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  1. Article ; Online: Can vulvar edema be the presenting sign of Crohn's disease? A case series.

    Rios Melendez, Sandra / Majluta, Aldo / Medina, Annette / Restrepo, Ricardo / Felipez, Lina M

    Journal of pediatric gastroenterology and nutrition

    2023  Volume 78, Issue 2, Page(s) 289–294

    Abstract: Vulvar involvement as an extraintestinal manifestation of Crohn's disease (CD) is a challenging diagnosis considering that vaginal findings may precede gastrointestinal symptoms. The aim of this study is to describe the clinical presentation, ... ...

    Abstract Vulvar involvement as an extraintestinal manifestation of Crohn's disease (CD) is a challenging diagnosis considering that vaginal findings may precede gastrointestinal symptoms. The aim of this study is to describe the clinical presentation, radiological findings, and treatment of vulvar Crohn's disease (VCD). We reviewed the time from initial presentation to diagnosis, presenting symptoms, radiological findings, gastrointestinal Crohn's disease Paris classification, and treatment response of five female pediatric patients. All the patients had radiological findings of vulvar inflammation on magnetic resonance imaging. Vaginal symptoms preceded gastrointestinal disease in two of the patients, which correlated with a delay in diagnosis. All patients had active disease on colonoscopy, with three of them having significant colorectal inflammation. Four of the patients were treated with infliximab, while one patient received ustekinumab with a resolution of their symptoms. In conclusion, VCD can precede gastrointestinal symptoms and is easily miss-diagnosed, leading to a delayed Crohn's disease diagnosis and treatment.
    MeSH term(s) Child ; Female ; Humans ; Crohn Disease/complications ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Edema/etiology ; Inflammation ; Infliximab/therapeutic use ; Vulvar Diseases/diagnosis ; Vulvar Diseases/etiology ; Vulvar Diseases/drug therapy
    Chemical Substances Infliximab (B72HH48FLU)
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1002/jpn3.12059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Use of Closed System Transfer Devices (CSTDs) with Protein-Based Therapeutic Drugs-A Non-Solution for a Non-Problem?

    Fast, Jonas / Christian, Twinkle / Crul, Mirjam / Jiskoot, Wim / Nejadnik, M Reza / Medina, Annette / Radwick, Allison / Sreedhara, Alavattam / Tole, Hugh

    Journal of pharmaceutical sciences

    2023  Volume 113, Issue 2, Page(s) 298–305

    MeSH term(s) Antineoplastic Agents ; Occupational Exposure ; Protective Devices ; Immunoconjugates
    Chemical Substances Antineoplastic Agents ; Immunoconjugates
    Language English
    Publishing date 2023-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2023.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Eosinophilic esophagitis, Barrett's esophagus and esophageal neoplasms in the pediatric patient: a narrative review.

    Medina, Annette L / Troendle, David M / Park, Jason Y / Thaker, Ameet / Dunbar, Kerry B / Cheng, Edaire

    Translational gastroenterology and hepatology

    2021  Volume 6, Page(s) 32

    Abstract: There are several esophageal disorders that can occur in the pediatric population. Eosinophilic esophagitis (EoE) is an eosinophil predominant inflammatory disease of the esophagus that was first characterized in the early 1900's. EoE is the most common ... ...

    Abstract There are several esophageal disorders that can occur in the pediatric population. Eosinophilic esophagitis (EoE) is an eosinophil predominant inflammatory disease of the esophagus that was first characterized in the early 1900's. EoE is the most common pediatric esophageal inflammatory condition after gastroesophageal reflux disease (GERD). Longstanding GERD is a known risk factor for the development of Barrett's esophagus (BE) in both children and adults. BE is associated with the development of dysplasia and, if left undiagnosed, may progress to the development of esophageal adenocarcinoma (EAC). EAC and esophageal squamous cell carcinoma (ESCC) comprise the majority of childhood esophageal malignant neoplasms. The prevalence of EoE continues to rise within the pediatric population. On the other hand, both BE and esophageal neoplasms remain extremely rare in children. The relationship between a chronic inflammatory condition like EoE to BE and/or esophageal neoplasms remains unclear. The current research of these disease entities is prioritized to further understanding the disease pathogenesis and disease progression, exploring new diagnostic modalities, and developing novel treatments or less invasive therapeutic options. The focus of the following narrative review is to provide a summary of the current clinical practices, future research and their implications on these various esophageal disorders.
    Language English
    Publishing date 2021-07-25
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-20-223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cachexia, chorea, and pain in chronic nonbacterial osteitis and inflammatory bowel disease: a case report.

    Agharokh, Ladan / Mamola, Katherine / Yu, Andrew G / Medina, Annette L / Gurram, Bhaskar / Fuller, Julie / Park, Jason Y / Chen, Weina / Rajaram, Veena / Hammer, Matthew R / Waugh, Jeff L

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 237

    Abstract: Background: Inflammatory bowel disease is an inflammatory disorder that primarily impacts the gastrointestinal tract, leading to malnutrition and chronic microscopic intestinal blood loss. Uncontrolled systemic inflammation can impact other parts of the ...

