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Article ; Online: Ecthyma gangrenosum in pediatric patients: 10-year experience at the National Institute of Pediatrics.

García-López, Constanza / Medina-Vera, Isabel / Orozco-Covarrubias, Luz / Saez-de-Ocariz, Marimar

2023 Volume 62, Issue 11, Page(s) 1359–1364

Abstract: Background: Ecthyma gangrenosum (EG) usually results from the hematogenous seeding of the skin in the setting of bacteremia, mostly by Pseudomonas aeruginosa, especially in immunocompromised patients. It presents as erythematous-violaceous macules, or ... ...

Abstract	Background: Ecthyma gangrenosum (EG) usually results from the hematogenous seeding of the skin in the setting of bacteremia, mostly by Pseudomonas aeruginosa, especially in immunocompromised patients. It presents as erythematous-violaceous macules, or plaques with surrounding erythema before rapidly progressing to bullae and necrotic-ulcerative eschars. Methods: We performed a retrospective chart review of EG patients diagnosed at the National Institute of Pediatrics. Data included demographics, underlying disease, cutaneous lesions, location, evolution, microbiologic, histopathologic findings, and treatment. Data were analyzed by descriptive statistics; Mann-Whitney U test and Fisher's exact test were used to evaluate differences between groups. Results: Seventeen patients with a mean age of 12.5 (6-16) years were included. The most common underlying disease was acute lymphoblastic leukemia (59%), three patients were not immunocompromised (17%). A total of 18 episodes of EG were recorded, 10 (55%) were disseminated at presentation. Systemic manifestations included fever (100%), pain (88.9%), asthenia and adynamia (22.2%). P. aeruginosa was isolated in 10 (55%) cases, followed by Staphylococcus aureus in four. Three patients had sepsis at onset (17%). A comparison between localized versus disseminated, pseudomonal versus nonpseudomonal, and bacteremic versus nonbacteremic EG was performed with no statistical difference between any of the groups, except for longer treatment time for pseudomonal EG, and longer hospitalization days for both pseudomonal EG and bacteremia. Conclusions: Fever and pain in the setting of rapidly evolving necrotic lesions should prompt the clinical suspicion of EG and the installment of empiric treatment pending culture results.
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16842
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Article ; Online: Higher versus lower protein intake in formula-fed term infants.

Gonzalez-Garay, Alejandro G / Serralde-Zúñiga, Aurora E / Medina Vera, Isabel / Velasco Hidalgo, Liliana / Alonso Ocaña, Mathy Victoria

The Cochrane database of systematic reviews

2023 Volume 11, Page(s) CD013758

Abstract: Background: Many infants are fed infant formulas to promote growth. Some formulas have a high protein content (≥ 2.5 g per 100 kcal) to accelerate weight gain during the first year of life. The risk-benefit balance of these formulas is unclear.: ... ...

Abstract	Background: Many infants are fed infant formulas to promote growth. Some formulas have a high protein content (≥ 2.5 g per 100 kcal) to accelerate weight gain during the first year of life. The risk-benefit balance of these formulas is unclear. Objectives: To evaluate the benefits and harms of higher protein intake versus lower protein intake in healthy, formula-fed term infants. Search methods: We searched CENTRAL, MEDLINE, Embase, CINAHL, LILACS, OpenGrey, clinical trial registries, and conference proceedings in October 2022. Selection criteria: We included randomized controlled trials (RCTs) of healthy formula-fed infants (those fed only formula and those given formula as a complementary food). We included infants of any sex or ethnicity who were fed infant formula for at least three consecutive months at any time from birth. We excluded quasi-randomized trials, observational studies, and infants with congenital malformations or serious underlying diseases. We defined high protein content as 2.5 g or more per 100 kcal, and low protein content as less than 1.8 g per 100 kcal (for exclusive formula feeding) or less than 1.7 g per 100 kcal (for complementary formula feeding). Data collection and analysis: Four review authors independently assessed the risk of bias and extracted data from trials, and a fifth review author resolved discrepancies. We performed random-effects meta-analyses, calculating risk ratios (RRs) or Peto odds ratios (Peto ORs) with 95% confidence intervals (CIs) for dichotomous outcomes, and mean differences (MDs) with 95% CIs for continuous outcomes. We used the GRADE approach to evaluate the certainty of the evidence. Main results: We included 11 RCTs (1185 infants) conducted in high-income countries. Seven trials (1629 infants) compared high-protein formula against standard-protein formula, and four trials (256 infants) compared standard-protein formula against low-protein formula. The longest follow-up was 11 years. High-protein formula versus standard-protein formula We found very low-certainty evidence that feeding healthy term infants high-protein formula compared to standard-protein formula has little or no effect on underweight (MD in weight-for-age z-score 0.05 SDs, 95% CI -0.09 to 0.19; P = 0.51, I Authors' conclusions: We are unsure if feeding healthy infants high-protein formula compared to standard-protein formula has an effect on undernutrition, overweight, or obesity. There may be little or no difference in the risk of adverse effects between infants fed with high-protein formula versus those fed with standard-protein formula. We are unsure if feeding healthy infants standard-protein formula compared to low-protein formula has any effect on undernutrition. There may be little or no difference in the risk of adverse effects between infants fed with standard-protein formula versus those fed with low-protein formula. The findings of six ongoing studies and two studies awaiting classification studies may change the conclusions of this review.
MeSH term(s)	Infant ; Humans ; Milk Hypersensitivity ; Overweight ; Thinness ; Growth Disorders ; Obesity ; Malnutrition ; Diarrhea ; Vomiting
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	1469-493X
ISSN (online)	1469-493X
DOI	10.1002/14651858.CD013758.pub2
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Article ; Online: Supplementation with antioxidants and phenolic compounds in ruminant feeding and its effect on dairy products: a systematic review.

