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Article ; Online: iPS Cell Differentiation into Brain Microvascular Endothelial Cells.

Medina, Angelica / Tang, Hengli

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2429, Page(s) 201–213

Abstract: The blood-brain barrier is a tissue structure that modulates the selective entry of molecules into the brain compartment. This barrier offers protection to the brain microenvironment from toxins or any fluctuations in the composition of the blood plasma ... ...

Abstract	The blood-brain barrier is a tissue structure that modulates the selective entry of molecules into the brain compartment. This barrier offers protection to the brain microenvironment from toxins or any fluctuations in the composition of the blood plasma via a layer of endothelial cells connected by tight junctions and supported by pericytes and astrocytes. Disruption of the barrier can be either a cause or a consequence of central nervous system pathogenesis. Therefore, research based on understanding the structure, function, and the mechanisms of breaching the blood-brain barrier is of primary interest for diverse disciplines including drug discovery, brain pathology, and infectious disease. The following protocol describes a detailed differentiation method that uses defined serum components during stem cell culture to deliver cellular cues in order to drive the cells towards brain endothelial cell lineage. This method can be used to obtain reproducible and scalable cultures of brain microvascular endothelial cells with barrier characteristics and functionality. These endothelial cells can also be stored long term or shipped frozen.
MeSH term(s)	Astrocytes ; Blood-Brain Barrier ; Brain ; Cell Differentiation/physiology ; Endothelial Cells ; Pericytes ; Tight Junctions
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1979-7_13
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Article ; Online: β-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome.

Brand-Rubalcava, Patricia Alejandra / Tejeda-Martínez, Aldo Rafael / González-Reynoso, Orfil / Nápoles-Medina, Angelica Yanet / Chaparro-Huerta, Verónica / Flores-Soto, Mario Eduardo

Parkinsonism & related disorders

2023 Volume 117, Page(s) 105906

Abstract: Introduction: Parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the Substantia Nigra pars compacta (SNpc), resulting in diminished dopamine levels in the striatum (STR) and ... ...

Abstract	Introduction: Parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the Substantia Nigra pars compacta (SNpc), resulting in diminished dopamine levels in the striatum (STR) and chronic neuroinflammation. Recent investigations have proposed the neuroprotective potential of the endocannabinoid system in neurodegenerative disorders. β-caryophyllene (BCP) is recognized for its antioxidant and anti-inflammatory properties, attributed to its activation of the type 2 cannabinoid receptor. This study aimed to assess the neuroprotective impact of BCP on dopaminergic neurons, with a particular focus on inhibiting the NLRP3 inflammasome. Methods: A model of hemiparkinsonism, induced by 6-hydroxydopamine (6-OHDA), served as the experimental framework. Motor function was evaluated using the cylinder test, and inflammasome inhibition was determined by assessing the expression of NLRP3, caspase-1, and the pro-inflammatory cytokine IL-1β in both the SNpc and STR through ELISA analysis. Furthermore, the evaluation of oxidative stress was facilitated by quantifying malondialdehyde (MDA) levels in the same regions. Results: BCP treatment demonstrated significant improvements in motor dysfunction, as assessed by the cylinder test (p=0.0011) and exhibited a neuroprotective effect on dopaminergic neurons within the SNpc (p=0.0017), as well as nerve fibers in the STR (p=0.0399). In terms of its ability to inhibit the inflammasome, BCP led to decreased expression levels of NLRP3 (p=0.0401 in STR and p = 0.0139 in SNpc), caspase-1 (p=0.0004 in STR), and MDA (p=0.0085 in STR and p=0.0414 in SNpc). Conclusion: These results point to BCP's potential in mitigating the motor deficit, inhibiting NLRP3 inflammasome activation, and attenuating lipid peroxidation induced by 6-OHDA.
MeSH term(s)	Humans ; Caspases/metabolism ; Caspases/pharmacology ; Disease Models, Animal ; Dopaminergic Neurons/metabolism ; Inflammasomes/metabolism ; Mice, Inbred C57BL ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Neuroprotection ; Neuroprotective Agents/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein ; Oxidopamine ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Mice ; Animals
Chemical Substances	caryophyllene (BHW853AU9H) ; Caspases (EC 3.4.22.-) ; Inflammasomes ; Neuroprotective Agents ; NLR Family, Pyrin Domain-Containing 3 Protein ; Oxidopamine (8HW4YBZ748)
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2023.105906
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Zs.A 4553: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Factores asociados a la mortalidad por tuberculosis en Paraguay, 2015-2016.

Medina, Angélica / López, Lucelly / Martínez, Celia / Aguirre, Sarita / Alarcón, Edith

Revista panamericana de salud publica = Pan American journal of public health

2019 Volume 43, Page(s) e102

Abstract: Objective: To describe the socio-demographic and clinical-epidemiological characteristics and to determine the factors associated with the mortality of people diagnosed with tuberculosis (TB) in Paraguay.: Methods: Operational research with a ... ...

