Article ; Online: Steroid-dependent polyarthritis induced by immune checkpoint inhibitor therapy successfully treated with bimekizumab.
2024 Volume 16, Issue 5, Page(s) 287–293
Abstract: Immune checkpoint inhibitors (ICIs) are an integral part of modern-day cancer therapy. Along with a greatly improved antitumor response come a number of immune-related adverse events (irAEs), musculoskeletal irAEs rank among the less frequent ... ...
| Abstract | Immune checkpoint inhibitors (ICIs) are an integral part of modern-day cancer therapy. Along with a greatly improved antitumor response come a number of immune-related adverse events (irAEs), musculoskeletal irAEs rank among the less frequent manifestations. The mechanisms behind these events are poorly understood, and so far clear guidelines for therapeutic management beyond treatment with glucocorticosteroids are lacking. We present the case of a 72-year-old patient who developed a severe ICI-induced polyarthritis that could not be controlled by glucocorticosteroids. We initiated an immunomodulating therapy with the IL-17A/F/AF-inhibitor bimekizumab, which lead to a full clinical and sonographic remission. |
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| MeSH term(s) | Humans ; Aged ; Immune Checkpoint Inhibitors/adverse effects ; Antibodies, Monoclonal, Humanized/adverse effects ; Arthritis/drug therapy ; Steroids |
| Chemical Substances | bimekizumab (09495UIM6V) ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized ; Steroids |
| Language | English |
| Publishing date | 2024-01-24 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2495964-9 |
| ISSN | 1750-7448 ; 1750-743X |
| ISSN (online) | 1750-7448 |
| ISSN | 1750-743X |
| DOI | 10.2217/imt-2023-0252 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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