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Article: The Preventive Role of Atropine Eye Drops on Myopia Progression: A Double-Blind Randomized Clinical Trial.

Medghalchi, Abdolreza / Behboudi, Hasan / Akbari, Mitra / Moghadam, Reza Soltani / Kazemnejad, Ehsan / Sabnan, Salah

International journal of preventive medicine

2023 Volume 14, Page(s) 45

Abstract: Background: In the present study, we investigated the effect of two doses of atropine eye drops versus placebo on myopia progression in children and adolescents.: Methods: In this double-blind, randomized clinical trial, 67 patients aged 6 to 18 ... ...

Abstract	Background: In the present study, we investigated the effect of two doses of atropine eye drops versus placebo on myopia progression in children and adolescents. Methods: In this double-blind, randomized clinical trial, 67 patients aged 6 to 18 years with myopia of -2 to -6 D were enrolled and randomized to receive a placebo eye drop, atropine 0.1%, or 0.01% ophthalmic solution (one drop per night for 6 months). All participants were followed-up with for one year after the beginning of the study (at zero, one, three, six, and 12 months) and their spherical equivalent (SE), axial length (AL), anterior chamber depth (ACD), and far and near visual acuity (VA) and the eye drops side effects were recorded. A comparison among the groups was performed using SPSS software, version 24.0. Results: Spherical equivalent, AL, and ACD decreased and far VA improved in atropine groups to a greater extent than the placebo group ( Conclusions: Atropine eye drops are effective for slowing down and preventing myopia progression. However, without long-term treatment, they will have a rebound effect. A lower dose (0.01%) is suggested for reducing the side effects and rebound effects.
Language	English
Publishing date	2023-04-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2574680-7
ISSN	2008-8213 ; 2008-7802
ISSN (online)	2008-8213
ISSN	2008-7802
DOI	10.4103/ijpvm.ijpvm_175_22
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Article: Corneal Astigmatic and Refractive Changes after Rectus Muscle Surgery.

Medghalchi, Abdolreza / Akbari, Mitra / Moghadam, Reza Soltani / Kazemnejad, Ehsan / Hoseininejad, Reza

Maedica

2023 Volume 17, Issue 4, Page(s) 846–855

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-01-24
Publishing country	Romania
Document type	Editorial
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
DOI	10.26574/maedica.2022.17.4.846
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Article ; Online: Survey of Paralytic Strabismus

Medghalchi Abdolreza

Acta Medica Iranica, Vol 47, Iss 3, Pp 221-

A Regional Survay

2009 Volume 224

Abstract: One of the important causes of strabismus in all ages is extraocular muscles paralysis due to 3rd, 4th and 6th cerebral nerve palsies. Exact and on-time treatment can result in improvement of deviation, am-blyopia and abnormal head posture. We studied ... ...

Abstract	One of the important causes of strabismus in all ages is extraocular muscles paralysis due to 3rd, 4th and 6th cerebral nerve palsies. Exact and on-time treatment can result in improvement of deviation, am-blyopia and abnormal head posture. We studied epidemiological characteristics of extraocular muscles paralysis. This retrospective study performed on 131 subjects (58% male). Records of patients with diagnosis of paralytic strabismus referred to private clinics between 1995 and 2005 were studied and their demographic data and clinical characters were extracted and evaluated. Average age of patients was 23 years old. Unilateral involvement was seen in 94% of cases. The types of paralysis were 4th nerve (70.2%), 6th nerve (17.8%), 3rd nerve (12%) and all nerves palsy (3,4 Nerves) (2.2%). The most common causes of nerve injury were congenital (62.5%), trauma (19.8%), vascular (3.8%), iatrogenic (3%), tumor and aneurysm (2.2%) and miscellaneous (9%). The most common causes in 3rd nerve palsy were trauma (40%), congenital (20%), iatrogenic (10%), aneurysm (5%), vascular (5%) and miscellaneous (10%). Pupilary involvement was seen in 55% of cases and complete form of 3th nerve in 50% of patients. The most common causes in 4th nerve palsy were congenital (81.5%), traumatic (8.5%) and miscellaneous (10%). In 6th nerve palsy, the most common causes were trauma (50%), vascular (13.6%), congenital (9%). This study indicates that the most common type of palsy is 4th, 6th and 3rd nerves and the most common causes are congenital and trauma.
Keywords	Strabismus ; oculomotor Muscles ; oculomotor nerve diseases ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2009-10-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Closantel retinal toxicity: Recovery from severe vision loss after corticosteroid therapy.