Title translation	Factors associated with tuberculosis mortality in Paraguay, 2015-2016Fatores associados à mortalidade por tuberculose no Paraguai, 2015-2016.
Abstract	Objective: To describe the socio-demographic and clinical-epidemiological characteristics and to determine the factors associated with the mortality of people diagnosed with tuberculosis (TB) in Paraguay. Methods: Operational research with a retrospective cohort design of cases diagnosed with TB in Paraguay between 2015-2016. The database of the National Tuberculosis Control Program was used. Chi-square and relative risk (RR) tests with a 95% confidence interval (95% CI) were used to determine the factors associated with mortality; in addition, a robust Poisson multiple regression model was adjusted. A significance level of 5% was used. Results: Five hundred and forty-one cases of TB were studied, of which 11.5% died. The factors increasing the risk of death were male sex (RR 1.26; 95% CI 1.1-1.50), infection with human immunodeficiency virus (RR 4.78; 95% CI 4.04-5.65) and chronic obstructive pulmonary disease (RR 1.70; 95% CI 1.19-2.42). Being deprived of one's liberty was a protective factor (RR 0.37; 95% CI 0.24-0.61). Conclusions: The highest risk of death is presented by men and people with TB/HIV coinfection and the lowest risk is presented by people deprived of liberty. There is a need to improve diagnosis and follow-up of TB cases, with effective implementation of directly observed treatment (DOTS) and timely management of associated diseases such as HIV and chronic obstructive pulmonary disease.
Language	Spanish
Publishing date	2019-12-20
Publishing country	United States
Document type	English Abstract ; Journal Article
ZDB-ID	1376934-0
ISSN	1680-5348 ; 1020-4989
ISSN (online)	1680-5348
ISSN	1020-4989
DOI	10.26633/RPSP.2019.102
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Article: Pigmented corn for brewing purpose: From grains to malt, a study of volatile composition

Romero‐Medina, Angélica / Estarrón‐Espinosa, Mirna / Verde‐Calvo, José Ramón / Lelièvre‐Desmas, Maud / Escalona‐Buendía, Héctor B.

Journal of food processing and preservation. 2021 Dec., v. 45, no. 12

2021

Abstract: Malt is one of the most important contributors to beer flavor, this research aimed to characterize the volatile profiles of two varieties of pigmented corn in their unmalted and malted form and determine the differences and similarities between pigmented ...

Abstract	Malt is one of the most important contributors to beer flavor, this research aimed to characterize the volatile profiles of two varieties of pigmented corn in their unmalted and malted form and determine the differences and similarities between pigmented corn malts and barley malts. A total of 173 volatiles were identified, where phenols and terpenes such as 2‐meyhoxy‐4‐vinylphenol, phenol, 4‐ethyl‐phenol, limonene, and geranyl acetone are the main compounds that characterize pigmented corn malts. Volatiles such as 4‐ethyl‐phenol,4‐ethyl‐2‐methoxy‐phenol, limonene, geranyl acetone, and α‐terpineol might be considered as flavor markers of the red and blue corn grains and corn malts. The results demonstrated there is a group of volatiles specific to corn malts and others that have in common to barley malt. These volatiles can be used as specific key markers for pigmented corn malts. The similarities between barley and corn malts open the possibility to use pigmented corn for brewing purposes. PRACTICAL APPLICATIONS: The similarities between corn and barley malts in their volatile profiles make pigmented corn a good alternative to produce beers using native ingredients from Mexico.
Keywords	acetone ; barley ; beers ; corn ; flavor ; limonene ; malt ; malting barley ; phenol ; volatile compounds ; Mexico
Language	English
Dates of publication	2021-12
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	243448-9
ISSN	1745-4549 ; 0145-8892
ISSN (online)	1745-4549
ISSN	0145-8892
DOI	10.1111/jfpp.16057
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening.

Strong, Caroline E / Zhang, Jiajing / Carrasco, Martin / Kundu, Srikanya / Boutin, Molly / Vishwasrao, Harshad D / Liu, Jiamin / Medina, Angelica / Chen, Yu-Chi / Wilson, Kelli / Lee, Emily M / Ferrer, Marc

Communications biology

2023 Volume 6, Issue 1, Page(s) 1211

Abstract: 3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating functional neural spheroids by cell-aggregation of differentiated human induced pluripotent ... ...

