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Article ; Online: Analysis of heavy metals and toxicity level in the tannery effluent and the environs.

Arti / Mehra, Rohit

2023 Volume 195, Issue 5, Page(s) 554

Abstract: Heavy metals have found a large number of applications in the recent times. These heavy metals are being continuously added to our environment through various natural and anthropogenic activities. Industries employ heavy metals to process raw materials ... ...

Abstract	Heavy metals have found a large number of applications in the recent times. These heavy metals are being continuously added to our environment through various natural and anthropogenic activities. Industries employ heavy metals to process raw materials into final products. Effluents from these industries carry heavy metals. Atomic absorption spectrophotometer and ICP-MS (inductively coupled plasma-mass spectrometer) are of great help in detecting various elements in the effluent. They have been extensively applied to solve problems related to environmental monitoring and assessment. Heavy metals like Cu, Cd, Ni, Pb, and Cr can be easily detected using both the techniques. Some of these heavy metals are toxic to both humans and animals. They can have significant related health effects. Presence of heavy metals in the industrial effluent has gained varied attention in the recent times and it has become one of the major causes of water and soil pollution. Significant contributions can be linked with the leather tanning industry. As the effluent from the tanning industry has been found to contain a large number of heavy metals in many studies. Continuous monitoring and treatment of the effluent is necessary to keep a check on the concentration of heavy metals in these effluents. This study focuses on the analysis of the various studies available on tannery effluents, methods used for heavy metal analysis, toxicity of these heavy metals, and the related major health effects. Data for heavy metals in the tannery effluent from different studies in last two decades has been collected and analysed. The data from various studies indicates that Cr, Cd, Pb, Zn, Cu, Fe, and Ni are the most commonly found heavy metals released from the tanning industry. Proper management of the tannery effluent is thus very essential for saving the environment.
MeSH term(s)	Humans ; Cadmium/analysis ; Lead/analysis ; Tanning ; Environmental Monitoring/methods ; Metals, Heavy/analysis
Chemical Substances	Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Metals, Heavy
Language	English
Publishing date	2023-04-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11154-4
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Article ; Online: Renal Cell Carcinoma Associated With TSC/MTOR Genomic Alterations: An Update on its Expanding Spectrum and an Approach to Clinicopathologic Work-up.

Shah, Rajal B / Mehra, Rohit

Advances in anatomic pathology

2023 Volume 31, Issue 2, Page(s) 105–117

Abstract: Renal cell carcinoma (RCC) with tuberous sclerosis complex (TSC)/mammalian target of rapamycin (MTOR) pathway-related genomic alterations have been classically described in hereditary TSC syndrome setting involving germline mutations, whereby cells with ... ...

Abstract	Renal cell carcinoma (RCC) with tuberous sclerosis complex (TSC)/mammalian target of rapamycin (MTOR) pathway-related genomic alterations have been classically described in hereditary TSC syndrome setting involving germline mutations, whereby cells with a bi-allelic inactivation of genes originate tumors in a classic tumor-suppressor "two-hit" Knudson paradigm. Initial studies of TSC-associated RCC categorized tumors into 3 broad heterogeneous morphologic groups: RCC with smooth muscle stroma, chromophobe-like, and eosinophilic-macrocytic. Recently, a similar morphologic spectrum has been increasingly recognized in novel and emerging entities characterized by somatic mutations in the TSC1/2 and MTOR in patients who do not suffer from the TSC. Correct recognition of RCC with TSC / MTOR mutations is critical for accurate prognostication because such tumors with aggressive behavior have the potential to be tailored to mTOR inhibitors. Whether TSC/MTOR mutated renal epithelial neoplasms represent a distinct molecular class has been confounded by the fact that TSC1/2 , and the gene encoding the downstream protein MTOR, are mutated secondarily in ∼5% of the more common subtypes of RCC, including the commonest subtype of clear cell RCC. This review summarizes the expanding morphologic spectrum of renal tumors with TSC/mTOR pathway alterations, specifically for sporadically occurring tumors where these genomic alterations likely are primary pathologic events. Finally, a practical surgical pathology approach to handling these tumors, and a conceptual framework of renal epithelial tumors with TSC/MTOR mutations as a "family of tumors", is presented.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/genetics ; Tuberous Sclerosis Complex 2 Protein/genetics ; Kidney Neoplasms/pathology ; TOR Serine-Threonine Kinases/genetics ; Tuberous Sclerosis/complications ; Genomics
Chemical Substances	Tuberous Sclerosis Complex 2 Protein ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; MTOR protein, human (EC 2.7.1.1)
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1212493-x
ISSN	1533-4031 ; 1072-4109
ISSN (online)	1533-4031
ISSN	1072-4109
DOI	10.1097/PAP.0000000000000419
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Article: Osteopathic Manipulative Treatment in Dysmenorrhea: A Systematic Review.

