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  1. Book ; Online: América Andina: integração regional, segurança e outros olhares

    Oliveira, Renata Peixoto de / Nogueira, Silvia Garcia / Melo, Filipe Reis

    2012  

    Abstract: O interesse sobre a região andina tem crescido diante de sua complexa realidade sociocultural, da grande instabilidade político-econômica, da controversa dinâmica de suas relações internacionais e das tensões e alianças formadas entre os países vizinhos. ...

    Abstract O interesse sobre a região andina tem crescido diante de sua complexa realidade sociocultural, da grande instabilidade político-econômica, da controversa dinâmica de suas relações internacionais e das tensões e alianças formadas entre os países vizinhos. É justamente por tratar-se de uma região que passou por profundas transformações, ao longo da última década, que os estudos sobre a região andina ganham relevância e merecem destaque. O livro América Andina: integração regional, segurança e outros olhares se dedica à análise dessa região, a partir de um enfoque multidisciplinar e interdisciplinar, abordando temas como integração regional, segurança, democracia e relações internacionais. Simboliza, ainda, o esforço conjunto de pesquisadores de seis instituições diferentes pertencentes a três países - Brasil, Colômbia e México - que contribui com distintos olhares para a compreensão dessa sub-região americana
    Keywords Business
    Size 1 electronic resource (306 p.)
    Publisher SciELO Books - EDUEPB
    Document type Book ; Online
    Note Portuguese ; Open Access
    HBZ-ID HT020088775
    ISBN 9788578791858 ; 8578791851
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Adrenergic signaling regulation of macrophage function: do we understand it yet?

    Freire, Beatriz Marton / de Melo, Filipe Menegatti / Basso, Alexandre S

    Immunotherapy advances

    2022  Volume 2, Issue 1, Page(s) ltac010

    Abstract: Macrophages are immune cells that are widespread throughout the body and critical for maintaining tissue homeostasis. Their remarkable plasticity allows them to acquire different phenotypes, becoming able either to fight infection (M1-like, classically ... ...

    Abstract Macrophages are immune cells that are widespread throughout the body and critical for maintaining tissue homeostasis. Their remarkable plasticity allows them to acquire different phenotypes, becoming able either to fight infection (M1-like, classically activated macrophages) or to promote tissue remodeling and repair (M2-like, alternatively activated macrophages). These phenotypes are induced by different cues present in the microenvironment. Among the factors that might regulate macrophage activation are mediators produced by different branches of the nervous system. The regulation exerted by the sympathetic nervous system (SNS) on macrophages (and the immune system in general) is becoming a subject of increasing interest, indeed a great number of articles have been published lately. Catecholamines (noradrenaline and adrenaline) activate α and β adrenergic receptors expressed by macrophages and shape the effector functions of these cells in contexts as diverse as the small intestine, the lung, or the adipose tissue. Activation of different subsets of receptors seems to produce antagonistic effects, with α adrenergic receptors generally associated with pro-inflammatory functions and β adrenergic receptors (particularly β2) related to the resolution of inflammation and tissue remodeling. However, exceptions to this paradigm have been reported, and the factors contributing to these apparently contradictory observations are still far from being completely understood. Additionally, macrophages
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-4303
    ISSN (online) 2732-4303
    DOI 10.1093/immadv/ltac010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Translation, Cross-Cultural Adaptation, and Psychometric Properties of Writing Readiness Inventory Tool in Context (WRITIC).

    Delgado, Paulo / Melo, Filipe / de Vries, Liesbeth / Hartingsveldt, Margo / Matias, Ana Rita

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 3

    Abstract: This article describes the translation and cultural adaptation process of the WRITIC (Writing Readiness Inventory Tool in Context) into European Portuguese. We examined the content and convergent validity, test-retest, and interrater reliability on the ... ...

