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Article ; Online: Cement leakage during vertebroplasty: comparison between intact and wall disruption in spinal metastases.

Gravel, Guillaume / Roussel, Alexandre / Guth, Axel / Mellot, François

Acta radiologica (Stockholm, Sweden : 1987)

2023 Volume 64, Issue 5, Page(s) 1912–1918

Abstract: Background: Percutaneous vertebroplasty (PVP) is an effective measure for painful metastases or impending pathological fractures of the spine with cement leakages being the most frequent complication. Posterior extrusion of cement into the spinal canal ... ...

Abstract	Background: Percutaneous vertebroplasty (PVP) is an effective measure for painful metastases or impending pathological fractures of the spine with cement leakages being the most frequent complication. Posterior extrusion of cement into the spinal canal may result in neurological symptoms and deficits. Purpose: To compare the occurrence of intraspinal canal cement leakage between vertebrae with posterior wall disruption and vertebrae without posterior wall disruption. Material and methods: A single-center retrospective study was conducted of all PVP for spine metastases between June 2020 and November 2021. All leaks were analyzed by a postprocedural computed tomography scan or cone-beam computed tomography. Results: A total of 77 patients with 143 vertebrae treated by PVP were included. Posterior wall disruption was observed in 64 (44.8%) vertebrae while 79 (55.2%) had a complete posterior wall. Spinal canal cement leakage occurred in 36 (25.2%) vertebrae and was comparable in both groups, occurring in 16 (25.0%) vertebrae with posterior wall disruption and 20 (25.3%) vertebrae without posterior wall disruption ( Conclusion: Our results suggest that an incomplete vertebral posterior wall does not increase the rate of spinal canal cement leakage during PVP.
MeSH term(s)	Humans ; Retrospective Studies ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/surgery ; Fractures, Compression/surgery ; Vertebroplasty/adverse effects ; Bone Cements/adverse effects ; Chest Pain/etiology ; Osteoporotic Fractures/surgery ; Treatment Outcome
Chemical Substances	Bone Cements
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851231152687
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Zs.MO 204: Show issues

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Article ; Online: A deep learning-based algorithm improves radiology residents' diagnoses of acute pulmonary embolism on CT pulmonary angiograms.

Vallée, Alexandre / Quint, Raphaelle / Laure Brun, Anne / Mellot, François / Grenier, Philippe A

European journal of radiology

2024 Volume 171, Page(s) 111324

Abstract: Purpose: To compare radiology residents' diagnostic performances to detect pulmonary emboli (PEs) on CT pulmonary angiographies (CTPAs) with deep-learning (DL)-based algorithm support and without.: Methods: Fully anonymized CTPAs (n = 207) of ... ...

Abstract	Purpose: To compare radiology residents' diagnostic performances to detect pulmonary emboli (PEs) on CT pulmonary angiographies (CTPAs) with deep-learning (DL)-based algorithm support and without. Methods: Fully anonymized CTPAs (n = 207) of patients suspected of having acute PE served as input for PE detection using a previously trained and validated DL-based algorithm. Three residents in their first three years of training, blinded to the index report and clinical history, read the CTPAs first without, and 2 months later with the help of artificial intelligence (AI) output, to diagnose PE as present, absent or indeterminate. We evaluated concordances and discordances with the consensus-reading results of two experts in chest imaging. Results: Because the AI algorithm failed to analyze 11 CTPAs, 196 CTPAs were analyzed; 31 (15.8 %) were PE-positive. Good-classification performance was higher for residents with AI-algorithm support than without (AUROCs: 0.958 [95 % CI: 0.921-0.979] vs. 0.894 [95 % CI: 0.850-0.931], p < 0.001, respectively). The main finding was the increased sensitivity of residents' diagnoses using the AI algorithm (92.5 % vs. 81.7 %, respectively). Concordance between residents (kappa: 0.77 [95 % CI: 0.76-0.78]; p < 0.001) improved with AI-algorithm use (kappa: 0.88 [95 % CI: 0.87-0.89]; p < 0.001). Conclusion: The AI algorithm we used improved between-resident agreements to interpret CTPAs for suspected PE and, hence, their diagnostic performances.
MeSH term(s)	Humans ; Deep Learning ; Artificial Intelligence ; Tomography, X-Ray Computed/methods ; Pulmonary Embolism/diagnostic imaging ; Angiography/methods ; Radiology ; Algorithms
Language	English
Publishing date	2024-01-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2024.111324
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Zs.A 1630: Show issues

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Article: The Potential Role of Artificial Intelligence in Lung Cancer Screening Using Low-Dose Computed Tomography.

Grenier, Philippe A / Brun, Anne Laure / Mellot, François

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 10

Abstract: Two large randomized controlled trials of low-dose CT (LDCT)-based lung cancer screening (LCS) in high-risk smoker populations have shown a reduction in the number of lung cancer deaths in the screening group compared to a control group. Even if various ... ...

