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  1. Article ; Online: Reduction of lithium induced interstitial fibrosis on co-administration with amiloride.

    Mehta, Paulomi M / Gimenez, Gregory / Walker, Robert J / Slatter, Tania L

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 14598

    Abstract: Long-term administration of lithium is associated with chronic interstitial fibrosis that is partially reduced with exposure to amiloride. We examined potential pathways of how amiloride may reduce interstitial fibrosis. Amiloride was administered to a ... ...

    Abstract Long-term administration of lithium is associated with chronic interstitial fibrosis that is partially reduced with exposure to amiloride. We examined potential pathways of how amiloride may reduce interstitial fibrosis. Amiloride was administered to a rat model of lithium induced interstitial fibrosis over a long term (6 months), as well as for short terms of 14 and 28 days. Kidney cortical tissue was subjected to RNA sequencing and microRNA expression analysis. Gene expression changes of interest were confirmed using immunohistochemistry on kidney tissue. Pathways identified by RNA sequencing of kidney tissue were related to 'promoting inflammation' for lithium and 'reducing inflammation' for amiloride. Validation of candidate genes found amiloride reduced inflammatory components induced by lithium including NF-κB/p65
    MeSH term(s) Amiloride ; Animals ; Fibrosis ; Inflammation ; Kidney ; Lithium ; Lung Diseases, Interstitial ; Rats
    Chemical Substances Amiloride (7DZO8EB0Z3) ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-18825-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis.

    Jesus, Alexandra N Boix De / Taha, Ahmad / Wang, David / Mehta, Paulomi M / Mehta, Sunali / Reily-Bell, Ashley / Lekamlage, Sasini Polwatta / Saraiva, Adriana Machado / Tahmeedzaman, Tahmeed / Ziad, Fouzia / Thotathil, Ziad / Gan, Peter Y C / Royds, Janice / Braithwaite, Antony / Hung, Noelyn / Slatter, Tania L

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: The Δ133p53β isoform is increased in many primary tumors and has many tumor-promoting properties that contribute to increased proliferation, migration and inflammation. Here we investigated whether Δ133p53β contributed to some of the most aggressive ... ...

    Abstract The Δ133p53β isoform is increased in many primary tumors and has many tumor-promoting properties that contribute to increased proliferation, migration and inflammation. Here we investigated whether Δ133p53β contributed to some of the most aggressive tumors that had metastasized to the brain.
    MeSH term(s) Humans ; Brain Neoplasms/metabolism ; Neoplasm Metastasis ; Protein Isoforms/genetics ; Tumor Suppressor Protein p53/genetics ; Gene Deletion
    Chemical Substances Protein Isoforms ; Tumor Suppressor Protein p53 ; TP53 protein, human
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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