    Abstract This article describes the translation and cultural adaptation process of the WRITIC (Writing Readiness Inventory Tool in Context) into European Portuguese. We examined the content and convergent validity, test-retest, and interrater reliability on the norm-referenced subdomain of the Portuguese (PT) WRITIC Task Performance (TP). To establish content validity, we consulted six experts in handwriting. Internal consistency was found with 70 children, test-retest reliability with 65, inter-rater reliability with 69, and convergent validity with 87. All participants were typically developing kindergarten children. Convergent validity was examined with the Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery™VMI-6) and the Nine Hole Peg-Test (9-HPT). On content validity, we found an agreement of 93%, a good internal consistency with Cronbach's alpha of 0.72, and an excellent test-retest and inter-rater reliability with ICCs of 0.88 and 0.93. Correlations with Beery™VMI-6 and 9-HPT were moderate (r from 0.39 to 0.65). Translation and cross-cultural adaptation of WRITIC into European Portuguese was successful. WRITIC-PT-TP is stable over time and between raters; it has excellent internal consistency and moderate correlations with Beery™VMI-6 and 9-HPT. This analysis of the European Portuguese version of WRITIC gives us the confidence to start the implementation process of WRITIC-PT in Portugal.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10030559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Effect of Expertise during Simulated Flight Emergencies on the Autonomic Response and Operative Performance in Military Pilots.

    Santos, Sara / Parraca, Jose A / Fernandes, Orlando / Villafaina, Santos / Clemente-Suarez, Vicente Javier / Melo, Filipe

    International journal of environmental research and public health

    2022  Volume 19, Issue 15

    Abstract: Heart rate variability (HRV) and performance response during emergency flight maneuvers were analyzed. Two expert pilots (ages 35 and 33) and two rookie pilots (ages 25) from the Portuguese Air Force participated in this case-control report study. ... ...

    Abstract Heart rate variability (HRV) and performance response during emergency flight maneuvers were analyzed. Two expert pilots (ages 35 and 33) and two rookie pilots (ages 25) from the Portuguese Air Force participated in this case-control report study. Participants had to complete the following emergency protocols in a flight simulator: (1) take-off engine failure, (2) flight engine failure close to the base, (3) flight engine failure far away from the base, and (4) alternator failure. The HRV was collected during all these maneuvers, as well as the performance data (the time it took to go through the emergency protocol and the subjective information from the flight simulator operator). Results regarding autonomic modulation showed a higher sympathetic response during the emergency maneuvers when compared to baseline. In some cases, there was also a higher sympathetic response during the emergency maneuvers when compared with the take-off protocol. Regarding performance data, the expert pilots accomplished the missions in less time than the rookie pilots. Autonomic modulation measured from HRV through portable devices can easily relay important information. This information is relevant since characterizing these maneuvers can provide helpful information to design training strategies to improve those psychophysiological responses.
    MeSH term(s) Adult ; Emergencies ; Heart Rate ; Humans ; Military Personnel ; Pilots ; Task Performance and Analysis
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19159141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Relationship between Product and Process Characteristics of Handwriting Skills of Children in the Second Grade of Elementary School.

    Coradinho, Helena / Melo, Filipe / Almeida, Gabriela / Veiga, Guida / Marmeleira, José / Teulings, Hans-Leo / Matias, Ana Rita

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 3

    Abstract: The purpose of this study was to analyze the relationship between the quality and speed of handwriting and the process characteristics of the handwriting of children in the second grade of elementary school considered as a function of age and gender. A ... ...

    Abstract The purpose of this study was to analyze the relationship between the quality and speed of handwriting and the process characteristics of the handwriting of children in the second grade of elementary school considered as a function of age and gender. A sample of 57 children (mean age 7.25 years, SD 0.43) participated in the study. The Concise Assessment Method for Children's Handwriting (BHK) was used to assess the quality and speed of handwriting. The characteristics of the process of handwriting were assessed using MovAlyzeR
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10030445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The relationship between acute pain and other types of suffering in pre-hospital trauma victims: An observational study.

    Mota, Mauro / Melo, Filipe / Henriques, Carla / Matos, Ana / Castelo-Branco, Miguel / Monteiro, Mariana / Cunha, Madalena / Reis Santos, Margarida

    International emergency nursing

    2023  Volume 71, Page(s) 101375

    Abstract: Background: Acute pain is an important complaint reported by trauma victims, however, the relationship between it and other types of discomfort, such as discomfort caused by cold, discomfort caused by immobilization, and psychological distress such as ... ...

