LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Meehl, Colleen M"
  2. AU="Kangas, Maria"
  3. AU="Liakata, Maria"
  4. AU="Iorember, Franca M"
  5. AU=Chen Clarice Zc
  6. AU="Harris, Robert A."
  7. AU="Wilson-Costello, Deanne"
  8. AU=Kaur Manjeet
  9. AU="Graham Linck, Emma J"
  10. AU="Kim, Eun Ho"
  11. AU="Sutherland, Scott M"
  12. AU="Chen, M.-C"
  13. AU="Riccio, Edward"
  14. AU="Baurecht, Hansjörg"
  15. AU="Rytelewski, Mateusz"
  16. AU="Kormiltsev, V"
  17. AU="Naesens, Lieve M J"
  18. AU=Young Allen
  19. AU="Varisco, Brian M"
  20. AU="Liu, Ziping"
  21. AU="Gianvittorio, Stefano"
  22. AU="Mendoza, Bernardo S"
  23. AU="Lieberman, Steven M"
  24. AU="Chen, Michel"
  25. AU=Serur I.P.
  26. AU="Docters W."
  27. AU="Prusa, Kenneth J"
  28. AU="Dworschak-Simpson, Sierra"
  29. AU="Jurisica, Igor"
  30. AU="Ye, Jessica Meng"
  31. AU="Kiyoshi Takahara"
  32. AU="Sofía Bauer"
  33. AU="Randriamboavonjy, Joseph Iharinjaka"
  34. AU="DiFazio, Louis T"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast.

    Blank, Heidi M / Sheltzer, Jason M / Meehl, Colleen M / Amon, Angelika

    Molecular biology of the cell

    2015  Band 26, Heft 8, Seite(n) 1440–1451

    Abstract: Genetic instability is a hallmark of aneuploidy in budding and fission yeast. All aneuploid yeast strains analyzed to date harbor elevated levels of Rad52-GFP foci, a sign of DNA damage. Here we investigate how continuously elevated levels of DNA damage ... ...

    Abstract Genetic instability is a hallmark of aneuploidy in budding and fission yeast. All aneuploid yeast strains analyzed to date harbor elevated levels of Rad52-GFP foci, a sign of DNA damage. Here we investigate how continuously elevated levels of DNA damage affect aneuploid cells. We show that Rad52-GFP foci form during S phase, consistent with the observation that DNA replication initiation and elongation are impaired in some aneuploid yeast strains. We furthermore find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequences. Many aneuploid yeast strains adapt to DNA damage and undergo mitosis despite the presence of unrepaired DNA leading to cell death. Wild-type cells exposed to low levels of DNA damage exhibit a similar phenotype, indicating that adaptation to low levels of unrepaired DNA is a general property of the cell's response to DNA damage. Our results indicate that by causing low levels of DNA damage, whole-chromosome aneuploidies lead to DNA breaks that persist into mitosis. Such breaks provide the substrate for translocations and deletions that are a hallmark of cancer.
    Mesh-Begriff(e) Aneuploidy ; DNA Damage/genetics ; DNA Repair ; DNA Replication ; DNA, Fungal/metabolism ; Mitosis ; Rad52 DNA Repair and Recombination Protein/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/physiology ; Saccharomyces cerevisiae Proteins/metabolism
    Chemische Substanzen DNA, Fungal ; RAD52 protein, S cerevisiae ; Rad52 DNA Repair and Recombination Protein ; Saccharomyces cerevisiae Proteins
    Sprache Englisch
    Erscheinungsdatum 2015-04-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E14-10-1442
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2853: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 410: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Single-chromosome Gains Commonly Function as Tumor Suppressors.

    Sheltzer, Jason M / Ko, Julie H / Replogle, John M / Habibe Burgos, Nicole C / Chung, Erica S / Meehl, Colleen M / Sayles, Nicole M / Passerini, Verena / Storchova, Zuzana / Amon, Angelika

    Cancer cell

    2017  Band 31, Heft 2, Seite(n) 240–255

    Abstract: Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all ... ...

    Abstract Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as xenografts, relative to genetically matched euploid cells. Moreover, the activation of several oncogenic pathways failed to alleviate the fitness defect induced by aneuploidy. However, following prolonged growth, trisomic cells acquired additional chromosomal alterations that were largely absent from their euploid counterparts and that correlated with improved fitness. Thus, while single-chromosome gains can suppress transformation, the genome-destabilizing effects of aneuploidy confer an evolutionary flexibility that may contribute to the aggressive growth of advanced malignancies with complex karyotypes.
    Mesh-Begriff(e) Aneuploidy ; Animals ; Cell Proliferation ; Cell Transformation, Neoplastic ; Chromosome Aberrations ; Genes, ras ; Genomic Instability ; HCT116 Cells ; Humans ; Neoplasms/genetics ; Neoplasms/prevention & control ; Oncogenes
    Sprache Englisch
    Erscheinungsdatum 2017-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2016.12.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5650: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang