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Article ; Online: The Impact of Organizational Supports on Nurses’ Occupational Stress in COVID‐19 Pandemic

Mehdi Yousefi / Fatemeh Salehi / Zahra Ebrahimi / Jamshid Jamali / Leila Mashhadi

Journal of Research & Health, Vol 12, Iss 4, Pp 271-

A Partial Least Squares Multigroup Analysis

2022 Volume 278

Abstract: Background: The safety and mental health issues of frontline nurses working during the coronavirus global outbreak must be a first/top priority. The present study aimed to investigate the association between nurses’ occupation stress and organizational ... ...

Abstract	Background: The safety and mental health issues of frontline nurses working during the coronavirus global outbreak must be a first/top priority. The present study aimed to investigate the association between nurses’ occupation stress and organizational support in both infectious and non-infectious intensive care units (ICUs) wards during the COVID-19 crisis. Methods: This was a descriptive-analytical and cross-sectional study. The study population comprised nurses caring for COVID‐19 patients in Imam Reza Hospital complex in Mashhad City, Iran. The sample size was 129 nurses selected through random quota sampling and examined with a standard questionnaire. To analyze the information and test the hypothesis, the structural equation modeling approach using Smart PLS 2.0 software has been used. Descriptive and analytical statistical tests were used in this study. Results: The results indicated a significant negative correlation between stress and perceived organizational support for ICU nurses (P<0.001). Considering subscales in stress, the highest mean occupational stress scores were related to the “death and dying” dimension (n=21, 13.98%). Also, the difference between the two groups of nurses was statistically significant in different workloads (P<0.001) and lack of support (P<0.001). Conclusion: The results of the present study highlighted the importance of organizational support to reduce stress in nurses. To get through this unprecedented situation, nurses need their employers and organizations to support them with action, planning, and resources.
Keywords	covid-19 ; nurse’s stress ; occupational stress ; nurse ; organizational support ; intensive care units ; Public aspects of medicine ; RA1-1270
Subject code	150
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Gonabad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure

Oldouz Shareghi-oskoue / Leili Aghebati-Maleki / Mehdi Yousefi

Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-

2021 Volume 13

Abstract: Abstract As one of the problems and diseases for women before 40 years, premature ovarian failure (POF) could be characterized by amenorrhea, low estrogen levels, infertility, high gonadotropin levels, and lack of mature follicles. Causes of the disease ... ...

Abstract	Abstract As one of the problems and diseases for women before 40 years, premature ovarian failure (POF) could be characterized by amenorrhea, low estrogen levels, infertility, high gonadotropin levels, and lack of mature follicles. Causes of the disease involve some genetic disorders, autoimmunity diseases, and environmental factors. Various approaches have been employed to treat POF, however with limited success. Today, stem cells are used to treat POF, since they have the potential to self-repair and regenerate, and are effective in treating ovarian failure and infertility. As mesenchymal stem cell (MSC) could simultaneously activate several mechanisms, many researchers consider MSC transplantation to be the best and most effective approach in cell therapy. A good source for mesenchymal stem cells is human umbilical cord (HUCMSC). Animal models with cyclophosphamide are required for stem cell treatment and performance of HUCMSC transplantation. Stem cell therapy could indicate the levels of ovarian markers and follicle-stimulating hormone receptor. It also increases ovarian weight, plasma E2 levels, and the amount of standard follicles. Herein, the causes of POF, effective treatment strategies, and the effect of HUCMSC transplantation for the treatment of premature ovarian failure are reviewed. Many studies have been conducted in this field, and the results have shown that stem cell treatment is an effective approach to treat infertility.
Keywords	Premature ovarian failure (POF) ; Human umbilical cord mesenchymal stem cell (HUCMSC) ; Stem cell transplantation ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
Subject code	571
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 Cases among Healthcare Workers in Imam Reza Hospital

Somayeh Fazaeli / Zahra Ebrahimi / Shaghyegh Yousefi / Mehdi Yousefi / Nafiseh Arfa Shahidi

Journal of Community Health Research, Vol 12, Iss 1, Pp 90-

A Cross-Sectional Study in 2020

2023 Volume 99

Abstract: Background: Healthcare workers caring for patients with coronavirus disease 2019 (COVID-19) are at high risk of contracting the infection. This study is designated in imam Reza hospital in Mashhad, which is the largest hospital in east Iran, to determine ...

