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  1. Article ; Online: Volunteer, state ambulance and austere medicine.

    Meister, Matthew

    Emergency medicine Australasia : EMA

    2023  Volume 35, Issue 6, Page(s) 1030–1031

    MeSH term(s) Humans ; Ambulances ; Medicine ; Emergency Medical Services ; Volunteers ; State Medicine
    Language English
    Publishing date 2023-10-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2161824-0
    ISSN 1742-6723 ; 1742-6731 ; 1035-6851
    ISSN (online) 1742-6723
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.14334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5940: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Learning, fast and slow.

    Meister, Markus

    Current opinion in neurobiology

    2022  Volume 75, Page(s) 102555

    Abstract: Animals can learn efficiently from a single experience and change their future behavior in response. However, in other instances, animals learn very slowly, requiring thousands of experiences. Here, I survey tasks involving fast and slow learning and ... ...

    Abstract Animals can learn efficiently from a single experience and change their future behavior in response. However, in other instances, animals learn very slowly, requiring thousands of experiences. Here, I survey tasks involving fast and slow learning and consider some hypotheses for what differentiates the underlying neural mechanisms. It has been proposed that fast learning relies on neural representations that favor efficient Hebbian modification of synapses. These efficient representations may be encoded in the genome, resulting in a repertoire of fast learning that differs across species. Alternatively, the required neural representations may be acquired from experience through a slow process of unsupervised learning from the environment.
    MeSH term(s) Animals ; Synapses/physiology
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2022.102555
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Thesis: In vitro und in vivo Evaluation der antimikrobiellen Aktivität von Folsäureantagonisten und Nukleosid-Analoga gegenüber Staphylococcus aureus

    Meister, Michael

    2012  

    Author's details von Michael Torsten Meister
    Language German
    Size III, 103 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2013
    HBZ-ID HT017755222
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 D 783 order for loan Magazin

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  4. Book ; Online: Learning, fast and slow

    Meister, Markus

    2022  

    Abstract: Animals can learn efficiently from a single experience and change their future behavior in response. However, in other instances, animals learn very slowly, requiring thousands of experiences. Here I survey tasks involving fast and slow learning and ... ...

    Abstract Animals can learn efficiently from a single experience and change their future behavior in response. However, in other instances, animals learn very slowly, requiring thousands of experiences. Here I survey tasks involving fast and slow learning and consider some hypotheses for what differentiates the underlying neural mechanisms. It has been proposed that fast learning relies on neural representations that favor efficient Hebbian modification of synapses. These efficient representations may be encoded in the genome, resulting in a repertoire of fast learning that differs across species. Alternatively, the required neural representations may be acquired from experience through a slow process of unsupervised learning from the environment.

    Comment: Submitted to Current Opinion in Neurobiology
    Keywords Quantitative Biology - Neurons and Cognition
    Publishing date 2022-04-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Functional cell types in the mouse superior colliculus.

    Li, Ya-Tang / Meister, Markus

    eLife

    2023  Volume 12

    Abstract: The superior colliculus (SC) represents a major visual processing station in the mammalian brain that receives input from many types of retinal ganglion cells (RGCs). How many parallel channels exist in the SC, and what information does each encode? Here, ...

    Abstract The superior colliculus (SC) represents a major visual processing station in the mammalian brain that receives input from many types of retinal ganglion cells (RGCs). How many parallel channels exist in the SC, and what information does each encode? Here, we recorded from mouse superficial SC neurons under a battery of visual stimuli including those used for classification of RGCs. An unsupervised clustering algorithm identified 24 functional types based on their visual responses. They fall into two groups: one that responds similarly to RGCs and another with more diverse and specialized stimulus selectivity. The second group is dominant at greater depths, consistent with a vertical progression of signal processing in the SC. Cells of the same functional type tend to cluster near each other in anatomical space. Compared to the retina, the visual representation in the SC has lower dimensionality, consistent with a sifting process along the visual pathway.
    MeSH term(s) Mice ; Animals ; Superior Colliculi/physiology ; Retina ; Retinal Ganglion Cells/physiology ; Visual Pathways/physiology ; Mice, Inbred C57BL ; Mammals
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Optimizing the order of actions in a model of contact tracing.

    Meister, Michela / Kleinberg, Jon

    PNAS nexus

    2023  Volume 2, Issue 3, Page(s) pgad003

    Abstract: Contact tracing is a key tool for managing epidemic diseases like HIV, tuberculosis, COVID-19, and monkeypox. Manual investigations by human-contact tracers remain a dominant way in which this is carried out. This process is limited by the number of ... ...

