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  1. Article ; Online: Utility of icteric index in clinical laboratories: more than a preanalytical indicator.

    Mondejar, Rufino / Mayor Reyes, María / Melguizo Madrid, Enrique / Cañavate Solano, Consuelo / Pérez Ramos, Santiago

    Biochemia medica

    2021  Volume 31, Issue 2, Page(s) 20703

    Abstract: Introduction: Total bilirubin tests are highly demanded in clinical laboratories. Since icteric index (I-index) has zero cost, we aimed to evaluate its clinical utility and cost-effectiveness to determine if total bilirubin is necessary to be tested. We ...

    Abstract Introduction: Total bilirubin tests are highly demanded in clinical laboratories. Since icteric index (I-index) has zero cost, we aimed to evaluate its clinical utility and cost-effectiveness to determine if total bilirubin is necessary to be tested. We took into account if haemolysis could interfere to icteric index determination.
    Material and methods: Retrospectively we reviewed I-index results in two cohorts (43,372 and 8507 non-haemolysed and haemolysed samples, respectively). All determinations were done using Alinity c chemistry analysers (Abbott Diagnostics). Receiver operating characteristic (ROC) curve was used to determine the optimal index cut-off to discriminate between normal and abnormal bilirubin concentration (20.5 µmol/L).
    Results: The ROC curve analysis suggested 21.4 µmol/L as the optimal I-index cut-off but differences in sensitivity and specificity were detected between patient derivation. For rejecting purpose, 15.4 µmol/L and 17.1 µmol/L I-index thresholds were selected based on patient derivation (inpatients and emergency room; and primary care and outpatients, respectively) with 97% sensitivity and 0.25% false negative results. Sensitivity was much lower in haemolysed samples. We selected 34.2 µmol/L I-index as threshold to detect hyperbilirubinemia with 99.7% specificity and 0.26% false positive results, independent of haemolysis. With the icteric index cut-offs proposed, we would save 66% of total bilirubin requested and analyse total bilirubin in around 2% of samples without total bilirubin requested.
    Conclusions: This study supports the use of I-index to avoid bilirubin determination and to identify patients with hyperbilirubinemia. This work considers that the economic and test savings could help to increase the efficiency in clinical laboratories.
    MeSH term(s) Bilirubin/blood ; Female ; Hemolysis ; Humans ; Hyperbilirubinemia/blood ; Laboratories, Hospital ; Male ; Retrospective Studies
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2021-04-15
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1208725-7
    ISSN 1846-7482 ; 1330-0962
    ISSN (online) 1846-7482
    ISSN 1330-0962
    DOI 10.11613/BM.2021.020703
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    Zs.A 4273: Show issues Location:
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  2. Article ; Online: Evaluation of the Congenital Hypothyroidism Detection Strategy in Extremely Preterm Infants in Western Andalusia.

    Rubio-Sánchez, Ricardo / Núñez-Jurado, David / Melguizo-Madrid, Enrique / Álvarez-Ríos, Ana I / Delgado-Pecellín, Carmen

    American journal of perinatology

    2021  Volume 40, Issue 13, Page(s) 1421–1424

    Abstract: Objective: This study aimed to identify extremely premature infants (< 31 weeks of gestation and/or <1,500 g) affected by congenital hypothyroidism (CH) with delayed elevation of thyrotropin (TSH) and to evaluate the detection strategy for this ... ...

    Abstract Objective: This study aimed to identify extremely premature infants (< 31 weeks of gestation and/or <1,500 g) affected by congenital hypothyroidism (CH) with delayed elevation of thyrotropin (TSH) and to evaluate the detection strategy for this pathology in our reference screening population.
    Study design: A descriptive and retrospective study was carried out with samples collected from western Andalusia and the autonomous city of Ceuta.
    Results: This protocol allowed us to detect six neonates with delayed TSH elevation. One of them, due to serious heart problems, died without being able to confirm CH. In two neonates, however, it was possible to detect CH, another two presented a persistent TSH elevation but normal free T4, and another one presented a temporary TSH elevation.
    Conclusion: It is essential to repeat the CH screening in extremely premature infants, not only at the age of 15 days but also with a third sample at the moment of hospital discharge to detect cases with delayed TSH elevation.
    Key points: · The Newborn Screening Programs are an essential activity of preventive medicine.. · Extremely preterm infants have a very high risk of CH.. · Optimal management of thyroid dysfunction in this population remains to be established..
    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Congenital Hypothyroidism/diagnosis ; Congenital Hypothyroidism/epidemiology ; Infant, Extremely Premature ; Retrospective Studies ; Thyrotropin ; Neonatal Screening/methods ; Thyroxine
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/a-1627-0240
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  3. Article ; Online: Prevalence of severe hypercholesterolemia observed in different hospitals in Andalusia and Ceuta.

