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Article ; Online: Correlative studies on vitamin D and total, free bioavailable testosterone levels in young, healthy men.

Książek, Anna / Mędraś, Marek / Zagrodna, Aleksandra / Słowińska-Lisowska, Małgorzata / Lwow, Felicja

2021 Volume 11, Issue 1, Page(s) 20198

Abstract: The relationship between vitamin D levels and testicular hormonal function in men has not been clearly established. Therefore, we aimed to investigate the relationship between deficiency/insufficiency levels of 25(OH)D and luteinizing hormone (LH), ... ...

Abstract	The relationship between vitamin D levels and testicular hormonal function in men has not been clearly established. Therefore, we aimed to investigate the relationship between deficiency/insufficiency levels of 25(OH)D and luteinizing hormone (LH), follicle-stimulating hormone (FSH), total (TT), free (FT), and bioavailable testosterone (BT), and sex hormone binding globulin (SHBG) in young, healthy men. We enrolled 176 healthy, active young men aged 18-35 years from a genetically homogenous population of Lower Silesia, Poland. Serum levels of 25(OH)D, LH, FSH, and TT were measured by electrochemiluminescence (ECLIA). FT levels were measured by enzyme-linked immunosorbent assay (ELISA). BT levels were calculated from TT, SHBG, and albumin. SHBG was measured by chemiluminescent immunoassay CLIA. We did not find any significant differences between the mean hormonal values (LH, FSH, TT, FT, BT, and SHBG) and the status of 25(OH)D level (deficient and insufficient). Based on our results, we concluded that there is no relationship between deficient and insufficient 25(OH)D concentration and androgen levels in young, healthy men.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Follicle Stimulating Hormone/blood ; Healthy Volunteers ; Humans ; Luteinizing Hormone/blood ; Male ; Poland ; Sex Hormone-Binding Globulin/metabolism ; Testosterone/blood ; Vitamin D/blood ; Young Adult
Chemical Substances	SHBG protein, human ; Sex Hormone-Binding Globulin ; Vitamin D (1406-16-2) ; Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2021-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-99571-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Central Effects of Androgenic-anabolic Steroid Use.

Mędraś, Marek / Brona, Anna / Jóźków, Paweł

Journal of addiction medicine

2018 Volume 12, Issue 3, Page(s) 184–192

Abstract: Millions of men use androgenic-anabolic steroids (AAS) to stimulate muscle growth and improve physical appearance. Although 1 out of 3 people who uses androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central ...

Abstract	: Millions of men use androgenic-anabolic steroids (AAS) to stimulate muscle growth and improve physical appearance. Although 1 out of 3 people who uses androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central nervous system and the psyche are still not well understood. Although most addictive substances improve mood immediately after administration, AAS exert less pronounced euphoric effects. Instead, they are primarily taken for the delayed gratification of increased muscle mass. Withdrawal from AAS may lead to a range of somatic and psychiatric symptoms, and, in many cases, comprehensive treatment supervised by an endocrinologist and a psychiatrist is required.
MeSH term(s)	Anabolic Agents/adverse effects ; Anabolic Agents/pharmacology ; Androgens/adverse effects ; Androgens/pharmacology ; Athletes ; Central Nervous System/drug effects ; Female ; Humans ; Hypogonadism/chemically induced ; Male ; Steroids/adverse effects ; Steroids/pharmacology ; Testosterone/blood ; Testosterone/pharmacology ; Testosterone Congeners/adverse effects ; Testosterone Congeners/pharmacology
Chemical Substances	Anabolic Agents ; Androgens ; Steroids ; Testosterone Congeners ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2018-03-20
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000000395
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Article ; Online: ASSOCIATIONS BETWEEN PITUITARY-GONADAL AXIS PARAMETERS AND SEMEN QUALITY IN YOUNG, HEALTHY MEN (AndroLS)

Józków Paweł / Medras Marek / Szmigiero Leszek / Słowinska-Lisowska Małgorzata / Lwow Felicja

Journal of Men's Health, Vol 15, Iss

2019 Volume 3

Abstract: Background and Objective Hormonal measurements play an important role in the evaluation of male fertility potential. In men without hypogonadism, the impact of androgen status on semen is rarely analyzed. Material and Methods We evaluated associations ... ...