    Abstract Contact tracing is a key tool for managing epidemic diseases like HIV, tuberculosis, COVID-19, and monkeypox. Manual investigations by human-contact tracers remain a dominant way in which this is carried out. This process is limited by the number of contact tracers available, who are often overburdened during an outbreak or epidemic. As a result, a crucial decision in any contact tracing strategy is, given a set of contacts, which person should a tracer trace next? In this work, we develop a formal model that articulates these questions and provides a framework for comparing contact tracing strategies. Through analyzing our model, we give provably optimal prioritization policies via a clean connection to a tool from operations research called a "branching bandit". Examining these policies gives qualitative insight into trade-offs in contact tracing applications.
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad003
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  7. Book ; Online: Curved Micro-Electrode Arrays

    Meister, Markus

    2021  

    Abstract: Multi-electrode arrays serve to record electrical signals of many neurons in the brain simultaneously. For most of the past century, electrodes that penetrate brain tissue have had exactly one shape: a straight needle. Certainly this was a good starting ... ...

    Abstract Multi-electrode arrays serve to record electrical signals of many neurons in the brain simultaneously. For most of the past century, electrodes that penetrate brain tissue have had exactly one shape: a straight needle. Certainly this was a good starting choice at the time, but there is no reason to think that a straight line would be the optimal shape in all Neuroscience applications. Here I argue that, in fact, a wide variety of curved shapes is equally practical: all possible helices. I discuss the manufacture and manipulation of such devices, and illustrate a few use cases where they will likely outperform conventional needles. With some collective action from the research community, curved arrays could be manufactured and distributed at low cost.

    Comment: 8 pages, 4 figures
    Keywords Quantitative Biology - Neurons and Cognition
    Publishing date 2021-07-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article: Memory System Neurons Represent Gaze Position and the Visual World.

    Meister, Miriam

    Journal of experimental neuroscience

    2018  Volume 12, Page(s) 1179069518787484

    Abstract: The entorhinal cortex, a brain area critical for memory, contains neurons that fire when a rodent is in a certain location (eg, grid cells), or when a monkey looks at certain locations. In rodents, these spatial representations align to visual objects in ...

    Abstract The entorhinal cortex, a brain area critical for memory, contains neurons that fire when a rodent is in a certain location (eg, grid cells), or when a monkey looks at certain locations. In rodents, these spatial representations align to visual objects in the environment by firing when the animal is in a preferred location defined by relative position of visual environmental features. Recently, our laboratory found that simultaneously recorded entorhinal neurons in monkeys can exhibit different spatial reference frames for gaze position, including a reference frame of visual environmental features. We also discovered that most of the neurons represent gaze position. These results suggest that gaze information in multiple spatial reference frames is a potent signal used in the primate memory system. Here, I describe how these findings support three underappreciated views of the hippocampal memory system.
    Language English
    Publishing date 2018-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659991-0
    ISSN 1179-0695
    ISSN 1179-0695
    DOI 10.1177/1179069518787484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Die historische Entwicklung der Nahsehproben

    Meister, Monika

    (Zürcher medizingeschichtliche Abhandlungen ; 277)

    1998  

    Author's details von Monika Meister
    Series title Zürcher medizingeschichtliche Abhandlungen ; 277
    Collection
    Keywords Nahsehschärfe ; Sehprobe ; Geschichte
    Language German
    Size 98 S.
    Publisher Juris Dr. und Verl
    Publishing place Dietikon
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss
    HBZ-ID HT009135227
    ISBN 3-260-05423-5 ; 978-3-260-05423-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 7385 order for loan Magazin

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  10. Article ; Online: Equilibrium landscape of ingress/egress channels and gating residues of the Cytochrome P450 3A4.

    Ackad, Edward Michael / Biggers, Laurence / Meister, Mary / Kontoyianni, Maria

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0298424

    Abstract: The Cytochrome P450 (CYP) enzymes metabolize a variety of drugs, which may potentially lead to toxicity or reduced efficacy when drugs are co-administered. These drug-drug interactions are often manifested by CYP3A4, the most prevalent of all CYP ... ...

    Abstract The Cytochrome P450 (CYP) enzymes metabolize a variety of drugs, which may potentially lead to toxicity or reduced efficacy when drugs are co-administered. These drug-drug interactions are often manifested by CYP3A4, the most prevalent of all CYP isozymes. We carried out multiple MD simulations employing CAVER to quantify the channels, and Hidden Markov Models (HMM) to characterize the behavior of the gating residues. We discuss channel properties, bottleneck residues with respect to their likelihood to deem the respective channel ingress or egress, gating residues regarding their open or closed states, and channel location relative to the membrane. Channels do not display coordinated motion and randomly transition between different conformations. Gateway residues also behave in a random fashion. Our findings shed light on the equilibrium behavior of the gating residues and channels in the apo state.
    MeSH term(s) Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions
    Chemical Substances Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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