Avila-Nava, Azalia / Medina-Vera, Isabel / Toledo-Alvarado, Hugo / Corona, Luis / Márquez-Mota, Claudia C

The Journal of dairy research

2023 Volume 90, Issue 3, Page(s) 216–226

Abstract: Milk and dairy products have great importance in human nutrition related to the presence of different nutrients, including protein, fatty acid profile and bioactive compounds. Dietary supplementation with foods containing these types of compounds may ... ...

Abstract	Milk and dairy products have great importance in human nutrition related to the presence of different nutrients, including protein, fatty acid profile and bioactive compounds. Dietary supplementation with foods containing these types of compounds may influence the chemical composition of milk and dairy products and hence, potentially, the consumer. Our objective was to summarize the evidence of the effect of supplementation with antioxidants and phenolic compounds in the diets of dairy animals and their effects on milk and dairy products. We conducted a systematic search in the MEDLINE/PubMed database for studies published up until July 2022 that reported on supplementation with antioxidants and phenolic compounds in diets that included plants, herbs, seeds, grains and isolated bioactive compounds of dairy animals such as cows, sheep and goats and their effects on milk and dairy products. Of the 94 studies identified in the search, only 15 met the inclusion criteria and were analyzed. The review revealed that supplementation with false flax cake, sweet grass,
MeSH term(s)	Female ; Cattle ; Sheep ; Animals ; Humans ; Antioxidants/analysis ; Diet/veterinary ; Milk/chemistry ; Fatty Acids/analysis ; Phenols/analysis ; Phenols/metabolism ; Goats/metabolism ; Dietary Supplements/analysis ; Lactation ; Animal Feed/analysis
Chemical Substances	Antioxidants ; Fatty Acids ; Phenols
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	242089-2
ISSN	1469-7629 ; 0022-0299
ISSN (online)	1469-7629
ISSN	0022-0299
DOI	10.1017/S0022029923000511
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Article ; Online: Relationship between lipid accumulation product and oxidative biomarkers by gender in adults from Yucatan, Mexico.

Lugo, Roberto / Avila-Nava, Azalia / Pech-Aguilar, Alfredo Geovanny / Medina-Vera, Isabel / Guevara-Cruz, Martha / Gutiérrez Solis, Ana Ligia

Scientific reports

2022 Volume 12, Issue 1, Page(s) 14338

Abstract: Excessive adipose tissue can lead to metabolic abnormalities resulting in lipid alteration and oxidative stress (OS) status. The lipid accumulation product (LAP) index is a biomarker that indicates central lipid accumulation and has been proposed as an ... ...

