LIVIVO - Search results -

Search results

Result 1 - 10 of total 36

Search options

Article ; Online: Radiometal chelators for infection diagnostics.

Akter, Asma / Lyons, Oliver / Mehra, Varun / Isenman, Heather / Abbate, Vincenzo

Frontiers in nuclear medicine (Lausanne, Switzerland)

2023 Volume 2, Page(s) 1058388

Abstract: Infection of native tissues or implanted devices is common, but clinical diagnosis is frequently difficult and currently available noninvasive tests perform poorly. Immunocompromised individuals (for example transplant recipients, or those with cancer) ... ...

Abstract	Infection of native tissues or implanted devices is common, but clinical diagnosis is frequently difficult and currently available noninvasive tests perform poorly. Immunocompromised individuals (for example transplant recipients, or those with cancer) are at increased risk. No imaging test in clinical use can specifically identify infection, or accurately differentiate bacterial from fungal infections. Commonly used [
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-8880
ISSN (online)	2673-8880
DOI	10.3389/fnume.2022.1058388
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Aspergillus Infections.

Ceesay, M Mansour / Mehra, Varun / Pagliuca, Antonio

The New England journal of medicine

2022 Volume 386, Issue 2, Page(s) 198

MeSH term(s)	Aspergillosis/diagnosis ; Humans
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2117819
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.34: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A rapidly expanding cutaneous tumour in the context of a Janus kinase inhibitor agent following allogeneic stem cell transplant.

Davies, Anna / Salisbury, Jon / Mehra, Varun / Papa, Sophie / Basu, Tanya

Clinical and experimental dermatology

2022 Volume 47, Issue 11, Page(s) 2059–2064

Abstract: Ruxolitinib is a selective, Janus kinase (JAK)1 and JAK2 inhibitor, which is effective in management of chronic graft-versus-host disease (cGvHD). However, the ensuing immunosuppressive effects can give rise to aggressive cutaneous tumours, including ... ...

Abstract	Ruxolitinib is a selective, Janus kinase (JAK)1 and JAK2 inhibitor, which is effective in management of chronic graft-versus-host disease (cGvHD). However, the ensuing immunosuppressive effects can give rise to aggressive cutaneous tumours, including Merkel cell carcinoma. We present this case to highlight the development of cutaneous tumours with ruxolitinib, an increasingly used therapy, and the challenge of managing such tumours in the context of refractory cGvHD. Click here for the corresponding questions to this CME article.
MeSH term(s)	Humans ; Janus Kinase Inhibitors/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease/drug therapy ; Stem Cell Transplantation ; Skin Neoplasms/drug therapy
Chemical Substances	ruxolitinib (82S8X8XX8H) ; Janus Kinase Inhibitors
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.15305
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1278: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Rising incidence of Pneumocystis pneumonia: A population-level descriptive ecological study in England.

Pates, Katharine / Periselneris, Jimstan / Russell, Mark D / Mehra, Varun / Schelenz, Silke / Galloway, James B

The Journal of infection

2023 Volume 86, Issue 4, Page(s) 385–390

Abstract: Objectives: Pneumocystis pneumonia (PCP) is an opportunistic infection that causes significant morbidity and mortality in the immunocompromised population. This population is growing and diversifying, yet contemporary epidemiology is lacking. We ... ...

Abstract	Objectives: Pneumocystis pneumonia (PCP) is an opportunistic infection that causes significant morbidity and mortality in the immunocompromised population. This population is growing and diversifying, yet contemporary epidemiology is lacking. We investigated the population-level incidence of PCP over the past decade. Methods: We conducted a descriptive study of all hospital admissions in England from April 2012 to March 2022. PCP episodes, age, median length of stay, gender and episodes of other respiratory fungal infections were collected. Consumption of Trimethoprim-Sulfamethoxazole was obtained between January 2019 and May 2022. Results: The incidence of PCP increased from 2·2-4·5/100,000 population between 2012/2013 and 2019/2020 (p < 0·0001). There was a drop in 2020/2021 to 2·7/100,000 before returning to 3.9/100,000 in 2021/2022. PCP episodes rose as a proportion of all-cause admissions as well as a proportion of episodes due to other fungal infections. The proportion of PCP patients aged 75+ increased from 14% to 26%. The median length of stay was 13.5 days. Consumption of intravenous Trimethoprim-Sulfamethoxazole increased from 0.24 × 100,000 to 0.30 × 100,000 defined daily doses. Conclusions: The incidence of PCP is rising rapidly and represents a significant burden to the healthcare system. Further study into who is at risk of PCP is needed to better determine who should be given prophylaxis.
MeSH term(s)	Humans ; Pneumonia, Pneumocystis/epidemiology ; Pneumonia, Pneumocystis/microbiology ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ; Incidence ; Opportunistic Infections ; England/epidemiology ; Retrospective Studies
Chemical Substances	Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.02.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 48: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Effect of customized vibratory device on orthodontic tooth movement: A prospective randomized control trial.

