LIVIVO - Search results -

Search results

Result 1 - 10 of total 73

Search options

Article ; Online: Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications.

Nurchi, Chiara / Buonvino, Silvia / Arciero, Ilaria / Melino, Sonia

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: One of the main criteria for ecological sustainability is that the materials produced for common use are green. This can include the use of biomaterials and materials that are environmentally friendly, biodegradable and produced at low cost. The ... ...

Abstract	One of the main criteria for ecological sustainability is that the materials produced for common use are green. This can include the use of biomaterials and materials that are environmentally friendly, biodegradable and produced at low cost. The exploration of natural resources as sustainable precursors leads to the production of biopolymers that are useful for 3D printing technology. Recently, waste vegetable oils have been found to be a good alternative source for the production of biopolymers in various applications from the engineering to the biomedicine. In this review, the processes for the synthesis of vegetable oil-based biomaterials are described in detail. Moreover, the functionalization strategies to improve the mechanical properties of these materials and the cell-material interaction for their potential use as micro-structured scaffolds in regenerative medicine are discussed.
MeSH term(s)	Plant Oils ; Biocompatible Materials ; Regenerative Medicine ; Biopolymers ; Printing, Three-Dimensional ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Plant Oils ; Biocompatible Materials ; Biopolymers
Language	English
Publishing date	2023-01-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032153
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: A hydrogel reveals an elusive cancer stem cell.

Melino, Sonia / Seliktar, Dror

Cell death & disease

2021 Volume 12, Issue 5, Page(s) 415

MeSH term(s)	Humans ; Hydrogels ; Neoplasms ; Neoplastic Stem Cells ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Hydrogels
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-03696-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Modelling the disease: H

Buonvino, Silvia / Arciero, Ilaria / Martinelli, Eugenio / Seliktar, Dror / Melino, Sonia

Materials today. Bio

2023 Volume 23, Page(s) 100862

Abstract: Three-dimensional (3D) cell culture systems provide more physiologically relevant information, representing more accurately the actual microenvironment where cells reside in tissues. However, the differences between the tissue culture plate (TCP) and 3D ... ...

Abstract	Three-dimensional (3D) cell culture systems provide more physiologically relevant information, representing more accurately the actual microenvironment where cells reside in tissues. However, the differences between the tissue culture plate (TCP) and 3D culture systems in terms of tumour cell growth, proliferation, migration, differentiation and response to the treatment have not been fully elucidated. Tumoroid microspheres containing the MDA-MB 231 breast cancer cell line were prepared using either tunable PEG-fibrinogen (PFs) or tunable PEG-silk fibroin (PSFs) hydrogels, respectively named MDAPFs and MDAPSFs. The cancer cells in the tumoroids showed changes both in globular morphology and at the protein expression level. A decrease of both Histone H3 acetylation and cyclin D1 expression in all 3D systems, compared to the 2D cell culture, was detected in parallel to changes of the matrix stiffness. The effects of a glutathionylated garlic extract (GSGa), a slow H
Language	English
Publishing date	2023-11-11
Publishing country	England
Document type	Journal Article
ISSN	2590-0064
ISSN (online)	2590-0064
DOI	10.1016/j.mtbio.2023.100862
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications.

Buonvino, Silvia / Arciero, Ilaria / Melino, Sonia

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract: Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such ...

Abstract	Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron-sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme.
MeSH term(s)	Cyanides/metabolism ; Mitochondria/metabolism ; Sulfur/metabolism ; Thiosulfate Sulfurtransferase/chemistry ; Thiosulfate Sulfurtransferase/genetics ; Thiosulfate Sulfurtransferase/metabolism ; Thiosulfates/metabolism
Chemical Substances	Cyanides ; Thiosulfates ; Sulfur (70FD1KFU70) ; Thiosulfate Sulfurtransferase (EC 2.8.1.1)
Language	English
Publishing date	2022-07-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158452
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: New Consensus pattern in Spike CoV-2: potential implications in coagulation process and cell-cell fusion.

Buonvino, Silvia / Melino, Sonia

Cell death discovery

2020 Volume 6, Page(s) 134

Abstract: Coagulopathy and syncytial formation are relevant effects of the SARS-CoV-2 infection, but the underlying molecular mechanisms triggering these processes are not fully elucidated. Here, we identified a potential consensus pattern in the Spike S ... ...

Abstract	Coagulopathy and syncytial formation are relevant effects of the SARS-CoV-2 infection, but the underlying molecular mechanisms triggering these processes are not fully elucidated. Here, we identified a potential consensus pattern in the Spike S glycoprotein present within the cytoplasmic domain; this consensus pattern was detected in only 79 out of 561,000 proteins (UniProt bank). Interestingly, the pattern was present in both human and bat the coronaviruses S proteins, in many proteins involved in coagulation process, cell-cell interaction, protein aggregation and regulation of cell fate, such as von Willebrand factor, coagulation factor X, fibronectin and Notch, characterized by the presence of the cysteine-rich EGF-like domain. This finding may suggest functional similarities between the matched proteins and the CoV-2 S protein, implying a new possible involvement of the S protein in the molecular mechanism that leads to the coagulopathy and cell fusion in COVID-19 disease.
Language	English
Publishing date	2020-11-27
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-020-00372-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: New vegetable-waste biomaterials by Lupin albus L. as cellular scaffolds for applications in biomedicine and food

Buonvino, Silvia / Ciocci, Matteo / Nanni, Francesca / Cacciotti, Ilaria / Melino, Sonia

Biomaterials. 2023 Feb., v. 293 p.121984-

2023

Abstract: The reprocessing of vegetal-waste represents a new research field in order to design novel biomaterials for potential biomedical applications and in food industry. Here we obtained a biomaterial from Lupinus albus L. hull (LH) that was characterized ... ...

