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  1. Article ; Online: Melanocytic matricoma with atypical features: A case of malignant melanocytic matricoma?

    Melson, Gabriella J / Hong, Sophiette G / Brem, Candice E

    The Journal of dermatology

    2022  Volume 49, Issue 11, Page(s) 1193–1197

    Abstract: Melanocytic matricoma is a rarely reported, benign cutaneous adnexal neoplasm composed of epithelial cells exhibiting differentiation towards hair matrix as well as admixed, pigmented, dendritic melanocytes. The proposed malignant counterpart to ... ...

    Abstract Melanocytic matricoma is a rarely reported, benign cutaneous adnexal neoplasm composed of epithelial cells exhibiting differentiation towards hair matrix as well as admixed, pigmented, dendritic melanocytes. The proposed malignant counterpart to melanocytic matricoma, malignant melanocytic matricoma (MMM), is even more rare. Here we report a case of a melanocytic matricoma with atypical features in a 92-year-old female with a 1.2-cm pigmented nodule on the right nasal sidewall. Histopathology revealed a well-circumscribed dermal tumor composed of atypical matrical cells with scattered aggregates of anucleate keratinocytes (ghost cells), prominent intratumoral pigment, numerous mitotic figures (88 mitosis/10 high-power field [HPF]), and intermixed dendritic melanocytes. A literature review was performed for MMM to determine if the current case fit diagnostic criteria for this entity. Including the current case, 12 cases of MMM were identified and analyzed to investigate common clinical and histopathologic features. MMM commonly occurred on the head and neck (7/12 cases) of older individuals (median age of 80) with a slight male predominance (male-to-female ratio of 3:1) and on histopathology presented as a multinodular dermal tumor composed of mitotically active (average mitotic rate of >50 mitoses/10 HPF) pleomorphic epithelial cells with foci of ghost cells. Dendritic melanocytes were found throughout the tumor lobules in all cases. Given that only two of 12 cases have exhibited locally aggressive behavior, further study is warranted to determine the true malignant potential of MMM.
    MeSH term(s) Male ; Female ; Humans ; Aged, 80 and over ; Pilomatrixoma/pathology ; Hair Diseases/pathology ; Skin Neoplasms/pathology ; Neoplasms, Adnexal and Skin Appendage/pathology ; Melanocytes/pathology
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1950: Show issues Location:
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  2. Article ; Online: Cryotherapy Techniques: A Survey-Based Analysis of Patient Preference.

    Pollack, Karlyn E / Melson, Gabriella / Wilson, Barbara B

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2020  Volume 47, Issue 2, Page(s) 310–311

    MeSH term(s) Cryotherapy/adverse effects ; Cryotherapy/methods ; Humans ; Nitrogen ; Pain/etiology ; Patient Preference ; Skin Diseases/therapy ; Surveys and Questionnaires ; Treatment Outcome
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2020-02-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Video-Audio Media
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000002340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Erythrodermic psoriasis after COVID-19 vaccination.

    Trepanowski, Nicole / Coleman, Emily L / Melson, Gabriella / Brem, Candice E / Lam, Christina S

    JAAD case reports

    2022  Volume 28, Page(s) 123–126

    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.07.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clear Cell Acanthoma with Malignant Cytologic Features: A Case Report and Review of the Literature.

    Melson, Gabriella / Saliba, Elie / Patel, Shreya / Eisen, Richard / Brem, Candice E

    Dermatopathology (Basel, Switzerland)

    2022  Volume 9, Issue 4, Page(s) 355–360

    Abstract: Clear cell acanthoma (CCA) is classically considered a benign epidermal tumor, although rare case reports have described CCA with malignant features. Here, we present a case of a patient with a biopsy proven CCA that regrew post-biopsy and was ... ...

    Abstract Clear cell acanthoma (CCA) is classically considered a benign epidermal tumor, although rare case reports have described CCA with malignant features. Here, we present a case of a patient with a biopsy proven CCA that regrew post-biopsy and was subsequently completely excised. Histologic examination of the tumor in the excision specimen revealed malignant cytologic features that were not present in the initial biopsy. A review of the literature identified five additional cases of CCA with similar malignant cytologic features. On analysis, common histopathologic characteristics included cellular pleomorphism, increased nuclear-to-cytoplasmic ratio, prominent nucleoli, and atypical mitotic figures. We support the designation of atypical clear cell acanthoma for these entities with features of both CCA and significant cytologic atypia. As none of these cases exhibited clinically aggressive behavior, further study is warranted.
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2777118-0
    ISSN 2296-3529
    ISSN 2296-3529
    DOI 10.3390/dermatopathology9040041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessment of lipid and pigment content in suspicious melanocytic lesions to improve melanoma detection.

    Amara, Shivkar V / Grbic, Nicole / Melson, Gabriella / Brem, Candice E / Almier, Nedaa / Bhawan, Jag / Alani, Rhoda M / Collard, Marianne

    Melanoma research

    2023  Volume 33, Issue 4, Page(s) 283–292

    Abstract: Melanoma is a highly aggressive form of skin cancer and the most frequent lethal malignancy diagnosed by dermatologists. Although there have been advances for predicting melanoma prognosis, there are few highly sensitive and specific diagnostic tools for ...

    Abstract Melanoma is a highly aggressive form of skin cancer and the most frequent lethal malignancy diagnosed by dermatologists. Although there have been advances for predicting melanoma prognosis, there are few highly sensitive and specific diagnostic tools for clinically evaluating suspicious melanocytic lesions prior to biopsy. We have recently determined that alterations in cellular lipid and pigment content are associated with tumor progression and melanoma metastasis. Here, we seek to determine if lipid droplet and pigment content assessments near the skin's surface are able to distinguish benign from malignant melanocytic lesions. We obtained 14 benign melanocytic lesions, classified as Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) class 1, and 22 malignant melanomas, classified as MPATH-Dx class 4 or 5, from Boston Medical Center. The malignant melanomas had an average greatest thickness of 1.8 ± 2.1 mm with 7/22 biopsies showing the presence of ulceration. Tissues were stained with the Fontana Masson stain to detect pigment or immunohistochemically stained for adipophilin, the main protein component of lipid droplets, to detect lipid droplets. Pigment and lipid droplets were quantified using ImageJ and CellProfiler, respectively. We found no significant difference in total pigment area between benign melanocytic lesions and malignant melanoma, and a 66% decrease in lipid content and 68% reduction in lipid/pigment content between benign melanocytic lesions and malignant melanoma ( P  < 0.05). Our results suggest that lipid content and lipid/pigment content ratios may distinguish benign and malignant melanocytic lesions, which may be useful as a diagnostic tool for histopathologically challenging pigmented lesions.
    MeSH term(s) Humans ; Melanoma/diagnosis ; Melanoma/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Melanocytes/pathology ; Prognosis ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1095779-0
    ISSN 1473-5636 ; 0960-8931
    ISSN (online) 1473-5636
    ISSN 0960-8931
    DOI 10.1097/CMR.0000000000000902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3378: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Lymphovascular invasion of malignant melanoma presenting as gray streaks on dermoscopy.

    Yi, Lauren G / Melson, Gabriella / Belote, Katherine / Flowers, Richard

    JAAD case reports

    2020  Volume 6, Issue 12, Page(s) 1258–1260

    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2020.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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