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  1. Article ; Online: PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

    Melusine Bleu / Swann Gaulis / Rui Lopes / Kathleen Sprouffske / Verena Apfel / Sjoerd Holwerda / Marco Pregnolato / Umut Yildiz / Valentina Cordoʹ / Antonella F. M. Dost / Judith Knehr / Walter Carbone / Felix Lohmann / Charles Y. Lin / James E. Bradner / Audrey Kauffmann / Luca Tordella / Guglielmo Roma / Giorgio G. Galli

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in ... ...

    Abstract Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
    Keywords Science ; Q
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

    Melusine Bleu / Swann Gaulis / Rui Lopes / Kathleen Sprouffske / Verena Apfel / Sjoerd Holwerda / Marco Pregnolato / Umut Yildiz / Valentina Cordoʹ / Antonella F. M. Dost / Judith Knehr / Walter Carbone / Felix Lohmann / Charles Y. Lin / James E. Bradner / Audrey Kauffmann / Luca Tordella / Guglielmo Roma / Giorgio G. Galli

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in ... ...

    Abstract Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
    Keywords Science ; Q
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: PAX8 and MECOM are interaction partners driving ovarian cancer

    Melusine Bleu / Fanny Mermet-Meillon / Verena Apfel / Louise Barys / Laura Holzer / Marianne Bachmann Salvy / Rui Lopes / Inês Amorim Monteiro Barbosa / Cecile Delmas / Alexandra Hinniger / Suzanne Chau / Markus Kaufmann / Simon Haenni / Karolin Berneiser / Maria Wahle / Ivana Moravec / Alexandra Vissières / Tania Poetsch / Erik Ahrné /
    Nathalie Carte / Johannes Voshol / Elisabeth Bechter / Jacques Hamon / Marco Meyerhofer / Dirk Erdmann / Matteo Fischer / Therese Stachyra / Felix Freuler / Sascha Gutmann / César Fernández / Tobias Schmelzle / Ulrike Naumann / Guglielmo Roma / Kate Lawrenson / Cristina Nieto-Oberhuber / Amanda Cobos-Correa / Stephane Ferretti / Dirk Schübeler / Giorgio Giacomo Galli

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 12

    Abstract: Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and ... ...

    Abstract Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.
    Keywords Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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