Abstract	Two large randomized controlled trials of low-dose CT (LDCT)-based lung cancer screening (LCS) in high-risk smoker populations have shown a reduction in the number of lung cancer deaths in the screening group compared to a control group. Even if various countries are currently considering the implementation of LCS programs, recurring doubts and fears persist about the potentially high false positive rates, cost-effectiveness, and the availability of radiologists for scan interpretation. Artificial intelligence (AI) can potentially increase the efficiency of LCS. The objective of this article is to review the performances of AI algorithms developed for different tasks that make up the interpretation of LCS CT scans, and to estimate how these AI algorithms may be used as a second reader. Despite the reduction in lung cancer mortality due to LCS with LDCT, many smokers die of comorbid smoking-related diseases. The identification of CT features associated with these comorbidities could increase the value of screening with minimal impact on LCS programs. Because these smoking-related conditions are not systematically assessed in current LCS programs, AI can identify individuals with evidence of previously undiagnosed cardiovascular disease, emphysema or osteoporosis and offer an opportunity for treatment and prevention.
Language	English
Publishing date	2022-10-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12102435
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Article ; Online: Anterior epidural carbon dioxide dissection during spine cryoablation.

Gravel, Guillaume / Roussel, Alexandre / Mellot, François

Japanese journal of radiology

2021 Volume 40, Issue 1, Page(s) 103–105

Abstract: Purpose: Spine cryoablation (SC) of posterior vertebral lesions exposes to neuronal damages and incomplete treatment due to the proximity of the spinal canal. Carbon dioxide (CO: Materials and methods: Three consecutives patients underwent SC of ... ...

Abstract	Purpose: Spine cryoablation (SC) of posterior vertebral lesions exposes to neuronal damages and incomplete treatment due to the proximity of the spinal canal. Carbon dioxide (CO Materials and methods: Three consecutives patients underwent SC of metastases abutting the posterior wall of the vertebra with anterior epidural CO Results: Peri-procedural anterior epidural injection of CO Conclusion: CO
MeSH term(s)	Carbon Dioxide ; Cryosurgery ; Dissection ; Epidural Space/diagnostic imaging ; Epidural Space/surgery ; Humans ; Retrospective Studies ; Spinal Canal ; Spine ; Treatment Outcome
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-07-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-021-01171-z
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Zs.A 2249: Show issues

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Article ; Online: Primary immunodeficiency diseases of adults: a review of pulmonary complication imaging findings.

Grenier, Philippe A / Brun, Anne Laure / Longchampt, Elisabeth / Lipski, Madeleine / Mellot, François / Catherinot, Emilie

European radiology

2023

Abstract: Our objective in this review is to familiarize radiologists with the spectrum of initial and progressive CT manifestations of pulmonary complications observed in adult patients with primary immunodeficiency diseases, including primary antibody deficiency ...

Abstract	Our objective in this review is to familiarize radiologists with the spectrum of initial and progressive CT manifestations of pulmonary complications observed in adult patients with primary immunodeficiency diseases, including primary antibody deficiency (PAD), hyper-IgE syndrome (HIES), and chronic granulomatous disease (CGD). In patients with PAD, recurrent pulmonary infections may lead to airway remodeling with bronchial wall-thickening, bronchiectasis, mucus-plugging, mosaic perfusion, and expiratory air-trapping. Interstitial lung disease associates pulmonary lymphoid hyperplasia, granulomatous inflammation, and organizing pneumonia and is called granulomatous-lymphocytic interstitial lung disease (GLILD). The CT features of GLILD are solid and semi-solid pulmonary nodules and areas of air space consolidation, reticular opacities, and lymphadenopathy. These features may overlap those of mucosa-associated lymphoid tissue (MALT) lymphoma, justifying biopsies. In patients with HIES, particularly the autosomal dominant type (Job syndrome), recurrent pyogenic infections lead to permanent lung damage. Secondary infections with aspergillus species develop in pre-existing pneumatocele and bronchiectasis areas, leading to chronic airway infection. The complete spectrum of CT pulmonary aspergillosis may be seen including aspergillomas, chronic cavitary pulmonary aspergillosis, allergic bronchopulmonary aspergillosis (ABPA)-like pattern, mixed pattern, and invasive. Patients with CGD present with recurrent bacterial and fungal infections leading to parenchymal scarring, traction bronchiectasis, cicatricial emphysema, airway remodeling, and mosaicism. Invasive aspergillosis, the major cause of mortality, manifests as single or multiple nodules, areas of airspace consolidation that may be complicated by abscess, empyema, or contiguous extension to the pleura or chest wall. CLINICAL RELEVANCE STATEMENT: Awareness of the imaging findings spectrum of pulmonary complications that can occur in adult patients with primary immunodeficiency diseases is important to minimize diagnostic delay and improve patient outcomes. KEY POINTS: • Unexplained bronchiectasis, associated or not with CT findings of obliterative bronchiolitis, should evoke a potential diagnosis of primary autoantibody deficiency. • The CT evidence of various patterns of aspergillosis developed in severe bronchiectasis or pneumatocele in a young adult characterizes the pulmonary complications of hyper-IgE syndrome. • In patients with chronic granulomatous disease, invasive aspergillosis is relatively frequent, often asymptomatic, and sometimes mimicking or associated with non-infectious inflammatory pulmonary lesions.
Language	English
Publishing date	2023-11-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10334-7
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Zs.A 3300: Show issues

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Article ; Online: SARS-CoV-2 RT-PCR and Chest CT, two complementary approaches for COVID-19 diagnosis.

