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  1. Article ; Online: Refined Landslide Susceptibility Mapping by Integrating the SHAP-CatBoost Model and InSAR Observations

    Zhaowei Yao / Meihong Chen / Jiewei Zhan / Jianqi Zhuang / Yuemin Sun / Qingbo Yu / Zhaoyue Yu

    Applied Sciences, Vol 13, Iss 23, p

    A Case Study of Lishui, Southern China

    2023  Volume 12817

    Abstract: Landslide susceptibility mapping based on static influence factors often exhibits issues of low accuracy and classification errors. To enhance the accuracy of susceptibility mapping, this study proposes a refined approach that integrates categorical ... ...

    Abstract Landslide susceptibility mapping based on static influence factors often exhibits issues of low accuracy and classification errors. To enhance the accuracy of susceptibility mapping, this study proposes a refined approach that integrates categorical boosting (CatBoost) with small baseline subset interferometric synthetic-aperture radar (SBAS-InSAR) results, achieving more precise and detailed susceptibility mapping. We utilized optical remote sensing images, the information value (IV) model, and fourteen influencing factors (elevation, slope, aspect, roughness, profile curvature, plane curvature, lithology, distance to faults, land use type, normalized difference vegetation index (NDVI), topographic wetness index (TWI), distance to rivers, distance to roads, and annual precipitation) to establish the IV-CatBoost landslide susceptibility mapping method. Subsequently, the Sentinel-1A ascending data from January 2021 to March 2023 were utilized to derive the deformation rates within the city of Lishui in the southern region of China. Based on the outcomes derived from IV-CatBoost and SBAS-InSAR, a discernment matrix was formulated to rectify inaccuracies in the partitioned regions, leading to the creation of a refined information value CatBoost integration (IVCI) landslide susceptibility mapping model. In the end, we utilized optical remote sensing interpretations alongside surface deformations obtained from SBAS-InSAR to cross-verify the excellence and accuracy of IVCI. Research findings indicate a distinct enhancement in susceptibility levels across 165,784 grids (149.20 km 2 ) following the integration of SBAS-InSAR correction. The enhanced susceptibility classes and the spectral characteristics of remote sensing images closely correspond to the trends of SBAS-InSAR cumulative deformation, reflecting a high level of consistency with field-based conditions. These improved classifications effectively enhance the refinement of landslide susceptibility mapping. The refined susceptibility mapping approach proposed in ...
    Keywords landslide susceptibility ; InSAR ; information value CatBoost integration (IVCI) ; SHAP ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 550
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

    Xiaodi Hu / Mingwei Sun / Qian Chen / Yixia Zhao / Na Liang / Siyuan Wang / Pengbin Yin / Yuanping Yang / Sin Man Lam / Qianying Zhang / Alimujiang Tudiyusufu / Yingying Gu / Xin Wan / Meihong Chen / Hu Li / Xiaofei Zhang / Guanghou Shui / Suneng Fu / Licheng Zhang /
    Peifu Tang / Catherine C. L. Wong / Yong Zhang / Dahai Zhu

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 18

    Abstract: Abstract MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in ... ...

    Abstract Abstract MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in regulating whole body energy homeostasis in vivo remains largely unknown. Here, we report that genetic deletion of Myod in male mice enhances the oxidative metabolism of muscle and, intriguingly, renders the male mice resistant to high fat diet-induced obesity. By performing lipidomic analysis in muscle-conditioned medium and serum, we identify 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) as a muscle-released lipid that is responsible for MyoD-orchestrated body energy homeostasis in male Myod KO mice. Functionally, the administration of DLPC significantly ameliorates HFD-induced obesity in male mice. Mechanistically, DLPC is found to induce white adipose browning via lipid peroxidation-mediated p38 signaling in male mice. Collectively, our findings not only uncover a novel function of MyoD in controlling systemic energy homeostasis through the muscle-derived lipokine DLPC but also suggest that the DLPC might have clinical potential for treating obesity in humans.
    Keywords Science ; Q
    Subject code 572
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses

    Meihong Chen / Jie Zhang / Yun Chen / Yan Qiu / Zi Luo / Sixia Zhao / Lei Du / Dongbo Tian

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 12

    Abstract: Abstract Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall ... ...

    Abstract Abstract Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, consolidation, alveolar hemorrhage, increased levels of inflammatory factors and recruitment of M1 macrophages. All these processes were attenuated in the presence of H2. We found that H/R-induced injury in our mouse model was associated with production of hydroxyl radicals as well as increased levels of colony-stimulating factors and circulating leukocytes. H2 attenuated H/R-induced production of hydroxyl radicals, up-regulation of colony-stimulating factors, and recruitment of neutrophils and M1 macrophages to lung tissues. However, H2 did not substantially affect the H/R-induced increase in erythropoietin or pulmonary artery remodeling. Our results suggest that H2 ameliorates H/R-induced lung injury by inhibiting hydroxyl radical production and inflammation in lungs. It may also prevent colony-stimulating factors from mobilizing progenitors in response to H/R-induced injury.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: MyoD is a 3D genome structure organizer for muscle cell identity

    Ruiting Wang / Fengling Chen / Qian Chen / Xin Wan / Minglei Shi / Antony K. Chen / Zhao Ma / Guohong Li / Min Wang / Yachen Ying / Qinyao Liu / Hu Li / Xu Zhang / Jinbiao Ma / Jiayun Zhong / Meihong Chen / Michael Q. Zhang / Yong Zhang / Yang Chen /
    Dahai Zhu

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 17

    Abstract: Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification. Here the authors provide further support for the role of ... ...