Khera, Amit K / Raghav, Pradeep / Mehra, Varun / Wadhawan, Ashutosh / Gupta, Navna / Phull, Tarun S

Journal of orthodontic science

2022 Volume 11, Page(s) 18

Abstract: Aims: The primary purpose of the present trial was to evaluate the effect of low-frequency (30Hz) vibrations on the rate of canine retraction.: Setting and design: Single-center, split mouth prospective randomized controlled clinical trial.: ... ...

Abstract	Aims: The primary purpose of the present trial was to evaluate the effect of low-frequency (30Hz) vibrations on the rate of canine retraction. Setting and design: Single-center, split mouth prospective randomized controlled clinical trial. Methods and material: 100 screened subjects (aged18-25 years) were selected; out of which 30 subjects having Class I bimaxillary protrusion or Class II div 1 malocclusion, requiring upper 1 Statistical analysis used: Independent "t" test. Results: There was no statistically significant differencein the rate of individual canine retraction among the experimental and control groups when the intergroup comparison was done using independent "t" test at T1-T0, ( Conclusion: The low-frequency vibratory stimulation of 30 Hz using a customized vibratory device did not significantly accelerate the rate of orthodontic tooth movement. Trial registration: Registered at ctri.nic.in (CTRI/2019/05/019043).
Language	English
Publishing date	2022-05-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2733594-X
ISSN	2278-0203 ; 2278-1897
ISSN (online)	2278-0203
ISSN	2278-1897
DOI	10.4103/jos.jos_127_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Haploidentical Transplant with Post-Transplant Cyclophosphamide for Acute Myeloid Leukaemia and Myelodysplastic Syndromes Patients: The Role of Previous Lines of Therapy.

Avenoso, Daniele / Serpenti, Fabio / Slonim, Liron Barnea / Bouziana, Styliani / Dazzi, Francesco / Hannah, Guy / Kenyon, Michelle / Mehra, Varun / Kulasekararaj, Austin / Krishamurthy, Pramila / Shah, Mili Naresh / Lionel, Sharon / Pagliuca, Antonio / Potter, Victoria

Mediterranean journal of hematology and infectious diseases

2024 Volume 16, Issue 1, Page(s) e2024002

Abstract: Background: Allogeneic haematopoietic stem-cell transplant is an option, potentially curative, for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows for the ... ...

Abstract	Background: Allogeneic haematopoietic stem-cell transplant is an option, potentially curative, for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows for the selection of haploidentical donors in patients who are eligible for the procedure but do not have a fully matched donor since it can overcome the HLA barrier. There is still an active debate on whether intensifying the conditioning regimen is necessary with haploidentical donors when peripheral blood stem cells are used as the graft source. Herein, we report our decennial experience of haploidentical stem-cell transplant using peripheral blood stem cells (haplo-PBSC) at King's College Hospital. Objectives: The primary objective was to evaluate overall survival (OS) following haplo-PBSC. Secondary objectives were total OS for patients with less than two previous lines of therapy, OS according to cytomegalovirus (CMV) reactivation, incidence of transplant-related mortality (TRM), graft-versus-host disease (GVHD) and GVHD-relapse-free survival (GRFS). Results: One-year and three-year total OS were 62% and 43%, respectively, with a median OS of 22 months. One-year and three-year OS for patients with ≤2 and those with >2 previous lines of therapy were 72% and 55%, and 60% and 22%, respectively (p-value=0.04). The median OS in patients with >2 previous and ≤2 lines of therapy was 16 and 49 months, respectively. Cumulative incidence (CI) of relapse was 25% with a median time to relapse of 5 months (range 1 - 38 months). Conclusions: Haploidentical haematopoietic stem-cell transplant is potentially curative in chemosensitive AML and MDS and offers a high rate of prolonged remission. Our cohort further confirms the role of consolidative haploidentical transplant in patients in complete remission and highlights that patients with heavily pre-treated disease may not benefit from this strategy.
Language	English
Publishing date	2024-01-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2674750-9
ISSN	2035-3006
ISSN	2035-3006
DOI	10.4084/MJHID.2024.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Estimating the value of demand-side management in low-cost, solar micro-grids

Mehra, Varun / Reja Amatya / Rajeev J. Ram

Energy. 2018 Nov. 15, v. 163

2018

Abstract: Demand-side management has the potential to reduce the cost of solar based community micro-grids and solar home systems for electricity access. This paper presents a methodology for optimal least-cost sizing of generation assets while meeting explicit ... ...

