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Article: A medical mystery.

Johnston, A M / Memon, A A

2015 Volume 340, Issue 13, Page(s) 1011

MeSH term(s)	Aged ; Diagnosis, Differential ; Facial Dermatoses/etiology ; Female ; Humans ; Pigmentation Disorders/etiology ; Scleral Diseases/etiology
Language	English
Publishing date	2015-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/nejm199904013401305
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Article ; Online: Macrophage Migration Inhibitory Factor and microRNA-451a in Response to Mindfulness-based Therapy or Treatment as Usual in Patients with Depression, Anxiety, or Stress and Adjustment Disorders.

Wang, Xiao / Sundquist, Kristina / Palmér, Karolina / Hedelius, Anna / Memon, A A / Sundquist, Jan

The international journal of neuropsychopharmacology

2018 Volume 21, Issue 6, Page(s) 513–521

Abstract: Background: Macrophage migration inhibitory factor is a proinflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a can directly target macrophage migration inhibitory factor and downregulate its expression in ... ...

Abstract	Background: Macrophage migration inhibitory factor is a proinflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a can directly target macrophage migration inhibitory factor and downregulate its expression in cells. However, the role of macrophage migration inhibitory factor and microRNA-451a in psychiatric patients treated with psychotherapeutic interventions is unknown. In this study, our aim was to investigate levels of macrophage migration inhibitory factor and its regulating microRNA-451a in patients with depression, anxiety, or stress and adjustment disorders who underwent mindfulness-based therapy or treatment as usual. Methods: A total of 168 patients with psychiatric disorders were included from a randomized controlled trial that compared mindfulness-based therapy with treatment as usual. Plasma levels of macrophage migration inhibitory factor and microRNA-451a were measured at baseline and after the 8-week follow-up using Luminex assay and qPCR. Results: Macrophage migration inhibitory factor levels decreased significantly in patients posttreatment, whereas microRNA-451a levels showed a nonsignificant change. Macrophage migration inhibitory factor levels were inversely associated with microRNA-451a expression levels at baseline (β=-0.04, P=.008). The change in macrophage migration inhibitory factor levels (follow-up levels minus baseline levels) was associated with the change in microRNA-451a (follow-up levels minus baseline levels) (β=-0.06, P < .0001). The change in either macrophage migration inhibitory factor or microRNA-451a was not associated with improvement in psychiatric symptoms. Conclusion: We demonstrate that the levels of macrophage migration inhibitory factor decreased after psychotherapeutic interventions in patients with psychiatric disorders. However, this reduction was not associated with an improvement in psychiatric symptoms in response to the treatment. We also found an association between macrophage migration inhibitory factor and its regulating microRNA. However, this association needs to be further examined in future studies.
MeSH term(s)	Adult ; Aged ; Anxiety Disorders/blood ; Anxiety Disorders/therapy ; Depressive Disorder/blood ; Depressive Disorder/therapy ; Female ; Follow-Up Studies ; Humans ; Macrophage Migration-Inhibitory Factors/blood ; Male ; MicroRNAs/blood ; Middle Aged ; Mindfulness ; Stress Disorders, Traumatic/blood ; Stress Disorders, Traumatic/therapy ; Treatment Outcome ; Young Adult
Chemical Substances	MIRN451 microRNA, human ; Macrophage Migration-Inhibitory Factors ; MicroRNAs
Language	English
Publishing date	2018-01-25
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1440129-0
ISSN	1469-5111 ; 1461-1457
ISSN (online)	1469-5111
ISSN	1461-1457
DOI	10.1093/ijnp/pyy001
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Article ; Online: Role of family history of venous thromboembolism and thrombophilia as predictors of recurrence: a prospective follow-up study.

Sundquist, K / Sundquist, J / Svensson, P J / Zöller, B / Memon, A A

Journal of thrombosis and haemostasis : JTH

2015 Volume 13, Issue 12, Page(s) 2180–2186

Abstract: Background: Several studies have shown that the family history of venous thromboembolism (FHVTE) is a predictor of first venous thromboembolism (VTE). However its role in recurrent VTE is still controversial.: Objectives: To investigate whether the ... ...