    Abstract Background: Acute pain is an important complaint reported by trauma victims, however, the relationship between it and other types of discomfort, such as discomfort caused by cold, discomfort caused by immobilization, and psychological distress such as fear, anxiety, and sadness is limitedly studied and documented.
    Aim: To assess the relationship between acute trauma pain and other types of suffering in pre-hospital trauma victims.
    Methods: This is a prospective multicentre cohort study conducted in Immediate Life Support Ambulances in Portugal. All adult trauma victims with a mechanism of blunt and penetrating injuries, falls, road accidents and explosions, were included.
    Results: 605 trauma victims were included, mainly male, with a mean age of 53.4 years. Before the intervention of the rescue teams, 90.5 % of the victims reported some level of pain, 39.0 % reported discomfort caused by cold, while 15.7 % felt fear, 8.4 % sadness, 49.8 % anxiety and 4.5 % apathy. Victims with high discomfort caused by cold tend to have higher pain levels. Significantly higher pain intensity were observed in victims with fear and anxiety. Univariate and multivariate analysis indicates that immobilization is associated with increased pain levels.
    Conclusions: There is a statistically significant relationship between acute trauma pain, anxiety, fear, cold and immobilization.
    MeSH term(s) Adult ; Humans ; Male ; Middle Aged ; Female ; Acute Pain ; Prospective Studies ; Cohort Studies ; Hospitals ; Anxiety/etiology ; Wounds and Injuries/complications
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2420747-0
    ISSN 1878-013X ; 1755-599X
    ISSN (online) 1878-013X
    ISSN 1755-599X
    DOI 10.1016/j.ienj.2023.101375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3822: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling.

    Feng, An-Chieh / Thomas, Brandon J / Purbey, Prabhat K / de Melo, Filipe Menegatti / Liu, Xin / Daly, Allison E / Sun, Fei / Lo, Jerry Hung-Hao / Cheng, Lijing / Carey, Michael F / Scumpia, Philip O / Smale, Stephen T

    Immunity

    2024  Volume 57, Issue 3, Page(s) 462–477.e9

    Abstract: Inducible nucleosome remodeling at hundreds of latent enhancers and several promoters shapes the transcriptional response to Toll-like receptor 4 (TLR4) signaling in macrophages. We aimed to define the identities of the transcription factors that promote ...

    Abstract Inducible nucleosome remodeling at hundreds of latent enhancers and several promoters shapes the transcriptional response to Toll-like receptor 4 (TLR4) signaling in macrophages. We aimed to define the identities of the transcription factors that promote TLR-induced remodeling. An analysis strategy based on ATAC-seq and single-cell ATAC-seq that enriched for genomic regions most likely to undergo remodeling revealed that the transcription factor nuclear factor κB (NF-κB) bound to all high-confidence peaks marking remodeling during the primary response to the TLR4 ligand, lipid A. Deletion of NF-κB subunits RelA and c-Rel resulted in the loss of remodeling at high-confidence ATAC-seq peaks, and CRISPR-Cas9 mutagenesis of NF-κB-binding motifs impaired remodeling. Remodeling selectivity at defined regions was conferred by collaboration with other inducible factors, including IRF3- and MAP-kinase-induced factors. Thus, NF-κB is unique among TLR4-activated transcription factors in its broad contribution to inducible nucleosome remodeling, alongside its ability to activate poised enhancers and promoters assembled into open chromatin.
    MeSH term(s) NF-kappa B/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Nucleosomes ; Signal Transduction ; Gene Expression Regulation ; Transcription Factor RelA/metabolism
    Chemical Substances NF-kappa B ; Toll-Like Receptor 4 ; Nucleosomes ; Transcription Factor RelA
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  8. Book: Dog Mendonça e Pizza Boy

    Cavia, Juan / Melo, Filipe

    2013  

    Author's details [Filipe Melo, Juan Cavia]
    Language Portuguese
    Size 118 S., überw. Ill.
    Edition 5. ed.
    Publisher Tinta da China
    Publishing place Lisboa
    Document type Book
    ISBN 9789896710279 ; 9896710279
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Dog Mendonça e Pizzaboy

    Cavia, Juan / Melo, Filipe

    2013  

    Author's details [Filipe Melo, Juan Cavia]
    Language Portuguese
    Size 128 S., überw. Ill.
    Edition 1. ed.
    Publisher Tinta da China
    Publishing place Lisboa
    Document type Book
    ISBN 9789896711870 ; 9896711879
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Proliferation of community exercise programs with limited evidence and expertise: Safety implications.

    Domingos, Josefa / Dean, John / Godinho, Catarina / Melo, Filipe

    Movement disorders : official journal of the Movement Disorder Society

    2018  Volume 33, Issue 8, Page(s) 1365–1366

    MeSH term(s) Exercise Therapy ; Humans ; Parkinson Disease/rehabilitation ; Regional Medical Programs ; Residence Characteristics
    Language English
    Publishing date 2018-08-25
    Publishing country United States
    Document type Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 238: Show issues

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