    Arrobas Velilla, Teresa / Varo Sánchez, Gema / Romero García, Irene / Melguizo Madrid, Enrique / Rodríguez Sánchez, Firma Isabel / León Justel, Antonio

    Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

    2021  Volume 33, Issue 5, Page(s) 217–223

    Abstract: Severe hypercholesterolaemia is a major cardiovascular risk factor. Early detection and treatment can reduce the incidence of cardiovascular disease. Given the high prevalence of hypercholesterolaemia in Andalusia, the development of a screening strategy ...

    Title translation Prevalencia de hipercolesterolemias severas observadas en los distintos hospitales de Andalucía y Ceuta.
    Abstract Severe hypercholesterolaemia is a major cardiovascular risk factor. Early detection and treatment can reduce the incidence of cardiovascular disease. Given the high prevalence of hypercholesterolaemia in Andalusia, the development of a screening strategy for its detection in Primary Care may be an efficient measure.
    Objective: To identify patients in Primary Care with severe hypercholesterolaemia that may increase their cardiovascular risk by reviewing LDL-cholesterol results in computerised laboratory systems.
    Material and methods: Observational, retrospective, multi-centre study in 16 hospitals in Andalusia and Ceuta. Anonymous analytical data were acquired from the different laboratory computer systems for the year 2018, and exclusively from Macarena Hospital for the year 2019.
    Results: From a total of 1,969,035 determinations on≥18 years old, 2,791 patients (0.14%) were detected with LDL-cholesterol>250mg/dl and from a total of 2.327.211 determinations studied in children under 18 years old, 3,804 patients (0.16%) were detected with LDL-cholesterol>135mg/dL. The highest incidence of possible genetic hypercholesterolaemia in adults corresponded to the province of Seville with 23.6 cases/1,000 determinations, while in minors, the highest incidence corresponded to the province of Cadiz with 75 possible cases/1,000 determinations. A geographical triangle of greater prevalence is observed between the provinces of Seville, Huelva and Cadiz.
    Conclusions: The development of a screening strategy using a computerised review of LDL-cholesterol in Primary Care detects a large number of subjects with severe hypercholesterolaemia that could benefit from an early intervention.
    MeSH term(s) Adolescent ; Adult ; Child ; Cholesterol, LDL ; Hospitals ; Humans ; Hypercholesterolemia/epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors
    Chemical Substances Cholesterol, LDL
    Language Spanish
    Publishing date 2021-04-02
    Publishing country Spain
    Document type Journal Article ; Multicenter Study ; Observational Study
    ISSN 1578-1879
    ISSN (online) 1578-1879
    DOI 10.1016/j.arteri.2020.12.009
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  4. Article: Evaluation of the Congenital Hypothyroidism Detection Strategy in Extremely Preterm Infants in Western Andalusia

    Rubio-Sánchez, Ricardo / Núñez-Jurado, David / Melguizo-Madrid, Enrique / Álvarez-Ríos, Ana I. / Delgado-Pecellín, Carmen

    American Journal of Perinatology

    2021  Volume 40, Issue 13, Page(s) 1421–1424

    Abstract: Objective: This study aimed to identify extremely premature infants (< 31 weeks of gestation and/or <1,500 g) affected by congenital hypothyroidism (CH) with delayed elevation of thyrotropin (TSH) and to evaluate the detection strategy for this ... ...