Farfour, Eric / Mellot, François / Lesprit, Philippe / Vasse, Marc

Japanese journal of radiology

2020 Volume 38, Issue 12, Page(s) 1209–1210

MeSH term(s)	Betacoronavirus ; COVID-19 ; COVID-19 Testing ; China ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-07-13
Publishing country	Japan
Document type	Letter ; Comment
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-020-01016-1
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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Bronchial artery embolization for hemoptysis in adult patients with cystic fibrosis: a single-center retrospective study.

Roussel, Alexandre / Sage, Edouard / Roux, Antoine / Guth, Axel / Mellot, François / Gravel, Guillaume

Acta radiologica (Stockholm, Sweden : 1987)

2022 Volume 64, Issue 4, Page(s) 1381–1389

Abstract: Background: Hemoptysis is a severe complication of cystic fibrosis (CF) for which bronchial artery embolization (BAE) is an efficient primary therapeutic option. However, recurrence is more frequent than for other etiologies of hemoptysis.: Purpose: ... ...

Abstract	Background: Hemoptysis is a severe complication of cystic fibrosis (CF) for which bronchial artery embolization (BAE) is an efficient primary therapeutic option. However, recurrence is more frequent than for other etiologies of hemoptysis. Purpose: To assess the safety and efficacy of BAE in patients with CF and hemoptysis and predictive factors for recurrent hemoptysis. Material and methods: This retrospective study reviewed all adult patients with CF treated by BAE for hemoptysis in our center from 2004 to 2021. The primary endpoint was the recurrence of hemoptysis after bronchial artery embolization. Secondary endpoints were overall survival and complications. We introduced the vascular burden (VB) defined as the sum of all bronchial artery diameters measured on pre-procedural enhanced computed tomography (CT) scans. Results: A total of 48 BAE were performed in 31 patients. A total of 19 recurrences occurred with a median recurrence-free survival of 3.9 years. In univariate analyzes, percentage of unembolized VB (%UVB) (hazard ratio [HR] = 1.034, 95% confidence interval [CI=1.016-1.052; Conclusion: When possible, unilateral BAE seems sufficient in patients with CF with hemoptysis even in such a diffuse disease involving both lungs. The efficiency of BAE could be improved by thoroughly targeting all arteries vascularizing the bleeding lung.
MeSH term(s)	Humans ; Adult ; Cystic Fibrosis/complications ; Hemoptysis/therapy ; Bronchial Arteries ; Embolization, Therapeutic/methods ; Retrospective Studies ; Treatment Outcome ; Male ; Female ; Middle Aged
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851221126833
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Zs.MO 204: Show issues

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Article: Lung Transplantation: CT Assessment of Chronic Lung Allograft Dysfunction (CLAD).

Brun, Anne-Laure / Chabi, Marie-Laure / Picard, Clément / Mellot, François / Grenier, Philippe A

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 5

Abstract: Chronic lung allograft rejection remains one of the major causes of morbi-mortality after lung transplantation. The term Chronic Lung Allograft Dysfunction (CLAD) has been proposed to describe the different processes that lead to a significant and ... ...

Abstract	Chronic lung allograft rejection remains one of the major causes of morbi-mortality after lung transplantation. The term Chronic Lung Allograft Dysfunction (CLAD) has been proposed to describe the different processes that lead to a significant and persistent deterioration in lung function without identifiable causes. The two main phenotypes of CLAD are Bronchiolitis Obliterans Syndrome (BOS) and Restrictive Allograft Syndrome (RAS), each of them characterized by particular functional and imaging features. These entities can be associated (mixed phenotype) or switched from one to the other. If CLAD remains a clinical diagnosis based on spirometry, computed tomography (CT) scan plays an important role in the diagnosis and follow-up of CLAD patients, to exclude identifiable causes of functional decline when CLAD is first suspected, to detect early abnormalities that can precede the diagnosis of CLAD (particularly RAS), to differentiate between the obstructive and restrictive phenotypes, and to detect exacerbations and evolution from one phenotype to the other. Recognition of early signs of rejection is crucial for better understanding of physiopathologic pathways and optimal management of patients.
Language	English
Publishing date	2021-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11050817
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Article: SARS-CoV-2 RT-PCR and Chest CT, two complementary approaches for COVID-19 diagnosis

Farfour, Eric / Mellot, François / Lesprit, Philippe / Vasse, Marc

Jpn. j. radiol. (Internet)

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #641231
Database	COVID19

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Article ; Online: SARS-CoV-2 RT-PCR and Chest CT, two complementary approaches for COVID-19 diagnosis

Farfour, Eric / Mellot, François / Lesprit, Philippe / Vasse, Marc

Japanese Journal of Radiology ; ISSN 1867-1071 1867-108X

2020

Keywords	Radiology Nuclear Medicine and imaging ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s11604-020-01016-1
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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