Abstract	Background: Healthcare workers caring for patients with coronavirus disease 2019 (COVID-19) are at high risk of contracting the infection. This study is designated in imam Reza hospital in Mashhad, which is the largest hospital in east Iran, to determine COVID-19 cases characteristics among healthcare workers (HCWs). Methods: In this descriptive, cross-sectional, single-center study in Imam Reza hospital in Iran, we enrolled confirmed healthcare workers with COVID-19 who worked at the forefront to fight against COVID-19 since its outbreak 2020. Demographic characteristics and work status and disease symptoms were studied in the affected personnel. Statistical analyses were conducted using SPSS software. The chi square test was used to investigate the relationship between the variables. Results: In total, out of 2195 people working in the two departments, 154 (7.01%) had coronary heart disease. most of HCWs who were infected to covid19 were nurse (60%) and women (65%) and the lowest has been observed in para clinical staff (1%). There was no significant difference between the use of personal protective equipment and disease in the general department (GD) and high-risk department (HRD). It was indicated that the HRD group had a higher risk of developing COVID-19 compared with the GD group. Common symptoms were Sweating (91.1%), fever (84.93%), Cough (79.31%), and gastrointestinal symptoms (78.77%). Conclusion: Results have found that Sweating and fever are common in HCWs with COVID-19. Also HCWs worked in HRD had a higher risk of COVID-19. However, further large sample studies are needed to confirm these findings.
Keywords	covid-19 ; health worker ; hospital ; iran ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cell-based therapy in thin endometrium and Asherman syndrome

Nastaran Gharibeh / Leili Aghebati-Maleki / Javad Madani / Ramin Pourakbari / Mehdi Yousefi / Javad Ahmadian Heris

Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Numerous treatment strategies have so far been proposed for treating refractory thin endometrium either without or with the Asherman syndrome. Inconsistency in the improvement of endometrial thickness is a common limitation of such therapies ... ...

Abstract	Abstract Numerous treatment strategies have so far been proposed for treating refractory thin endometrium either without or with the Asherman syndrome. Inconsistency in the improvement of endometrial thickness is a common limitation of such therapies including tamoxifen citrate as an ovulation induction agent, acupuncture, long-term pentoxifylline and tocopherol or tocopherol only, low-dose human chorionic gonadotropin during endometrial preparation, aspirin, luteal gonadotropin-releasing hormone agonist supplementation, and extended estrogen therapy. Recently, cell therapy has been proposed as an ideal alternative for endometrium regeneration, including the employment of stem cells, platelet-rich plasma, and growth factors as therapeutic agents. The mechanisms of action of cell therapy include the cytokine induction, growth factor production, natural killer cell activity reduction, Th17 and Th1 decrease, and Treg cell and Th2 increase. Since cell therapy is personalized, dynamic, interactive, and specific and could be an effective strategy. Despite its promising nature, further research is required for improving the procedure and the safety of this strategy. These methods and their results are discussed in this article.
Keywords	Cell therapy ; Endometrium ; Asherman syndrome ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The association of Treg and Th17 cells development factors and anti-TPO autoantibodies in patients with recurrent pregnancy loss

Mitra Niafar / Vajihe Samaie / Mohammad Sadegh Soltani-Zangbar / Roza Motavalli / Sanam Dolati / Shahla Danaii / Amir Mehdizadeh / Mehdi Yousefi

BMC Research Notes, Vol 16, Iss 1, Pp 1-

2023 Volume 7

Abstract: Abstract Objectives Thyroid autoimmunity is considered as the most prevalent autoimmune condition in women in fertility age. There are different clinical evidences indicating the association between thyroid autoimmunity and increased risk of RPL. This ... ...

