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  1. Article ; Online: The risks associated with the widespread use of telemedicine in oncology: Four cases and review of the literature.

    Panet, François / Tétreault-Langlois, Marianne / Morin, Vincent / Sultanem, Khalil / Melnychuk, David / Panasci, Lawrence

    Cancer reports (Hoboken, N.J.)

    2021  Volume 5, Issue 7, Page(s) e1531

    Abstract: Background: COVID-19 changed the way we practice oncology in multiple ways. Because most cancer patients are comorbid or immunocompromised, we are trying as much as possible to reduce their risk of infection. Marginal just 2 years ago, telemedicine ... ...

    Abstract Background: COVID-19 changed the way we practice oncology in multiple ways. Because most cancer patients are comorbid or immunocompromised, we are trying as much as possible to reduce their risk of infection. Marginal just 2 years ago, telemedicine quickly became preeminent with the pandemic to reduce hospital exposure. However, using only virtual visits in oncology patients risk delaying cancer diagnosis or the identification of a complication.
    Case series: We present here four cases where a serious medical problem evident on physical exam was overlooked during a virtual visit. Two of our patients experienced a delay in cancer diagnosis thus putting them at risk of local or distant spread. The two others were established oncology patients where a serious medical complication was missed on a virtual visit.
    Conclusions: Now more than a year into the pandemic, telemedicine has clearly been a useful tool by limiting unnecessary hospital visits. Yet, as our cases illustrate, its use in oncology without clear boundary can undermine the quality of care. Now that effective vaccines are reducing the transmission and the severity of infection, most oncology patients can be evaluated by a real-time visit.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Neoplasms/diagnosis ; Neoplasms/therapy ; Pandemics/prevention & control ; SARS-CoV-2 ; Telemedicine
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1531
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  2. Article: Age-related changes phospholipids of sterlet in liver and dorsal muscles.

    Suleimanova, R R / Hudz, E A / Melnychuk, D O / Kalachniuk, L H

    Ukrainian biochemical journal

    2017  Volume 89, Issue 1, Page(s) 71–75

    Abstract: Study of phospholipids changes peculiarities in the liver and dorsal muscles of sterlet (Acipenser ruthenus Linnaeus) may be important to determine the etiology and pathogenesis of fatty liver. We established that the content of total phospholipids in ... ...

    Abstract Study of phospholipids changes peculiarities in the liver and dorsal muscles of sterlet (Acipenser ruthenus Linnaeus) may be important to determine the etiology and pathogenesis of fatty liver. We established that the content of total phospholipids in tissues of the liver and dorsal muscles of three-year-old sterlet was less than for two-year-old fish by 15% and 20% (P ≤ 0.01), respectively. The amount of phosphatidylcholine (P ≤ 0.05), phosphatidylethanolamine, phosphatidylserine (P ≤ 0.01), phosphatidylinositol (P ≤ 0.01) and cardiolipin in the liver of 3-year-old sterlet was lower than for the 2-year-old fish, while quantitative indices for lysophosphatidylcholine and sphingomyelin were slightly increased. Similarly, in the cells of the dorsal muscles, the amount of phospholipid components (except lysophosphatidylcholine) was decreased with age. A decrease in the amount of phosphatidylethanolamine and phosphatidylserine in the dorsal muscles of 3-year-old sterlet was significant. The major phospholipids respective distribution was stable, except for phosphatidylethanolamine and particularly sphingomyelin.
    MeSH term(s) Aging/metabolism ; Animals ; Cardiolipins/metabolism ; Fishes ; Liver/chemistry ; Liver/metabolism ; Lysophosphatidylcholines/metabolism ; Muscles/chemistry ; Muscles/metabolism ; Phosphatidylcholines/metabolism ; Phosphatidylethanolamines/metabolism ; Phosphatidylinositols/metabolism ; Phosphatidylserines/metabolism ; Phospholipids/metabolism ; Sphingomyelins/metabolism
    Chemical Substances Cardiolipins ; Lysophosphatidylcholines ; Phosphatidylcholines ; Phosphatidylethanolamines ; Phosphatidylinositols ; Phosphatidylserines ; Phospholipids ; Sphingomyelins ; phosphatidylethanolamine (39382-08-6)
    Language English
    Publishing date 2017-01
    Publishing country Ukraine
    Document type Journal Article
    ZDB-ID 2719941-1
    ISSN 2413-5003 ; 2409-4943 ; 0201-8470
    ISSN (online) 2413-5003
    ISSN 2409-4943 ; 0201-8470
    DOI 10.15407/ubj89.01.071
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  3. Article: Pertussis outbreak in the West Island region of Montreal.