Bonner, Paige E / Paul, Heather A / Mehra, Rohit S

Cureus

2024 Volume 16, Issue 1, Page(s) e52794

Abstract: The majority of women experience dysmenorrhea during their lifetime. The current standard-of-care treatment consists of nonsteroidal anti-inflammatory drugs, oral contraceptive pills, or intrauterine devices. Osteopathic manipulative treatment (OMT) is a ...

Abstract	The majority of women experience dysmenorrhea during their lifetime. The current standard-of-care treatment consists of nonsteroidal anti-inflammatory drugs, oral contraceptive pills, or intrauterine devices. Osteopathic manipulative treatment (OMT) is a beneficial tool for improving non-musculoskeletal (non-MSK) conditions such as migraines, gastroesophageal reflux disease (GERD), and anxiety. OMT should be utilized to improve other non-MSK conditions, such as dysmenorrhea. The current review aims to evaluate the effects of OMT in women with dysmenorrhea. An extensive search was conducted in Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, Biomedical Reference Collection: Comprehensive, and Nursing & Allied Health Collection: Comprehensive from inception to June 2022. Studies evaluating the use of OMT in patients with dysmenorrhea were included, while editorial/opinion articles were excluded. Three independent reviewers evaluated the studies. Ten studies evaluating the use of OMT in patients with dysmenorrhea were included. Overall, OMT was shown to provide relief of symptoms, including back and menstrual pain; however, there was no guideline on which OMT techniques are the most successful. Numerous positive effects were found, including a reduction in the duration of pain, reduction of pain intensity, and reduction of analgesic use. However, the low number of studies supports the need for further investigations. Dysmenorrhea patients could benefit from a prospective randomized controlled trial targeting spinal facilitation and viscerosomatic reflexes to decrease pain duration, pain intensity, and analgesic use. Non-MSK-focused OMT has a large body of mostly anecdotal evidence for relief of conditions such as migraine, GERD, and anxiety. It has helped when traditional standards of care have failed. Non-MSK-focused OMT research represents a relatively untouched field of research that can have a profound and positive global impact, particularly in areas with poor income/healthcare access.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52794
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emergency endovascular management of a shrapnel injury to the left common carotid artery with impending blow-out.

Mehra, Rohit / Patra, V / Dhillan, R / Jha, M

BMJ military health

2024 Volume 170, Issue 1, Page(s) 80–81

MeSH term(s)	Humans ; Carotid Artery, Common/surgery ; Endovascular Procedures
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	3011686-7
ISSN	2633-3775 ; 2633-3767
ISSN (online)	2633-3775
ISSN	2633-3767
DOI	10.1136/bmjmilitary-2022-002083
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Article ; Online: Self-reducing intrathoracic organo-axial gastric volvulus with paraoesophageal hiatus hernia in a toddler.

Manral, Sushma / Nischal, Neha / Mehra, Rohit / Luthra, Meera

BMJ case reports

2024 Volume 17, Issue 2

Abstract: A toddler presented with complaints of multiple episodes of vomiting lasting 1 week. He had a history of similar episodes of vomiting several times as an infant. Clinically, he was underweight and had tachypnoea and tachycardia. Laboratory investigations ...

Abstract	A toddler presented with complaints of multiple episodes of vomiting lasting 1 week. He had a history of similar episodes of vomiting several times as an infant. Clinically, he was underweight and had tachypnoea and tachycardia. Laboratory investigations revealed hyponatraemic metabolic acidosis. His chest radiograph revealed an intrathoracic herniation of the stomach with an atypical presence towards the right hemithorax, suggestive of a torsion. A contrast-enhanced CT of the chest and abdomen confirmed an intrathoracic gastric herniation, with an organo-axial gastric volvulus, with no features of strangulation. He underwent an emergency laparotomy and intraoperatively the stomach was found to have reduced to its intra-abdominal position, and the hernia and volvulus had also self-reduced. In view of the multiple symptomatic episodes, an anterior gastropexy was performed to prevent recurrences. The patient recuperated well and has not had any recurrences in the follow-up period. This report adds to the minimalistic literature.
MeSH term(s)	Male ; Infant ; Humans ; Child, Preschool ; Hernia, Hiatal/complications ; Hernia, Hiatal/diagnostic imaging ; Hernia, Hiatal/surgery ; Stomach Volvulus/complications ; Stomach Volvulus/diagnostic imaging ; Stomach Volvulus/surgery ; Vomiting/etiology ; Vomiting/surgery ; Laparotomy
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-257585
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Article ; Online: Complex aortic-arch pseudoaneurysm with aorto-innominate vein fistula in a case of traumatic chest injury.

Mehra, Rohit / Swain, Pranati / Aggarwal, Rohit / Balasubramaniam, Dhanalakshmi

BMJ case reports

2024 Volume 17, Issue 3

Abstract: A patient in his late 30s presented with issues of retrosternal chest pain and palpitations. He had sustained a splinter injury to the left hemithorax a year ago for which he had been managed with a tube thoracostomy. During subsequent evaluations, he ... ...

