk of rupture of aneurysms in the Kazakh population. Similar results were obtained after adjusting for the confounding factors of arterial hypertension and age.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Collagen Type III/genetics ; DNA-Binding Proteins/genetics ; Endoglin/genetics ; Female ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Intracranial Aneurysm/genetics ; Kazakhstan ; Lim Kinases/genetics ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Polymorphism, Single Nucleotide ; Repressor Proteins/genetics ; Rho Guanine Nucleotide Exchange Factors/genetics ; SOXF Transcription Factors/genetics ; Serpins/genetics ; Ubiquitin-Protein Ligases/genetics ; Versicans/genetics
    Chemical Substances ARHGEF1 protein, human ; COL3A1 protein, human ; Collagen Type III ; DNA-Binding Proteins ; ENG protein, human ; Endoglin ; JDP2 protein, human ; KMT2D protein, human ; Neoplasm Proteins ; Repressor Proteins ; Rho Guanine Nucleotide Exchange Factors ; SERPINA3 protein, human ; SOX17 protein, human ; SOXF Transcription Factors ; Serpins ; VCAN protein, human ; Versicans (126968-45-4) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; PRDM9 protein, human (EC 2.1.1.43) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; LIMK1 protein, human (EC 2.7.11.1) ; Lim Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2018-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-018-1134-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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