    Abstract Objective: This study aimed to identify extremely premature infants (< 31 weeks of gestation and/or <1,500 g) affected by congenital hypothyroidism (CH) with delayed elevation of thyrotropin (TSH) and to evaluate the detection strategy for this pathology in our reference screening population.
    Study Design: A descriptive and retrospective study was carried out with samples collected from western Andalusia and the autonomous city of Ceuta.
    Results: This protocol allowed us to detect six neonates with delayed TSH elevation. One of them, due to serious heart problems, died without being able to confirm CH. In two neonates, however, it was possible to detect CH, another two presented a persistent TSH elevation but normal free T4, and another one presented a temporary TSH elevation.
    Conclusion: It is essential to repeat the CH screening in extremely premature infants, not only at the age of 15 days but also with a third sample at the moment of hospital discharge to detect cases with delayed TSH elevation.
    Key Points: The Newborn Screening Programs are an essential activity of preventive medicine. Extremely preterm infants have a very high risk of CH. Optimal management of thyroid dysfunction in this population remains to be established.
    Keywords congenital hypothyroidism ; extremely preterm infants ; neonatal screening ; TSH ; FT4
    Language English
    Publishing date 2021-08-31
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/a-1627-0240
    Database Thieme publisher's database

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    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Coexistence of anti-Jo1 and anti-signal recognition particle antibodies in a polymyositis patient.

    Melguizo Madrid, Enrique / Fernández Riejos, Patricia / Toyos Sáenz de Miera, Francisco Javier / Fernández Pérez, Berta / González Rodríguez, Concepción

    Reumatologia clinica

    2018  Volume 15, Issue 6, Page(s) e111–e113

    Abstract: Idiopathic inflammatory myopathies are a heterogeneous group of potentially treatable myopathies. They are classified, on the basis of clinical and histopathological features, into four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune ... ...

    Title translation Coexistencia de anticuerpos anti-histidil-tRNA-sintetasa y anti-partícula de reconocimiento de la señal en un paciente con polimiositis.
    Abstract Idiopathic inflammatory myopathies are a heterogeneous group of potentially treatable myopathies. They are classified, on the basis of clinical and histopathological features, into four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune myositis and inclusion-body myositis. Myositis-associated antibodies and myositis-specific autoantibodies are frequently found in patients with idiopathic inflammatory myopathies, and are useful in the diagnosis and classification. Anti-histidyl transfer RNA synthetase antibody is the most widely prevalent and is highly specific for polymyositis. Signal recognition particle antibody is also a specific autoantibody for polymyositis, but it is infrequent and rarely found in patients having other myositis-specific autoantibodies. We present a man with polymyositis who had both antibodies in serum, which is considered an extremely rare clinical situation. Here we analyze the clinical course and findings, and examine the effect of the coexistence and possible interaction on prognosis.
    MeSH term(s) Autoantibodies/blood ; Histidine-tRNA Ligase/immunology ; Humans ; Male ; Middle Aged ; Polymyositis/blood ; Signal Recognition Particle/immunology
    Chemical Substances Autoantibodies ; Signal Recognition Particle ; Histidine-tRNA Ligase (EC 6.1.1.21)
    Language Spanish
    Publishing date 2018-03-28
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2173-5743
    ISSN (online) 2173-5743
    DOI 10.1016/j.reuma.2017.12.003
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  6. Article ; Online: Resultados del cribado neonatal de Andalucía Occidental tras una década de experiencia.

    Delgado-Pecellín, Carmen / Álvarez Ríos, Isabel / Bueno Delgado, María Del Amor / Jiménez Jambrina, Margarita María / Quintana Gallego, María Esther / Ruiz Salas, Pedro / Marcos Luque, Irene / Melguizo Madrid, Enrique

    Revista espanola de salud publica

    2020  Volume 94

    Abstract: Objective: The main justification of this study was to describe our experience in neonatal screening and to define the prevalence of the diseases included in the neonatal screening program in Andalusia, among which are congenital hypothyroidism, ... ...

