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  1. Article ; Online: Monitoring colonoscopy screening program quality at the provider level, the institution level, and beyond.

    Melson, Joshua

    Gastrointestinal endoscopy

    2022  

    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2022.08.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The pathway to monitoring quality of care for patients with adenomatous oligopolyposis of unknown etiology.

    Melson, Joshua

    Endoscopy

    2022  Volume 54, Issue 7, Page(s) 698–699

    MeSH term(s) Adenoma ; Adenomatous Polyposis Coli ; Humans ; Quality of Health Care
    Language English
    Publishing date 2022-02-25
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1743-2712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The pathway to monitoring quality of care for patients with adenomatous oligopolyposis of unknown etiology

    Melson, Joshua

    Endoscopy

    2022  Volume 54, Issue 07, Page(s) 698–699

    Language English
    Publishing date 2022-02-25
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1743-2712
    Database Thieme publisher's database

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  4. Article ; Online: Early steps on the pathway to develop quality metrics that have an impact on postendoscopy upper gastrointestinal cancer rates.

    Post, Zoe / Melson, Joshua

    Gastrointestinal endoscopy

    2022  Volume 96, Issue 3, Page(s) 476–478

    MeSH term(s) Benchmarking ; Gastrointestinal Neoplasms/epidemiology ; Humans ; Upper Gastrointestinal Tract
    Language English
    Publishing date 2022-07-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2022.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Equal Pay for Equal Screening: Impact of Patient and Provider Gender on Reimbursement for Screening Colonoscopy.

    Post, Zoe / Melson, Joshua

    Digestive diseases and sciences

    2021  Volume 67, Issue 3, Page(s) 739–741

    MeSH term(s) Colonoscopy ; Humans ; Mass Screening
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-07083-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rev up your engines: a new approach to access the deep small bowel by motorized spiral enteroscopy.

    Barlass, Usman / Melson, Joshua

    Gastrointestinal endoscopy

    2021  Volume 93, Issue 6, Page(s) 1371–1372

    Language English
    Publishing date 2021-03-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2020.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: DNA methylation and miRNA expression in colon adenomas compared with matched normal colon mucosa and carcinomas.

    Gebrekiristos, Mezgebe / Melson, Joshua / Jiang, Alice / Buckingham, Lela

    International journal of experimental pathology

    2022  Volume 103, Issue 3, Page(s) 74–82

    Abstract: Dysregulation of DNA methylation patterns and non-coding RNA, including miRNAs, has been implicated in colon cancer, and these changes may occur early in the development of carcinoma. In this study, the role of epigenetics as early changes in colon ... ...

    Abstract Dysregulation of DNA methylation patterns and non-coding RNA, including miRNAs, has been implicated in colon cancer, and these changes may occur early in the development of carcinoma. In this study, the role of epigenetics as early changes in colon tumorigenesis was examined through paired sample analysis of patient-matched normal, adenoma and carcinoma samples. Global methylation was assessed by genomic 5-methyl cytosine (5-mC) and long interspersed nuclear element-1 (LINE-1) promoter methylation by pyrosequencing. KRAS mutations were also assessed by pyrosequencing. Expression of miRNA, specifically, two microRNA genes-miR-200a and let-7c-was analysed using RT-qPCR. Differences in global methylation in adenomas were not observed, compared with normal tissue. However, LINE-1 methylation was decreased in adenomas (p = .056) and carcinomas (p = .011) compared with normal tissue. Expressions of miRNA, miR-200a and let-7c were significantly higher in adenomas than normal tissues (p = .008 and p = .045 respectively). Thus the significant changes in LINE-1 methylation and microRNA expression in precancerous lesions support an early role for epigenetic changes in the carcinogenic process. Epigenetic characteristics in adenomas may provide potential diagnostic and prognostic therapeutic targets early in cancer development at the adenoma stage.
    MeSH term(s) Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Carcinogenesis/genetics ; Carcinoma/genetics ; Carcinoma/metabolism ; Carcinoma/pathology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; DNA Methylation ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; MicroRNAs/biosynthesis ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016006-1
    ISSN 1365-2613 ; 0958-4625 ; 0007-1021 ; 0959-9673
    ISSN (online) 1365-2613
    ISSN 0958-4625 ; 0007-1021 ; 0959-9673
    DOI 10.1111/iep.12432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Will magnet-assisted capsule endoscopy become a viable screening tool for Barrett's esophagus and esophageal varices?

    Alsayid, Muhammad / Melson, Joshua

    Gastrointestinal endoscopy

    2020  Volume 91, Issue 4, Page(s) 782–784

    MeSH term(s) Barrett Esophagus ; Capsule Endoscopy ; Esophageal Neoplasms ; Esophageal and Gastric Varices ; Esophagoscopy ; Humans ; Magnets
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2019.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Connecting colonoscopy quality improvement initiatives with reduced rates of interval colorectal cancers.

    Ma, Karen / Melson, Joshua

    Gastrointestinal endoscopy

    2020  Volume 92, Issue 2, Page(s) 365–367

    MeSH term(s) Adenoma ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Humans ; Quality Improvement
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2020.03.3860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of Cold Snare vs Cold Forceps Resection of Diminutive Adenomas on Segmental Incomplete Resection Rate.

    Van, Jeremy / Alsayid, Muhammad / Ma, Karen / Vemulapalli, Krishna / Rex, Douglas / Melson, Joshua

    The American journal of gastroenterology

    2023  Volume 118, Issue 8, Page(s) 1410–1418

    Abstract: Introduction: Polypectomy technique, for diminutive lesion resection, is variable among colonoscopists using either cold snare polypectomy (CSP) or cold forceps polypectomy (CFP). While it is well described that CSP is a preferred technique to resect ... ...

    Abstract Introduction: Polypectomy technique, for diminutive lesion resection, is variable among colonoscopists using either cold snare polypectomy (CSP) or cold forceps polypectomy (CFP). While it is well described that CSP is a preferred technique to resect small lesions, there is little data evaluating the impact resection techniques have on metachronous adenoma burden. The aim of this study was to evaluate the rate of incomplete resection attributable to CSP and CFP of diminutive adenomas.
    Methods: This is a 2-center retrospective cohort study evaluating the segmental incomplete resection rate (S-IRR) of diminutive tubular adenomas (TA). S-IRR was calculated by subtracting the segmental metachronous adenoma rate in a specific colonic segment without adenoma from segments with adenoma on index colonoscopy. The primary outcome was the S-IRR of diminutive TA resected by CSP or CFP on index colonoscopy.
    Results: A total of 1,504 patients were included in the analysis: 1,235 with TA <6 mm and 269 with TA 6-9 mm as the most advanced lesion. The S-IRR in a segment that had a <6-mm TA incompletely resected by CFP on index colonoscopy was 13%. The S-IRR in a segment that had a <6-mm TA incompletely resected by CSP was 0%. Among 12 included colonoscopists, the range of overall S-IRR was 1.1%-24.4% with an average S-IRR of 10.3%.
    Discussion: S-IRR was 13% higher with CFP resection of diminutive TA than with CSP. A proposed S-IRR metric of <5% is a target goal for all diminutive polyp resection because 3/12 colonoscopists achieved this low rate. S-IRR can be used as a methodology to compare and quantify the difference in segmental metachronous adenoma burden across various polypectomy removal methods.
    MeSH term(s) Humans ; Colonic Polyps/surgery ; Colonic Polyps/pathology ; Colonoscopy/methods ; Retrospective Studies ; Treatment Outcome ; Adenoma/surgery ; Adenoma/pathology ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Surgical Instruments
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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