Abstract	3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating functional neural spheroids by cell-aggregation of differentiated human induced pluripotent stem cell (hiPSC)-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain. Recordings of intracellular calcium oscillations were used as functional assays, and the utility of this spheroids system was shown through disease modeling, drug testing, and formation of assembloids to model neurocircuitry. As a proof of concept, we generated spheroids incorporating neurons with Alzheimer's disease-associated alleles, as well as opioid use disorder modeling spheroids induced by chronic treatment of a mu-opioid receptor agonist. We reversed baseline functional deficits in each pilot disease model with clinically approved treatments and showed that assembloid activity can be chemogenetically manipulated. Here, we lay the groundwork for brain region-specific neural spheroids as a robust functional assay platform for HTS studies.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Brain ; Cell Differentiation/physiology ; Neurons ; High-Throughput Screening Assays/methods
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05582-8
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Article ; Online: Oral Administration of

Nápoles-Medina, Angélica Y / Aguilar-Uscanga, Blanca R / Solís-Pacheco, Josué R / Tejeda-Martínez, Aldo R / Ramírez-Jirano, Luis J / Urmeneta-Ortiz, María F / Chaparro-Huerta, Veronica / Flores-Soto, Mario E

Behavioural neurology

2023 Volume 2023, Page(s) 6686037

Abstract: It has recently been shown that the administration of probiotics can modulate the microbiota-gut-brain axis and may have favorable effects in models of Parkinson's disease. In this study, we used a hemiparkinsonism model induced by the neurotoxin 6-OHDA ... ...

Abstract	It has recently been shown that the administration of probiotics can modulate the microbiota-gut-brain axis and may have favorable effects in models of Parkinson's disease. In this study, we used a hemiparkinsonism model induced by the neurotoxin 6-OHDA to evaluate the efficacy of the administration of a four-week administration of a mixture containing the microorganisms
MeSH term(s)	Humans ; Lactobacillus ; Blood-Brain Barrier ; Parkinsonian Disorders ; Administration, Oral ; Permeability
Language	English
Publishing date	2023-11-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1001896-7
ISSN	1875-8584 ; 0953-4180
ISSN (online)	1875-8584
ISSN	0953-4180
DOI	10.1155/2023/6686037
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Article: Renewing Traditions: A Sensory and Chemical Characterisation of Mexican Pigmented Corn Beers.

Romero-Medina, Angélica / Estarrón-Espinosa, Mirna / Verde-Calvo, José Ramón / Lelièvre-Desmas, Maud / Escalona-Buendía, Héctor B

Foods (Basel, Switzerland)

2020 Volume 9, Issue 7

Abstract: This study was undertaken to explore how the use of pigmented corn as brewing ingredient influences the sensory profile of craft beers, by using both sensory and chemical analyses. Six pigmented corn and barley beers were brewed and then analysed to ... ...

Abstract	This study was undertaken to explore how the use of pigmented corn as brewing ingredient influences the sensory profile of craft beers, by using both sensory and chemical analyses. Six pigmented corn and barley beers were brewed and then analysed to obtain their sensory characteristics, volatile composition and non-volatile (alcohol, bitterness, anthocyanins and polyphenol content) composition. ANOVAs, Principal Component Analysis (PCA) and Multiple Factor Analysis (MFA) were used to visualise these data for exploring the differences between beers based on the type of malt and to characterise corn beers considering the relationships between their sensory characteristics and their chemical parameters. The sensory attributes such as fermented fruits, cooked vegetables, tortillas, bread, dried fruits and dried chili characterised beers made 100% with pigmented corn. Over 100 volatiles were identified by head space-solid phase micro-extraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS). Among them, phenols and terpenes were the groups of volatiles that better characterised beers containing corn. The content of anthocyanins in corn beers provide the 'amber-red-cooper' colours in beers and may prevent the development of off-aromas and tastes. The use of pigmented corn seems to be a good option to renew the traditional 'Sendechó' while preserving some of its sensory attributes.
Language	English
Publishing date	2020-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods9070886
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Article ; Online: Inhibition of zika virus infection by fused tricyclic derivatives of 1,2,4,5-tetrahydroimidazo[1,5-a]quinolin-3(3aH)-one.

Xu, Bin / Lee, Emily M / Medina, Angelica / Sun, Xia / Wang, Decai / Tang, Hengli / Zhou, Guo-Chun

Bioorganic chemistry

2020 Volume 104, Page(s) 104205

Abstract: Zika virus (ZIKV) infection represents a significant threat to the global health system, and the search for efficient antivirals to ZIKV remains necessary and urgent. In this study, we extended the exploration of our previously discovered scaffold of 1H- ... ...