    Title translation Results of the neonatal screening on Western Andalusia after a decade of experience.
    Abstract Objective: The main justification of this study was to describe our experience in neonatal screening and to define the prevalence of the diseases included in the neonatal screening program in Andalusia, among which are congenital hypothyroidism, expanded screening (aminoacidopathies, mitochondrial beta-oxidation defects and organic acidurias), cystic fibrosis, and screening for sickle cell anemia.
    Methods: The study was carried out in the Metabolopathies Unit of the Virgen del Rocío Hospital in Seville with samples of newborns from Western Andalusia (Cádiz, Córdoba, Huelva and Seville) and autonomous city of Ceuta. A total of 435,141 newborns were studied (from the period from April 1st 2009 to December 31st 2019) to rule out congenital hypothyroidism and expanded screening; 378,306 for cystic fibrosis from May 1st 2011 to the same date described above. Finally, sickle cell anemia screening was included, which comprised a total of 55,576 newborns from November 26th, 2018 to the same period as the previous ones. Statistical analysis was performed using IBM SPSS software (version 22, SPSS INC., USA).
    Results: The study revealed a prevalence of 1:1565 newborns for congenital hypothyroidism, 1:1532 newborns for extended screening, 1:6.878 newborns for cystic fibrosis, and a 1:11.115 newborns for sickle cell disease.
    Conclusions: The neonatal screening program allows a large number of newborns to benefit from the early detection of certain serious congenital diseases. This aim improves the morbidity and mortality of those who suffer from them.
    MeSH term(s) Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/epidemiology ; Congenital Hypothyroidism/diagnosis ; Congenital Hypothyroidism/epidemiology ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/epidemiology ; Early Diagnosis ; Humans ; Infant, Newborn ; Longitudinal Studies ; Metabolism, Inborn Errors/diagnosis ; Metabolism, Inborn Errors/epidemiology ; Neonatal Screening ; Prevalence ; Retrospective Studies ; Spain/epidemiology
    Language Spanish
    Publishing date 2020-12-16
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
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    Zs.A 483: Show issues Location:
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  7. Article ; Online: Zenit RA evaluation, a solid-phase chemiluminescence immunoassay for detection of anti-cellular antibodies.

    Melguizo Madrid, Enrique / González-Rodríguez, Concepción / Ávila-García, María de Gracia / Arrobas-Velilla, Teresa / Fernández-Riejos, Patricia

    Bioanalysis

    2017  Volume 9, Issue 5, Page(s) 435–445

    Abstract: Aim: The objective was to compare Zenit RA chemiluminescent immunoassay (CLIA) from Menarini Diagnostics and ELISA from INOVA Diagnostics for the presence of specific anti-Ro/SS-A, anti-La/SS-B, anti-U1snRNP, anti-Sm, anti-Scl-70, anti-Jo-1 antibodies. ... ...

    Abstract Aim: The objective was to compare Zenit RA chemiluminescent immunoassay (CLIA) from Menarini Diagnostics and ELISA from INOVA Diagnostics for the presence of specific anti-Ro/SS-A, anti-La/SS-B, anti-U1snRNP, anti-Sm, anti-Scl-70, anti-Jo-1 antibodies. Results/methodology: We studied 501 samples (178 connective autoimmune disease, 150 other autoimmune or inflammatory disease and 173 other disease or healthy). All samples were analyzed using CLIA and ELISA. The Kappa agreement was excellent for anti-SSA/Ro (0.864), good for anti-SSB/La (0.735), anti-Scl-70 (0.685) and ENA-screening (0.778), moderate for anti-RNP (0.563) and bad for anti-Sm (0.266) and anti-Jo-1 (0.243). Different combination of cut-off improved the specificity and agreement.
    Conclusion: Zenit RA CLIA for detecting autoantibodies, provides a simple, useful and accurate tool.
    MeSH term(s) Antibodies, Antinuclear/analysis ; Autoimmune Diseases/diagnosis ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoassay ; Logistic Models ; Luminescent Measurements ; Nuclear Proteins/immunology ; Ribonucleoproteins, Small Nuclear/immunology
    Chemical Substances Antibodies, Antinuclear ; Jo-1 antibody ; Nuclear Proteins ; Ribonucleoproteins, Small Nuclear ; SNRNP35 protein, human ; Scl 70 antigen, human
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio-2016-0252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association between serum dickkopf-1 levels and disease duration in axial spondyloarthritis.