    Abstract Background: Inflammatory bowel disease is an inflammatory disorder that primarily impacts the gastrointestinal tract, leading to malnutrition and chronic microscopic intestinal blood loss. Uncontrolled systemic inflammation can impact other parts of the body, known as extraintestinal manifestations. Up to 25% of patients with inflammatory bowel disease are reported to have these complications in their skin, joints, bones, eyes, liver, lung, and pancreas (Rogler et al. in Gastroenterology 161(4):1118-1132, 2021). Neurologic involvement as extraintestinal manifestations are less common, reported at 3-19%, including neuropathies, demyelination, and cerebrovascular events (Morís in World J Gastroenterol. 20(5):1228-1237, 2014).
    Case presentation: A 13-year-old Caucasian boy presented with 1 month of progressive lower-extremity pain, weakness, and weight loss. His physical examination was notable for cachexia, lower-extremity weakness, and chorea. Labs revealed normocytic anemia and systemic inflammation. Imaging revealed symmetric abnormal marrow signal in the pelvis and upper femurs. Pathologic examination of the bone revealed chronic inflammation consistent with chronic nonbacterial osteitis. Endoscopy revealed colonic inflammation consistent with inflammatory bowel disease.
    Conclusions: Children and adolescents with musculoskeletal pain lasting more than 2 weeks with systemic signs or symptoms like weight loss should prompt evaluation for systemic inflammatory disorders such as chronic nonbacterial osteitis, which can occur in isolation or associated with inflammatory bowel disease. This patient also had a nonspecific neurologic abnormality, chorea, which resolved with treatment of underlying inflammatory disorder. These extraintestinal manifestations may be concurrent with or precede intestinal inflammation, requiring a high index of suspicion when investigating nonspecific systemic inflammation.
    MeSH term(s) Male ; Child ; Adolescent ; Humans ; Osteitis/pathology ; Chorea ; Cachexia/complications ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/pathology ; Inflammation/complications ; Pain ; Weight Loss
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03894-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current Industry Best Practice on in-use Stability and Compatibility Studies for Biological Products.

    Blümel, Markus / Liu, Jing / de Jong, Isabella / Weiser, Sarah / Fast, Jonas / Litowski, Jennifer / Shuman, Melissa / Mehta, Shyam B / Amery, Leanne / Tan, David Cheng Thiam / Jia, Feng / Shekhawat, Dushyant / Dagallier, Camille / Emamzadeh, Mina / Medina, Annette / Santos, Camilla / Gasser, Florian / Urban, Christian

    Journal of pharmaceutical sciences

    2023  Volume 112, Issue 9, Page(s) 2332–2346

    Abstract: Evaluating the in-use stability of a biological product including its compatibility with administration components allows to define handling instructions and potential hold times that retain product quality during dose preparation and administration. The ...

    Abstract Evaluating the in-use stability of a biological product including its compatibility with administration components allows to define handling instructions and potential hold times that retain product quality during dose preparation and administration. The intended drug product usage may involve the dilution of drug formulation into admixtures for infusion and exposure to new interfaces of administration components like intravenous (iv) bags, syringes, and tubing. In-use studies assess the potential impact on product quality by simulating drug handling throughout the defined in-use period. Considering the wide range of in-use conditions and administration components available globally, only limited guidance is available from regulators on expected in-use stability data. A working group reviewed and consolidated industry approaches to assess physicochemical stability of traditional protein-based biological products during clinical development and for commercial use. The insights compiled in this review article can be leveraged across the industry and encompass topics such as representative drug product material and administration components, testing conditions, quality attributes evaluated and respective acceptance criteria, applied quality standards, and regulatory requirements. These practices may help companies in the study design, and they may inform discussions with global regulators.
    MeSH term(s) Biological Products ; Pharmaceutical Preparations ; Drug Compounding ; Drug Stability ; Drug Industry
    Chemical Substances Biological Products ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-05-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2023.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uf I Zs.50: Show issues Location:
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  6. Article: Covalent modification of a metal–organic framework with isocyanates: probing substrate scope and reactivity

    Dugan, Emily / Wang, Zhenqiang / Okamura, Marilyn / Medina, Annette / Cohen, Seth M

    Chemical communications. 2008 July 16, , no. 29

    2008  

    Abstract: Isoreticular metal–organic framework-3 (IRMOF-3) has been postsynthetically modified with isocyanates to generate unprecedented, microporous urea-functionalized frameworks. ...

    Abstract Isoreticular metal–organic framework-3 (IRMOF-3) has been postsynthetically modified with isocyanates to generate unprecedented, microporous urea-functionalized frameworks.
    Keywords chemical reactions ; coordination polymers ; porous media
    Language English
    Dates of publication 2008-0716
    Size p. 3366-3368.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b806150e
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Covalent modification of a metal-organic framework with isocyanates: probing substrate scope and reactivity.

    Dugan, Emily / Wang, Zhenqiang / Okamura, Marilyn / Medina, Annette / Cohen, Seth M

    Chemical communications (Cambridge, England)

    2008  , Issue 29, Page(s) 3366–3368

    Abstract: Isoreticular metal-organic framework-3 (IRMOF-3) has been postsynthetically modified with isocyanates to generate unprecedented, microporous urea-functionalized frameworks. ...

    Abstract Isoreticular metal-organic framework-3 (IRMOF-3) has been postsynthetically modified with isocyanates to generate unprecedented, microporous urea-functionalized frameworks.
    Language English
    Publishing date 2008-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b806150e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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