    Melnychuk, D

    Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada

    1990  Volume 16, Issue 23, Page(s) 107–110

    MeSH term(s) Adolescent ; Canada ; Child ; Child, Preschool ; Disease Outbreaks/prevention & control ; Disease Outbreaks/statistics & numerical data ; Erythromycin/therapeutic use ; Humans ; Incidence ; Infant ; Medical Records ; Vaccination ; Whooping Cough/drug therapy ; Whooping Cough/epidemiology
    Chemical Substances Erythromycin (63937KV33D)
    Language French
    Publishing date 1990-06-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1034928-5
    ISSN 0382-232X
    ISSN 0382-232X
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    Zs.A 3396: Show issues Location:
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  4. Article ; Online: Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study.

    Henry, Melissa / Harvey, Raphaële / Chen, Lawrence M / Meaney, Michael / Nguyen, Thi Thu Thao / Kao, Han-Tin / Rosberger, Zeev / Frenkiel, Saul / Hier, Michael / Zeitouni, Anthony / Kost, Karen / Mlynarek, Alex / Richardson, Keith / Greenwood, Celia M T / Melnychuk, David / Gold, Phil / Chartier, Gabrielle / Black, Martin / Mascarella, Marco /
    MacDonald, Christina / Sadeghi, Nader / Sultanem, Khalil / Shenouda, Georges / Cury, Fabio / O'Donnell, Kieran John

    Journal of affective disorders

    2023  Volume 331, Page(s) 149–157

    Abstract: Objective: The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head ... ...

    Abstract Objective: The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival.
    Methods: Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews.
    Results: Symptom burden at 3 months was predicted by (R
    Conclusions: Our results outline three potential pathways of symptom burden in patients with head and neck cancer: a genetic predisposition towards depression; an initial anxiety disorder upon being diagnosed with cancer or high levels of anxiety upon diagnosis; and a dose-related response to radiotherapy. One may want to investigate early interventions in these areas to alleviate symptom burden in patients faced with a life-threatening disease, as well as consider targeting genetic predisposition towards depression and inflammation implicated in survival. The high prevalence of distress in patients with head and neck cancer is an opportunity to study genetic predispositions, which could potentially be broadly generalized to other cancers and diseases.
    MeSH term(s) Adult ; Humans ; Longitudinal Studies ; Genetic Predisposition to Disease/genetics ; Prospective Studies ; Depression/genetics ; Depression/diagnosis ; Anxiety/genetics ; Anxiety/psychology ; Head and Neck Neoplasms/genetics ; Inflammation/genetics
    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2023.03.007
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    Zs.A 1485: Show issues Location:
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  5. Article: Revaccination of children during school-based measles outbreak: potential impact of a new policy recommendation

    Melnychuk, D.

    CMAJ. Canadian Medical Association J.

    1992  Volume 146, Issue 6, Page(s) 929–936

    Institution 310-175 Stillview Rd., CDN-Pointe-Claire, PQ H9R 4S3
    Keywords Masern ; Impfung ; Kind ; Schule ; Epidemie ; Kanada ; Zweitimpfung
    Language English
    Document type Article
    Database Social Medicine (SOMED)

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  6. Article: Re: five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors.

    Panasci, L C / Melnychuk, D

    Journal of the National Cancer Institute

    1997  Volume 89, Issue 21, Page(s) 1631–1632

    MeSH term(s) Age Factors ; Antineoplastic Agents, Hormonal/administration & dosage ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Estrogen Antagonists/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Middle Aged ; Receptors, Estrogen/drug effects ; Survival Analysis ; Tamoxifen/administration & dosage ; Time Factors ; Treatment Outcome
    Chemical Substances Antineoplastic Agents, Hormonal ; Estrogen Antagonists ; Receptors, Estrogen ; Tamoxifen (094ZI81Y45)
    Language English
    Publishing date 1997-11-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/89.21.1631-a
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    Uh III Zs.131: Show issues Location:
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  7. Article: Adjuvant therapy for breast cancer.

    Melnychuk, D / Panasci, L C

    The New England journal of medicine

    1994  Volume 331, Issue 11, Page(s) 741–2; author reply 744–5

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Chemotherapy, Adjuvant ; Cisplatin/therapeutic use ; Female ; Fluorouracil/therapeutic use ; Humans ; Methotrexate/therapeutic use
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 1994-09-15
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
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    Ua VI Zs.34: Show issues Location:
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  8. Article: Revaccination of children during school-based measles outbreaks: potential impact of a new policy recommendation.

    Osterman, J W / Melnychuk, D

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    1992  Volume 146, Issue 6, Page(s) 929–936

    Abstract: Objective: To evaluate the potential impact of revaccination on measles outbreak control during school-based epidemics.: Design: Retrospective cohort study.: Setting: Thirty-two public elementary and high schools in 14 communities on the west ... ...