Abstract	Abstract Objectives Thyroid autoimmunity is considered as the most prevalent autoimmune condition in women in fertility age. There are different clinical evidences indicating the association between thyroid autoimmunity and increased risk of RPL. This study aimed to analyze the association of Tregs and Th17 cells development factors and anti–thyroid peroxidase (anti-TPO) antibodies in RPL patients. Healthy controls (n = 36), TPO + controls (n = 25) and TPO + RPL (n = 32) participated in this study. After blood sampling, the frequency of Th17 and Tregs was evaluated using flow cytometry. Real-time PCR and ELISA was used to assess the status of Tregs and Th17 related transcription factors and cytokines in mRNA and protein level, respectively. Results TPO + RPL group showed a higher Th17 frequency compared to healthy controls and TPO + controls groups (p = 0.0002 and p = 0.04, respectively). Additionally, mRNA expression levels of RORγT and IL-17 were significantly higher in TPO + RPL compared to healthy controls and TPO + controls groups. In contrast, Foxp3 and TGFβ expression was lower in TPO + RPL. ELISA findings also indicated a significantly higher IL-17 and lower TGFβ secretion in TPO + RPL compared to healthy controls and TPO + controls. Thyroid autoimmunity should intensely be controlled specially in patients with RPL history.
Keywords	Thyroid autoimmunity ; Interleukin-17 ; TGFβ ; Pregnancy loss ; Th17 ; Tregs ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers

Atieh Yaghoubi / Samira Asli / Maryam Parhizkar / Maryam Mohammadpour / Ali Khorsand / Mehdi Yousefi / Taravat Bamdad / Saeid Amel Jamehdar

Iranian Journal of Immunology, Vol 20, Iss 1, Pp 76-

2023 Volume 82

Abstract: Background: Measuring the level of antibodies produced post-vaccination in response to the SARS-CoV-2 spike protein is considered a strategy for estimating the effectiveness of the COVID-19 vaccines.Objective: To examine the antibody levels among the ... ...

Abstract	Background: Measuring the level of antibodies produced post-vaccination in response to the SARS-CoV-2 spike protein is considered a strategy for estimating the effectiveness of the COVID-19 vaccines.Objective: To examine the antibody levels among the healthcare workers in different hospitals in Mashhad, Iran after receiving the second dose of Sputnik V.Methods: In this study, we enrolled 230 healthcare workers for evaluating the Gam-COVID-Vac or Sputnik V after the second administration in different hospitals in Mashhad. Antibody levels of spike protein were quantitatively evaluated in a sample of 230 negative RT-PCR tests for the COVID-19 individuals. The analysis has been done based on an immunological assay using enzyme-linked immunosorbent assay (ELISA). The infection history of the subjects and their families was examined through their medical records.Results: Our results demonstrated a significant association between a higher titer of IgG and a previous history of the COVID-19 infection (P<0.001). Moreover, the chance of detecting antibodies titer more than 50 AU/ml was 16.99 in these people which was significantly higher than in people without a history of infection pre-vaccination [CI: (7.38,39.12), P<0.001].Conclusion: This result demonstrates that the efficacy of antibody production is related to the previous history of the SARS-CoV-2 infections. Ongoing monitoring of the level of antibody among vaccinated populations will help evaluating the effect of vaccines on humoral immunity status.
Keywords	covid-19 ; gam-covid-vac ; sars-cov-2 ; sputnik v ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the immune checkpoint factors in idiopathic membranous nephropathy

Roza Motavalli / Maryam Hosseini / Mohammad Sadegh Soltani-Zangbar / Abbas Karimi / Mohammadreza Sadeghi / Sanam Dolati / Mehdi Yousefi / Jalal Etemadi

Molecular and Cellular Probes, Vol 69, Iss , Pp 101914- (2023)

2023

Abstract: Idiopathic membranous nephropathy (IMN), a single-organ autoimmune disease, is recognized by autoantibodies to podocyte proteins and identified as the most frequent cause of nephrotic syndrome in adults. T cells are important contributors in autoimmunity ...

Abstract	Idiopathic membranous nephropathy (IMN), a single-organ autoimmune disease, is recognized by autoantibodies to podocyte proteins and identified as the most frequent cause of nephrotic syndrome in adults. T cells are important contributors in autoimmunity since they promote B–cell development, antibody production, direct inflammation, and organ tissue cytotoxicity. This study investigated the inhibitory immune checkpoint (ICP) receptors expressed on T lymphocytes and other immune cells. Thus, PBMCs from IMN patients were obtained before treatment, and the levels of ICPs such as programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), lymphocyte activation gene-3 (LAG-3), and T cell immunoglobulin-3 (TIM-3) were examined at both gene and protein expression using real time PCR and Western blot tests respectively. The results illustrated that gene expression levels of ICPs reduced significantly in comparison to the control which were verified by related fold changes of protein expression sequentially. Our study revealed that CTLA-4, PD-1, TIM-3, and LAG-3 expression is impaired in IMN patients before treatment which could be a potential target for therapy.
Keywords	Nephropathy ; Immune checkpoint ; CTLA-4 ; PD-1 ; TIM-3 ; LAG-3 ; Biology (General) ; QH301-705.5 ; Medicine ; R
Subject code	570 ; 616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Late‐onset Wilson disease in older patient without ophthalmological findings, a case report

Mehdi Yousefi / Masoud Yousefi / Anneh M. Gharravi

Clinical Case Reports, Vol 7, Iss 6, Pp 1253-

2019 Volume 1258

Abstract: Abstract A 60‐year‐old man was referred to hospital for loss of consciousness. Her late‐onset Wilson disease was diagnosed with elevated serum bilirubin, hepatic copper concentration, and urinary copper excretion. Zinc sulfate administration decreased ... ...

Abstract	Abstract A 60‐year‐old man was referred to hospital for loss of consciousness. Her late‐onset Wilson disease was diagnosed with elevated serum bilirubin, hepatic copper concentration, and urinary copper excretion. Zinc sulfate administration decreased the majority of clinical symptoms.
Keywords	copper ; liver ; older ; patient ; Wilson disease ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: study the volume of environmental health activities in health centers

rasoul alinezhad / Mehdi Yousefi / Hossein Ebrahimipour / Ali Taghipour / amin mohammadi

Pizhūhish dar Bihdāsht-i Muḥīṭ., Vol 6, Iss 2, Pp 182-

Application of a work-time study model

2020 Volume 192

Abstract: Background and purpose: One of the most important relations between reducing organizational costs and maintaining the quality of services provided is the use of appropriate models for managing staff performance; Using these models can increase employee ... ...

Abstract	Background and purpose: One of the most important relations between reducing organizational costs and maintaining the quality of services provided is the use of appropriate models for managing staff performance; Using these models can increase employee productivity. Therefore, this study aimed to evaluate the volume of environmental health activities in health centers. Materials and methods: This study was a descriptive and applied study that was done in both quantitative and qualitative dimensions. The pilot design of the model was carried out at Mazandaran University of Medical Sciences. Every 10 minutes was considered a unit of work. Results: 51 fields of activity were identified in the field of environmental health activities. The total number of units in the field of environmental health was calculated to be 1019 units. Out of the identified activities, the most frequent repetitions were conduct inspection and recorded in the system, followed by daily chlorometry with 100 and 84 repetitions, respectively. Conclusion: Personnel in any organization need a decisive mechanism to reduce inequality and a model of value for the amount of work that one does to improve productivity, increase efficiency, work motivation, and reduce inappropriate psychological stimuli in the workplace. This will be achieved using models such as the model presented in this study.
Keywords	pricing ; professional component ; health centers ; environmental health ; work study system ; Environmental sciences ; GE1-350 ; Public aspects of medicine ; RA1-1270
Language	Persian
Publishing date	2020-08-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Productivity Loss of Diabetes in Iran (South Khorasan Province)

Hossein Ebrahimipour / Zahra Keyvanlo / Hamid Heidarian Miri / Mehdi Yousefi / Mehdi Ariafar

Journal of Research & Health, Vol 11, Iss 6, Pp 403-

2021 Volume 412

Abstract: Background: This study aims to assess the productivity loss in diabetic patients living in South Khorasan Province, Iran, in 2017. Methods: This cost of illness and analytical study was performed on 1003 patients with diabetes referred to hospitals and ... ...

Abstract	Background: This study aims to assess the productivity loss in diabetic patients living in South Khorasan Province, Iran, in 2017. Methods: This cost of illness and analytical study was performed on 1003 patients with diabetes referred to hospitals and healthcare centers in South Khorasan Province. After being randomly selected, the participants filled the short form health and labor questionnaire by the human capital method to estimate the productivity loss caused by health problems. Data were collected in person or via phone interviews. The collected data were analyzed by data quantile regression model using Stata v. 11. Results: The Mean±SD productivity loss based on actual and labor law income was 19.61±46.24 and 16.61±49.39 dollars, respectively. In addition, the results showed that the Mean±SD number of lost working days is 0.81±2.39 days. According to the regression model, gender, educational levels, marital status, and employment status affected the number of working days lost at 0.25 quantile (P≤0.05). Conclusion: Improving productivity in diabetic patients and consequently reducing the resulting economic burden is essential to promoting their physical, mental, and social health.
Keywords	health care costs ; productivity ; diabetes ; chronic disease ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Gonabad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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