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Article: Editorial: The role of iron in cancer progression.

Hamaï, Ahmed / Gong, Chang / Mehrpour, Maryam

2022 Volume 12, Page(s) 1026420

Language	English
Publishing date	2022-09-21
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1026420
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Article ; Online: Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy.

Duan, Zhuxi / Shi, Yu / Lin, Qun / Hamaï, Ahmed / Mehrpour, Maryam / Gong, Chang

Cells

2022 Volume 11, Issue 15

Abstract: Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a "double-edged sword" that can both promote and ... ...

Abstract	Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a "double-edged sword" that can both promote and inhibit tumor progression. Autophagy acts on innate and adaptive immunity and interacts with immune cells to modulate tumor immunotherapy. The discovery of autophagy inducers and autophagy inhibitors also provides new insights for clinical anti-tumor therapy. However, there are also difficulties in the application of autophagy-related regulators, such as low bioavailability and the lack of efficient selectivity. This review focuses on autophagy-related immunogenic regulation and its application in cancer therapy.
MeSH term(s)	Adaptive Immunity ; Autophagy/physiology ; Homeostasis ; Humans ; Immunotherapy ; Neoplasms/metabolism
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11152324
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Article ; Online: Homéostasie du fer et autophagie.

Hamaï, Ahmed / Mehrpour, Maryam

Medecine sciences : M/S

2017 Volume 33, Issue 3, Page(s) 260–267

Abstract: Iron is an essential nutrient to life. However, the ability of iron to cycle between the oxidized and reduced forms contributes to the formation of reactive oxygen species. The generation of free radicals leads to oxidative stress and the initiation of ... ...

Title translation	Autophagy and iron homeostasis.
Abstract	Iron is an essential nutrient to life. However, the ability of iron to cycle between the oxidized and reduced forms contributes to the formation of reactive oxygen species. The generation of free radicals leads to oxidative stress and the initiation of signaling pathways involved in cell survival or cell death. The iron homeostasis is very carefully regulated and dysregulation of iron metabolism contributes to various human pathologies. The work carried out in recent years has revealed new cellular processes and mechanisms like ferritinophagy, that deepen our understanding of iron homeostasis. Ferritinophagy is a form of selective macroautophagy whereby ferritin, an iron storage protein, is degraded in the lysosome. Here, we describe iron homeostasis and review recent discoveries regarding the mechanism of ferritinophagy and its relationship to a new form of cell-death iron-dependent, the ferroptosis.
MeSH term(s)	Animals ; Autophagy/physiology ; Ferritins/metabolism ; Homeostasis/physiology ; Humans ; Iron/metabolism ; Lysosomes/metabolism ; Metabolic Networks and Pathways
Chemical Substances	Ferritins (9007-73-2) ; Iron (E1UOL152H7)
Language	French
Publishing date	2017-03
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/20173303012
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Article ; Online: Crosstalk between autophagy and metabolic regulation of cancer stem cells.

El Hout, Mouradi / Cosialls, Emma / Mehrpour, Maryam / Hamaï, Ahmed

Molecular cancer

2020 Volume 19, Issue 1, Page(s) 27

Abstract: Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In ...

Abstract	Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key player but also drives stemness. In this review, we first summarize our current understanding of how autophagy influences cancer stem cell phenotype. We emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. We then provide an update on the role of metabolic reprogramming and plasticity in cancer stem cells. Finally, we discuss how metabolic pathways in cancer stem cells could be therapeutically targeted.
MeSH term(s)	Animals ; Autophagy ; Humans ; Metabolic Networks and Pathways ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment
Language	English
Publishing date	2020-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-019-1126-8
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Article ; Online: Ferroptosis: Cancer Stem Cells Rely on Iron until "to Die for" It.

Cosialls, Emma / El Hage, Rima / Dos Santos, Leïla / Gong, Chang / Mehrpour, Maryam / Hamaï, Ahmed

Cells

2021 Volume 10, Issue 11

Abstract: Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer therapies, they are thought responsible for tumor recurrence and metastasis. ... ...