Abstract	The reprocessing of vegetal-waste represents a new research field in order to design novel biomaterials for potential biomedical applications and in food industry. Here we obtained a biomaterial from Lupinus albus L. hull (LH) that was characterized micro-structurally by scanning electron microscopy and for its antimicrobial and scaffolding properties. A good adhesion and proliferation of human mesenchymal stem cells (hMSCs) seeded on LH scaffold were observed. Thanks to its high content of cellulose and beneficial phytochemical substances, LH and its derivatives can represent an available source for fabrication of biocompatible and bioactive scaffolds. Therefore, a reprocessing protocol of LH was optimized for producing a new LH bioplastic named BPLH. This new biomaterial was characterized by chemico-physical analyses. The water uptake, degradability and antimicrobial properties of BPLH were evaluated, as well as the mechanical properties. A good adhesion and proliferation of both fibroblasts and hMSCs on BPLH were observed over 2 weeks, and immunofluorescence analysis of hMSCs after 3 weeks indicates an initial commitment toward muscle differentiation. Our work represents a new approach toward the recovery and valorization of the vegetal waste showing the remarkable properties of LH and BPLH as cellular waste-based scaffold with potential applications in cell-based food field as well as in medicine for topical patches in wound healing and bedsores treatment.
Keywords	Lupinus albus ; adhesion ; biocompatible materials ; bioplastics ; cellulose ; electron microscopy ; fibroblasts ; fluorescent antibody technique ; food industry ; humans ; medicine ; muscles ; phytochemicals ; wastes ; water uptake ; Mesenchymal stem cells ; Circular economy ; Bioeconomy ; Vegetable-patch ; Cell-based food ; α-SMA ; ATR-FTIR ; BPLH ; DASH ; DMSO ; ECM ; FEG ; FLH ; GA ; GAE ; GI ; hMSCs ; HR ; IL ; iPSCs ; LH ; MTT ; Nf-kB ; NHDFs ; RH ; RP-HPLC ; SEM ; TCA ; TFA ; WHO ; WST-1 ; WU
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121984
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.B 2371: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: New vegetable-waste biomaterials by Lupin albus L. as cellular scaffolds for applications in biomedicine and food.

Buonvino, Silvia / Ciocci, Matteo / Nanni, Francesca / Cacciotti, Ilaria / Melino, Sonia

Biomaterials

2022 Volume 293, Page(s) 121984

Abstract	The reprocessing of vegetal-waste represents a new research field in order to design novel biomaterials for potential biomedical applications and in food industry. Here we obtained a biomaterial from Lupinus albus L. hull (LH) that was characterized micro-structurally by scanning electron microscopy and for its antimicrobial and scaffolding properties. A good adhesion and proliferation of human mesenchymal stem cells (hMSCs) seeded on LH scaffold were observed. Thanks to its high content of cellulose and beneficial phytochemical substances, LH and its derivatives can represent an available source for fabrication of biocompatible and bioactive scaffolds. Therefore, a reprocessing protocol of LH was optimized for producing a new LH bioplastic named BPLH. This new biomaterial was characterized by chemico-physical analyses. The water uptake, degradability and antimicrobial properties of BPLH were evaluated, as well as the mechanical properties. A good adhesion and proliferation of both fibroblasts and hMSCs on BPLH were observed over 2 weeks, and immunofluorescence analysis of hMSCs after 3 weeks indicates an initial commitment toward muscle differentiation. Our work represents a new approach toward the recovery and valorization of the vegetal waste showing the remarkable properties of LH and BPLH as cellular waste-based scaffold with potential applications in cell-based food field as well as in medicine for topical patches in wound healing and bedsores treatment.
MeSH term(s)	Humans ; Biocompatible Materials/chemistry ; Tissue Scaffolds/chemistry ; Vegetables ; Lupinus ; Mesenchymal Stem Cells ; Cell Differentiation ; Cell Proliferation ; Osteogenesis ; Tissue Engineering/methods
Chemical Substances	Biocompatible Materials
Language	English
Publishing date	2022-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121984
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2371: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Photo-Polymerization Damage Protection by Hydrogen Sulfide Donors for 3D-Cell Culture Systems Optimization.