Behboudi, Hassan / Alizadeh, Yousef / Medghalchi, Abdolreza / Soltani-Moghadam, Reza / Azaripour, Ebrahim / Moravvej, Zahra

European journal of ophthalmology

2022 Volume 33, Issue 4, Page(s) NP91–NP94

Abstract: Purpose: To present a relatively rare case of retinal toxicity and consequent severe vision loss due to Closantel ingestion.: Case report: A 37-year-old female presented with sudden painless decrease vision in both eyes. She had no previous history ... ...

Abstract	Purpose: To present a relatively rare case of retinal toxicity and consequent severe vision loss due to Closantel ingestion. Case report: A 37-year-old female presented with sudden painless decrease vision in both eyes. She had no previous history of medical disease and denied any trauma. The patient had accidentally ingested Closantel a few days prior to presentation. Closantel is a veterinary anti-helminthic drug used mainly in livestock. Best corrected visual acuity (BCVA) at presentation was 20/200 bilaterally. There was no relative afferent pupillary defect (RAPD) and red saturation test was normal. Macular optical coherence tomography (OCT) revealed disruption in the outer retinal layer and ellipsoid zone in both eyes. A diagnosis of retinal toxicity due to Closantel was made and the patient was started on 1 mg/kg oral prednisolone acetate. On the 45th day after presentation, her BCVA had improved to 20/20 bilaterally. Conclusion: Closantel is a potentially toxic drug causing destruction of the neurosensory retina and visual disturbances. We suggest eye-care personnel awareness regarding the risk of Closantel-induced retinal toxicity and prompt treatment with systemic steroids should be considered.
MeSH term(s)	Humans ; Female ; Adult ; Retina ; Salicylanilides/adverse effects ; Tomography, Optical Coherence ; Vision Disorders/chemically induced ; Adrenal Cortex Hormones
Chemical Substances	closantel (EUL532EI54) ; Salicylanilides ; Adrenal Cortex Hormones
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221111887
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Article: Role of Overcorrecting Minus Lens Therapy in Intermittent Exotropia for Prevention of Constant Exotropia in Children Under the Age of 7 Years.

Alizadeh, Yousef / Medghalchi, Abdolreza / Soltanipour, Soheil / Mohammadi, Mohammad J / Soltani-Moghadam, Reza / Behboudi, Hassan / Azaripour, Ebrahim / Soleimani, Altinai

International journal of preventive medicine

2023 Volume 14, Page(s) 80

Abstract: Background: The basis of the overcorrecting minus lens is to induce compliance and consequently prevent constant exotropia. Some previous studies advocated early surgical therapy and others suggested over-minus treatment. Our purpose is to evaluate the ... ...

Abstract	Background: The basis of the overcorrecting minus lens is to induce compliance and consequently prevent constant exotropia. Some previous studies advocated early surgical therapy and others suggested over-minus treatment. Our purpose is to evaluate the success rate of the over-minus lens. Methods: This descriptive cross-sectional study was carried out on 106 patients under the age of 7 years with intermittent exotropia (IXT) who attended Amir-Al-Momenin Hospital at Guilan University of Medical Sciences, Iran. The data was gathered by a form including sex, age, level of cycloplegic refraction, the amount of deviation before and after using the over-minus glasses, visual acuity, the amount of the over-minus glasses, duration of treatment, recovery, and follow-up. The success rate was defined as decreasing exotropia to less than ten prism diopters or exophoria. Results: A total of 106 patients with a mean age of 2.25 ± 0.74 years were enrolled in this study. The mean exotropia before and after treatment was 20.96 ± 8.20 and 12.16 ± 11.04 prism diopters, respectively, and there was a statistically significant difference ( Conclusions: According to the results of this study, treatment of IXT by over-correcting lenses can be a safe procedure and effective in preventing exotropia.
Language	English
Publishing date	2023-06-22
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2574680-7
ISSN	2008-8213 ; 2008-7802
ISSN (online)	2008-8213
ISSN	2008-7802
DOI	10.4103/ijpvm.ijpvm_130_22
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Article: Macular Optical Coherence Tomography before Cataract Surgery.