Abstract	Background: Several studies have shown that the family history of venous thromboembolism (FHVTE) is a predictor of first venous thromboembolism (VTE). However its role in recurrent VTE is still controversial. Objectives: To investigate whether the presence of FHVTE is a risk factor for VTE recurrence in patients from a well-characterized Malmö thrombophilia study. Methods: VTE patients from the Malmö Thrombophilia Study were followed from discontinuation of warfarin treatment until diagnosis of VTE recurrence or to the end of the study (maximum follow-up 9.8 years). Results: There were 127 events of VTE recurrence (12.2%) registered during the follow-up. Multivariate Cox regression analysis in patients with unprovoked first VTE showed that FHVTE was associated with higher risk of VTE recurrence (hazard ratio [HR] 1.9, 95% confidence interval [CI] 1.2-2.9) compared with patients with no FHVTE. Stratification of data according to thrombophilia status of patients showed that compared with the reference group (no FHVTE or thrombophilia), thrombophilia together with FHVTE was associated with a higher risk of VTE recurrence (HR 3.2, 95% CI 1.8-5.9) than thrombophilia alone (HR 1.8, 95% CI 1.02-3.2) independent of DVT location and duration of warfarin treatment. FHVTE was mainly an important risk factor of VTE recurrence in women (HR 3.1, 95% CI 1.6-5.8) but not in men (HR 1.1, 95% CI 0.6-2.2). Conclusion: Our results show that FHVTE is a risk factor for VTE recurrence in patients who had unprovoked first VTE. Furthermore, presence of FHVTE may be an additional risk factor of VTE recurrence in thrombophilia-positive patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Chi-Square Distribution ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Heredity ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Pedigree ; Phenotype ; Proportional Hazards Models ; Prospective Studies ; Recurrence ; Risk Assessment ; Risk Factors ; Sweden ; Thrombophilia/complications ; Thrombophilia/diagnosis ; Thrombophilia/genetics ; Time Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/genetics ; Young Adult
Language	English
Publishing date	2015-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.13154
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Article: The association between apolipoprotein M and insulin resistance varies with country of birth

Memon, A.A / B. Dahlbäck / B. Zöller / J. Sundquist / K. Palmér / K. Sundquist / L. Bennet / X. Wang

Nutrition, metabolism, and cardiovascular diseases. 2014 Nov., v. 24, no. 11

2014

Abstract: Risk of type 2 diabetes mellitus (T2DM) differs according to ethnicity. Levels of apolipoprotein M (ApoM) have been shown to be decreased in T2DM. However, its role in different ethnicities is not known. We examined the differences in plasma ApoM levels ... ...

Abstract	Risk of type 2 diabetes mellitus (T2DM) differs according to ethnicity. Levels of apolipoprotein M (ApoM) have been shown to be decreased in T2DM. However, its role in different ethnicities is not known. We examined the differences in plasma ApoM levels in Swedish residents born in Iraq (Iraqis) and Sweden (Swedes) in relation to T2DM and insulin resistance (IR).Iraqis and Swedes, aged 45–65 years residing in Rosengård area of Malmö were randomly selected from census records and underwent an oral glucose tolerance test. Plasma levels of ApoM were quantified in 162 participants (Iraqis, n=91; Swedes, n=71) by a sandwich ELISA method.Age-, sex-, and body mass index (BMI) adjusted plasma ApoM levels differed by country of birth, with Swedes having 18% higher levels compared to Iraqis (p=0.001). ApoM levels (mean±SD) were significantly decreased in Swedes with T2DM (0.73±0.18) compared to those with normal glucose tolerance (NGT) (0.89±0.24; p=0.03). By contrast, no significant difference in ApoM levels was found between Iraqis with T2DM (0.70±0.17) and those with NGT (0.73±0.13; p=0.41). In multivariate linear regression analysis with an interaction term between IR and country of birth, low ApoM levels remained significantly associated with IR in Swedes (p=0.008), independently of age, sex, BMI, family history of diabetes, HDL, LDL, and triglycerides, but not in Iraqis (p=0.35).Our results show that ApoM levels differ according to country of birth and are associated with IR and T2DM only in Swedes.
Keywords	body mass index ; cardiovascular diseases ; diabetes ; enzyme-linked immunosorbent assay ; glucose tolerance ; glucose tolerance tests ; high density lipoprotein ; insulin resistance ; low density lipoprotein ; nationalities and ethnic groups ; regression analysis ; risk ; triacylglycerols ; Iraq ; Sweden
Language	English
Dates of publication	2014-11
Size	p. 1174-1180.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2014.05.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of ascorbic acid concentrations, methods of cooling and freezing on Boer goat semen cryopreservation.