Abstract	Excessive adipose tissue can lead to metabolic abnormalities resulting in lipid alteration and oxidative stress (OS) status. The lipid accumulation product (LAP) index is a biomarker that indicates central lipid accumulation and has been proposed as an accurate and independent indicator of risk for several cardiometabolic related conditions. There is a lack of information about the possible association of LAP and OS biomarkers. Therefore, this work aimed to investigate the relationship between LAP and OS biomarkers in adults. A cross-sectional study was performed in 250 subjects attending the Hospital Regional de Alta Especialidad de la Península de Yucatán. Anthropometrical and clinical parameters were measured. The serum oxidative biomarkers such as malondialdehyde (MDA) and total antioxidant capacity (TAC) were evaluated by spectrophotometry and by the oxygen radical absorbance capacity (ORAC), respectively. A positive and significant correlation between serum levels of MDA and LAP (r = 0.162, p = 0.010) was observed. This relationship was stronger in women (r = 0.189, p = 0.013) than in men. The association between them remained significant after adjusting for confounders (r = 0.23, p < 0.001). A cutoff of LAP of 73.73 predicts high levels of MDA in women aged between 40 and 59. LAP index was associated with OS biomarkers in women and men from Yucatan, Mexico. Therefore, the elevation of the LAP index could identify an imbalance in the redox status.
MeSH term(s)	Adult ; Biomarkers ; Cross-Sectional Studies ; Female ; Humans ; Lipid Accumulation Product ; Lipids ; Male ; Mexico ; Middle Aged ; Oxidation-Reduction ; Oxidative Stress
Chemical Substances	Biomarkers ; Lipids
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-18705-8
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Article ; Online: Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico.

Avila-Nava, Azalia / Pech-Aguilar, Alfredo Geovanny / Lugo, Roberto / Medina-Vera, Isabel / Guevara-Cruz, Martha / Gutiérrez-Solis, Ana Ligia

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 1058813

Abstract: Background: Activation of the immune system response is associated with the generation of oxidative stress (OS). Several alterations are involved in OS, such as excessive production of reactive oxygen species (ROS) and decreased antioxidant activity, ... ...

Abstract	Background: Activation of the immune system response is associated with the generation of oxidative stress (OS). Several alterations are involved in OS, such as excessive production of reactive oxygen species (ROS) and decreased antioxidant activity, which together lead to an imbalance in redox status. The role of OS during SARS-CoV-2 infection is not fully understood. The aim of this study was to determine OS biomarkers and assess their usefulness as a predictor of mortality in COVID-19 patients. Methods: Baseline characteristics and serum samples were collected from hospitalized COVID-19 patients and compared with healthy controls. The serum OS biomarkers, including malondialdehyde (MDA) and total antioxidant capacity (TAC), were assessed by spectrophotometric and oxygen radical absorbance capacity (ORAC) methods, respectively. Results: A total of 152 individuals were analyzed (COVID-19 patients vs. healthy controls). Compared with healthy controls ( Conclusion: This study concludes that OS is increased in patients with COVID-19 and is associated with mortality. To our knowledge, this is the first evidence of the expression of OS biomarkers and their association with mortality among the Mexican population.
MeSH term(s)	Antioxidants/metabolism ; Biomarkers/metabolism ; COVID-19 ; Humans ; Mexico/epidemiology ; Oxidative Stress ; SARS-CoV-2
Chemical Substances	Antioxidants ; Biomarkers
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/1058813
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Article: Association between phase angle and the nutritional status in pediatric populations: a systematic review.

Franco-Oliva, Andrea / Ávila-Nava, Azalia / Rodríguez-Aguilar, Estíbaliz Amairani / Trujillo-Mercado, Ander / García-Guzmán, Alda Daniela / Pinzón-Navarro, Beatriz Adriana / Fuentes-Servín, Jimena / Guevara-Cruz, Martha / Medina-Vera, Isabel

Frontiers in nutrition

2023 Volume 10, Page(s) 1142545

Abstract: Background and aims: Malnutrition is prevalent in pediatric populations with any disease, and it is also related to changes in body composition. In addition, recent studies have documented relationships between these changes and phase angle (PhA), an ... ...