Abstract	Background and Objective Hormonal measurements play an important role in the evaluation of male fertility potential. In men without hypogonadism, the impact of androgen status on semen is rarely analyzed. Material and Methods We evaluated associations between parameters of the pituitary-gonadal axis: luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), free testosterone (FT), calculated testosterone (TC), bioavailable testosterone (TB), sex hormone-binding globulin (SHBG), free androgen index, and semen quality parameters in healthy young men. Results In our study group, sperm concentration and sperm count were associated with FSH and FT. The percentage of immotile sperm was associated with LH and T. The percentage of vital sperm was negatively related to LH. We identified negative, independent associations between T and semen volume (p<0.026) and TC and semen volume (p<0.025). We observed negative, independent association between FSH, FT, and total sperm count (both P<0.002) and between FT and the percentage of normal forms (P<0.012). There were positive associations between LH and T and the percentage of immotile sperm (P<0.007 and P<0.034, respectively). There were no relationships between sperm morphology parameters and the parameters of the pituitary-gonadal axis. Conclusion In healthy eugonadal men, variations in FSH, LH, T, and FT (within normal limits) are reflected in semen characteristics but not in sperm morphology features.
Keywords	luteinizing hormone ; follicle stimulating hormone ; testosterone ; semen quality ; hormones ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	IMR Press
Document type	Article ; Online
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Article ; Online: Psychological stress and the function of male gonads.

Jóźków, Paweł / Mędraś, Marek

Endokrynologia Polska

2012 Volume 63, Issue 1, Page(s) 44–49

Abstract: Stress is generally a natural phenomenon that affects behaviour, physiological processes, and neuroendocrine, neurochemical, neurological and immune responses. Many somatic and mental disorders are thought to result from chronic stress. Stress-induced ... ...

Abstract	Stress is generally a natural phenomenon that affects behaviour, physiological processes, and neuroendocrine, neurochemical, neurological and immune responses. Many somatic and mental disorders are thought to result from chronic stress. Stress-induced gonadal dysfunction is not restricted to humans, but is observed in all higher animals. Stress-induced gonadal dysfunction comprises disturbances of the hypothalamic-pituitary-gonadal axis and of spermatogenesis. Various stressors induce changes in the secretion of neurotransmitters and hormones, such as CRH, ADH, beta-endorphins, somatostatin, VIP, PRL, GH, TSH, dopamine, serotonin, neuropeptide Y, melatonin, ACTH, glucocorticosteroids, catecholamines and androgens. In acute stress, testicular function is principally modified by cytokines and fluctuating concentrations of gonadotropins, while in chronic stress, hypogonadotropic hypogonadism and disruption of spermatogenesis of varying severity, including spermatogenetic arrest, are observed. In spite of the decades-long interest in the relationships between psychological stress and the function of male gonads, many questions in this area remain unanswered.
MeSH term(s)	Androgens/physiology ; Androgens/secretion ; Animals ; Gonadotropins/physiology ; Gonadotropins/secretion ; Humans ; Male ; Spermatogenesis/physiology ; Stress, Psychological/physiopathology ; Testis/physiology ; Testis/secretion
Chemical Substances	Androgens ; Gonadotropins
Language	English
Publishing date	2012
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
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Article: Trends in the prevalence of autoimmune thyroiditis in the leading private health-care provider in Poland.

Jóźków, Paweł / Lwow, Felicja / Słowińska-Lisowska, Małgorzata / Mędraś, Marek

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2017 Volume 26, Issue 3, Page(s) 497–503

Abstract: Background: Autoimmune thyroiditis (AT) is one of the most common endocrine disorders affecting a significant percent of the population, especially women. It may have serious and long-lasting consequences. The etiology of AT is multifactorial and it ... ...

Abstract	Background: Autoimmune thyroiditis (AT) is one of the most common endocrine disorders affecting a significant percent of the population, especially women. It may have serious and long-lasting consequences. The etiology of AT is multifactorial and it arises from an interplas between environmental and genetic factors. Tendencies in AT prevalence and incidence are unclear. In Poland there are no national registers covering the data on AT prevalence. Objectives: The aim of the investigation was to assess changes in diagnosing AT in the largest chain of outpatient medical centers in Poland. Material and methods: We compared freqnancy at which AT and hypothyroidism diagnoses were made during endocrinology consultations in the period 2006-2013. The data was extracted from the database of LUXMED (part of BUPA). Results: Within 8 years, the prevalence of newly diagnosed AT dropped from 10.4% to 4.8% (p < 0.001) alongside with a decrease in the prevalence of newly diagnosed hypothyroidism from 17.8% to 7.7% (p < 0.00001). AT was widespread in young women aged 20-39. There were relatively more cases in the southern areas of Poland. Conclusions: The analyzed data does not support a hypothesis indicating a growing incidence of AT in the last years. Detailed epidemiological studies would be helpful in designing screening strategies for patients with this common disorder.
MeSH term(s)	Adult ; Female ; Humans ; Hypothyroidism/epidemiology ; Incidence ; Male ; Middle Aged ; Poland/epidemiology ; Prevalence ; Thyroiditis, Autoimmune/epidemiology ; Young Adult
Language	English
Publishing date	2017-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/60862
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Article ; Online: Transseksualizm--aspekty diagnostyczne i terapeutyczne.

Mędraś, Marek / Jóźków, Paweł

Endokrynologia Polska

2010 Volume 61 Suppl 1, Page(s) 27–31

Abstract: Gender identity disorder (GID, transsexualism) is a multidisciplinary problem of an unclear aetiology. Although the diagnosis of GID is generally established by psychiatrists, the diagnostic team always includes an endocrinologist, who is responsible for ...

Title translation	Transsexualism--diagnostic and therapeutic aspects.
Abstract	Gender identity disorder (GID, transsexualism) is a multidisciplinary problem of an unclear aetiology. Although the diagnosis of GID is generally established by psychiatrists, the diagnostic team always includes an endocrinologist, who is responsible for hormonal therapy. Hormonal therapy is the first step in the sex reassignment procedure and requires careful monitoring in the initial phase and in later years of treatment. In this paper we review the latest aspects of the diagnosis and treatment of transsexualism and the most common complications of hormonal intervention.
MeSH term(s)	Female ; Gender Identity ; Gonadal Hormones/therapeutic use ; Humans ; Male ; Patient Satisfaction ; Sex Reassignment Procedures/methods ; Sex Reassignment Procedures/psychology ; Sex Reassignment Procedures/standards ; Time Factors ; Transsexualism/diagnosis ; Transsexualism/psychology ; Transsexualism/therapy
Chemical Substances	Gonadal Hormones
Language	Polish
Publishing date	2010
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
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Article: Transsexualism--diagnostic and therapeutic aspects.

Medraś, Marek / Jóźków, Paweł

Endokrynologia Polska

2010 Volume 61, Issue 4, Page(s) 412–416

Abstract	Gender identity disorder (GID, transsexualism) is a multidisciplinary problem of an unclear aetiology. Although the diagnosis of GID is generally established by psychiatrists, the diagnostic team always includes an endocrinologist, who is responsible for hormonal therapy. Hormonal therapy is the first step in the sex reassignment procedure and requires careful monitoring in the initial phase and in later years of treatment. In this paper we review the latest aspects of the diagnosis and treatment of transsexualism and the most common complications of hormonal intervention.
MeSH term(s)	Drug Administration Schedule ; Female ; Hormones/adverse effects ; Hormones/therapeutic use ; Humans ; Male ; Polycystic Ovary Syndrome/chemically induced ; Prostatic Neoplasms/etiology ; Transsexualism/diagnosis ; Transsexualism/drug therapy ; Venous Thromboembolism/chemically induced
Chemical Substances	Hormones
Language	English
Publishing date	2010-07
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	419270-9
ISSN	0423-104X
ISSN	0423-104X
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Article: Zastosowanie testosteronu i steroidów androgenno-anabolicsznych w sporcie.

Medraś, Marek / Jóźków, Paweł

Endokrynologia Polska

2009 Volume 60, Issue 3, Page(s) 204–209

Abstract: Anabolic androgenic steroids (AAS) and testosterone are the most frequently detected prohibited doping agents in sport. Professional competitors have been taking them since the fifties of the 20th century, they are used at present mainly by sport ... ...