Memon, A A / Wahid, H / Rosnina, Y / Goh, Y M / Ebrahimi, M / Nadia, F M

Reproduction in domestic animals = Zuchthygiene

2013 Volume 48, Issue 2, Page(s) 325–330

Abstract: To improve the Boer goat semen quality during cryopreservation process, three experiments were carried out to investigate the effect of (i) different concentration of ascorbic acid supplementation (ii) rate of cooling with chilled semen characteristics ... ...

Abstract	To improve the Boer goat semen quality during cryopreservation process, three experiments were carried out to investigate the effect of (i) different concentration of ascorbic acid supplementation (ii) rate of cooling with chilled semen characteristics and (iii) method of freezing on post-thaw Boer goat sperm using Tris-based extender. Ascorbic acid at 8.5 mg/ml improved the sperm parameters (motility, integrity of membrane and acrosome, morphology and viability), compared to control in cooled samples (p < 0.05). With regard to other concentrations and post-thawed parameters, ascorbic acid at 2.5-8.5 mg/ml led to higher percentages of sperm motility and integrities of membrane and acrosome when compared to control (p < 0.05). Slow cooling rises to higher percentages of sperm motility, acrosome integrity and viability, in comparison with fast cooling, in terms of cooled and frozen samples (p < 0.05). Programmable freezing method produced the higher percentages of sperm motility, integrities of membrane and acrosome and viability when compared to the freezing method of polystyrene box during goat sperm freezing (p < 0.05). In conclusion, chilled and post-thawed sperm quality of Boer goat was improved when a Tris-based extender supplemented with ascorbic acid was used at stages of different cooling rates and freezing methods.
MeSH term(s)	Animals ; Ascorbic Acid/pharmacology ; Cell Membrane/physiology ; Cryoprotective Agents/pharmacology ; Freezing ; Goats/physiology ; Male ; Semen Preservation/methods ; Semen Preservation/veterinary ; Spermatozoa/physiology
Chemical Substances	Cryoprotective Agents ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2013-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/j.1439-0531.2012.02155.x
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Article: Assay of phenolic compounds from four species of ber (Ziziphus mauritiana L.) fruits: Comparison of three base hydrolysis procedure for quantification of total phenolic acids

Memon, A. A. / Memon, N. / Bhanger, M. I. / Luthria, D. L.

Food chemistry

2013 Volume 139, Issue 1/4, Page(s) 496

Language	English
Document type	Article
ZDB-ID	243123-3
ISSN	0308-8146
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Prevalence and distribution of Arcobacter spp. in raw milk and retail raw beef.

Shah, A H / Saleha, A A / Murugaiyah, M / Zunita, Z / Memon, A A

Journal of food protection

2012 Volume 75, Issue 8, Page(s) 1474–1478

Abstract: A total of 106 beef samples which consisted of local (n = 59) and imported (n = 47) beef and 180 milk samples from cows (n = 86) and goats (n = 94) were collected from Selangor, Malaysia. Overall, 30.2% (32 of 106) of beef samples were found positive for ...

