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Article ; Online: Mortality risks from a spectrum of causes associated with sand and dust storms in China

Can Zhang / Meilin Yan / Hang Du / Jie Ban / Chen Chen / Yuanyuan Liu / Tiantian Li

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Sand and Dust Storms (SDS) pose considerable health risks worldwide. Previous studies only indicated risk of SDS on overall mortality. This nationwide multicenter time-series study aimed to examine SDS-associated mortality risks extensively. We ... ...

Abstract	Abstract Sand and Dust Storms (SDS) pose considerable health risks worldwide. Previous studies only indicated risk of SDS on overall mortality. This nationwide multicenter time-series study aimed to examine SDS-associated mortality risks extensively. We analyzed 1,495,724 deaths and 2024 SDS events from 1 February to 31 May (2013–2018) in 214 Chinese counties. The excess mortality risks associated with SDS were 7.49% (95% CI: 3.12–12.05%), 5.40% (1.25–9.73%), 4.05% (0.41–7.83%), 3.45% (0.34–6.66%), 3.37% (0.28–6.55%), 3.33% (0.07–6.70%), 8.90% (4.96–12.98%), 12.51% (6.31–19.08%), and 11.55% (5.55–17.89%) for ischemic stroke, intracerebral hemorrhagic stroke, hypertensive heart disease, myocardial infarction, acute myocardial infarction, acute ischemic heart disease, respiratory disease, chronic lower respiratory disease, and chronic obstructive pulmonary disease (COPD), respectively. SDS had significantly added effects on ischemic stroke, chronic lower respiratory disease, and COPD mortality. Our results suggest the need to implement public health policy against SDS.
Keywords	Science ; Q
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cardiovascular mortality risks during the 2017 exceptional heatwaves in China

Meilin Yan / Yang Xie / Huanhuan Zhu / Jie Ban / Jicheng Gong / Tiantian Li

Environment International, Vol 172, Iss , Pp 107767- (2023)

2023

Abstract: Climate change has made disastrous heatwaves more frequent. Heatwave-related health impacts are much more devastating for more intense heatwaves. In the summer of 2017, exceptional heatwaves occurred in many regions, including China. This study aims to ... ...

Abstract	Climate change has made disastrous heatwaves more frequent. Heatwave-related health impacts are much more devastating for more intense heatwaves. In the summer of 2017, exceptional heatwaves occurred in many regions, including China. This study aims to evaluate the cardiovascular mortality risk associated with the 2017 exceptional heatwaves and compare the mortality risk of the severe heatwaves with those in other years. Using daily data for a spectrum of cardiovascular mortality and temperature for 102 Chinese counties (2014–2017), we estimated the association between heatwave and mortality by generalized linear mixed-effects models. Compared with matched non-heatwave days, mortality risks on heatwaves days in 2017 increased 27.8% (95% CI, 14.8–42.3%), 26.7% (8.0–48.5%), 30.1% (10.2–53.7%), 27.3% (1.4–59.9%), 32.2% (3.4–68.4%), and 25.2% (1.0–57.7%) for total circulatory diseases, cerebrovascular disease, ischemic heart disease (IHD), acute IHD, chronic IHD, and myocardial infarction. The 2017 exceptional heatwaves impacted ischemic heart disease mortality and myocardial infarction mortality more than heatwaves in 2014–2016. Here we show that the severe heatwaves in 2017 posed catastrophic death threats for those under-studied cardiovascular diseases.
Keywords	Severe Heatwave ; Cardiovascular Disease ; High Temperature ; Environmental sciences ; GE1-350
Subject code	310
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associations of pregnancy complications with ambient air pollution in China

Meilin Yan / Nana Liu / Yunfei Fan / Liangkun Ma / Tianjia Guan

Ecotoxicology and Environmental Safety, Vol 241, Iss , Pp 113727- (2022)

2022

Abstract: Background: Gestational hypertension (GH), preeclampsia (PE), and gestational diabetes mellitus (GDM) are common pregnancy complications and can result in maternal and prenatal morbidity and mortality. Air pollution exposure could adversely impact ... ...