Abstract	Demand-side management has the potential to reduce the cost of solar based community micro-grids and solar home systems for electricity access. This paper presents a methodology for optimal least-cost sizing of generation assets while meeting explicit reliability constraints in micro-grids that are capable of active demand management. The battery management model considers kinetic constraints on battery operation and represents dispatch in the field to regulate the depth of discharge. The model allows consideration of the trade-off between depth of discharge, cycle life, and calendar lifetime in lead-acid batteries. Separate reliability targets for disaggregated, residential load profiles at hourly timesteps are considered to evaluate the performance and cost reduction potential of demand-side management capabilities — with economic results and sensitivity analyses around key input assumptions subsequently presented. We find that demand-side management can reduce the number and cost of requisite solar panels and batteries with the integration of real-time management and controls – a key result for justifying next generation micro-grids for electricity access.
Keywords	assets ; batteries ; cost effectiveness ; electricity ; models ; solar collectors
Language	English
Dates of publication	2018-1115
Size	p. 74-87.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2018.07.204
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Fludarabine-Melphalan-Campath, Followed by Unmanipulated Peripheral-Blood Haematopoietic Stem Cells, Can Still Cure Lymphoma.

Avenoso, Daniele / Alabdulwahab, Amal / Kenyon, Michelle / Mehra, Varun / Krishnamurthy, Pramila / Dazzi, Francesco / Leung, Ye Ting / Anteh, Sandra / Shah, Mili Naresh / Kuhnl, Andrea / Sanderson, Robin / Patten, Piers / Yallop, Deborah / Pagliuca, Antonio / Potter, Victoria

Mediterranean journal of hematology and infectious diseases

2023 Volume 15, Issue 1, Page(s) e2023041

Abstract: Background: The second decade of this millennium was characterized by a widespread availability of chimeric antigen receptor T-cell (CAR-T) therapies to treat relapsed and refractory lymphomas. As expected, the role and indication of allogeneic ... ...

Abstract	Background: The second decade of this millennium was characterized by a widespread availability of chimeric antigen receptor T-cell (CAR-T) therapies to treat relapsed and refractory lymphomas. As expected, the role and indication of allogeneic haematopoietic stem cell transplant (allo-HSCT) in the management of lymphoma changed. Currently, a non-neglectable proportion of patients will be considered candidate for an allo-HSCT, and the debate of which transplant platform should be offered is still active. Objectives: to report the outcome of patients affected with relapsed/refractory lymphoma and transplanted following reduced intensity conditioning at King's College Hospital, London, between January 2009 and April 2021. Methods: Conditioning was with 150mg/m2 of fludarabine and melphalan of 140mg/m2. The graft was unmanipulated G-CSF mobilized peripheral blood haematopoietic stem cells (PBSC). Graft- Results: One-year and five years OS were 87% and 79.9%, respectively, and median OS was not reached. The cumulative incidence of relapse was 16%. The incidence of acute GVHD was 48% (only grade I/II); no cases of grade III/IV were diagnosed. Chronic GVHD occurred in 39% of patients. TRM was 12%, with no cases developed within day 100 and 18 months after the procedure. Conclusions: The outcomes of heavily pretreated lymphoma patients are favorable, with median OS and survival not reached after a median of 49 months. In conclusion, even if some lymphoma subgroups cannot be treated (yet) with advanced cellular therapies, this study confirms the role of allo-HSCT as a safe and curative strategy.
Language	English
Publishing date	2023-07-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2674750-9
ISSN	2035-3006
ISSN	2035-3006
DOI	10.4084/MJHID.2023.041
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Guidelines for the management of Toxoplasma gondii infection and disease in patients with haematological malignancies and after haematopoietic stem-cell transplantation: guidelines from the 9th European Conference on Infections in Leukaemia, 2022.