Abstract	Background and aims: Malnutrition is prevalent in pediatric populations with any disease, and it is also related to changes in body composition. In addition, recent studies have documented relationships between these changes and phase angle (PhA), an important parameter of functional nutritional assessment. PhA could be a new marker of nutritional status. Many studies have generated information about the association between PhA and malnutrition in various pathologies, although the vast majority of this information is from adult populations. In this systematic review, we answered the following question: What is the association between PhA and the nutritional status in pediatric populations? Methods: We performed a systematic search of the Medline/PubMed and Latin American and Caribbean Health Sciences Literature databases (LILACS) databases for studies published up to October 2022. The inclusion criteria were pediatric subjects, which reported the relationship between PhA and the nutritional status with any objective nutritional indicator, and PhA was measured by electric impedance and reported at 50 kHz. We synthesized data from the studies that reported cutoff analysis of PhA with receiver operating characteristic (ROC) curves, mean PhA values presented by nutritional status strata, and correlations between PhA and nutritional status indicators. We assessed the risk of bias by using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies and the Quality Assessment for Diagnostic Accuracy Studies. Results: Of the 126 studies we identified, 15 met the inclusion criteria. The included studies reported the association between PhA and objective indicators of nutritional status, including weight-for-age z-score (WAZ) <-1 standard deviation (SD) for malnutrition, height-for-age z-score (HAZ) for malnutrition-stunting, body mass index (BMI) for the starvation state, body mass index z-score (BMIz) and BMI for malnutrition, mid-upper arm circumference (MUAC) <11 cm for severe acute malnutrition (SAM), and fat-free mass index z-score (FFMIz) <-2 z-score for moderate malnutrition, among others. The report of these associations between PhA and nutritional status was based on cutoff points generated with ROC curve analysis or comparison of mean PhA values, which were reported stratified by the presence or absence of malnutrition, and correlations between PhA and anthropometric indicators for the evaluation of the nutritional status in the pediatric population. It was difficult to compare the studies due to the heterogeneity of the bioelectrical impedance analysis models used, how PhA was reported (standardized, percentiles, or degrees), and the anthropometric indicators used to diagnose malnutrition. Conclusion: The early identification of malnutrition is relevant to establish the correct nutritional treatment; PhA appears to be a sensitive indicator of nutritional status and is easy to obtain. Although the results of this review are inadequate to establish PhA cutoff points associated with malnutrition in pediatric populations, in most of the studies, there was an association between PhA and objective indicators of nutritional status. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022362413, identifier: PROSPERO 2022 CRD42022362413.
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1142545
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Article ; Online: Oxidative Stress Biomarkers in Mexican Subjects with Overweight and Obesity: A Systematic Review.

Gutiérrez-Solis, Ana Ligia / Garrido-Dzib, Angel Gabriel / Rochel-Pérez, Andrea / Magallón-Zertuche, Valeria / Chávez-Loría, Geovanni / Medina-Vera, Isabel / Avila-Nava, Azalia

Metabolic syndrome and related disorders

2023 Volume 21, Issue 4, Page(s) 188–196

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Overweight/epidemiology ; Mexico/epidemiology ; Body Mass Index ; Obesity/epidemiology ; Obesity/prevention & control ; Weight Gain ; Biomarkers ; Oxidative Stress
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2023.0001
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Article ; Online: Hipótesis sobre las conexiones entre COVID-19 severo en niños y nutrición: una revisión narrativa.

León-Lara, Ximena / Vargas-Castillo, Ariana / Ávila-Nava, Azalia / Guevara-Cruz, Martha / Serralde Zúñiga, Aurora E / Medina-Vera, Isabel

Nutricion hospitalaria

2021 Volume 38, Issue 3, Page(s) 622–630

Abstract: Introduction: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Compared with adults, children with SARS-CoV-2 infection may have fewer and less severe symptoms. Gastrointestinal symptoms are ... ...