Alizadeh, Yousef / Akbari, Mitra / Moghadam, Reza Soltani / Medghalchi, Abdolreza / Dourandeesh, Maryam / Bromandpoor, Fariborz

Journal of current ophthalmology

2021 Volume 33, Issue 3, Page(s) 317–322

Abstract: Purpose: To determine the benefits of performing preoperative spectral domain optical coherence tomography (SD-OCT) and to identify occult macular pathologies in patients scheduled for routine cataract surgery.: Methods: In this cross-sectional study, ...

Abstract	Purpose: To determine the benefits of performing preoperative spectral domain optical coherence tomography (SD-OCT) and to identify occult macular pathologies in patients scheduled for routine cataract surgery. Methods: In this cross-sectional study, macular SD-OCT scans were performed on all patients with clinically undetected macular abnormalities who were scheduled for cataract surgery. Patients with clinically evident macular abnormalities were excluded from the study. A retinal specialist reviewed all the scans. The severity of the cataract was determined using the Oxford Clinical Cataract Classification and Grading System. Results: Of the 598 evaluated cases, 33 patients (5.52%) had an occult macular abnormality. The most common pathology found in these patients was idiopathic epiretinal membrane, which was detected in 17 eyes (51.52%), followed by vitreomacular traction in nine eyes (27.27%), and dry age-related macular degeneration in four eyes (12.12%). Full-thickness macular holes and a lamellar macular hole were found in two patients (6.06%) and one patient (3.03%), respectively. The frequency of cortical cataracts was significantly lower in patients without macular lesions ( Conclusions: Macular SD-OCT can be used to detect occult macular lesions and provide useful information about a macula before cataract surgery. Although preoperative OCT found macular abnormalities in about 5% of patients with presumed normal fundus examination, it can result in changing the surgical plan in 0.83% of all patients.
Language	English
Publishing date	2021-10-22
Publishing country	India
Document type	Journal Article
ISSN	2452-2325
ISSN	2452-2325
DOI	10.4103/joco.joco_240_20
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Article ; Online: Retinopathy of prematurity: applicability of international and national screening guidelines in the north of Iran.

Alizadeh, Yousef / Behboudi, Hassan / Dourandeesh, Maryam / Soltani-Moghadam, Reza / Akbari, Mitra / Medghalchi, Abdolreza / Azaripour, Ebrahim / Moravvej, Zahra

The Turkish journal of pediatrics

2022 Volume 64, Issue 2, Page(s) 221–227

Abstract: Background: To determine the applicability of current international and national retinopathy of prematurity (ROP) screening guidelines and to identify a suitable community-based screening criterion.: Methods: A retrospective study on premature ... ...