Abstract	Zika virus (ZIKV) infection represents a significant threat to the global health system, and the search for efficient antivirals to ZIKV remains necessary and urgent. In this study, we extended the exploration of our previously discovered scaffold of 1H-pyrrolo[1,2-c]imidazol-1-one and revealed that two trans isomers of compounds 2 and 7 and one mixture with major trans isomer of compound 3 as novel tetrahydroquinoline-fused imidazolone derivatives are active against ZIKV infection but they are not virucidal. Western Blot and ELISA analyses of ZIKV NS5 and NS1 further demonstrate that compounds of (±)-2, (±)-3 and (±)-7 act as effective agents against ZIKV infection. We show that the N10's basicity is not the basic requirement for these compounds' antiviral activity in the current work. Importantly, tuning of some pharmacophores including substituents at arene can generate promising candidates for anti-ZIKV agents.
MeSH term(s)	Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cells, Cultured ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Vero Cells ; Viral Nonstructural Proteins/analysis ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism ; Zika Virus/drug effects ; Zika Virus Infection/drug therapy ; Zika Virus Infection/metabolism
Chemical Substances	Antiviral Agents ; NS1 protein, zika virus ; NS5 protein, flavivirus ; Viral Nonstructural Proteins
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2020.104205
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Article ; Online: Association between perceived social support and induced abortion: A study in maternal health centers in Lima, Peru.

Sánchez-Siancas, Luis E / Rodríguez-Medina, Angélica / Piscoya, Alejandro / Bernabe-Ortiz, Antonio

PloS one

2018 Volume 13, Issue 4, Page(s) e0192764

Abstract: Objectives: This study aimed to assess the association between perceived social support and induced abortion among young women in Lima, Peru. In addition, prevalence and incidence of induced abortion was estimated.: Methods/principal findings: A ... ...

Abstract	Objectives: This study aimed to assess the association between perceived social support and induced abortion among young women in Lima, Peru. In addition, prevalence and incidence of induced abortion was estimated. Methods/principal findings: A cross-sectional study enrolling women aged 18-25 years from maternal health centers in Southern Lima, Peru, was conducted. Induced abortion was defined as the difference between the total number of pregnancies ended in abortion and the number of spontaneous abortions; whereas perceived social support was assessed using the DUKE-UNC scale. Prevalence and incidence of induced abortion (per 100 person-years risk) was estimated, and the association of interest was evaluated using Poisson regression models with robust variance. A total of 298 women were enrolled, mean age 21.7 (± 2.2) years. Low levels of social support were found in 43.6% (95%CI 38.0%-49.3%), and 17.4% (95%CI: 13.1%- 21.8%) women reported at least one induced abortion. The incidence of induced abortion was 2.37 (95%CI: 1.81-3.11) per 100 person-years risk. The multivariable model showed evidence of the association between low perceived social support and induced abortion (RR = 1.94; 95%CI: 1.14-3.30) after controlling for confounders. Conclusions: There was evidence of an association between low perceived social support and induced abortion among women aged 18 to 25 years. Incidence of induced abortion was similar or even greater than rates of countries where abortion is legal. Strategies to increase social support and reduce induced abortion rates are needed.
MeSH term(s)	Abortion, Induced/psychology ; Abortion, Induced/statistics & numerical data ; Adolescent ; Cross-Sectional Studies ; Female ; Humans ; Maternal-Child Health Centers ; Multivariate Analysis ; Peru/epidemiology ; Pregnancy ; Social Support ; Young Adult
Language	English
Publishing date	2018-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0192764
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Article ; Online: Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model.

Cheng, Yichen / Medina, Angelica / Yao, Zhenlan / Basu, Mausumi / Natekar, Janhavi P / Lang, Jianshe / Sanchez, Egan / Nkembo, Mezindia B / Xu, Chongchong / Qian, Xuyu / Nguyen, Phuong T T / Wen, Zhexing / Song, Hongjun / Ming, Guo-Li / Kumar, Mukesh / Brinton, Margo A / Li, Melody M H / Tang, Hengli

Cell reports

2022 Volume 39, Issue 9, Page(s) 110885

Abstract: Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these barriers is poorly understood. We utilize induced ... ...

Abstract	Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these barriers is poorly understood. We utilize induced pluripotent stem cell (iPSC)-derived human brain microvascular endothelial cells (iBMECs) to study virus-blood-brain barrier (BBB) interactions. These iPSC-derived cells faithfully recapitulate a striking difference in in vivo neuroinvasion by two alphavirus isolates and are selectively permissive to neurotropic flaviviruses. A model of cocultured iBMECs and astrocytes exhibits high transendothelial electrical resistance and blocks non-neurotropic flaviviruses from getting across the barrier. We find that iBMECs constitutively express an interferon-induced gene, IFITM1, which preferentially restricts the replication of non-neurotropic flaviviruses. Barrier cells from blood-testis and blood-retinal barriers also constitutively express IFITMs that contribute to the viral resistance. Our application of a renewable human iPSC-based model for studying virus-BBB interactions reveals that intrinsic immunity at the barriers contributes to virus exclusion.
MeSH term(s)	Antiviral Agents ; Blood-Brain Barrier ; Brain/physiology ; Endothelial Cells/physiology ; Humans ; Induced Pluripotent Stem Cells/physiology ; Male
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.110885
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