    Rubio Vargas, Roxana / Melguizo Madrid, Enrique / González Rodríguez, Concepción / Navarro Sarabia, Federico / Dominguez Quesada, Carmen / Ariza Ariza, Rafael / Navarro Compán, Victoria

    Reumatologia clinica

    2017  Volume 13, Issue 4, Page(s) 197–200

    Abstract: Background: Axial spondyloarthritis (axSpA) is characterized by new bone formation. The complex systems underlying this process involve Wnt-signaling pathway. It has been observed that serum levels of dickkopf-1 (DKK-1), an important inhibitor of Wnt- ... ...

    Abstract Background: Axial spondyloarthritis (axSpA) is characterized by new bone formation. The complex systems underlying this process involve Wnt-signaling pathway. It has been observed that serum levels of dickkopf-1 (DKK-1), an important inhibitor of Wnt-signaling, are decreased in patients with axSpA. However, these data are from studies including only patients with long-standing disease. The aim of this study is to investigate if symptom duration influences on serum DKK-1 levels in patients with axSpA.
    Material and methods: A cross-sectional study including consecutive patients with axSpA (ASAS criteria) naïve for anti-TNF therapy. Collected data included demographic and disease characteristics, time since first symptom onset, assessment of disease activity and function, and determination of DKK-1 serum levels. Patients were classified as early axSpA (symptom duration ≤5 years) and established axSpA (>5 years). Linear regression models were employed to investigate the variables related to DKK-1 serum levels.
    Results: In total, 90 patients were included. Sixty-eight patients had early axSpA and 22 had established disease. Serum levels of DKK-1 were significantly higher in patients with early axSpA compared with established axSpA (22.1±12.6 vs 16.4±10.7pM; p=0.04). Among all tested variables, only symptom duration was significantly and inversely correlated with DKK-1 serum levels (beta: -0.041; p=0.01).
    Conclusion: Serum DKK-1 levels in axSpA depend on disease duration. As disease duration increases, DKK-1 serum levels decrease. Based on this, an intensive treatment at early stages of the disease could have a better outcome on inhibiting/slowing radiographic progression in patients with axSpA.
    Language Spanish
    Publishing date 2017-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2477196-X
    ISSN 1885-1398 ; 1699-258X
    ISSN (online) 1885-1398
    ISSN 1699-258X
    DOI 10.1016/j.reuma.2016.04.013
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  9. Article ; Online: Interaction between oxidative stress and smoking is associated with an increased risk of rheumatoid arthritis: a case-control study.

    Navarro-Compán, Victoria / Melguizo-Madrid, Enrique / Hernández-Cruz, Blanca / Santos-Rey, Koldo / Leyva-Prado, Christian / González-Martín, Carmen / Navarro-Sarabia, Federico / González-Rodríguez, Concepción

    Rheumatology (Oxford, England)

    2013  Volume 52, Issue 3, Page(s) 487–493

    Abstract: Objective: To investigate the relationship between oxidative stress and smoking and development of RA.: Methods: A case-control study was conducted in treatment-naïve early-onset RA patients and healthy controls, matched by age, gender and current ... ...

    Abstract Objective: To investigate the relationship between oxidative stress and smoking and development of RA.
    Methods: A case-control study was conducted in treatment-naïve early-onset RA patients and healthy controls, matched by age, gender and current smoking habit. Plasma lipid hydroperoxides (LOOH), carbonyl protein (CP) and malonyldialdehyde (MDA) levels were measured to estimate oxidative stress. Smoking exposure was quantified in pack-years. The presence of an interaction between oxidative stress and smoking exposure was investigated using three measures of additive interaction: relative excess risk due to the interaction (RERI), attributable proportion due to the interaction (AP) and the synergy index (S).
    Results: A total of 65 RA patients and 65 healthy controls were included. Statistically significant differences were observed in RA-related variables, age, BMI and smoking dose between cases and controls. Plasma LOOH and CP levels were associated with RA risk, which was more prominent for LOOH levels >27.9 µM [odds ratio (OR) 18.8] and CP levels >64.3 µM (OR 24.9). A reverse association was observed between MDA levels and RA risk, OR 6.4 for MDA levels <8.5 µM. Having >20 pack-years increased risk for RA with an OR of 19.7. The interaction between smoking and oxidative stress increased RA risk significantly, and RERI between LOOH, CP or MDA and smoke exposure were 8.2, 5.0 and 51.5, respectively.
    Conclusion: These data suggest that the interaction between oxidative stress and smoking increases RA risk.
    MeSH term(s) Adult ; Antioxidants/physiology ; Arthritis, Rheumatoid/etiology ; Case-Control Studies ; Female ; Humans ; Lipid Peroxides/blood ; Lipoproteins, HDL/blood ; Male ; Malondialdehyde/blood ; Middle Aged ; Oxidative Stress/physiology ; Protein Carbonylation/physiology ; Risk ; Smoking/adverse effects ; Uric Acid/blood
    Chemical Substances Antioxidants ; Lipid Peroxides ; Lipoproteins, HDL ; Uric Acid (268B43MJ25) ; Malondialdehyde (4Y8F71G49Q)
    Language English
    Publishing date 2013-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kes286
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  10. Article ; Online: Inicio, evolución y situación actual de los Programas de Cribado Neonatal en España.