Title translation	Use of testosterone and anabolic androgenic steroids in sport.
Abstract	Anabolic androgenic steroids (AAS) and testosterone are the most frequently detected prohibited doping agents in sport. Professional competitors have been taking them since the fifties of the 20th century, they are used at present mainly by sport amateurs. Anabolic Androgenic Steroids are very often used in combination with other doping agents (erythropoietin, growth hormone, thyroxin). Apart from desirable for athletes anabolic and anticatabolic properties AAS have many side effects. In extreme cases doping with AAS can be life-threatening.
MeSH term(s)	Adult ; Anabolic Agents/administration & dosage ; Doping in Sports/statistics & numerical data ; Erythropoietin/administration & dosage ; Female ; Human Growth Hormone/administration & dosage ; Humans ; Male ; Testosterone/administration & dosage ; Thyroxine/administration & dosage ; Young Adult
Chemical Substances	Anabolic Agents ; Erythropoietin (11096-26-7) ; Human Growth Hormone (12629-01-5) ; Testosterone (3XMK78S47O) ; Thyroxine (Q51BO43MG4)
Language	Polish
Publishing date	2009-05
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	419270-9
ISSN	0423-104X
ISSN	0423-104X
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Article: Metabolizm testosteronu w aspekcie kontroli antydopingowej.

Laczmański, Łukasz / Medraś, Marek

Endokrynologia Polska

2009 Volume 60, Issue 1, Page(s) 58–62

Abstract: Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: ... ...

Title translation	Testosterone metabolism and doping test results.
Abstract	Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: UGT2B7, UGT2B15 and UGT2B17. Glucuronide products are more polar, water soluble, less toxic and easily extracted form the body. Testosterone is a common androgen abused in sport. The norm for urinary testosterone/epitestosterone ratio is below 4.0. Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ratio level.
MeSH term(s)	Animals ; Doping in Sports ; Epitestosterone/metabolism ; Genotype ; Glucuronosyltransferase/genetics ; Humans ; Metabolism ; Minor Histocompatibility Antigens ; Polymorphism, Genetic ; Sequence Deletion ; Substance-Related Disorders/genetics ; Substance-Related Disorders/metabolism ; Testosterone/pharmacology ; Testosterone/urine
Chemical Substances	Minor Histocompatibility Antigens ; Testosterone (3XMK78S47O) ; Epitestosterone (481-30-1) ; Glucuronosyltransferase (EC 2.4.1.17) ; UGT2B17 protein, human (EC 2.4.1.17)
Language	Polish
Publishing date	2009-01
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	419270-9
ISSN	0423-104X
ISSN	0423-104X
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Article: Growth hormone and IGF-1 as doping agents in competitive sport.

Jóźków, Paweł / Medraś, Marek

Endokrynologia Polska

2009 Volume 60, Issue 5, Page(s) 389–394

Abstract: Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are often used by athletes as doping agents. It is estimated that up to 25% of sportsmen using anabolic-androgenic steroids also take GH. Available data do not confirm the influence of GH or ... ...

Title translation	Growth hormone and IGF-1 as doping agents in competitive sport.
Abstract	Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are often used by athletes as doping agents. It is estimated that up to 25% of sportsmen using anabolic-androgenic steroids also take GH. Available data do not confirm the influence of GH or IGF-1 preparations on physical performance improvement. However, there is some evidences for many adverse effects in athletes using this form of doping. Blood tests to detect growth hormone abuse are available since several years. Surprisingly, no one has been proven to use illegal doping agents influencing GH/IGF-1 axis.
MeSH term(s)	Athletic Performance ; Doping in Sports/methods ; Human Growth Hormone/administration & dosage ; Human Growth Hormone/blood ; Humans ; Insulin-Like Growth Factor I/administration & dosage ; Insulin-Like Growth Factor I/adverse effects ; Muscle Strength/drug effects ; Substance Abuse Detection/methods
Chemical Substances	Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
Language	Polish
Publishing date	2009-09
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	419270-9
ISSN	0423-104X
ISSN	0423-104X
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