Title translation	Hypothesis regarding the connections between severe COVID-19 in children and nutrition: a narrative review.
Abstract	Introduction: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Compared with adults, children with SARS-CoV-2 infection may have fewer and less severe symptoms. Gastrointestinal symptoms are commonly reported in children, sometimes as the only manifestation of the disease, and most often manifest as anorexia, diarrhea, nausea and vomiting, or abdominal pain. Although most children have asymptomatic or mild disease, 10 % of those infected may experience serious or critical disease, or even death. Multisystem inflammatory syndrome is a rare but serious condition recently reported in children with COVID-19. Studies indicate that children with obesity are at higher risk of developing severe COVID-19, and inflammation associated with obesity could be one of the factors that worsens COVID-19 symptoms due to an increased inflammatory response involving molecules such as interleukin 6, tumor necrosis factor alpha, and monocyte chemoattractant protein. On the other hand, evidence has been reported of a higher protein expression of ACE2 in the visceral adipose tissue of obese and malnourished humans, and this could be associated with complications and severity of COVID-19. Therefore, regulation of the intake of macronutrients or micronutrients could be used as a strategy to reduce the consequences of COVID-19. Diet in general and bioactive compounds could play an important role in the prevention of the inflammatory cascade. The micronutrients with the most evidence suggesting a role in immune support are vitamins C and D, zinc, and polyphenols.
MeSH term(s)	Abdominal Pain/etiology ; Angiotensin-Converting Enzyme 2/metabolism ; Anorexia/etiology ; Ascorbic Acid/administration & dosage ; COVID-19/complications ; COVID-19/etiology ; COVID-19/metabolism ; Child ; Diarrhea/etiology ; Female ; Gastrointestinal Diseases/etiology ; Humans ; Inflammation/complications ; Male ; Nausea/etiology ; Overweight/complications ; Oxidative Stress ; Pediatric Obesity/complications ; Pediatric Obesity/metabolism ; Polyphenols/administration & dosage ; Systemic Inflammatory Response Syndrome/etiology ; Thinness/complications ; Thinness/metabolism ; Vitamin D/administration & dosage ; Vitamins/administration & dosage ; Vomiting/etiology ; Zinc/administration & dosage ; Zinc/deficiency
Chemical Substances	Polyphenols ; Vitamins ; Vitamin D (1406-16-2) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Zinc (J41CSQ7QDS) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2021-03-22
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1481223-x
ISSN	1699-5198 ; 0212-1611
ISSN (online)	1699-5198
ISSN	0212-1611
DOI	10.20960/nh.03452
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Article ; Online: Evaluation of Cardiovascular Risk by Waist-to-Height Ratio in School-Age Children.

Domingo-Bolio, Vanessa / Medina-Vera, Isabel / Shamah-Levy, Teresa / Moreno-Macías, Lidia / Avila-Nava, Azalia

Metabolic syndrome and related disorders

2021 Volume 19, Issue 10, Page(s) 531–536

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Body Height ; Body Mass Index ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Child ; Child, Preschool ; Heart Disease Risk Factors ; Humans ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis ; Pediatric Obesity/epidemiology ; Risk Factors ; Waist Circumference ; Waist-Height Ratio
Language	English
Publishing date	2021-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2021.0048
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Article: Dietary Strategies by Foods with Antioxidant Effect on Nutritional Management of Dyslipidemias: A Systematic Review

Medina-Vera, Isabel / Gómez-de-Regil, Lizzette / Gutiérrez-Solis, Ana Ligia / Lugo, Roberto / Guevara-Cruz, Martha / Pedraza-Chaverri, José / Avila-Nava, Azalia

Antioxidants. 2021 Feb. 03, v. 10, no. 2

2021

Abstract: Nutrition plays a fundamental role in the prevention and treatment of dyslipidemias and its oxidative-related complications. Currently, there is evidence about the beneficial effects of isolated antioxidants or foods enriched or added with antioxidant ... ...

Abstract	Nutrition plays a fundamental role in the prevention and treatment of dyslipidemias and its oxidative-related complications. Currently, there is evidence about the beneficial effects of isolated antioxidants or foods enriched or added with antioxidant compounds. However, the application of the natural foods is more integrated than the analysis of a single nutrient. Our aim is compiling scientific literature regarding the nutritional strategies by foods with antioxidant effect in blood lipids, enzymatic and non-enzymatic antioxidants, and oxidative and inflammatory markers of subjects with dyslipidemia. We searched in MEDLINE/PubMed, Scopus, and Web of Science. From a total of 263 studies screened, 16 were included. Dietary strategies included walnuts, olive oil, raw almonds, G. paraguayase, white sesame, mate tea, Brazil nut flour, red wine, granulated Brazil nuts, grapes, wolfberry fruit, fermented beverage, coffee, orange, and blackberry juices showed significant differences in blood lipids, antioxidant activity, antioxidant enzymes, and oxidative and inflammatory markers. This systematic review compiling scientific studies about dietary strategies using foods with antioxidant effect to improve the antioxidant status in dyslipidemias.
Keywords	Brazil nuts ; Lycium ; antioxidant activity ; blackberries ; blood ; flour ; fruits ; hyperlipidemia ; nutrition ; olive oil ; red wines ; systematic review ; tea ; Brazil
Language	English
Dates of publication	2021-0203
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10020225
Database	NAL-Catalogue (AGRICOLA)

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