Abstract	Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer therapies, they are thought responsible for tumor recurrence and metastasis. Recent accumulated evidence supports that iron metabolism with the recent discovery of ferroptosis constitutes a promising new lead in the field of anti-CSC therapeutic strategies. Indeed, iron uptake, efflux, storage and regulation pathways are all over-engaged in the tumor microenvironment suggesting that the reprogramming of iron metabolism is a crucial occurrence in tumor cell survival. In particular, recent studies have highlighted the importance of iron metabolism in the maintenance of CSCs. Furthermore, the high concentration of iron found in CSCs, as compared to non-CSCs, underlines their iron addiction. In line with this, if iron is an essential macronutrient that is nevertheless highly reactive, it represents their Achilles' heel by inducing ferroptosis cell death and therefore providing opportunities to target CSCs. In this review, we first summarize our current understanding of iron metabolism and its regulation in CSCs. Then, we provide an overview of the current knowledge of ferroptosis and discuss the role of autophagy in the (regulation of) ferroptotic pathways. Finally, we discuss the potential therapeutic strategies that could be used for inducing ferroptosis in CSCs to treat cancer.
MeSH term(s)	Animals ; Autophagy ; Ferroptosis ; Humans ; Iron/metabolism ; Models, Biological ; Molecular Targeted Therapy ; Neoplastic Stem Cells/pathology
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2021-11-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10112981
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Article ; Online: Non-coding RNAs as new autophagy regulators in cancer progression.

Lin, Qun / Shi, Yu / Liu, Zihao / Mehrpour, Maryam / Hamaï, Ahmed / Gong, Chang

Biochimica et biophysica acta. Molecular basis of disease

2021 Volume 1868, Issue 1, Page(s) 166293

Abstract: Recent advances highlight that non-coding RNAs (ncRNAs) are emerging as fundamental regulators in various physiological as well as pathological processes by regulating macro-autophagy. Studies have disclosed that macro-autophagy, which is a highly ... ...

Abstract	Recent advances highlight that non-coding RNAs (ncRNAs) are emerging as fundamental regulators in various physiological as well as pathological processes by regulating macro-autophagy. Studies have disclosed that macro-autophagy, which is a highly conserved process involving cellular nutrients, components, and recycling of organelles, can be either selective or non-selective and ncRNAs show their regulation on selective autophagy as well as non-selective autophagy. The abnormal expression of ncRNAs will result in the impairment of autophagy and contribute to carcinogenesis and cancer progression by regulating both selective autophagy as well as non-selective autophagy. This review focuses on the regulatory roles of ncRNAs in autophagy and their involvement in cancer which may provide valuable therapeutic targets for cancer management.
MeSH term(s)	Autophagy/genetics ; Carcinogenesis/genetics ; Disease Progression ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; RNA, Untranslated/genetics
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2021-10-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2021.166293
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Article ; Online: Association of FTH1-Expressing Circulating Tumor Cells With Efficacy of Neoadjuvant Chemotherapy for Patients With Breast Cancer: A Prospective Cohort Study.

Jia, Shijie / Yang, Yaping / Zhu, Yingying / Yang, Wenqian / Ling, Li / Wei, Yanghui / Fang, Xiaolin / Lin, Qun / Hamaï, Ahmed / Mehrpour, Maryam / Gao, Jingbo / Tan, Weige / Xia, Yuan / Chen, Jiayi / Jiang, Wenguo / Gong, Chang

The oncologist

2023 Volume 29, Issue 1, Page(s) e25–e37

Abstract: Background: The association between different phenotypes and genotypes of circulating tumor cells (CTCs) and efficacy of neoadjuvant chemotherapy (NAC) remains uncertain. This study was conducted to evaluate the relationship of FTH1 gene-associated CTCs ...

Abstract	Background: The association between different phenotypes and genotypes of circulating tumor cells (CTCs) and efficacy of neoadjuvant chemotherapy (NAC) remains uncertain. This study was conducted to evaluate the relationship of FTH1 gene-associated CTCs (F-CTC) with/without epithelial-mesenchymal transition (EMT) markers, or their dynamic changes with the efficacy of NAC in patients with non-metastatic breast cancer. Patients and methods: This study enrolled 120 patients with non-metastatic breast cancer who planned to undergo NAC. The FTH1 gene and EMT markers in CTCs were detected before NAC (T0), after 2 cycles of chemotherapy (T1), and before surgery (T2). The associations of these different types of CTCs with rates of pathological complete response (pCR) and breast-conserving surgery (BCS) were evaluated using the binary logistic regression analysis. Results: F-CTC in peripheral blood ≥1 at T0 was an independent factor for pCR rate in patients with HER2-positive (odds ratio [OR]=0.08, 95% confidence interval [CI], 0.01-0.98, P = .048). The reduction in the number of F-CTC at T2 was an independent factor for BCS rate (OR = 4.54, 95% CI, 1.14-18.08, P = .03). Conclusions: The number of F-CTC prior to NAC was related to poor response to NAC. Monitoring of F-CTC may help clinicians formulate personalized NAC regimens and implement BCS for patients with non-metastatic breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/surgery ; Neoplastic Cells, Circulating/pathology ; Prospective Studies ; Neoadjuvant Therapy ; Mastectomy, Segmental ; Ferritins/therapeutic use ; Oxidoreductases/therapeutic use
Chemical Substances	FTH1 protein, human (EC 1.-) ; Ferritins (9007-73-2) ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad195
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells.

El Hout, Mouradi / Dos Santos, Leïla / Hamaï, Ahmed / Mehrpour, Maryam

Seminars in cancer biology

2018 Volume 53, Page(s) 125–138

Abstract: Iron is an essential nutrient that facilitates cell proliferation and growth. Iron can be detrimental, however. The ability of iron to cycle between oxidized and reduced forms contributes to the formation of free radicals. An excess of free radicals ... ...

Abstract	Iron is an essential nutrient that facilitates cell proliferation and growth. Iron can be detrimental, however. The ability of iron to cycle between oxidized and reduced forms contributes to the formation of free radicals. An excess of free radicals leads to lipid peroxidation, more reactive oxygen species and oxidative stress, damage to DNA and other biomolecules, and, if potentially, tumorigenesis. Iron also has a role in the maintenance of the tumor microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage, and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumor cell survival. Recent studies have shed light on the role of iron metabolism in cancer stem cells (CSC) and suggest that specific targeting of iron metabolism in CSCs may improve the efficacy of cancer therapy. In this review, we first summarize briefly our current understanding of the intracellular processes involving iron, the effect of dietary iron, and its relation to cancer. We emphasize the importance of modifier "iron genes" in cancer and the possibility that these genes may encode biomarkers that may be used clinically. We then provide an update on the role of iron in metabolic reprogramming, the epithelial-mesenchymal transition, and the regulation of epigenetic marks essential for CSC maintenance and plasticity. Finally, we discuss the potential of targeting a recently discovered form of iron-regulated cell death, ferroptosis, in CSCs for treatment of cancer.
MeSH term(s)	Animals ; Antineoplastic Agents/therapeutic use ; Cell Death/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Homeostasis/drug effects ; Homeostasis/genetics ; Homeostasis/physiology ; Humans ; Iron/metabolism ; Iron Chelating Agents/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism
Chemical Substances	Antineoplastic Agents ; Iron Chelating Agents ; Iron (E1UOL152H7)
Language	English
Publishing date	2018-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2018.07.009
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Article: MiR-92b-3p Inhibits Proliferation of HER2-Positive Breast Cancer Cell by Targeting circCDYL.

Liang, Gehao / Ling, Yun / Lin, Qun / Shi, Yu / Luo, Qing / Cen, Yinghuan / Mehrpour, Maryam / Hamai, Ahmed / Li, Jun / Gong, Chang

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 707049

Abstract: Objectives: Circular RNA (circRNA) is a novel class of RNA, which exhibits powerful biological function in regulating cellular fate of various tumors. Previously, we had demonstrated that over-expression of circRNA circCDYL promoted progression of HER2- ... ...

Abstract	Objectives: Circular RNA (circRNA) is a novel class of RNA, which exhibits powerful biological function in regulating cellular fate of various tumors. Previously, we had demonstrated that over-expression of circRNA circCDYL promoted progression of HER2-negative (HER2 Materials and methods: qRT-PCR and Results: CircCDYL was high-expressed in HER2 Conclusion: MiR-92b-3p-dependent cleavage of circCDYL was an essential mechanism in regulating cell proliferation of HER2
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.707049
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Article ; Online: mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions.

Cosialls, Emma / Pacreau, Emeline / Duruel, Clémence / Ceccacci, Sara / Elhage, Rima / Desterke, Christophe / Roger, Kevin / Guerrera, Chiara / Ducloux, Romane / Souquere, Sylvie / Pierron, Gérard / Nemazanyy, Ivan / Kelly, Mairead / Dalmas, Elise / Chang, Yunhua / Goffin, Vincent / Mehrpour, Maryam / Hamaï, Ahmed

Cell death & disease

2023 Volume 14, Issue 11, Page(s) 744

Abstract: Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was ... ...

Abstract	Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was able to eliminate CSCs by triggering ferroptosis. Here, in a well-established breast CSCs model (human mammary epithelial HMLER CD24
MeSH term(s)	Humans ; Female ; Ferroptosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Iron/metabolism ; Neoplastic Stem Cells/metabolism
Chemical Substances	salinomycin (62UXS86T64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-06262-5
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