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  1. Article: Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence?

    Deen, Jacqueline / Mellick, Nick / Wheller, Laura

    Case reports in dermatological medicine

    2018  Volume 2018, Page(s) 2812439

    Abstract: Sarcoidosis is a rare, chronic, multisystem disease of unknown aetiology, characterised by non-caseating epithelioid cell granulomas. Its association with internal malignancy, in particular haematological cancers has been strongly documented in the ... ...

    Abstract Sarcoidosis is a rare, chronic, multisystem disease of unknown aetiology, characterised by non-caseating epithelioid cell granulomas. Its association with internal malignancy, in particular haematological cancers has been strongly documented in the literature, while its link with solid organ malignancies is less extensively reported. We present an atypical case of cutaneous sarcoidosis occurring in association with breast cancer recurrence in a 49-year-old female. Physician recognition of this link between sarcoidosis and internal malignancy is vital because many cases of sarcoidosis in association with neoplasia present initially, or even exclusively, with cutaneous sarcoidal lesions that may precede the development of cancer by several years, or as in our case, present as a cutaneous marker of concomitant underlying malignancy. Our case highlights the importance of age-appropriate cancer screening in additional to a routine work-up for systemic sarcoidosis in a patient with cutaneous sarcoidosis.
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2684644-5
    ISSN 2090-6471 ; 2090-6463
    ISSN (online) 2090-6471
    ISSN 2090-6463
    DOI 10.1155/2018/2812439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Immunohistochemical studies of the kynurenine pathway in morphea.

    Noakes, Rowland / Mellick, Nick

    International journal of tryptophan research : IJTR

    2013  Volume 6, Page(s) 97–102

    Abstract: Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of ... ...

    Abstract Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.
    Language English
    Publishing date 2013-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.4137/IJTR.S13371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dermatomyositis panniculitis: a case report.

    Carroll, Melissa / Mellick, Nick / Wagner, Godfrey

    The Australasian journal of dermatology

    2015  Volume 56, Issue 3, Page(s) 224–226

    Abstract: Dermatomyositis-related panniculitis is a rare cutaneous manifestation of dermatomyositis. There are few reported cases in the medical literature. We present the case of a 60-year-old woman with a 2-year history of dermatomyositis and recent biopsy- ... ...

    Abstract Dermatomyositis-related panniculitis is a rare cutaneous manifestation of dermatomyositis. There are few reported cases in the medical literature. We present the case of a 60-year-old woman with a 2-year history of dermatomyositis and recent biopsy-confirmed panniculitis treated with prednisone, cyclophosphamide and i.v. immunoglobulin.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Cyclophosphamide/therapeutic use ; Dermatomyositis/complications ; Drug Therapy, Combination ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Middle Aged ; Panniculitis/drug therapy ; Panniculitis/etiology ; Panniculitis/pathology ; Prednisone/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Immunoglobulins, Intravenous ; Immunologic Factors ; Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2015-08
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.12172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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