Abstract	A total of 106 beef samples which consisted of local (n = 59) and imported (n = 47) beef and 180 milk samples from cows (n = 86) and goats (n = 94) were collected from Selangor, Malaysia. Overall, 30.2% (32 of 106) of beef samples were found positive for Arcobacter species. Imported beef was significantly more contaminated (46.80%) than local beef (16.9%). Arcobacter butzleri was the species isolated most frequently from imported (81.8%) and local (60%) beef, followed by Arcobacter cryaerophilus in local (33.3%) and imported (18.2%) beef samples. Only one local beef sample (10%) yielded Arcobacter skirrowii. Arcobacter species were detected from cow's milk (5.8%), with A. butzleri as the dominant species (60%), followed by A. cryaerophilus (40%), whereas none of the goat's milk samples were found positive for Arcobacter. This is the first report of the detection of Arcobacter in milk and beef in Malaysia.
MeSH term(s)	Animals ; Arcobacter/isolation & purification ; Cattle ; Colony Count, Microbial ; Consumer Product Safety ; Food Contamination/analysis ; Food Microbiology ; Goats ; Humans ; Malaysia ; Meat/microbiology ; Milk/microbiology ; Prevalence ; Species Specificity
Language	English
Publishing date	2012-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X.JFP-11-487
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Article: The epidermal growth factor family has a dual role in deciding the fate of cancer cells.

Memon, A A / Sorensen, Sandahl B / Nexo, E

Scandinavian journal of clinical and laboratory investigation

2006 Volume 66, Issue 7, Page(s) 623–630

Abstract: Expression of the epidermal growth factor (EGF) receptors HER1 and HER2 has been implicated in tumour growth and poor survival, whereas expression of HER3 and HER4 has been associated with improved survival of bladder cancer patients. The balance between ...

Abstract	Expression of the epidermal growth factor (EGF) receptors HER1 and HER2 has been implicated in tumour growth and poor survival, whereas expression of HER3 and HER4 has been associated with improved survival of bladder cancer patients. The balance between the expression of the EGF family members may therefore have a role to play in determining the final outcome in cancer cells. To check this, we examined the effect of HER1 activation and inhibition on the expression of the EGF receptors HER3 and HER4 and ligands - the heregulins (HRGs). RT4 bladder cancer cells were treated with 1nM HB-EGF (known to induce cell proliferation by activating HER1 receptor) and the mRNA content of the two receptors (HER3 and HER4) and their activating ligands (HRG1-HRG4) was quantified by real time PCR at indicated time-points. Expressions of HRG1alpha and HRG1beta increased 8-fold and 9-fold, respectively, whereas the expressions of HRG2alpha (4-fold), HRG2beta (2.5-fold) and HRG4 (3.5-fold) decreased. In contrast, inhibition of tyrosine kinase activity of HER1 with 5 microM Iressa (a specific inhibitor of HER1) resulted in an increase in mRNA expression of HRG2alpha (2.5-fold) and HRG4 (1.5-fold). In addition, expression of the receptors HER3 (1.5-fold) and HER4 (2-fold) was also increased. In conclusion, we demonstrate that activation of the HER1 receptor suppressed the expression of a specific set of HRGs. A decrease in expression of HRG2 and HRG4 during HB-EGF treatment supports their role in growth inhibition, whereas an increase in HRG1 expression points to a role as a growth stimulatory member of the EGF family.
MeSH term(s)	Biomarkers/metabolism ; Cell Differentiation ; Cell Line, Tumor ; Epidermal Growth Factor/genetics ; Epidermal Growth Factor/metabolism ; Epidermal Growth Factor/physiology ; Gene Expression Regulation, Neoplastic ; Humans ; Ligands ; Multigene Family ; Quinazolines/pharmacology ; RNA, Messenger/metabolism ; Receptor, Epidermal Growth Factor/antagonists & inhibitors ; Receptor, Epidermal Growth Factor/genetics ; Receptor, Epidermal Growth Factor/metabolism ; Receptor, Epidermal Growth Factor/physiology ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-3/genetics ; Receptor, ErbB-3/metabolism ; Receptor, ErbB-3/physiology ; Receptor, ErbB-4 ; Urinary Bladder Neoplasms/metabolism
Chemical Substances	Biomarkers ; Ligands ; Quinazolines ; RNA, Messenger ; Epidermal Growth Factor (62229-50-9) ; EGFR protein, human (EC 2.7.10.1) ; ERBB4 protein, human (EC 2.7.10.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptor, ErbB-3 (EC 2.7.10.1) ; Receptor, ErbB-4 (EC 2.7.10.1) ; gefitinib (S65743JHBS)
Language	English
Publishing date	2006
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365510600891458
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Article: Mystery of the blue pigmentation.