Abstract	Background: Gestational hypertension (GH), preeclampsia (PE), and gestational diabetes mellitus (GDM) are common pregnancy complications and can result in maternal and prenatal morbidity and mortality. Air pollution exposure could adversely impact pregnancy complications; however, evidence remains limited in China, where ambient air pollution is relatively severe. Objective: This study aims to examine the associations of GH, PE, and GDM with exposure to six air pollutants (PM2.5, PM10, SO2, NO2, O3, and CO) during pregnancy. Methods: Leveraging a multicenter birth cohort study among pregnant women in 24 hospitals from 15 provinces in China, we obtained data for maternal characteristics and pregnancy outcomes. We generated ambient concentrations of the six air pollutants using a combination of chemical transport model simulations with monitoring data. We used multivariable logistic regression models to estimate the effects on pregnancy complications from exposure to six air pollutants in each trimester and the entire pregnancy. Results: Among the total 3754 pregnant women in this study, the prevalences of GH, GDM, and PE were 2.6 %, 11.2 %, and 0.7 %, respectively. GH risk increased 11.9 % (95 % CI, −8.5 %, 36.8 %) and 13.8 % (1.4 %, 27.8 %) per 10 μg/m3 increases in PM2.5 and PM10 in the entire pregnancy, respectively. PM2.5 and PM10 exposures in the first trimester were significantly associated with an increased risk of GDM. Exposure to O3, SO2, NO2, and CO in early pregnancy could be associated with GDM risk. Geographic region and season of conception may influence the associations of GH and PE with air pollution. Conclusions: Ambient particulate matter pollution adversely affects GH, GDM, and PE among Chinese pregnant women. Since most regions of China still suffer from hazardous levels of air pollution, our findings indicate importance of better protecting pregnant women from the risk of air pollution.
Keywords	Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction and Characterization of Immortalized Fibroblast Cell Line from Bactrian Camel

Meilin Yan / Fang Yong / Wangye Ji / Lili Zhang / Shuqin Zhao / Yuan Gao

Life, Vol 13, Iss 1337, p

2023 Volume 1337

Abstract: Immortalized cell lines with many advantages are widely used in various experimental contexts by many different labs. However, the absence of available cell lines poses difficulties for research in some species, such as camels. To establish an ... ...

Abstract	Immortalized cell lines with many advantages are widely used in various experimental contexts by many different labs. However, the absence of available cell lines poses difficulties for research in some species, such as camels. To establish an immortalized Bactrian camel fibroblast (iBCF) cell line and understand its biological characteristics, primary fibroblast cells from Bactrian camels were isolated and purified using enzymatic digestion in this study, and telomerase reverse transcriptase (hTERT) vectors were introduced into primary BCF (pBCF) for continuous passage to 80 generations after screening with G418. The cell morphology of different generations was examined under a microscope. Cell cycle and viability were evaluated by flow cytometry and CCK-8 assay, respectively. Cellular genes expression was monitored by qPCR, immunofluorescence, and Western blot, respectively. Chromosomes were determined by karyotyping. The results showed that like most other cells, both pBCF and iBCF were sensitive to nutrient concentrations and adapted to culture in the medium with 4.5 g/L glucose and 10% fetal bovine serum (FBS) concentration. hTERT gene was introduced and stably expressed in iBCF cells, which promoted BCF cell immortalization. The fibroblast specific marker vimentin (VIM) is expressed in both pBCF and iBCF, but epithelial marker cytokeratin18 (CK18) expression is weak in BCF cells. Proliferation and viability detection showed that hTERT-induced iBCF exhibits faster growth rates and higher viability than pBCF. Karyotyping showed that iBCF maintained the same number and morphology of chromosomes as the pBCF. This study demonstrated that we have successfully constructed an immortalized Bactrian camel fibroblast cell line, which was named BCF23. The establishment of the BCF23 cell line provides a foundation for expanding camel-related research.
Keywords	Bactrian camel ; fibroblast ; BCF23 ; hTERT ; VIM ; Science ; Q
Subject code	571
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tropical cyclones and risk of preterm birth

