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  1. Article: Work from home-Work engagement amid COVID-19 lockdown and employee happiness.

    Mehta, Prashant

    Journal of public affairs

    2021  Volume 21, Issue 4, Page(s) e2709

    Abstract: Prolonged lockdown as a part of the community mitigation steps to control the spread of the corona virus has led to massive work reorganization throughout the world. Companies as well as individuals are attempting to adjust to this new world of work. ... ...

    Abstract Prolonged lockdown as a part of the community mitigation steps to control the spread of the corona virus has led to massive work reorganization throughout the world. Companies as well as individuals are attempting to adjust to this new world of work. Organizations have shifted substantial parts of their work for certain sets of jobs to a "work from home (WFH)" format. The aim of this study is to investigate the relationship between WFH) work engagement and perceived employee happiness. WFH work engagement was hypothesized to be influenced by WFH autonomy, WFH convenience, and WFH psychosocial safety. All of the constructs were adapted from established scales. Convenience sampling was used for data collection as, under the circumstances, this was the only viable method. Partial least squares structural equation modelling was used for data analysis. Results from this study indicate that WFH work engagement was able to predict a 23.9% variance in perceived happiness, while exogenous constructs, such as WFH autonomy, WFH convenience, and WFH psychosocial safety, were able to predict a 25.2% variance in WFH work engagement. Further
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2080323-0
    ISSN 1479-1854 ; 1472-3891
    ISSN (online) 1479-1854
    ISSN 1472-3891
    DOI 10.1002/pa.2709
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  2. Article: Preventive oncology: Role of the primary diabetes care professional.

    Mehta, Prashant / Kalra, Sanjay

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 4, Page(s) 935–936

    Abstract: Cancer is a major cause of disease and death across the world, including South Asia. Much of the cancer burden is due to modifiable behavioural/lifestyle related factors (the modifiable 'exposome'), such as the five S's: smoking, spirit (alcohol), ... ...

    Abstract Cancer is a major cause of disease and death across the world, including South Asia. Much of the cancer burden is due to modifiable behavioural/lifestyle related factors (the modifiable 'exposome'), such as the five S's: smoking, spirit (alcohol), stoutness (obesity), unsafe sex, and sugar (hyperglycaemia). The primary diabetes care professional works not only to manage disease, but also to encourage healthy behaviours and promote health. This communication highlights how the diabetes care professional can play a significant part in preventing cancer and reducing the burden of disease.
    MeSH term(s) Humans ; Risk Factors ; Health Promotion ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/prevention & control ; Obesity ; Neoplasms/prevention & control
    Language English
    Publishing date 2023-04-13
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.23-27
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  3. Book ; Online: A Survey of Feedback Particle Filter and related Controlled Interacting Particle Systems (CIPS)

    Taghvaei, Amirhossein / Mehta, Prashant G.

    2023  

    Abstract: In this survey, we describe controlled interacting particle systems (CIPS) to approximate the solution of the optimal filtering and the optimal control problems. Part I of the survey is focussed on the feedback particle filter (FPF) algorithm, its ... ...

    Abstract In this survey, we describe controlled interacting particle systems (CIPS) to approximate the solution of the optimal filtering and the optimal control problems. Part I of the survey is focussed on the feedback particle filter (FPF) algorithm, its derivation based on optimal transportation theory, and its relationship to the ensemble Kalman filter (EnKF) and the conventional sequential importance sampling-resampling (SIR) particle filters. The central numerical problem of FPF -- to approximate the solution of the Poisson equation -- is described together with the main solution approaches. An analytical and numerical comparison with the SIR particle filter is given to illustrate the advantages of the CIPS approach. Part II of the survey is focussed on adapting these algorithms for the problem of reinforcement learning. The survey includes several remarks that describe extensions as well as open problems in this subject.
    Keywords Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control
    Subject code 518
    Publishing date 2023-01-02
    Publishing country us
    Document type Book ; Online
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  4. Article: PARP inhibitors in hereditary breast and ovarian cancer and other cancers: A review.

    Mehta, Prashant / Bothra, Sneha J

    Advances in genetics

    2021  Volume 108, Page(s) 35–80

    Abstract: There has been a paradigm shift in the management of cancer, with the immense progress in cancer genomics. More and more targeted therapies are becoming available by the day and personalized medicine is becoming popular with specific drugs being designed ...

    Abstract There has been a paradigm shift in the management of cancer, with the immense progress in cancer genomics. More and more targeted therapies are becoming available by the day and personalized medicine is becoming popular with specific drugs being designed for selected subgroups of patients. One such new class of targeted drugs in the armamentarium is Poly ADP Ribose Polymerase (PARP) inhibitors (PARPi), which inhibit the enzyme PARP, thus interfering with DNA repair. This strategy utilizes a pre-existing genomic lesion in tumors with homologous recombination repair defects (including BRCA mutations), weakening tumor cells further by blocking the alternate pathway of DNA repair. In this review, we discuss in detail, the evolution, genetics, mechanism of action, mechanism of resistance, indications of use of PARP inhibitors, as well as combination with other agents and future directions.
    MeSH term(s) DNA Repair/genetics ; Humans ; Mutation ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Poly(ADP-ribose) Polymerases/therapeutic use
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
    Language English
    Publishing date 2021-10-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 148-x
    ISSN 0065-2660
    ISSN 0065-2660
    DOI 10.1016/bs.adgen.2021.08.002
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    In stock of ZB MED Cologne/Königswinter

    Se 836: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Three-way Philadelphia Translocation [t(46, XX, t(9;22;16) (q34;q11.2;q24)] in Chronic Myeloid Leukemia: A Report of Two Cases with Review of the Literature.

    Bhardwaj, Mohit / Mishra, Sourav K / Gupta, Aastha / Mehta, Prashant / Sharma, Shivani / Mohanty, Sambit K

    Journal of cancer research and therapeutics

    2024  

    Abstract: Abstract: Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm that is genetically characterized by the presence of the Philadelphia (Ph) chromosome. Variant Ph translocation has been observed in 5% to 10% of the CML cases. In the ... ...

    Abstract Abstract: Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm that is genetically characterized by the presence of the Philadelphia (Ph) chromosome. Variant Ph translocation has been observed in 5% to 10% of the CML cases. In the previous studies, many different types of variant Ph translocations have been observed involving chromosomes 1p36, 3p21, 5q13, 6p21, 9q22, 11q13, 12p13, 17p13, and 10p15. According to the published literature, only two cases with the complex translocations involving long arm of chromosome 16 at band q24 have been reported. We report two female patients with complex translocation (three-way) involving chromosomes 9, 22, and 16 at breakpoint q24 and both patients responded well to Imatinib. The present study included 469 patients of clinically diagnosed CML patients who were referred for cytogenetic analysis to our laboratory. Cytogenetic analysis was performed by GTG banding, and the karyotype was designated according to the International System for Human Cytogenetic Nomenclature. Fluorescence in situ hybridization (FISH) analysis was performed for complex and variant BCR-ABL cases. Of total 469 cases, 248 patients showed classical Ph chromosome [t(9;22)(q34;q11.2)], 198 cases were normal, and 23 patients had variant and complex Ph chromosome translocation. Two patients showed three-way translocation involving long arm of chromosomes 9, 22, and 16 at band 9q34, 22q11.2, and 16q24. In this report, patients with variant Ph translocation did not have a significantly different outcome as compared to the classical translocation. Both cases responded well to Imatinib.
    Language English
    Publishing date 2024-01-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.jcrt_274_21
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  6. Article: Framework of Indian healthcare system and its challenges

    Mehta, Prashant

    Health economics and healthcare reform : breakthroughs in research and practice , p. 405-429

    an insight

    2018  , Page(s) 405–429

    Author's details Prashant Mehta
    Language English
    Publisher IGI Global, Disseminator of Knowledge
    Publishing place Hershey, PA, USA
    Document type Article
    ISBN 978-1-5225-3168-5 ; 1-5225-3168-8
    Database ECONomics Information System

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  7. Book ; Online: Passive elasticity properties of $\textit{Octopus rubescens}$ arm

    Halder, Udit / Gribkova, Ekaterina / Gillette, Rhanor / Mehta, Prashant G.

    2023  

    Abstract: In this report, passive elasticity properties of $\textit{Octopus rubescens}$ arm tissue are investigated using a multidisciplinary approach encompassing biomechanical experiments, computational modeling, and analyses. Tensile tests are conducted to ... ...

    Abstract In this report, passive elasticity properties of $\textit{Octopus rubescens}$ arm tissue are investigated using a multidisciplinary approach encompassing biomechanical experiments, computational modeling, and analyses. Tensile tests are conducted to obtain stress-strain relationships of the arm under axial stretch. Rheological tests are also performed to probe into dynamic shear response of the arm tissue. Based on these tests, comparisons against three different viscoelasticity models are reported.
    Keywords Physics - Biological Physics ; Condensed Matter - Materials Science
    Publishing date 2023-11-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Aviation waste management: An insight

    Mehta, Prashant

    International journal of environmental sciences. 2015, v. 6, no. 1

    2015  

    Abstract: Today's there is unprecedented growth in worldwide tourism, domestic and international movement of goods and services, and mobility becomes an integral factor in lives of people both for recreation and professional reasons. This would not be possible ... ...

    Abstract Today's there is unprecedented growth in worldwide tourism, domestic and international movement of goods and services, and mobility becomes an integral factor in lives of people both for recreation and professional reasons. This would not be possible without exponential growth of air transport industry and associated services. As a result commercial aviation today becomes one of the fastest-growing industries in the world. With such growth it is important that aviation of any nature across the globe is safe, comfortable, eco friendly, and imbibes universal hygiene principles in its overall operations. The potentially large environmental impact of aviation industry particularly airports in terms of air quality, noise, and handling of solid hazardous solid wastes, needs to be addressed by developing more sustainable environmental practices followed by its management, and safe disposal. Be it from managing infections due to ever growing burden disposed solid waste, exposure to hazardous materials, noise etc. Technical progress and new developments in aviation industry often goes hand in hand with developments in new environmental and waste recycling technologies for maintaining hygiene and protection of environment both on the ground and in air. As more and more waste related legislation are passed with stringent measures, airports and airlines are struggling to modernize their obsolete waste management systems and recovery processes. Aviation industry is therefore considering to swiftly implementing wide range of measures to keep the environmental impacts to minimum. In the context of above discussion my paper briefly identifies various categories of wastes generated by airlines, airports, and related industry (with emphasis on India) and how such waste generated at airports can be effectively handled for maintaining the sustainable ecosystem at the airports and the surrounding areas.
    Keywords air ; air quality ; air transportation ; airports ; aviation ; ecosystems ; environment ; environmental impact ; hygiene ; laws and regulations ; management systems ; paper ; people ; public services and goods ; recreation ; recycling ; solid wastes ; sounds ; tourism ; toxic substances ; India
    Language English
    Size p. 179-186.
    Publishing place Integrated Publishing Association
    Document type Article
    Note NAL-light
    ZDB-ID 2581485-0
    ISSN 0976-4402
    ISSN 0976-4402
    DOI 10.6088/ijes.6020
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online: Convex Q-Learning, Part 1

    Mehta, Prashant G. / Meyn, Sean P.

    Deterministic Optimal Control

    2020  

    Abstract: It is well known that the extension of Watkins' algorithm to general function approximation settings is challenging: does the projected Bellman equation have a solution? If so, is the solution useful in the sense of generating a good policy? And, if the ... ...

    Abstract It is well known that the extension of Watkins' algorithm to general function approximation settings is challenging: does the projected Bellman equation have a solution? If so, is the solution useful in the sense of generating a good policy? And, if the preceding questions are answered in the affirmative, is the algorithm consistent? These questions are unanswered even in the special case of Q-function approximations that are linear in the parameter. The challenge seems paradoxical, given the long history of convex analytic approaches to dynamic programming. The paper begins with a brief survey of linear programming approaches to optimal control, leading to a particular over parameterization that lends itself to applications in reinforcement learning. The main conclusions are summarized as follows: (i) The new class of convex Q-learning algorithms is introduced based on the convex relaxation of the Bellman equation. Convergence is established under general conditions, including a linear function approximation for the Q-function. (ii) A batch implementation appears similar to the famed DQN algorithm (one engine behind AlphaZero). It is shown that in fact the algorithms are very different: while convex Q-learning solves a convex program that approximates the Bellman equation, theory for DQN is no stronger than for Watkins' algorithm with function approximation: (a) it is shown that both seek solutions to the same fixed point equation, and (b) the ODE approximations for the two algorithms coincide, and little is known about the stability of this ODE. These results are obtained for deterministic nonlinear systems with total cost criterion. Many extensions are proposed, including kernel implementation, and extension to MDP models.

    Comment: This pre-print is written in a tutorial style so it is accessible to new-comers. It will be a part of a handout for upcoming short courses on RL. A more compact version suitable for journal submission is in preparation
    Keywords Mathematics - Optimization and Control ; Computer Science - Machine Learning ; 68T05 (Primary) 93E35 ; 49L20 (Secondary)
    Subject code 518
    Publishing date 2020-08-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Feedback Particle Filter for Collective Inference

    Kim, Jin Won / Mehta, Prashant G.

    Abstract: The purpose of this paper is to describe the feedback particle filter algorithm for problems where there are a large number ($M$) of non-interacting agents (targets) with a large number ($M$) of non-agent specific observations (measurements) that ... ...

    Abstract The purpose of this paper is to describe the feedback particle filter algorithm for problems where there are a large number ($M$) of non-interacting agents (targets) with a large number ($M$) of non-agent specific observations (measurements) that originate from these agents. In its basic form, the problem is characterized by data association uncertainty whereby the association between the observations and agents must be deduced in addition to the agent state. In this paper, the large-$M$ limit is interpreted as a problem of collective filtering. This viewpoint is used to derive the equation for the empirical distribution of the hidden agent states. A feedback particle filter algorithm for this problem is presented and illustrated via numerical simulations. The simulations help show that the algorithm well approximates the empirical distribution of the hidden states for large $M$.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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