Johnston, A M / Memon, A A

The New England journal of medicine

1999 Volume 340, Issue 20, Page(s) 1597–1598

MeSH term(s)	Aged ; Anti-Bacterial Agents/adverse effects ; Diagnosis, Differential ; Facial Dermatoses/chemically induced ; Female ; Humans ; Minocycline/adverse effects ; Pigmentation Disorders/chemically induced ; Rosacea/drug therapy ; Scleral Diseases/chemically induced
Chemical Substances	Anti-Bacterial Agents ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	1999-05-20
Publishing country	United States
Document type	Case Reports ; Comment ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJM199905203402018
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Article ; Online: The association between apolipoprotein M and insulin resistance varies with country of birth.

Memon, A A / Bennet, L / Zöller, B / Wang, X / Palmér, K / Dahlbäck, B / Sundquist, J / Sundquist, K

Nutrition, metabolism, and cardiovascular diseases : NMCD

2014 Volume 24, Issue 11, Page(s) 1174–1180

Abstract: Background and aims: Risk of type 2 diabetes mellitus (T2DM) differs according to ethnicity. Levels of apolipoprotein M (ApoM) have been shown to be decreased in T2DM. However, its role in different ethnicities is not known. We examined the differences ... ...

Abstract	Background and aims: Risk of type 2 diabetes mellitus (T2DM) differs according to ethnicity. Levels of apolipoprotein M (ApoM) have been shown to be decreased in T2DM. However, its role in different ethnicities is not known. We examined the differences in plasma ApoM levels in Swedish residents born in Iraq (Iraqis) and Sweden (Swedes) in relation to T2DM and insulin resistance (IR). Methods and results: Iraqis and Swedes, aged 45-65 years residing in Rosengård area of Malmö were randomly selected from census records and underwent an oral glucose tolerance test. Plasma levels of ApoM were quantified in 162 participants (Iraqis, n = 91; Swedes, n = 71) by a sandwich ELISA method. Age-, sex-, and body mass index (BMI) adjusted plasma ApoM levels differed by country of birth, with Swedes having 18% higher levels compared to Iraqis (p = 0.001). ApoM levels (mean ± SD) were significantly decreased in Swedes with T2DM (0.73 ± 0.18) compared to those with normal glucose tolerance (NGT) (0.89 ± 0.24; p = 0.03). By contrast, no significant difference in ApoM levels was found between Iraqis with T2DM (0.70 ± 0.17) and those with NGT (0.73 ± 0.13; p = 0.41). In multivariate linear regression analysis with an interaction term between IR and country of birth, low ApoM levels remained significantly associated with IR in Swedes (p = 0.008), independently of age, sex, BMI, family history of diabetes, HDL, LDL, and triglycerides, but not in Iraqis (p = 0.35). Conclusion: Our results show that ApoM levels differ according to country of birth and are associated with IR and T2DM only in Swedes.
MeSH term(s)	Aged ; Apolipoproteins/blood ; Apolipoproteins/genetics ; Apolipoproteins M ; Body Mass Index ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/ethnology ; European Continental Ancestry Group ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Insulin Resistance/ethnology ; Iraq/ethnology ; Lipocalins/blood ; Lipocalins/genetics ; Male ; Middle Aged ; Sweden/epidemiology ; Triglycerides/blood
Chemical Substances	APOM protein, human ; Apolipoproteins ; Apolipoproteins M ; Cholesterol, HDL ; Cholesterol, LDL ; Insulin ; Lipocalins ; Triglycerides
Language	English
Publishing date	2014-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2014.05.007
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