Abstract	Background: To determine the applicability of current international and national retinopathy of prematurity (ROP) screening guidelines and to identify a suitable community-based screening criterion. Methods: A retrospective study on premature neonates (≤37 weeks gestation) referred to a tertiary eye hospital ROP clinic in the north of Iran was conducted over a 10-year period. Neonates were classified as no ROP, with ROP and type 1 ROP. Data consisting of birth weight (BW), gestational age (GA) and chief risk factors were evaluated. Various screening criteria and currently established screening guidelines were applied and compared for applicability using a receiver operating characteristic curve. Results: A total of 716 neonates with a mean GA of 31.4 ± 2.8 weeks and BW of 1629 ± 502 grams were screened. The incidence of ROP was 22.9% and type 1 ROP requiring treatment was 0.28%. When applying the national Ministry of Health Guidelines, all neonates with type 1 ROP requiring treatment were identified; These criteria had a specificity of 7% for the diagnosis of type 1 ROP, and a large number of neonates (n=645) who are not at risk for type 1 ROP will be redundantly screened. Guidelines of the American Academy of Pediatrics and the UK would miss 4.5% of patients requiring ROP treatment. According to our data a threshold of GA≤32 weeks and/or BW ≤1600 grams demonstrated a sensitivity of 95.7% and specificity of 33.6% for the diagnosis of any ROP and a sensitivity of 100% and specificity of 26.8% for type 1 ROP requiring treatment. Conclusions: The ideal ROP screening guideline is one that is very sensitive and identifies patients requiring treatment without delay. To minimize redundant screening while maintaining optimum ROP requiring treatment diagnosis, we proposed a new local evidence-based screening guideline.
MeSH term(s)	Birth Weight ; Child ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Iran/epidemiology ; Neonatal Screening ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-05-21
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2021.1943
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Article ; Online: Survey of Nerve Fiber Layer Thickness in Anisometropic and Strabismic Amblyopia.

Soltani Moghaddam, Reza / Medghalchi, Abdolreza / Alizadeh, Yousef

Acta medica Iranica

2017 Volume 55, Issue 1, Page(s) 24–28

Abstract: To investigate the effect of anisometropic and strabismic amblyopia on the nerve fiber layer thickness. This cross-sectional study was done on 54 amblyopic subjects, equally in both strabismic and anisometropic groups. The thickness otonerve fiber ... ...

Abstract	. To investigate the effect of anisometropic and strabismic amblyopia on the nerve fiber layer thickness. This cross-sectional study was done on 54 amblyopic subjects, equally in both strabismic and anisometropic groups. The thickness otonerve fiber layer measured in superior, inferior, nasal, temporal quadrants and as a whole in both eyes of both groups. The means of thickness were compared in amblyopic and sound eyes. In strabismus group, the average nerve fiber layer thickness of the sound eye , in superior, inferior, nasal and temporal quadrants and as a whole were 113.23±14, 117.37±25, 68.96±6, 69.55±14 and 93.40±8 microns respectively. In amblyopic eyes of the same group, these measurements were 103.11±18, 67.74±11, and 69.59±16 and 89.59±12 microns in superior, inferior, nasal, temporal quadrants and as whole respectively. In anisometropic groups, the sound eye measurements were as 130.96±22, 129.07±29, 80.62±12, and 83.88±20 and 107.7±13 microns in superior, inferior, nasal and temporal quadrants and as a whole orderly. In amblyopic eyes of this group the mean thicknesses were 115.63±29, 133.15±25, 78.8±15, 80.2±16 and 109.17±21 microns in superior, inferior, nasal, temporal quadrants and as a whole respectively. Statistically, there were no significant differences between amblyopic and sound eyes (P>0.5). Our study did not support any significant change in a nerve fiber layer thickness of amblyopic patients; however, decreased thickness in superior and nasal quadrants of strabismic amblyopia and except inferior quadrant and as a whole. These measurements may be a clue for management and prognosis of amblyopia in old age.
MeSH term(s)	Adolescent ; Amblyopia/pathology ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Nerve Fibers/metabolism ; Prognosis ; Strabismus/pathology ; Surveys and Questionnaires
Language	English
Publishing date	2017-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	603042-7
ISSN	1735-9694 ; 0044-6025
ISSN (online)	1735-9694
ISSN	0044-6025
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Article ; Online: Prevalence of cataract and its contributing factors in Iranian elderly population: the Gilan eye study.