Abstract	A patient in his late 30s presented with issues of retrosternal chest pain and palpitations. He had sustained a splinter injury to the left hemithorax a year ago for which he had been managed with a tube thoracostomy. During subsequent evaluations, he was found to have atrial fibrillations and a CT angiography revealed an arch of the aorta pseudoaneurysm with a fistulous communication with the innominate vein, which being a rare condition has no established treatment protocols. Endovascular salvage of the condition required an aortic Ishimaru zone 2 deployment of the thoracic endovascular aortic repair stent graft to provide an adequate landing zone. The elective left subclavian artery revascularisation was obtained by a left carotid artery to left subclavian artery bypass. Post procedure there was complete exclusion of the pseudoaneurysm sac, and the fistulous aorto-venous communication inflow tract. The patient recuperated well and has returned to full active duties.
MeSH term(s)	Humans ; Male ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aorta, Thoracic/injuries ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Brachiocephalic Veins/diagnostic imaging ; Brachiocephalic Veins/surgery ; Endovascular Procedures ; Prosthesis Design ; Stents ; Thoracic Injuries/surgery ; Treatment Outcome ; Adult
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2024-260184
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Article ; Online: An Insight into the "Dark Matter" of Kidney Cancer.

Mehra, Rohit

European urology

2018 Volume 74, Issue 6, Page(s) 764–766

MeSH term(s)	Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Prognosis ; RNA, Long Noncoding
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2018-08-31
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2018.08.023
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Article ; Online: Renal cell carcinoma associated with tuberous sclerosis complex (TSC)/mammalian target of rapamycin (MTOR) genetic alterations.

Argani, Pedram / Mehra, Rohit

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2022 Volume 35, Issue 3, Page(s) 296–297

MeSH term(s)	Humans ; Carcinoma, Renal Cell/genetics ; Carotenoids ; Kidney Neoplasms/genetics ; TOR Serine-Threonine Kinases/genetics ; Tuberous Sclerosis/complications ; Tuberous Sclerosis/genetics ; Vitamin A/analogs & derivatives
Chemical Substances	Carotenoids (36-88-4) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Vitamin A (11103-57-4)
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Editorial
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/s41379-021-00971-y
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Article: Dosimetric impact of natural terrestrial radioactivity on residents of lower Himalayas, India

Kaur, Sarabjot / Mehra, Rohit

Environmental geochemistry and health. 2022 Feb., v. 44, no. 2

2022

Abstract: A comprehensive radio-ecological evaluation of soil samples of Solan and Shimla districts of Himachal Pradesh has been carried out for risk and dose assessment. Twenty-six randomly selected environmental soil samples were analysed for natural ... ...

Abstract	A comprehensive radio-ecological evaluation of soil samples of Solan and Shimla districts of Himachal Pradesh has been carried out for risk and dose assessment. Twenty-six randomly selected environmental soil samples were analysed for natural radionuclide concentrations (²²⁶Ra, ²³²Th and ⁴⁰K) using NaI(Tl) scintillator detector. The average concentration of ²²⁶Ra, ²³²Th and ⁴⁰K was observed as 37, 59 and 430 Bq kg⁻¹, respectively, which exceeded the worldwide average of 33, 45 and 412 Bq kg⁻¹ reported by UNSCEAR (Sources and effects of ionizing radiation. Report to the general assembly with scientific annexes, New York, 2008). Radium equivalent activity (Raₑq), hazard indices (Hₑₓ, Hᵢₙ) and radioactivity level indices (Iϒᵣ, Iα, AUI) and Clark value were checked against their threshold limits, and their mean values were safely below the recommended criteria. This confirms the soil applicability for construction purposes. Indoor and outdoor dose rates (Ḋ), age-dependent annual effective doses (AED), organ-specific doses and lifetime attributable cancer risk (both cancer incidence and cancer mortality) were also computed. Strong positive correlation was established between radon/thoron exhalation rate and their parent radionuclides. Multivariate statistical technique was employed to explore spatial distribution of radionuclides and homogeneity between various radiological parameters.
Keywords	geochemistry ; mortality ; radioactivity ; radium ; radon ; risk ; soil ; Himalayan region ; India ; New York
Language	English
Dates of publication	2022-02
Size	p. 603-629.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00748-3
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Article ; Online: Thermoluminescence dosimeter (TLD) studies of Ca

Chand, Sansar / Mehra, Rohit / Chopra, Vibha

Luminescence : the journal of biological and chemical luminescence

2023 Volume 38, Issue 10, Page(s) 1780–1788

Abstract: This study reports the thermoluminescence (TL) aspects of ... ...

Abstract	This study reports the thermoluminescence (TL) aspects of Ca
MeSH term(s)	Radiation Dosimeters ; Thermoluminescent Dosimetry/methods ; Gamma Rays ; Radiometry
Chemical Substances	Cobalt-60 (5C8182XDPZ)
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4564
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