Aerts, Robina / Mehra, Varun / Groll, Andreas H / Martino, Rodrigo / Lagrou, Katrien / Robin, Christine / Perruccio, Katia / Blijlevens, Nicole / Nucci, Marcio / Slavin, Monica / Bretagne, Stéphane / Cordonnier, Catherine

The Lancet. Infectious diseases

2023 Volume 24, Issue 5, Page(s) e291–e306

Abstract: Patients with haematological malignancies might develop life-threatening toxoplasmosis, especially after allogeneic haematopoietic stem-cell transplantation (HSCT). Reactivation of latent cysts is the primary mechanism of toxoplasmosis following HSCT; ... ...

Abstract	Patients with haematological malignancies might develop life-threatening toxoplasmosis, especially after allogeneic haematopoietic stem-cell transplantation (HSCT). Reactivation of latent cysts is the primary mechanism of toxoplasmosis following HSCT; hence, patients at high risk are those who were seropositive before transplantation. The lack of trimethoprim-sulfamethoxazole prophylaxis and various immune status parameters of the patient are other associated risk factors. The mortality of toxoplasma disease-eg, with organ involvement-can be particularly high in this setting. We have developed guidelines for managing toxoplasmosis in haematology patients, through a literature review and consultation with experts. In allogeneic HSCT recipients seropositive for Toxoplasma gondii before transplant, because T gondii infection mostly precedes toxoplasma disease, we propose weekly blood screening by use of quantitative PCR (qPCR) to identify infection early as a pre-emptive strategy. As trimethoprim-sulfamethoxazole prophylaxis might fail, prophylaxis and qPCR screening should be combined. However, PCR in blood can be negative even in toxoplasma disease. The duration of prophylaxis should be a least 6 months and extended during treatment-induced immunosuppression or severe CD4 lymphopenia. If a positive qPCR test occurs, treatment with trimethoprim-sulfamethoxazole, pyrimethamine-sulfadiazine, or pyrimethamine-clindamycin should be started, and a new sample taken. If the second qPCR test is negative, clinical judgement is recommended to either continue or stop therapy and restart prophylaxis. Therapy must be continued until a minimum of two negative PCRs for infection, or for at least 6 weeks for disease. The pre-emptive approach is not indicated in seronegative HSCT recipients, after autologous transplantation, or in non-transplant haematology patients, but PCR should be performed with a high level of clinical suspicion.
MeSH term(s)	Humans ; Toxoplasmosis/diagnosis ; Toxoplasmosis/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Toxoplasma ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/therapy ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ; Antiprotozoal Agents/therapeutic use
Chemical Substances	Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Antiprotozoal Agents
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00495-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5743: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Insights into horizontal acquisition patterns of dormancy and reactivation regulon genes in mycobacterial species using a partitioning-based framework.

Mehra, Varun / Ghosh, Tarini Shankar / Mande, Sharmila S

Journal of biosciences

2016 Volume 41, Issue 3, Page(s) 475–485

Abstract: Horizontal Gene Transfer (HGT) events, initially thought to be rare in Mycobacterium tuberculosis, have recently been shown to be involved in the acquisition of virulence operons in M. tuberculosis. We have developed a new partitioning framework based ... ...

Abstract	Horizontal Gene Transfer (HGT) events, initially thought to be rare in Mycobacterium tuberculosis, have recently been shown to be involved in the acquisition of virulence operons in M. tuberculosis. We have developed a new partitioning framework based HGT prediction algorithm, called Grid3M, and applied the same for the prediction of HGTs in Mycobacteria. Validation and testing using simulated and real microbial genomes indicated better performance of Grid3M as compared with other widely used HGT prediction methods. Specific analysis of the genes belonging to dormancy/reactivation regulons across 14 mycobacterial genomes indicated that horizontal acquisition is specifically restricted to important accessory proteins. The results also revealed Burkholderia species to be a probable source of HGT genes belonging to these regulons. The current study provides a basis for similar analyses investigating the functional/evolutionary aspects of HGT genes in other pathogens. A database of Grid3M predicted HGTs in completely sequenced genomes is available at https://metagenomics.atc.tcs.com/Grid3M/.
MeSH term(s)	Algorithms ; Burkholderia/genetics ; Evolution, Molecular ; Gene Transfer, Horizontal/genetics ; Genome, Bacterial ; Humans ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/pathogenicity ; Operon/genetics ; Phylogeny ; Tuberculosis/genetics ; Tuberculosis/microbiology
Language	English
Publishing date	2016-08-23
Publishing country	India
Document type	Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/s12038-016-9622-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito