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Article ; Online: Non-Iterative Multiscale Estimation for Spatial Autoregressive Geographically Weighted Regression Models.

Gao, Shi-Jie / Mei, Chang-Lin / Xu, Qiu-Xia / Zhang, Zhi

2023 Volume 25, Issue 2

Abstract: Multiscale estimation for geographically weighted regression (GWR) and the related models has attracted much attention due to their superiority. This kind of estimation method will not only improve the accuracy of the coefficient estimators but also ... ...

Abstract	Multiscale estimation for geographically weighted regression (GWR) and the related models has attracted much attention due to their superiority. This kind of estimation method will not only improve the accuracy of the coefficient estimators but also reveal the underlying spatial scale of each explanatory variable. However, most of the existing multiscale estimation approaches are backfitting-based iterative procedures that are very time-consuming. To alleviate the computation complexity, we propose in this paper a non-iterative multiscale estimation method and its simplified scenario for spatial autoregressive geographically weighted regression (SARGWR) models, a kind of important GWR-related model that simultaneously takes into account spatial autocorrelation in the response variable and spatial heterogeneity in the regression relationship. In the proposed multiscale estimation methods, the two-stage least-squares (2SLS) based GWR and the local-linear GWR estimators of the regression coefficients with a shrunk bandwidth size are respectively taken to be the initial estimators to obtain the final multiscale estimators of the coefficients without iteration. A simulation study is conducted to assess the performance of the proposed multiscale estimation methods, and the results show that the proposed methods are much more efficient than the backfitting-based estimation procedure. In addition, the proposed methods can also yield accurate coefficient estimators and such variable-specific optimal bandwidth sizes that correctly reflect the underlying spatial scales of the explanatory variables. A real-life example is further provided to demonstrate the applicability of the proposed multiscale estimation methods.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25020320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Polycystic Kidney Disease and Renal Fibrosis.

Xue, Cheng / Mei, Chang-Lin

Advances in experimental medicine and biology

2019 Volume 1165, Page(s) 81–100

Abstract: Polycystic kidney disease (PKD) is a common genetic disorder characterized by formations of numerous cysts in kidneys and most caused by PKD1 or PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD). The interstitial inflammation and ... ...

Abstract	Polycystic kidney disease (PKD) is a common genetic disorder characterized by formations of numerous cysts in kidneys and most caused by PKD1 or PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD). The interstitial inflammation and fibrosis is one of the major pathological changes in polycystic kidney tissues with an accumulation of inflammatory cells, chemokines, and cytokines. The immune response is observed across different stages and occurs prior to or coincident with cyst formation in ADPKD. Evidence for inflammation as an important contributor to cyst growth and fibrosis includes increased interstitial macrophages, upregulated expressions of pro-inflammatory cytokines, activated complement system, and activated pathways including NF-κB and JAK-STAT signaling in polycystic kidney tissues. Inflammatory cells are responsible for overproduction of several pro-fibrotic growth factors which promote renal fibrosis in ADPKD. These growth factors trigger epithelial mesenchymal transition and myofibroblast/fibrocyte activation, which stimulate the expansion of extracellular matrix (ECM) including collagen I, III, IV, V, and fibronectin, leading to renal fibrosis and reduced renal function. Besides, there are imbalanced ECM turnover regulators which lead to the increased ECM production and inadequate degradation in polycystic kidney tissues. Several fibrosis associated signaling pathways, such as TGFβ-SMAD, Wnt, and periostin-integrin-linked kinase are also activated in polycystic kidney tissues. Although the effective anti-fibrotic treatments are limited at the present time, slowing the cyst expansion and fibrosis development is very important for prolonging life span and improving the palliative care of ADPKD patients. The inhibition of pro-fibrotic cytokines involved in fibrosis might be a new therapeutic strategy for ADPKD in the future.
MeSH term(s)	Complement System Proteins ; Cytokines ; Extracellular Matrix ; Fibrosis ; Humans ; Intercellular Signaling Peptides and Proteins ; Kidney/pathology ; Macrophages ; Polycystic Kidney Diseases/physiopathology ; Polycystic Kidney, Autosomal Dominant ; Signal Transduction
Chemical Substances	Cytokines ; Intercellular Signaling Peptides and Proteins ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-13-8871-2_5
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Article ; Online: Pancreatic extracorporeal shock wave lithotripsy for a patient concurrent with autosomal dominant polycystic kidney disease: a case report.