Shengzhi Sun / Kate R. Weinberger / Meilin Yan / G. Brooke Anderson / Gregory A. Wellenius

Environment International, Vol 140, Iss , Pp - (2020)

A retrospective analysis of 20 million births across 378 US counties

2020

Abstract: Background: The public health impacts of tropical cyclones (TCs) are expected to increase due to the continued growth of coastal populations and the increasing severity of these events. However, the impact of TCs on pregnant women, a vulnerable ... ...

Abstract	Background: The public health impacts of tropical cyclones (TCs) are expected to increase due to the continued growth of coastal populations and the increasing severity of these events. However, the impact of TCs on pregnant women, a vulnerable population, remains largely unknown. We aimed to estimate the association between prenatal exposure to TCs and risk of preterm birth in the eastern United States (US) and to assess whether the association varies by individual- and area-level characteristics. Methods: We included data on 19,529,748 spontaneous singleton births from 1989 to 2002 across 378 US counties. In each county, we classified days as exposed to a TC when TC-associated peak sustained winds at the county’s population-weighted center were >17.2 m/s (gale-force winds or greater). We defined preterm birth as births delivered prior to 37 completed weeks of gestation. We used distributed lag log-linear mixed-effects models to estimate the relative risk (RR) and absolute risk difference (ARD) for TC exposure by comparing preterm births occurring in TC-periods (from 2 days before to 30 days after the TC’s closest approach to the county’s population center) to matched non-TC periods. We conducted secondary analyses using other wind thresholds (12 m/s and 22 m/s) and other exposure metrics: county distance to storm track (30 km, 60 km, and 100 km) and cumulative rainfall within the county (75 mm, 100 mm, and 125 mm). Results: During the study period, there were 1,981,797 (10.1%) preterm births and 58 TCs that affected at least one US county on which we had birth data. The risk of preterm birth was positively associated with TC exposure defined as peak sustained wind speed >17.2 m/s (gale-force winds or greater) [RR: 1.01 (95% CI: 0.99, 1.03); ARD: 9 (95% CI: −7, 25) per 10,000 pregnancies], distance to storm track <60 km [RR: 1.02 (95% CI: 1.01, 1.04); ARD: 23 (95% CI: 9, 38) per 10,000 pregnancies], and cumulative rainfall >100 mm [RR: 1.04 (95% CI: 1.02, 1.06); ARD: 36 (95% CI: 16, 56) per 10,000 pregnancies]. Results were comparable when considering other wind, distance, or rain thresholds. The association was more pronounced among early preterm births and mothers living in more socially vulnerable counties but did not vary across strata of other hypothesized risk factors. Conclusions: Maternal exposure to TC was associated with a higher risk of preterm birth. Our findings provide initial evidence that severe storms may trigger preterm birth.
Keywords	Preterm birth ; Birth cohort ; Tropical cyclone ; United States ; Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mortality risks from a spectrum of causes associated with wide-ranging exposure to fine particulate matter

Tiantian Li / Meilin Yan / Qinghua Sun / G. Brooke Anderson

Environment International, Vol 111, Iss , Pp 52-

A case-crossover study in Beijing, China

2018 Volume 59

Abstract: Background: Exposure to fine particulate matter (≤2.5μm in aerodynamic diameter; PM2.5) has been shown to be associated with an increased risk of mortality due to cardiovascular, respiratory, and other pulmonary diseases. However, fewer studies have ... ...

Abstract	Background: Exposure to fine particulate matter (≤2.5μm in aerodynamic diameter; PM2.5) has been shown to be associated with an increased risk of mortality due to cardiovascular, respiratory, and other pulmonary diseases. However, fewer studies have investigated the relationship between ambient PM2.5 and human mortality for a wider range of causes of death, or for more specific causes of death within these broader categories, especially at the high PM2.5 concentrations currently experienced in Chinese megacities. Beijing, China, has a very large population and a wide range of PM2.5 exposures, allowing a prime opportunity to estimate such risks across a broad spectrum of causes, including rarer causes of death. Objective: To estimate the relative risk of cause-specific mortality associated with PM2.5 for a spectrum of causes of death, as well as characterize the time course of cause-specific mortality following PM2.5 exposure, in a location where PM2.5 concentrations are representative of common exposures in Chinese megacities. Methods: We collected daily data on mortality counts of Beijing residents and Beijing weather and air pollution measurements for January 1, 2009 to December 31, 2012. We used a time-stratified case-crossover study design to estimate the association between ambient PM2.5 concentrations and risk of death from several broad causes of death and from more refined specific causes within these broader categories. Primary results were estimated for risks the day of and the day following exposure (lag 0–1), but the time pattern of associated risk was also explored up to seven days following exposure. Results: Increased concentrations of PM2.5 were associated with increased risks at lag days 0–1 of all-cause mortality (0.26% increase per 10μg/m3; 95% confidence interval [CI]: 0.12%–0.39%), non-accidental deaths (0.25%; 95% CI: 0.11%–0.38%), circulatory deaths (0.39%; 95% CI: 0.21%–0.59%), respiratory deaths (0.43%; 95% CI: 0.05%–0.81%), intentional self-harm deaths (1.94%; 95% CI: 0.19%–3.73%) and nervous system deaths (0.9%; 95% CI: −0.2%–2%), although the observed increase was not statistical significant for the final one rarer cause of death. In addition to these five broad death outcomes, risk also increased following PM2.5 exposure at lag days 0–1 for deaths from several specific causes, including most of the specific circulatory causes considered. The largest observed increased risk by far was for one of the rarest causes of death considered, extrapyramidal and movement disorders (2.35%; 95% CI: 0.03%–4.72%). Conclusions: This study indicates that exposure to PM2.5 in a study location more representative of exposures in developing cities is associated with an increased risk of mortality from broad range of causes of death, including some causes rarely studied previously in association with PM2.5 exposure. Keywords: PM2.5, Cause-specific, Circulatory, Respiratory, Intentional self-harm, Nervous system
Keywords	Environmental sciences ; GE1-350
Subject code	310
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mortality risks from a spectrum of causes associated with wide-ranging exposure to fine particulate matter: A case-crossover study in Beijing, China

Li, Tiantian / G. Brooke Anderson / Meilin Yan / Qinghua Sun

Environment international. 2018 Feb., v. 111

2018

Abstract: Exposure to fine particulate matter (≤2.5μm in aerodynamic diameter; PM2.5) has been shown to be associated with an increased risk of mortality due to cardiovascular, respiratory, and other pulmonary diseases. However, fewer studies have investigated the ...

Abstract	Exposure to fine particulate matter (≤2.5μm in aerodynamic diameter; PM2.5) has been shown to be associated with an increased risk of mortality due to cardiovascular, respiratory, and other pulmonary diseases. However, fewer studies have investigated the relationship between ambient PM2.5 and human mortality for a wider range of causes of death, or for more specific causes of death within these broader categories, especially at the high PM2.5 concentrations currently experienced in Chinese megacities. Beijing, China, has a very large population and a wide range of PM2.5 exposures, allowing a prime opportunity to estimate such risks across a broad spectrum of causes, including rarer causes of death.To estimate the relative risk of cause-specific mortality associated with PM2.5 for a spectrum of causes of death, as well as characterize the time course of cause-specific mortality following PM2.5 exposure, in a location where PM2.5 concentrations are representative of common exposures in Chinese megacities.We collected daily data on mortality counts of Beijing residents and Beijing weather and air pollution measurements for January 1, 2009 to December 31, 2012. We used a time-stratified case-crossover study design to estimate the association between ambient PM2.5 concentrations and risk of death from several broad causes of death and from more refined specific causes within these broader categories. Primary results were estimated for risks the day of and the day following exposure (lag 0–1), but the time pattern of associated risk was also explored up to seven days following exposure.Increased concentrations of PM2.5 were associated with increased risks at lag days 0–1 of all-cause mortality (0.26% increase per 10μg/m3; 95% confidence interval [CI]: 0.12%–0.39%), non-accidental deaths (0.25%; 95% CI: 0.11%–0.38%), circulatory deaths (0.39%; 95% CI: 0.21%–0.59%), respiratory deaths (0.43%; 95% CI: 0.05%–0.81%), intentional self-harm deaths (1.94%; 95% CI: 0.19%–3.73%) and nervous system deaths (0.9%; 95% CI: −0.2%–2%), although the observed increase was not statistical significant for the final one rarer cause of death. In addition to these five broad death outcomes, risk also increased following PM2.5 exposure at lag days 0–1 for deaths from several specific causes, including most of the specific circulatory causes considered. The largest observed increased risk by far was for one of the rarest causes of death considered, extrapyramidal and movement disorders (2.35%; 95% CI: 0.03%–4.72%).This study indicates that exposure to PM2.5 in a study location more representative of exposures in developing cities is associated with an increased risk of mortality from broad range of causes of death, including some causes rarely studied previously in association with PM2.5 exposure.
Keywords	air pollution ; cities ; confidence interval ; death ; experimental design ; humans ; mortality ; movement disorders ; nervous system ; particulates ; relative risk ; respiratory tract diseases ; weather ; China
Language	English
Dates of publication	2018-02
Size	p. 52-59.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2017.10.023
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Associations between time-weighted personal air pollution exposure and amino acid metabolism in healthy adults

Xinyan Hu / Meilin Yan / Linchen He / Xinghua Qiu / Junfeng Zhang / Yinping Zhang / Jinhan Mo / Drew B Day / Jianbang Xiang / Jicheng Gong

Environment International, Vol 156, Iss , Pp 106623- (2021)

2021

Abstract: The molecular mechanisms underlying the associations between air pollution exposure and adverse cardiopulmonary effects remain to be better understood. Altered amino acid metabolism may plays an important role in the development of cardiopulmonary ... ...

Abstract	The molecular mechanisms underlying the associations between air pollution exposure and adverse cardiopulmonary effects remain to be better understood. Altered amino acid metabolism may plays an important role in the development of cardiopulmonary diseases and may be perturbed by air pollution exposure. To test this hypothesized molecular mechanism, we conducted an association analysis from an existing intervention study to examine the relations of air pollution exposures with amino acids in 43 Chinese healthy adults. Plasma levels of amino acids were measured using a UPLC-QqQ-MS system. Time-weighted personal exposure to O3, PM2.5, NO2, and SO2 over four time windows, i.e., 12 h, 24 h, 1 week, and 2 weeks, were calculated using the measured indoor and outdoor concentrations coupled with the time-activity data for each participant. Linear mixed-effects models were used to estimate the associations between air pollutants at each exposure window and amino acids by controlling for potential confounders. We observed significant associations between exposures and plasma concentrations of amino acids, with the direction of associations varying by amino acid and air pollutant. While there is little evidence of associations for NO2 and SO2, the associations with amino acids were fairly pronounced for exposure to PM2.5 and O3. In particular, independent O3 (12- and 24-hour) associations were observed with changes in the amino acids that were related to the urea cycle, including aspartate, asparagine, glutamate, arginine, citrulline, and ornithine. Our findings indicated that air pollution may cause acute perturbation of amino acid metabolism, and that O3 and PM2.5 may affect the metabolism of amino acids in different pathways.Main finding: Acute air pollution exposure might affect the perturbation of amino acid metabolism, and in particular, was associated with amino acids in relation to the urea cycle.
Keywords	Air pollutant exposure ; Amino acid metabolism ; Temporal-dependent response ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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