    Abstract Objective: To evaluate the potential impact of revaccination on measles outbreak control during school-based epidemics.
    Design: Retrospective cohort study.
    Setting: Thirty-two public elementary and high schools in 14 communities on the west island of Montreal.
    Participants: All 19,439 children attending these schools during the 1989 measles epidemic in Quebec.
    Intervention: After notification of a case children with provider-verified records of vaccination on or after their first birthday were identified; the remaining children were vaccinated or excluded from school.
    Outcome measure: Clinical or confirmed measles cases not prevented by this intervention that could have been prevented had revaccination been included during the outbreak.
    Results: Of the 88 measles cases (74 confirmed) proof of one adequate vaccination was present in 48 (55%). Intervention generally occurred within 5 school days after case notification. The nonpreventable cases involved 75 children who had measles onset before the intervention and 11 (7 vaccinated) who had onset within 8 days after the intervention. The two remaining cases occurred 20 and 25 days after the intervention among nonvaccinated students who refused to be vaccinated. Except for these two cases measles was eliminated at every school. Application of the new Canadian guidelines for measles outbreak control would have required the administration of at least 10,000 additional doses during the outbreak to students vaccinated before 1980; implementation of the new US guidelines would have required the administration of 16,629 additional doses to children previously vaccinated only once. Well-enforced provincial regulations ensuring vaccination of every student upon school entry might have prevented 38 (43%) of the cases. The US recommendation of two routine doses of vaccine before school entry might have prevented 86 (98%) of the cases. However, revaccination during the outbreak would not have prevented a single additional case.
    Conclusion: Revaccination of previously vaccinated students during a measles outbreak would have been costly and of little benefit.
    MeSH term(s) Adolescent ; Child ; Cohort Studies ; Disease Outbreaks/prevention & control ; Health Policy ; Humans ; Immunization, Secondary ; Measles/epidemiology ; Measles/immunology ; Measles/prevention & control ; Quebec ; Retrospective Studies ; Schools ; Vaccination
    Language English
    Publishing date 1992-03-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0820-3946 ; 0008-4409
    ISSN (online) 1488-2329
    ISSN 0820-3946 ; 0008-4409
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    Ua VI Zs.136: Show issues Location:
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  9. Article: Multinomial phase II cancer trials incorporating response and early progression.

    Zee, B / Melnychuk, D / Dancey, J / Eisenhauer, E

    Journal of biopharmaceutical statistics

    1999  Volume 9, Issue 2, Page(s) 351–363

    Abstract: The objective of a phase II clinical trial in oncology is to assess the antitumor activity of a specific treatment regimen. A multiple-testing procedure is commonly used to decide whether the experimental treatment warrants further investigation based on ...

    Abstract The objective of a phase II clinical trial in oncology is to assess the antitumor activity of a specific treatment regimen. A multiple-testing procedure is commonly used to decide whether the experimental treatment warrants further investigation based on patients' tumor response. There are ethical concerns about exposing patients to a new drug when the response rate is low and a relatively large number of patients have early progressive disease. Ensign et al. (1) proposed a stopping rule that rejects a drug early when there is a long run of early treatment failures. However, this approach may not be sensitive to pick up early progressors mixed with other nonresponders. In this paper, we present a multiple-stage stopping rule for a single-arm trial of an experimental treatment in which both tumor response and early progression are considered simultaneously. We use a multinomial model to accommodate an outcome of discrete multivariate responses in order to improve the efficiency of the stopping rule. The proposed multiple-testing procedure requires that both the numbers of responses and early progressions fall within the boundaries satisfying the stopping criteria in order to stop the study. Simulation is performed to validate these results and to compare them with other commonly used designs. Other applications of this method are also discussed.
    MeSH term(s) Clinical Trials, Phase II as Topic/methods ; Clinical Trials, Phase II as Topic/statistics & numerical data ; Computer Simulation ; Disease Progression ; Humans ; Mathematical Computing ; Models, Statistical ; Multivariate Analysis ; Neoplasms/drug therapy
    Language English
    Publishing date 1999-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1131763-2
    ISSN 1520-5711 ; 1054-3406
    ISSN (online) 1520-5711
    ISSN 1054-3406
    DOI 10.1081/BIP-100101181
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    Zs.A 3511: Show issues Location:
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  10. Article: Regulation or contagion? Measles vaccination policy in Quebec.

    Osterman, J W / Melnychuk, D

    Canadian journal of public health = Revue canadienne de sante publique

    1991  Volume 82, Issue 6, Page(s) 369–71; discussion 372

    MeSH term(s) Child ; Child, Preschool ; Disease Outbreaks ; Health Policy ; Humans ; Measles/epidemiology ; Measles/prevention & control ; Measles Vaccine ; Quebec/epidemiology
    Chemical Substances Measles Vaccine
    Language English
    Publishing date 1991-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 417262-0
    ISSN 0008-4263
    ISSN 0008-4263
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