Wang, Dan / Xu, Jing / Bi, Ya-Wei / Mei, Chang-Lin / Li, Zhao-Shen / Hu, Liang-Hao

The Journal of international medical research

2022 Volume 50, Issue 5, Page(s) 3000605221100748

Abstract: Whether pancreatic extracorporeal shock wave lithotripsy (ESWL) is safe for patients with autosomal dominant polycystic kidney disease (ADPKD) is unclear. A woman in her early 30s was admitted to our hospital because of intermittent upper abdominal pain ... ...

Abstract	Whether pancreatic extracorporeal shock wave lithotripsy (ESWL) is safe for patients with autosomal dominant polycystic kidney disease (ADPKD) is unclear. A woman in her early 30s was admitted to our hospital because of intermittent upper abdominal pain and recurrent pancreatitis. The imaging results confirmed the diagnosis of pancreatic stones and ADPKD. We performed pancreatic ESWL using a third-generation lithotripter to pulverize the pancreatic stones. A maximum of 5000 shock waves was delivered per therapeutic session. A second session of ESWL was performed the next day. The patient developed no adverse events or complications related to pancreatic ESWL. Three years after treatment, the patient had developed no relapse of pancreatitis or abdominal pain. Shock waves do not lead to complications such as hematuria, cyst rupture, or deterioration of the inner bleeding of renal cysts. Multiple kidney cysts are not a contraindication for pancreatic ESWL.
MeSH term(s)	Abdominal Pain/complications ; Abdominal Pain/therapy ; Calculi ; Female ; Humans ; Lithotripsy/adverse effects ; Neoplasm Recurrence, Local/etiology ; Pancreatic Ducts ; Pancreatitis/complications ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/therapy
Language	English
Publishing date	2022-05-30
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605221100748
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Article: Effect of Statins on Renal Function and Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease.

Xue, Cheng / Zhang, Li-Ming / Zhou, Chenchen / Mei, Chang-Lin / Yu, Sheng-Qiang

Kidney diseases (Basel, Switzerland)

2020 Volume 6, Issue 6, Page(s) 407–413

Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary nephropathy with few treatments to slow renal progression. The evidence on the effect of lipid-lowering agents (statins) on ADPKD progression remains ... ...

Abstract	Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary nephropathy with few treatments to slow renal progression. The evidence on the effect of lipid-lowering agents (statins) on ADPKD progression remains inconclusive. Methods: We performed a systematic review and meta-analysis by searching the PubMed, Embase, Web of Science, and Cochrane databases (up to November 2019). Changes in estimated glomerular filtration rate (eGFR) and total kidney volume (TKV) were the primary outcomes. Mean differences (MDs) for continuous outcomes and 95% confidence intervals (CIs) were calculated by a random-effects model. Results: Five clinical studies with 648 participants were included. Statins did not show significant benefits in the yearly change in eGFR (4 studies, MD = -0.13 mL/min/m Conclusion: Despite these proteinuria and lipid-lowering benefits, the effect of statins on ADPKD progression was uncertain.
Language	English
Publishing date	2020-07-29
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2817963-8
ISSN	2296-9357 ; 2296-9381
ISSN (online)	2296-9357
ISSN	2296-9381
DOI	10.1159/000509087
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Article: A two-step local smoothing approach for exploring spatio-temporal patterns with application to the analysis of precipitation in the mainland of China during 1986–2005

Yan, Na / Mei, Chang-Lin

Environmental and ecological statistics. 2014 June, v. 21, no. 2

2014

Abstract: There has been a growing interest on using local modelling techniques for the analysis of spatio-temporal data because of their powerfulness in extracting the underlying local patterns in the data. In this study, we propose a two-step local smoothing ... ...

Abstract	There has been a growing interest on using local modelling techniques for the analysis of spatio-temporal data because of their powerfulness in extracting the underlying local patterns in the data. In this study, we propose a two-step local smoothing approach to explore spatial patterns and temporal trends of spatio-temporal data via combining the geographically weighted regression and the local polynomial smoothing procedure. The proposed method incorporates both spatial and temporal information into the calibration process and makes it easier to implement visualization of the results. A simulation experiment is conducted to assess the performance of the proposed method and the results show that the method works satisfactorily. A real-world spatio-temporal data set is analyzed to demonstrate the practical usefulness of the method.
Keywords	atmospheric precipitation ; data collection ; models ; spatial variation ; temporal variation ; China
Language	English
Dates of publication	2014-06
Size	p. 373-390.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2000906-9
ISSN	1573-3009 ; 1352-8505
ISSN (online)	1573-3009
ISSN	1352-8505
DOI	10.1007/s10651-013-0259-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Translationally-controlled tumor protein activates the transcription of Oct-4 in kidney-derived stem cells.

