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  1. Article ; Online: Symptomatic postoperative compressive pneumocephalus after cholecystectomy

    Zaky Mehdi Benamar / Camille Huet / Maxime Rousseau / Léa Docquier / Emmanuel Andres / Pascal Bilbaut / Noel Lorenzo-Villalba

    European Journal of Case Reports in Internal Medicine (2023)

    2023  

    Abstract: A 75-year-old woman with a history of chronic hydrocephalus due to stenosis of the aqueduct of Sylvius was examined at the emergency department for altered mental status. There was placement of a ventriculoperitoneal shunt in 1970 complicated by ... ...

    Abstract A 75-year-old woman with a history of chronic hydrocephalus due to stenosis of the aqueduct of Sylvius was examined at the emergency department for altered mental status. There was placement of a ventriculoperitoneal shunt in 1970 complicated by meningitis, leading to removal of the material and ventriculociternostomy as definitive treatment in 2004. About one month previously, she had undergone a laparoscopic cholecystectomy complicated by an intra-abdominal collection. Clinical examination at the emergency department revealed a Glasgow score of 8 (E3 V1 M4). In the emergency department the patient presented a tonic-clonic seizure before a cerebral CT scan was performed showing a massive compressive pneumocephalus, then a second seizure. The patient was finally admitted to the neurosurgery department and underwent surgery.
    Keywords pneumocephalus ; cerebral ct scan ; cholescystectomy ; Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

    Valentina Poli / Victor Pui-Yan Ma / Marco Di Gioia / Achille Broggi / Mehdi Benamar / Qian Chen / Ralph Mazitschek / Stephen J. Haggarty / Talal A. Chatila / Jeffrey M. Karp / Ivan Zanoni

    iScience, Vol 24, Iss 11, Pp 103256- (2021)

    2021  

    Abstract: Summary: Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as well as in numerous immune-mediated disorders. Histone citrullination by the enzyme ... ...

    Abstract Summary: Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as well as in numerous immune-mediated disorders. Histone citrullination by the enzyme peptidylarginine deiminase 4 (PAD4) and the consequent decondensation of chromatin are hallmarks in the induction of NETs. Nevertheless, additional histone modifications that may govern NETosis are largely overlooked. Herein, we show that histone deacetylases (HDACs) play critical roles in driving NET formation in human and mouse neutrophils. HDACs belonging to the zinc-dependent lysine deacetylases family are necessary to deacetylate histone H3, thus allowing the activity of PAD4 and NETosis. Of note, HDAC inhibition in mice protects against microbial-induced pneumonia and septic shock, decreasing NETosis and inflammation. Collectively, our findings illustrate a new fundamental step that governs the release of NETs and points to HDAC inhibitors as therapeutic agents that may be used to protect against ARDS and sepsis.
    Keywords Molecular biology ; Immunology ; Cell biology ; Functional aspects of cell biology ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children

    Mehdi Benamar / Qian Chen / Janet Chou / Amélie M. Julé / Rafik Boudra / Paola Contini / Elena Crestani / Peggy S. Lai / Muyun Wang / Jason Fong / Shira Rockwitz / Pui Lee / Tsz Man Fion Chan / Ekin Zeynep Altun / Eda Kepenekli / Elif Karakoc-Aydiner / Ahmet Ozen / Perran Boran / Fatih Aygun /
    Pinar Onal / Ayse Ayzit Kilinc Sakalli / Haluk Cokugras / Metin Yusuf Gelmez / Fatma Betul Oktelik / Esin Aktas Cetin / Yuelin Zhong / Maria Lucia Taylor / Katherine Irby / Natasha B. Halasa / Elizabeth H. Mack / Overcoming COVID-19 Investigators / Sara Signa / Ignazia Prigione / Marco Gattorno / Nicola Cotugno / Donato Amodio / Raif S. Geha / Mary Beth Son / Jane Newburger / Pankaj B. Agrawal / Stefano Volpi / Paolo Palma / Ayca Kiykim / Adrienne G. Randolph / Gunnur Deniz / Safa Baris / Raffaele De Palma / Klaus Schmitz-Abe / Louis-Marie Charbonnier / Lauren A. Henderson / Talal A. Chatila

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 1

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with Notch4 ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with Notch4 expression on Tregs, here, we show that Tregs in MIS-C were destabilized through a Notch1-dependent mechanism. Genetic analysis revealed that patients with MIS-C had enrichment of rare deleterious variants affecting inflammation and autoimmunity pathways, including dominant-negative mutations in the Notch1 regulators NUMB and NUMBL leading to Notch1 upregulation. Notch1 signaling in Tregs induced CD22, leading to their destabilization in a mTORC1-dependent manner and to the promotion of systemic inflammation. These results identify a Notch1/CD22 signaling axis that disrupts Treg function in MIS-C and point to distinct immune checkpoints controlled by individual Treg Notch receptors that shape the inflammatory outcome in SARS-CoV-2 infection.
    Keywords COVID-19 ; Immunology ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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