    Marín Soria, José Luis / González de Aledo Castillo, José Manuel / Argudo Ramírez, Ana / López Galera, Rosa Mª / Pajares García, Sonia / Ribes Rubió, Antonia / García Villoria, Judith / Yahyaoui Macías, Raquel / Álvarez Ríos, Ana Isabel / Melguizo Madrid, Enrique / González Irazabal, Yolanda / Hernández de Abajo, Guillermo / Prieto García, Belén / Cardo González, Leire / Martínez Morillo, Eduardo / Robles Bauza, Juan / Bauçà Rosselló, Josep Miquel / Pérez Esteban, Gerardo / Díaz-Flores Estevez, Felícitas /
    Pérez Mangas, Eva / Cañadas Garzó, Verónica / Muñoz Boyero, Ana Cristina / Redondo Cardeña, Pedro A / Bueno Llarena, Mª Josefa / Sánchez Alarcon, Javier / Castiñeiras Ramos, Daisy / Cocho de Juan, José Ángel / Colón Mejeras, Cristóbal / Blanco Soto, Paula / Cambra Conejero, Ana / Fernández Ruano, Miguel L / Ortiz Temprado, Alicia / Egea Mellado, José Mª / González Gallego, Inmaculada / Juan Fita, Mª Jesús / Espada Saenz-Torre, Mercedes / Rausell Felix, Dolores / Marcos Tomás, Jose Vicente / Ruiz Aja, Sandra / Delgado Pecellín, Carmen / Bóveda Fontán, Mª Dolores

    Revista espanola de salud publica

    2021  Volume 95

    Abstract: Newborn Screening Programs (NSP) in Spain were born in the city of Granada in 1968. Till the 1980s, they were developed around the so-called "National Plan for Preventing Subnormality", covering up to 30% of the Spanish newborns. From 1982, when the ... ...

    Title translation Beginnings, evolution and current situation of the Newborn Screening Programs in Spain.
    Abstract Newborn Screening Programs (NSP) in Spain were born in the city of Granada in 1968. Till the 1980s, they were developed around the so-called "National Plan for Preventing Subnormality", covering up to 30% of the Spanish newborns. From 1982, when the health system management was transferred to the different autonomous regions, the NSP began to expand, and the bases to transform them into an organized and multidisciplinary activity, integrated and coordinated from the National Health System were settled. Despite this expansion, it is not until the 1990s when their coverage reaches almost 100% newborns in Spain. NSP grew up asymmetrically across the different autonomous regions. In 2005 and 2006 the scientific societies SEQC (Spanish Society of Clinical Chemistry) and AECNE (Spanish Society of Newborn Screening), coordinated by the Health Promotion Area of the General Directorate of Public Health, gathered together the necessary information to elaborate a report on the NSP in Spain addressed to the Interterritorial Council of the National Health System. In July 2013, that Council approved the seven diseases that should be part of each region newborn screening panel, being the first step towards the NSP harmonization in Spain. Currently, the NSP include between 8 and 29 diseases in their panels, thus more still more efforts are needed in order to achieve a higher uniformity.
    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Infant, Newborn ; Neonatal Screening/history ; Neonatal Screening/organization & administration ; Spain
    Language Spanish
    Publishing date 2021-02-23
    Publishing country Spain
    Document type Historical Article ; Journal Article
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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