Ramezani, Amirreza / Sabbaghi, Hamideh / Katibeh, Marzieh / Ahmadieh, Hamid / Kheiri, Bahareh / Yaseri, Mehdi / Moradian, Siamak / Alizadeh, Yousef / Soltani Moghadam, Reza / Medghalchi, Abdolreza / Etemad, Koorosh / Behboudi, Hassan

International ophthalmology

2023 Volume 43, Issue 12, Page(s) 4503–4514

Abstract: Purpose: To report the prevalence and the associated factors leading to cataract among the Iranian population living in Gilan Province, Iran.: Methods: This population-based cross-sectional study was performed from June to November 2014 on 2,975 ... ...

Abstract	Purpose: To report the prevalence and the associated factors leading to cataract among the Iranian population living in Gilan Province, Iran. Methods: This population-based cross-sectional study was performed from June to November 2014 on 2,975 residents aged ≥ 50 years old living in urban and rural regions of the Gilan Province in Iran. A representative sample of residents in the province was recruited into the study through door-to-door visiting, and baseline data were collected by questionnaire. All participants were referred to the medical center for comprehensive ophthalmic examination, laboratory tests, and blood pressure measurement. Results: Among the population, 2,588 (86.99%) subjects were eligible to be included in this study, categorized either into the cataract or the non-cataract group. The mean age of participants was 62.59 ± 8.92 years, and 57.5% were female. Higher prevalence of cataract was found in individuals of older ages (odds ratio (OR) = 1.13; 95% confidence interval (CI) = 1.10 to 1.16; P < 0.001) and a history of previous ocular surgery (OR = 5.78; 95% CI = 2.28 to 14.63; P < 0.001). At the same time, a lower prevalence of cataract was seen in patients exposed to sunlight for more than 4 h per day (OR = 0.49; 95% CI = 0.32 to 0.73; P = 0.001). Conclusion: Cataract affects 50.50% of the study population, especially those over 80. The mildest form of cataract, grade zero, is the most common. Surgery for cataract has good outcomes. The risk of cataract is higher for those older or who have had eye surgeries. People not affected by cataract tend to be exposed to more sunlight.
MeSH term(s)	Humans ; Aged ; Female ; Middle Aged ; Male ; Iran/epidemiology ; Cataract Extraction ; Prevalence ; Cross-Sectional Studies ; Risk Factors ; Cataract/epidemiology ; Cataract/diagnosis ; Rural Population
Language	English
Publishing date	2023-08-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02851-7
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Article: The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran.

Medghalchi, Abdolreza / Akbari, Mitra / Alizadeh, Yousef / Moghadam, Reza Soltani

Journal of current ophthalmology

2018 Volume 30, Issue 4, Page(s) 353–358

Abstract: Purpose: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran.: Methods: Patients with TED who were referred to Amir- ... ...

Abstract	Purpose: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran. Methods: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March 2014 were enrolled in this cross-sectional study. The measurements of proptosis, lid width, lagophthalmos, extraocular muscle function, and visual acuity were recorded. The activity of ophthalmopathy was scored according to the clinical activity score (CAS). Results: TED was diagnosed in 103 patients with a mean age of 42.1 ± 13.91 years. Of those patients, 52.4% were women, and 80% had hyperthyroidism. The mean duration of TED was 36.5 ± 53.12 months. Extraocular muscle involvement (98%) and eyelid retraction (88.3%) were the most common manifestations. Per the CAS results, 86 (83.5%) patients were at stage 0, and there was a significant difference in CAS scores between male and female patients, Conclusions: The characteristics of TED in patients of the studied referral center during a two-year period, including common signs and symptoms, disease duration, treatment, an activity of disease were determined. Notably, many patients in this study had orbital squeal of TED meaning that they had inactive TED. Proper management of this serious complication requires close cooperation between endocrinologists and ophthalmologists to ensure timely referrals for appropriate care.
Language	English
Publishing date	2018-07-19
Publishing country	India
Document type	Journal Article
ISSN	2452-2325
ISSN	2452-2325
DOI	10.1016/j.joco.2018.07.001
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