Jing, Ying / He, Liang-Liang / Mei, Chang-Lin

Experimental and therapeutic medicine

2016 Volume 13, Issue 1, Page(s) 280–284

Abstract: The molecular mechanisms underlying translationally-controlled tumor protein (TCTP) in the activation of octamer-binding transcription factor 4 (Oct-4) in kidney-derived stem cells have not been characterized. The aim of the present study was to identify ...

Abstract	The molecular mechanisms underlying translationally-controlled tumor protein (TCTP) in the activation of octamer-binding transcription factor 4 (Oct-4) in kidney-derived stem cells have not been characterized. The aim of the present study was to identify the transcriptional activation of Oct-4 by TCTP in kidney-derived stem cells. Homology-directed repair cDNA inserted into Fisher 344 transgenic (Tg) rats and the mouse strain 129/Svj were used for the experiments. Diphtheria toxin (DT; 10 ng/kg) injected into the Tg rats created the kidney injury, which was rapidly restored by the activation of kidney-derived stem cells. Kidney-derived stem cells were isolated from the DT-injured Tg rats using cell culture techniques. The co-expression of Oct-4 and TCTP were observed in the isolated kidney-derived stem cells. Immunoblotting and reverse transcription-polymerase chain reaction analysis of TCTP null mutant (TCTP
Language	English
Publishing date	2016-12-05
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2016.3955
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Article ; Online: Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.

Chen, Jie / Zhang, Di / Ji, Ming-Fei / Liu, Tao / Mei, Chang-Lin / Tang, Xiao-Jing

Journal of cellular physiology

2019 Volume 234, Issue 8, Page(s) 14109–14122

Abstract: Nephrolithiasis is a common disease of the urinary system, of which idiopathic calcium oxalate (CaOx) kidney stones, in particular, are one of the special types. In the initial stages of CaOx kidney stone formation, Randall's plaques (RPs) develop. Liver ...

Abstract	Nephrolithiasis is a common disease of the urinary system, of which idiopathic calcium oxalate (CaOx) kidney stones, in particular, are one of the special types. In the initial stages of CaOx kidney stone formation, Randall's plaques (RPs) develop. Liver X receptors (LXRs) inhibit oxidative stress and inﬂammatory in other diseases; nevertheless, the role of LXRs in nephrolithiasis has yet to be elucidated. In this study, the role of LXRs in the progression of RP formation was investigated. Microarray analysis revealed that LXR/RXR levels were significantly greater in low-plaque tissues (<5%) than in high-plaque tissues (>5%), confirming the link between LXR activation and RP formation. Correspondingly, expression levels of two LXR target genes, LXRα and LXRβ, were lower in high-plaque tissues than in low-plaque tissues. In vitro, LXR agonist alleviated calcium oxalate monohydrate-induced cellular calcium deposits and apoptosis. LXR activation decreased reactive oxygen species production and gene expression of inflammatory mediators, including osteopontin that has recently been demonstrated to correlate with the development of RPs. Moreover, p38 MAPK and JNK signaling may mediate LXR-regulated expression in HK-2 cells. In an animal model, the deposition was reduced by activating LXR, and osteopontin expression was also inhibited. Our findings suggest a role for LXRs in the progression of idiopathic CaOx kidney stones; LXR agonists may have therapeutic potential for the treatment of nephrolithiasis.
MeSH term(s)	Animals ; Apoptosis/genetics ; Calcium Oxalate/metabolism ; Disease Models, Animal ; Female ; Gene Expression Regulation/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Kidney/metabolism ; Kidney/pathology ; Kidney Calculi/drug therapy ; Kidney Calculi/genetics ; Kidney Calculi/pathology ; Liver X Receptors/agonists ; Liver X Receptors/genetics ; Male ; Mice ; Microarray Analysis ; Middle Aged ; Nephrolithiasis/drug therapy ; Nephrolithiasis/genetics ; Nephrolithiasis/pathology ; Osteopontin/genetics ; Oxidative Stress/genetics ; Reactive Oxygen Species/metabolism ; p38 Mitogen-Activated Protein Kinases/genetics
Chemical Substances	Liver X Receptors ; Reactive Oxygen Species ; Osteopontin (106441-73-0) ; Calcium Oxalate (2612HC57YE) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2019-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.28101
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Article: The Clinical Manifestation and Management of Autosomal Dominant Polycystic Kidney Disease in China.

Xue, Cheng / Zhou, Chen-Chen / Wu, Ming / Mei, Chang-Lin

Kidney diseases (Basel, Switzerland)

2016 Volume 2, Issue 3, Page(s) 111–119

Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic hereditary kidney disease characterized by progressive enlargement of renal cysts. The incidence is 1-2‰ worldwide. Mutations in two genes (: Key messages: ... ...

Abstract	Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic hereditary kidney disease characterized by progressive enlargement of renal cysts. The incidence is 1-2‰ worldwide. Mutations in two genes ( Key messages: ADPKD affects about 1.5 million people in China. An additional Facts from east and west: (1) ADPKD is diagnosed globally by ultrasound detection of kidney enlargement and presence of cysts. Recent analyses of variants of the
Language	English
Publishing date	2016-10-06
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2817963-8
ISSN	2296-9357 ; 2296-9381
ISSN (online)	2296-9357
ISSN	2296-9381
DOI	10.1159/000449030
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Article: A note on the null distribution of the local spatial heteroscedasticity (LOSH) statistic

Xu, Min / Mei, Chang-lin / Yan, Na

The annals of regional science : an international journal of urban, regional and environmental research and policy ; official journal of the Western Regional Science Association Vol. 52, No. 3 , p. 697-710

2014 Volume 52, Issue 3, Page(s) 697–710

Author's details	Min Xu; Chang-Lin Mei; Na Yan
Keywords	Heteroskedastizität ; Modellierung ; Regionalökonomik
Language	English
Size	graph. Darst.
Publisher	Springer
Publishing place	Berlin ; Heidelberg
Document type	Article
ZDB-ID	280074-3 ; 1471201-5
ISSN	1432-0592 ; 0570-1864
ISSN (online)	1432-0592
ISSN	0570-1864
Database	ECONomics Information System

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Article ; Online: Effect of Sheng Xue Ning Tablets on Renal Anemia in Patients Subject to Maintenance Hemodialysis and Safety Evaluation: A Multi-setting Prospective Randomized Study.

Tang, Xiao-Jing / Rong, Shu / Mei, Chang-Lin / Ni, Zhao-Hui / Jiang, Geng-Ru / Yuan, Wei-Jie / Wang, Nian-Song / Guo, Zhi-Yong / Ma, Jun / Yan, Hai-Dong / ZHang, Li-Ming

Current medical science

2020 Volume 40, Issue 2, Page(s) 327–331

Abstract: This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis (MHD). A total of 94 patients ... ...

Abstract	This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis (MHD). A total of 94 patients undergoing MHD were randomly assigned to an experiment group (receiving oral SXN tablets, SXN group) and a control group (orally given FS tablets, FS group) and followed up for 12 weeks. Erythropoietin (EPO) was used in both groups. The efficacy was assessed by detecting the subsequent changes in hemoglobin (Hb), serum iron (SI), SF and transferrin saturation (TSAT). At the 12th week, Hb and TSAT levels in both groups were significantly increased compared to those in the screening period (P<0.05). However, no significant difference in Hb and TSAT was found between the two groups. The average weekly EPO dosage used was lower in SXN group than in FS group (P<0.05) at the 10th week and the 12th week. Our study showed that SXN tablets can effectively ameliorate renal anemia and keep iron metabolism stable in MHD patients, and its efficacy is virtually close to that of FS tablets. Meanwhile, SXN tablets can reduce the dosage of EPO and have a good safety profile.
MeSH term(s)	Administration, Oral ; Adult ; Aged ; Anemia/drug therapy ; Anemia/etiology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Female ; Ferrous Compounds/administration & dosage ; Ferrous Compounds/therapeutic use ; Hemoglobins/analysis ; Humans ; Iron/blood ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis/adverse effects ; Tablets ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; Ferrous Compounds ; Hemoglobins ; Tablets ; shengxuening ; ferrous succinate (818ZYK7N91) ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-04-26
Publishing country	China
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-020-2179-z
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