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  1. AU="Mella, Sebastian"
  2. AU="Pogurschi, Elena"
  3. AU="Ali, Athar"
  4. AU="Chen, DeChao"
  5. AU=Markman Maurie
  6. AU="Tembo, Yamanya"
  7. AU="Vogel, Gretchen"
  8. AU="Bernd W Böttiger"
  9. AU="Burk, Robert D"
  10. AU=Hussain Mushtaq AU=Hussain Mushtaq
  11. AU="Reuter, Susanne"
  12. AU="Thomas P. Quinn"
  13. AU="Grant, April"
  14. AU="Naddaf, Elie"
  15. AU="Park, Do-Hyun"
  16. AU="Posti, Jussi P"
  17. AU="Singh, Gargi"
  18. AU="Fuhrman, Dana Y"
  19. AU="Cholak, Spencer"
  20. AU="Tanowitz, Herbert B."
  21. AU="Gao, Jia-Pei"
  22. AU="Alvarez-Lerma, Francisco"
  23. AU="Junno, Juho-Antti"
  24. AU="Livermore, Polly"
  25. AU="Pervin, Irin"
  26. AU=Upadhyay Avnish K AU=Upadhyay Avnish K
  27. AU="Yabu, Hiroshi"
  28. AU="Soares, Mario J."
  29. AU="Haeusler, Gabrielle M"
  30. AU="Wang, Weiqing"
  31. AU="Fehr, Fabio"
  32. AU="Sasirekha, R" AU="Sasirekha, R"
  33. AU="Rajendraprasad, Girish"
  34. AU="Golbek, Thaddeus W"
  35. AU="Pranav Keshan"

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  1. Artikel ; Online: Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures.

    Girolamo, Daniela Di / Benavente-Diaz, Maria / Murolo, Melania / Grimaldi, Alexandre / Lopes, Priscilla Thomas / Evano, Brendan / Kuriki, Mao / Gioftsidi, Stamatia / Laville, Vincent / Tinevez, Jean-Yves / Letort, Gaëlle / Mella, Sebastian / Tajbakhsh, Shahragim / Comai, Glenda

    Development (Cambridge, England)

    2024  Band 151, Heft 4

    Abstract: Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial MuSCs are reported to have greater proliferative and regenerative capacity when compared with those in the limb. A comprehensive understanding of the mechanisms ... ...

    Abstract Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial MuSCs are reported to have greater proliferative and regenerative capacity when compared with those in the limb. A comprehensive understanding of the mechanisms underlying this functional heterogeneity is lacking. Here, we have used clonal analysis, live imaging and single cell transcriptomic analysis to identify crucial features that distinguish extraocular muscle (EOM) from limb muscle stem cell populations. A MyogeninntdTom reporter showed that the increased proliferation capacity of EOM MuSCs correlates with deferred differentiation and lower expression of the myogenic commitment gene Myod. Unexpectedly, EOM MuSCs activated in vitro expressed a large array of extracellular matrix components typical of mesenchymal non-muscle cells. Computational analysis underscored a distinct co-regulatory module, which is absent in limb MuSCs, as driver of these features. The EOM transcription factor network, with Foxc1 as key player, appears to be hardwired to EOM identity as it persists during growth, disease and in vitro after several passages. Our findings shed light on how high-performing MuSCs regulate myogenic commitment by remodelling their local environment and adopting properties not generally associated with myogenic cells.
    Mesh-Begriff(e) Mice ; Animals ; Muscle, Skeletal/metabolism ; Oculomotor Muscles/metabolism ; Mice, Inbred C57BL ; Cell Proliferation ; Stem Cells
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.202144
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle.

    Comai, Glenda / Heude, Eglantine / Mella, Sebastian / Paisant, Sylvain / Pala, Francesca / Gallardo, Mirialys / Langa, Francina / Kardon, Gabrielle / Gopalakrishnan, Swetha / Tajbakhsh, Shahragim

    eLife

    2019  Band 8

    Abstract: In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, ... ...

    Abstract In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence of a primary skeletal muscle scaffold. Using mouse chimeras, we show that the transcription factors
    Mesh-Begriff(e) Animals ; Body Patterning ; Esophagus/embryology ; Gene Expression Regulation, Developmental ; Hepatocyte Growth Factor/metabolism ; LIM-Homeodomain Proteins/metabolism ; Mesoderm/embryology ; Mice ; Muscle, Striated/embryology ; Proto-Oncogene Proteins c-met/metabolism ; Signal Transduction ; T-Box Domain Proteins/metabolism ; Transcription Factors/metabolism
    Chemische Substanzen HGF protein, mouse ; LIM-Homeodomain Proteins ; T-Box Domain Proteins ; Tbx1 protein, mouse ; Transcription Factors ; insulin gene enhancer binding protein Isl-1 ; Hepatocyte Growth Factor (67256-21-7) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2019-09-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.47460
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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