    Abstract Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification. Here the authors provide further support for the role of MyoD in 3D genome architecture in muscle stem cells by comparing MyoD knockout and wild-type mice.
    Keywords Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Bisphenol analogues in surface water and sediment from the shallow Chinese freshwater lakes: Occurrence, distribution, source apportionment, and ecological and human health risk

    Yan, Zhengyu / Jianqiu Chen / Kun Yan / Meihong Chen / Qiulian Yang / Ruixin Guo / Shenghu Zhang / Shengmin Wu / Yanhua Liu / Zhihua Han

    Chemosphere. 2017 Oct., v. 184

    2017  

    Abstract: Compared to Bisphenol A (BPA), current knowledge on the spatial distribution, potential sources and environmental risk assessment of other bisphenol analogues (BPs) remains limited. The occurrence, distribution and sources of seven BPs were investigated ... ...

    Abstract Compared to Bisphenol A (BPA), current knowledge on the spatial distribution, potential sources and environmental risk assessment of other bisphenol analogues (BPs) remains limited. The occurrence, distribution and sources of seven BPs were investigated in the surface water and sediment from Taihu Lake and Luoma Lake, which are the Chinese shallow freshwater lakes. Because there are many industries and living areas around Taihu Lake, the total concentrations of ∑BPs were much higher than that in Luoma Lake, which is away from the industry-intensive areas. For the two lakes, BPA was still the dominant BPs in both surface water and sediment, followed by BPF and BPS. The spatial distribution and principal component analysis showed that BPs in Luoma Lake was relatively homogeneous and the potential sources were relatively simple than that in Taihu Lake. The spatial distribution of BPs in sediment of Taihu Lake indicated that ∑BPs positively correlated with the TOC content. For both Taihu Lake and Luoma Lake, the risk assessment at the sampling sites showed that no high risk in surface water and sediment (RQt < 1.0, and EEQt < 1.0 ng E2/L).
    Keywords bisphenol A ; correlation ; environmental assessment ; freshwater lakes ; human health ; industry ; principal component analysis ; risk ; risk assessment ; sediments ; surface water
    Language English
    Dates of publication 2017-10
    Size p. 318-328.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2017.06.010
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Diverse genetic mechanisms underlie worldwide convergent rice feralization

    Jie Qiu / Lei Jia / Dongya Wu / Xifang Weng / Lijuan Chen / Jian Sun / Meihong Chen / Lingfeng Mao / Bowen Jiang / Chuyu Ye / Guilherme Menegol Turra / Longbiao Guo / Guoyou Ye / Qian-Hao Zhu / Toshiyuki Imaizumi / Beng-Kah Song / Laura Scarabel / Aldo Merotto / Kenneth M. Olsen /
    Longjiang Fan

    Genome Biology, Vol 21, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: Abstract Background Worldwide feralization of crop species into agricultural weeds threatens global food security. Weedy rice is a feral form of rice that infests paddies worldwide and aggressively outcompetes cultivated varieties. Despite increasing ... ...

    Abstract Abstract Background Worldwide feralization of crop species into agricultural weeds threatens global food security. Weedy rice is a feral form of rice that infests paddies worldwide and aggressively outcompetes cultivated varieties. Despite increasing attention in recent years, a comprehensive understanding of the origins of weedy crop relatives and how a universal feralization process acts at the genomic and molecular level to allow the rapid adaptation to weediness are still yet to be explored. Results We use whole-genome sequencing to examine the origin and adaptation of 524 global weedy rice samples representing all major regions of rice cultivation. Weed populations have evolved multiple times from cultivated rice, and a strikingly high proportion of contemporary Asian weed strains can be traced to a few Green Revolution cultivars that were widely grown in the late twentieth century. Latin American weedy rice stands out in having originated through extensive hybridization. Selection scans indicate that most genomic regions underlying weedy adaptations do not overlap with domestication targets of selection, suggesting that feralization occurs largely through changes at loci unrelated to domestication. Conclusions This is the first investigation to provide detailed genomic characterizations of weedy rice on a global scale, and the results reveal diverse genetic mechanisms underlying worldwide convergent rice feralization.
    Keywords Weedy rice ; Oryza sativa ; Crop feralization ; Global population ; De-domestication block ; Parallel evolution ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Subject code 571
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD

    Xiaohua Yu / Yong Zhang / Tingting Li / Zhao Ma / Haixue Jia / Qian Chen / Yixia Zhao / Lili Zhai / Ran Zhong / Changyin Li / Xiaoting Zou / Jiao Meng / Antony K. Chen / Pier Lorenzo Puri / Meihong Chen / Dahai Zhu

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 12

    Abstract: Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes. ...

    Abstract Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes.
    Keywords Science ; Q
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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