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  1. Book: Epigenetic mechanisms in cellular reprogramming

    Meissner, Alexander / Walter, Jörn

    (Epigenetics and human health)

    2015  

    Author's details Alexander Meissner ; Jörn Walter ed
    Series title Epigenetics and human health
    Keywords Cellular therapy ; Epigenetics ; Humangenetik ; Epigenetik ; Molekularbiologie ; DNS ; Methylierung
    Subject Desoxyribonucleinsäure ; DNA ; DNA-Molekül ; Desoxyribonukleinsäure ; Molekulare Biologie ; Medizinische Genetik ; Anthropogenetik ; Mensch ; Medizin
    Subject code 616.0277
    Language English
    Size XVIII, 230 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018516555
    ISBN 978-3-642-31973-0 ; 9783642319747 ; 3-642-31973-4 ; 3642319742
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 267 available for loan (reading room) Lesesaal EG

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  2. Book ; Thesis: Aussagekraft der chromatografischen Analysen des Remedi HS-Drug-Profiling-Systems bei 1432 opiatpositiven Urinproben bezüglich der Metabolisierung von Codein, Morphin und Heroin

    Meißner, Alexander

    1998  

    Author's details vorgelegt von Alexander Meißner
    Language German
    Size 132, 26 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 1998
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT011129918
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 MB 1251 order for loan Magazin

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  3. Article ; Online: Single-cell technologies: a new lens into epigenetic regulation in development.

    Bolondi, Adriano / Kretzmer, Helene / Meissner, Alexander

    Current opinion in genetics & development

    2022  Volume 76, Page(s) 101947

    Abstract: The totipotent zygote gives rise to diverse cell types through a series of well-orchestrated regulatory mechanisms. Epigenetic modifiers play an essential, though still poorly understood, role in the transition from pluripotency towards organogenesis. ... ...

    Abstract The totipotent zygote gives rise to diverse cell types through a series of well-orchestrated regulatory mechanisms. Epigenetic modifiers play an essential, though still poorly understood, role in the transition from pluripotency towards organogenesis. However, recent advances in single-cell technologies have enabled an unprecedented, high-resolution dissection of this crucial developmental window, highlighting more cell-type-specific functions of these ubiquitous regulators. In this review, we discuss and contextualize several recent studies that explore epigenetic regulation during mouse embryogenesis, emphasizing the opportunities presented by single-cell technologies, in vivo perturbation approaches as well as advanced in vitro models to characterize dynamic developmental transitions.
    MeSH term(s) Animals ; Embryonic Development/genetics ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Developmental/genetics ; Mice ; Zygote/metabolism
    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2022.101947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: (Epi)genomics approaches and their applications.

    Meissner, Alexander

    Methods (San Diego, Calif.)

    2015  Volume 72, Page(s) 1–2

    MeSH term(s) Epigenomics/methods ; Epigenomics/trends ; Genome, Human ; Genomics/methods ; Humans
    Language English
    Publishing date 2015-01-15
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2014.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3239: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: DNA methylation: a historical perspective.

    Mattei, Alexandra L / Bailly, Nina / Meissner, Alexander

    Trends in genetics : TIG

    2022  Volume 38, Issue 7, Page(s) 676–707

    Abstract: In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance was not intuitive for several decades. After this initial lag, the ubiquitous presence of this methylated base emerged across all domains of life and revealed a ... ...

    Abstract In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance was not intuitive for several decades. After this initial lag, the ubiquitous presence of this methylated base emerged across all domains of life and revealed a range of essential biological functions. Today, we are armed with the knowledge of the key factors that establish, maintain, and remove DNA methylation and have access to a staggering and rapidly growing number of base-resolution methylation maps. Despite this, several fundamental details about the precise role and interpretation of DNA methylation patterns remain under investigation. Here, we review the field of DNA methylation from its beginning to present day, with an emphasis on findings in mammalian systems, and point the reader to select experiments that form the foundation of this field.
    MeSH term(s) 5-Methylcytosine ; Animals ; DNA Methylation/genetics ; Mammals
    Chemical Substances 5-Methylcytosine (6R795CQT4H)
    Language English
    Publishing date 2022-04-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2022.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2272: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online ; Thesis: Reacquisition and maintenance of pluripotency

    Riemenschneider, Christina [Verfasser] / Meissner, Alexander [Akademischer Betreuer] / Bartfel, Sina [Gutachter] / Meissner, Alexander [Gutachter]

    2023  

    Author's details Christina Riemenschneider ; Gutachter: Sina Bartfel, Alexander Meissner ; Betreuer: Alexander Meissner
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Technische Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  7. Article ; Online: Lambda3: homology search for protein, nucleotide, and bisulfite-converted sequences.

    Hauswedell, Hannes / Hetzel, Sara / Gottlieb, Simon G / Kretzmer, Helene / Meissner, Alexander / Reinert, Knut

    Bioinformatics (Oxford, England)

    2023  Volume 40, Issue 3

    Abstract: Motivation: Local alignments of query sequences in large databases represent a core part of metagenomic studies and facilitate homology search. Following the development of NCBI Blast, many applications aimed to provide faster and equally sensitive ... ...

    Abstract Motivation: Local alignments of query sequences in large databases represent a core part of metagenomic studies and facilitate homology search. Following the development of NCBI Blast, many applications aimed to provide faster and equally sensitive local alignment frameworks. Most applications focus on protein alignments, while only few also facilitate DNA-based searches. None of the established programs allow searching DNA sequences from bisulfite sequencing experiments commonly used for DNA methylation profiling, for which specific alignment strategies need to be implemented.
    Results: Here, we introduce Lambda3, a new version of the local alignment application Lambda. Lambda3 is the first solution that enables the search of protein, nucleotide as well as bisulfite-converted nucleotide query sequences. Its protein mode achieves comparable performance to that of the highly optimized protein alignment application Diamond, while the nucleotide mode consistently outperforms established local nucleotide aligners. Combined, Lambda3 presents a universal local alignment framework that enables fast and sensitive homology searches for a wide range of use-cases.
    Availability and implementation: Lambda3 is free and open-source software publicly available at https://github.com/seqan/lambda/.
    MeSH term(s) Algorithms ; Sequence Alignment ; Software ; Proteins ; Sulfites
    Chemical Substances hydrogen sulfite (OJ9787WBLU) ; Proteins ; Sulfites
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btae097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Dissecting the epigenetic regulation of the placental methylome

    Weigert, Raha [Verfasser] / Meissner, Alexander [Akademischer Betreuer] / Bartfeld, Sina [Gutachter] / Meissner, Alexander [Gutachter]

    2022  

    Author's details Raha Weigert ; Gutachter: Sina Bartfeld, Alexander Meissner ; Betreuer: Alexander Meissner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Technische Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Article ; Online: What can epigenomics do for you?

    Meissner, Alexander

    Genome biology

    2012  Volume 13, Issue 10, Page(s) 420

    MeSH term(s) Animals ; DNA Methylation ; Epigenomics/economics ; Epigenomics/methods ; Humans
    Language English
    Publishing date 2012-10-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/gb-2012-13-10-420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Spatiotemporal architecture of mouse embryogenesis at single-cell resolution

    Sampath Kumar, Abhishek [Verfasser] / Rappsilber, Juri [Akademischer Betreuer] / Meissner, Alexander [Akademischer Betreuer] / Rappsilber, Juri [Gutachter] / Meissner, Alexander [Gutachter]

    2023  

    Author's details Abhishek Sampath Kumar ; Gutachter: Juri Rappsilber, Alexander Meissner ; Juri Rappsilber, Alexander Meissner
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Technische Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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