Buonvino, Silvia / Ciocci, Matteo / Seliktar, Dror / Melino, Sonia

International journal of molecular sciences

2021 Volume 22, Issue 11

Abstract: Photo-polymerized hydrogels are ideally suited for stem-cell based tissue regeneration and three dimensional (3D) bioprinting because they can be highly biocompatible, injectable, easy to use, and their mechanical and physical properties can be ... ...

Abstract	Photo-polymerized hydrogels are ideally suited for stem-cell based tissue regeneration and three dimensional (3D) bioprinting because they can be highly biocompatible, injectable, easy to use, and their mechanical and physical properties can be controlled. However, photo-polymerization involves the use of potentially toxic photo-initiators, exposure to ultraviolet light radiation, formation of free radicals that trigger the cross-linking reaction, and other events whose effects on cells are not yet fully understood. The purpose of this study was to examine the effects of hydrogen sulfide (H
MeSH term(s)	Cell Culture Techniques/methods ; Cell Survival/drug effects ; Humans ; Hydrogels/pharmacology ; Hydrogen Sulfide/pharmacology ; Light ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/radiation effects ; Polymerization/drug effects ; Polymerization/radiation effects ; Printing, Three-Dimensional ; Tissue Engineering ; Tissue Scaffolds ; Wound Healing/drug effects ; Wound Healing/radiation effects
Chemical Substances	Hydrogels ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2021-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22116095
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Vegetable waste scaffolds for 3D-stem cell proliferating systems and low cost biosensors

Cancelliere, Rocco / Zurlo, Francesca / Micheli, Laura / Melino, Sonia

Talanta. 2021 Feb. 01, v. 223

2021

Abstract: Vegetable wastes represent an inexpensive and sustainable source of valuable bioproducts for several applications. Natural micro-porous and fibrous materials can be obtained from a very cheap and abundant cellulosic bio-waste. Here we demonstrated that ... ...

Abstract	Vegetable wastes represent an inexpensive and sustainable source of valuable bioproducts for several applications. Natural micro-porous and fibrous materials can be obtained from a very cheap and abundant cellulosic bio-waste. Here we demonstrated that vegetable waste derivatives can be suitable as scaffolds for biosensors and 3D cell growth. Many studies have been addressed to fabricate biocompatible 3D scaffolds for mammalian stem cells cultures and develop novel systems able to reproduce the complexity of the in vivo microenvironment. Many of these products are proprietary, expensive or require chemical synthesis. The recycling and revaluation of vegetable derived tissues to fabricate scaffolds for analytical biosensors 3D stem cell cultures platforms may represent a very low-cost approach for toxicological and environmental analyses. In this approach, potential applications of vegetable-derived tissue for biosensing and 3D stem cell cultures were investigated. Micro-structured scaffolds from stalk of broccoli, named BrcS, were either functionalized for production of enzymatic 3D-biosensors or preconditioned to be used them as 3D-scaffolds for human mesenchymal stem cells cultures. The conditions to fabricate 3D-biosensors and scaffolds for cell growth were here optimized studying all analytical parameters and demonstrating the feasibility to combine these two properties for an innovative solution to ennoble vegetable wastes.
Keywords	biobased products ; biosensors ; broccoli ; cell culture ; cell growth ; humans ; materials ; mesenchymal stromal cells ; recycling ; stem cells ; synthesis ; toxicology ; vegetable residues ; wastes
Language	English
Dates of publication	2021-0201
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2020.121671
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Vegetable waste scaffolds for 3D-stem cell proliferating systems and low cost biosensors.

Cancelliere, Rocco / Zurlo, Francesca / Micheli, Laura / Melino, Sonia

Talanta

2020 Volume 223, Issue Pt 1, Page(s) 121671

Abstract	Vegetable wastes represent an inexpensive and sustainable source of valuable bioproducts for several applications. Natural micro-porous and fibrous materials can be obtained from a very cheap and abundant cellulosic bio-waste. Here we demonstrated that vegetable waste derivatives can be suitable as scaffolds for biosensors and 3D cell growth. Many studies have been addressed to fabricate biocompatible 3D scaffolds for mammalian stem cells cultures and develop novel systems able to reproduce the complexity of the in vivo microenvironment. Many of these products are proprietary, expensive or require chemical synthesis. The recycling and revaluation of vegetable derived tissues to fabricate scaffolds for analytical biosensors 3D stem cell cultures platforms may represent a very low-cost approach for toxicological and environmental analyses. In this approach, potential applications of vegetable-derived tissue for biosensing and 3D stem cell cultures were investigated. Micro-structured scaffolds from stalk of broccoli, named BrcS, were either functionalized for production of enzymatic 3D-biosensors or preconditioned to be used them as 3D-scaffolds for human mesenchymal stem cells cultures. The conditions to fabricate 3D-biosensors and scaffolds for cell growth were here optimized studying all analytical parameters and demonstrating the feasibility to combine these two properties for an innovative solution to ennoble vegetable wastes.
MeSH term(s)	Animals ; Biosensing Techniques ; Cell Culture Techniques ; Cell Differentiation ; Cell Proliferation ; Humans ; Stem Cells ; Tissue Scaffolds ; Vegetables
Language	English
Publishing date	2020-09-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2020.121671
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito