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Article ; Online: Application of the 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease in a seronegative rheumatoid arthritis cohort.

Codes-Méndez, Helena / Sainz, Luis / Park, Hye Sang / Corominas, Hèctor / Diaz-Torne, Cesar

2024 Volume 10, Issue 2

MeSH term(s)	Humans ; Chondrocalcinosis/diagnosis ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Severity of Illness Index
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Letter
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2024-004173
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Article ; Online: Emergency Surgical Treatment and Triage: Targeting Optimal Outcomes for Emergency Surgical Patients From Index Encounter Through Definitive Care.

Kliewer, Jaclyn / Luque, Ilko / Javier, Mariel A / Moorefield, Amanda / Mendez, Hector / Martinez, Zulmari / Oster, Jacob / Rangel, Alexis / Morejón, Orlando

The American surgeon

2024 , Page(s) 31348241248783

Abstract: Background: Patients with emergency surgical conditions (ESCs) experience higher complication rates than those without emergency conditions. Our purpose was to improve time-based key performance indicators (KPIs) of care for ESC patients, including ... ...

Abstract	Background: Patients with emergency surgical conditions (ESCs) experience higher complication rates than those without emergency conditions. Our purpose was to improve time-based key performance indicators (KPIs) of care for ESC patients, including diagnostic workup, empiric stabilization, and referral to definitive care. Methods: A rapid response program (ESTAT) was developed to screen for and coordinate optimal, timely care for a spectrum of high-risk ESCs, from the patient's index clinical encounter up to definitive care. The Mann-Whitney test assessed whether any differences in KPIs were statistically significant ( Results: 98 patients were identified: 44 in ESTAT group (70% age ≥55, 57% male); 54 in control group (57% age ≥55, 44% male). There were significant decreases from time of index clinical encounter to resuscitation (5 min. vs 34 min., Discussion: Improving time-based KPIs for delivery of clinical services is a common goal of medical emergency response systems (MERS) in numerous specialties. Implementation of an ESTAT program provides a screening tool for at-risk patients and reduces time to stabilize, diagnose and triage to definitive surgical intervention. These time benefits may ultimately translate to reduced complication rates for ESC patients. ESTAT may also represent a patient onboarding mechanism for surgical specialty verification programs promoted by quality improvement committees of various professional societies.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348241248783
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Article ; Online: Euro-Burn I: Assessment of burnout syndrome in health workers in a mediterranean country during the SARS-CoV-2 pandemic.

María Diaz Vizcaya, Rosa / José Rodríguez Rivas, María / Mariño Méndez, Helia / Teresa Alvés Pérez, María / López Castro, José

The International journal of social psychiatry

2023 Volume 69, Issue 7, Page(s) 1682–1692

Abstract: Background: Burnout syndrome (BS) has a negative impact among health professionals.: Aims: Our research objective is to quantify the level of burnout in health workers of the Spanish National Health System during the COVID-19 pandemic using and ... ...

Abstract	Background: Burnout syndrome (BS) has a negative impact among health professionals. Aims: Our research objective is to quantify the level of burnout in health workers of the Spanish National Health System during the COVID-19 pandemic using and comparing two independent measurement instruments. Methods: Cross-sectional, descriptive and multicenter study conducted through an anonymous online survey among health workers of the National Health System, measuring the level of burnout using the Maslach Burnout Inventory (MBI) and the Copenhagen Burnout Inventory (CBI). Results: A total of 448 questionnaires were analyzed, the mean age of the participants was 43.53 years (range: 20-64), 365 (81.5%) women. 161 (35.9%) participants presented BS measured with the MBI and 304 (67.9%) measured with the CBI. Regarding work contract, those who had greater job stability presented a higher degree of cynicism with respect to the eventual ones ( Conclusions: The results obtained show a high level of BS among the health workers who participated in our study. Both tests have an excellent correlation in the degree of exhaustion and cynicism, but not in efficacy. The BS measurement must be performed with at least two validated instruments to increase its reliability.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Male ; SARS-CoV-2 ; Pandemics ; Cross-Sectional Studies ; Reproducibility of Results ; COVID-19/epidemiology ; Burnout, Psychological/epidemiology ; Burnout, Professional/diagnosis ; Burnout, Professional/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	3062-4
ISSN	1741-2854 ; 0020-7640
ISSN (online)	1741-2854
ISSN	0020-7640
DOI	10.1177/00207640231174364
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Article: Evaluating Inpatient Hospital Charges Associated With Trauma Service Patients Participating in an Accountable Care Organization.

Salhany, Richard J / Genovese-Scullin, Daniel / Eversley-Danso, Jasmin A / Mendez, Humroy / Rubinshteyn, Vladimir / Lakhi, Nisha

Health services insights

2023 Volume 16, Page(s) 11786329231166367

Abstract: Background: The Medicare Accountable Care Organization (ACO) Program has created a vehicle for providers who practice cost containment and exceed quality for the Medicare population. The success of ACO's nationwide have been well documented. However, ... ...

Abstract	Background: The Medicare Accountable Care Organization (ACO) Program has created a vehicle for providers who practice cost containment and exceed quality for the Medicare population. The success of ACO's nationwide have been well documented. However, there is little research evaluating if there is a cost saving benefit in trauma care with respect to participating in an ACO. Thus, the primary objective of this study was to evaluate inpatient hospital charges associated with trauma service utilization of patients participating in the ACO compared to non-ACO patients. Methods: This case-control retrospective study includes a comparison of inpatients charges of ACO patients (cases) and general trauma patients (controls) presenting to our trauma center in Staten Island, New York from January 1st, 2019 to December 31st, 2021. A 1:1 matching of case to control was performed based on age, sex, race, and injury severity score. Statistical analysis was performed with IBM SPSS, with Results: A total of 80 patients were included in the ACO cohort and 80 matched in the General Trauma cohort. Patient demographics were similar. Comorbidities were similar with the exception of a higher in incidence of hypertension (75.0% vs 47.5%, Conclusion: In spite of increased incidence of hypertension and cardiac disease in ACO trauma patients, mean Injury Severity Score, number of visits, length of hospital stay, ICU admission rate and charge total was similar compared to general trauma patients presenting to our Level 1 Adult Trauma Center.
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2803340-1
ISSN	1178-6329
ISSN	1178-6329
DOI	10.1177/11786329231166367
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Article ; Online: Biosynthesis of a new skyllamycin in

Song, Yuhao / Amaya, Jose A / Murarka, Vidhi C / Mendez, Hugo / Hogan, Mark / Muldoon, Jimmy / Evans, Paul / Ortin, Yannick / Kelly, Steven L / Lamb, David C / Poulos, Thomas L / Caffrey, Patrick

Organic & biomolecular chemistry

2024 Volume 22, Issue 14, Page(s) 2835–2843

Abstract: Activation of a silent gene cluster ... ...

Abstract	Activation of a silent gene cluster in
MeSH term(s)	Cytochrome P-450 Enzyme System/chemistry ; Depsipeptides ; Peptides, Cyclic/chemistry ; Streptomyces
Chemical Substances	skyllamycins ; Cytochrome P-450 Enzyme System (9035-51-2) ; Depsipeptides ; Peptides, Cyclic
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d4ob00178h
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Article ; Online: Hepatic signal transducer and activator of transcription-3 signalling drives early-stage pancreatic cancer cachexia via suppressed ketogenesis.

Arneson-Wissink, Paige C / Mendez, Heike / Pelz, Katherine / Dickie, Jessica / Bartlett, Alexandra Q / Worley, Beth L / Krasnow, Stephanie M / Eil, Robert / Grossberg, Aaron J

Journal of cachexia, sarcopenia and muscle

2024

Abstract: Background: Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from cachexia, a wasting syndrome that significantly reduces both quality of life and survival. Although advanced cachexia is associated with inflammatory signalling and ... ...

Abstract	Background: Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from cachexia, a wasting syndrome that significantly reduces both quality of life and survival. Although advanced cachexia is associated with inflammatory signalling and elevated muscle catabolism, the early events driving wasting are poorly defined. During periods of nutritional scarcity, the body relies on hepatic ketogenesis to generate ketone bodies, and lipid metabolism via ketogenesis is thought to protect muscle from catabolizing during nutritional scarcity. Methods: We developed an orthotopic mouse model of early PDAC cachexia in 12-week-old C57BL/6J mice. Murine pancreatic cancer cells (KPC) were orthotopically implanted into the pancreas of wild-type, IL-6 Results: Pre-cachectic PDAC mice did not preserve gastrocnemius muscle mass during 3-day food restriction (-13.1 ± 7.7% relative to food-restricted sham, P = 0.0117) and displayed impaired fatty acid oxidation during fasting, resulting in a hypoketotic state (ketogenic response to octanoate bolus, -83.0 ± 17.3%, P = 0.0328; Hmgcs2 expression, -28.3 ± 7.6%, P = 0.0004). PDAC human patients display impaired fasting ketones (-46.9 ± 7.1%, P < 0.0001) and elevated circulating interleukin-6 (IL-6) (12.4 ± 16.5-fold increase, P = 0.0001). IL-6 Conclusions: In early PDAC cachexia, muscle vulnerability to wasting is dependent on inflammation-driven metabolic reprogramming in the liver. PDAC suppresses lipid β-oxidation and impairs ketogenesis in the liver, which is reversed in genetically modified mouse models deficient in IL-6/STAT3 signalling or through ketogenic diet supplementation. This work establishes a direct link between skeletal muscle homeostasis and hepatic metabolism. Dietary and anti-inflammatory interventions that restore ketogenesis may be a viable preventative approach for pre-cachectic patients with pancreatic cancer.
Language	English
Publishing date	2024-04-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13466
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Article ; Online: Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.

Vermehren-Schmaedick, Anke / Joshi, Sonali / Wagoner, Wendy / Norgard, Mason A / Packwood, William / Diba, Parham / Mendez, Heike / Fedorov, Lev M / Rakshe, Shauna / Park, Byung / Marks, Daniel L / Grossberg, Aaron / Luoh, Shiuh-Wen

Endocrinology

2024 Volume 165, Issue 5

Abstract: Objectives: Growth factor receptor bound protein 7 (GRB7) is a multidomain signaling adaptor. Members of the Grb7/10/14 family, specifically Gbrb10/14, have important roles in metabolism. We ablated the Grb7 gene in mice to examine its metabolic ... ...

Abstract	Objectives: Growth factor receptor bound protein 7 (GRB7) is a multidomain signaling adaptor. Members of the Grb7/10/14 family, specifically Gbrb10/14, have important roles in metabolism. We ablated the Grb7 gene in mice to examine its metabolic function. Methods: Global ablation of Grb7 in FVB/NJ mice was generated. Growth, organ weight, food intake, and glucose homeostasis were measured. Insulin signaling was examined by Western blotting. Fat and lean body mass was measured by nuclear magnetic resonance, and body composition after fasting or high-fat diet was assessed. Energy expenditure was measured by indirect calorimetry. Expression of adiposity and lipid metabolism genes was measured by quantitative PCR. Results: Grb7-null mice were viable, fertile, and without obvious phenotype. Grb7 ablation improved glycemic control and displayed sensitization to insulin signaling in the liver. Grb7-null females but not males had increased gonadal white adipose tissue mass. Following a 12-week high-fat diet, Grb7-null female mice gained fat body mass and developed relative insulin resistance. With fasting, there was less decrease in fat body mass in Grb7-null female mice. Female mice with Grb7 ablation had increased baseline food intake, less energy expenditure, and displayed a decrease in the expression of lipolysis and adipose browning genes in gonadal white adipose tissue by transcript and protein analysis. Conclusion: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.
MeSH term(s)	Animals ; Female ; Male ; Mice ; Abdominal Fat/metabolism ; Blood Glucose/metabolism ; Body Composition/genetics ; Diet, High-Fat ; Energy Metabolism/genetics ; GRB7 Adaptor Protein/genetics ; GRB7 Adaptor Protein/metabolism ; Insulin/metabolism ; Insulin Resistance/genetics ; Mice, Knockout ; Signal Transduction
Chemical Substances	Blood Glucose ; GRB7 Adaptor Protein (149058-53-7) ; Insulin ; Grb7 protein, mouse
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/endocr/bqae045
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Article ; Online: Return-to-Play Outcomes in Professional Baseball Players After Nonoperative Treatment of Incomplete Medial Ulnar Collateral Ligament Injuries: A Long-Term Follow-up Study.

Walker, Clark M / Genuario, James W / Houck, Darby A / Murayama, Scott / Mendez, Hanna / Noonan, Thomas J

The American journal of sports medicine

2021 Volume 49, Issue 5, Page(s) 1137–1144

Abstract: Background: Medial ulnar collateral ligament (UCL) injuries are common among baseball players. There is sparse literature on long-term results after nonoperative treatment of UCL injuries in professional baseball players.: Purpose: The primary ... ...

Abstract	Background: Medial ulnar collateral ligament (UCL) injuries are common among baseball players. There is sparse literature on long-term results after nonoperative treatment of UCL injuries in professional baseball players. Purpose: The primary purpose was to assess long-term follow-up on reinjury rates, performance metrics, rate of return to the same level of play or higher (RTP), and ability to advance to the next level of play in professional baseball players after nonoperative treatment of incomplete UCL injuries. The secondary aim was to perform a matched-pair comparison between pitchers treated nonoperatively and a control group without a history of UCL injuries. Study design: Cohort study; Level of evidence, 3. Methods: Twenty-eight professional baseball players (18 pitchers, 10 position players) treated nonoperatively were identified from a previous retrospective review of a single professional baseball organization between 2006 and 2011. UCL reinjury rates and player performance metrics were evaluated at long-term (minimum, 9 years) follow-up. Rates of RTP were calculated. A matched-pair comparison was made between the pitchers treated nonoperatively and pitchers without a history of UCL injuries. Results: Overall, 27 players (17 pitchers, 10 position players) were available for long-term follow-up at a mean follow-up of 12 years (SD, 2 years). The overall rate of RTP was 85% (23/27), with the rate of RTP being 82% (14/17) in pitchers and 90% (9/10) in position players. Of the 23 players who did RTP, 18 (78%) reached a higher level of play and 5 (21.7%) stayed at the same level. Of the 9 position players who did RTP, the median number of seasons played after injury was 4.5 (interquartile range, 3.3). Of the 14 pitchers who did RTP, the mean number of seasons played after injury was 5.8 (SD, 3.8). In the matched-pair analysis, no significant differences were observed in any performance metrics (P > .05). The overall reinjury rate was 11.1% (3/27), with no players requiring UCL reconstruction. Conclusion: There was a high rate of RTP for professional baseball players treated nonoperatively for incomplete UCL injuries. Compared with a matched cohort with no history of UCL injury, professional baseball pitchers treated nonoperatively had similar performance metrics. Reinjury rates were low, and no player had reinjury requiring UCL reconstruction. Nonoperative treatment of incomplete UCL injuries in professional baseball players, specifically pitchers, is a viable treatment option in the long term.
MeSH term(s)	Baseball ; Cohort Studies ; Collateral Ligament, Ulnar/surgery ; Elbow Joint/surgery ; Follow-Up Studies ; Humans ; Retrospective Studies ; Return to Sport ; Ulnar Collateral Ligament Reconstruction
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/0363546521996706
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Article ; Online: Sexual health and function among patients receiving systemic therapy for primary gynecologic cancers.

Kulkarni, Amita / Sun, Grace / Manuppelli, Sarah / Mendez, Heidy / Rezendes, Jocelyn / Marin, Christine / Raker, Christina A / Robison, Katina

Gynecologic oncology

2022 Volume 165, Issue 2, Page(s) 323–329

Abstract: Objective: Sexual dysfunction has been reported after gynecologic cancer treatment but few studies have examined sexual function during treatment. Our objectives were to describe sexual function among women receiving systemic therapy for gynecologic ... ...

Abstract	Objective: Sexual dysfunction has been reported after gynecologic cancer treatment but few studies have examined sexual function during treatment. Our objectives were to describe sexual function among women receiving systemic therapy for gynecologic cancers and to compare sexual function between women receiving upfront treatment versus treatment for cancer recurrence. Methods: We conducted a prospective study of women 18yo and older receiving systemic therapy for gynecologic cancer in the upfront or recurrent setting. Patients receiving radiation were excluded. Participants completed a survey with questions from the Patient Reported Outcome Measurement Information System (PROMIS) SexFS and Female Sexual Function Index (FSFI). Clinical information was collected from chart review. Statistical analysis included t-test, Wilcoxon rank sum test, and Fisher's exact test. Results: Of 145 patients approached, 100 (69%) enrolled and 97 (67%) completed the survey. Median age was 65yo. Most patients had ovarian cancer (58%), then endometrial cancer (34%) and cervical cancer (8%). Fifty-two (54%) were receiving recurrent treatment and 45 (46%) upfront treatment. Thirty-eight (76%) in the recurrent group and 34 (75%) in the upfront group hadn't been sexually active in the last month (p = 1.0); however, 61 (67%) participants reported a desire for future sexual activity. Of the 31 patients who completed all FSFI questions, the median FSFI score was 24.0 and 21 (68%) had sexual dysfunction. Vaginal dryness was more common among patients receiving recurrent treatment (p = 0.09) while a "health condition" was a more common reason for sexual inactivity in the upfront setting (p = 0.07). Conclusion: Many patients receiving systemic therapy for gynecologic cancers are willing to discuss sexual function. Most patients reported sexual dysfunction and weren't currently sexually active. Understanding patients' sexual function concerns will allow providers to intervene.
MeSH term(s)	Aged ; Female ; Genital Neoplasms, Female/drug therapy ; Humans ; Male ; Neoplasm Recurrence, Local ; Prospective Studies ; Sexual Behavior ; Sexual Dysfunction, Physiological ; Sexual Health ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2022.03.008
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Article ; Online: Long-term results of genital prolapse surgery with polypropylene mesh.

González Palanca, S J / González Veiga, E J / Palmeiro Fernández, G / Domínguez Salgado, J C / Mariño Méndez, H / Varela Ponte, C

Actas urologicas espanolas

2019 Volume 43, Issue 5, Page(s) 254–261

Abstract: Introduction and objective: The risk of intervention due to urogenital prolapse in a woman's life is 11.1%. Recurrences after classic surgery reach up to 38%. With the aim of improving these results, transvaginal mesh kits are used. The purpose of the ... ...

Title translation	Resultados a largo plazo de la cirugía de prolapsos genitales con mallas de polipropileno.
Abstract	Introduction and objective: The risk of intervention due to urogenital prolapse in a woman's life is 11.1%. Recurrences after classic surgery reach up to 38%. With the aim of improving these results, transvaginal mesh kits are used. The purpose of the study is to describe the results of efficacy and long-term safety of vaginal prolapse surgery with polypropylene mesh, assess subjective symptoms before and after surgery and the level of satisfaction. Patients and methods: A descriptive, retrospective study of 58 women with symptomatic genital prolapses operated with polypropylene mesh between September / 2011-November / 2016. Mean age: 66.53 years, 98.27% menopausal women, 77.59% overweight/obesity, 29.31% with previous gynaecological surgery and 55.17% with combined prolapse. 46 Elevate anterior and 12 posterior were inserted. The mean follow-up period was 34.02 months. The PFDI questionnaire was used pre and post-surgery, as well as the satisfaction questionnaire. Results: Healing rate of 91.38%. Recurrences were associated with a higher BMI and with background of recurrence of previous surgery. Mean length of stay: 2.5 days. 70.69% did not need analgesia at discharge. Clavien-Dindo complications: 1 type I (urinary retention), 5 type II (urinary tract infection) and 1 type IIIa (erosion). De novo stress urinary incontinence occurred in 3.44%, while de novo dyspareunia 14.28%. 89.36% patients improved subjective symptoms, and 95.92% were satisfied. Conclusion: This surgery achieves high healing rates, with few complications, improvement of subjective symptoms and high level of satisfaction of the patients.
MeSH term(s)	Aged ; Dyspareunia ; Female ; Humans ; Length of Stay ; Polypropylenes ; Postoperative Complications ; Recurrence ; Retrospective Studies ; Surgical Mesh ; Symptom Assessment ; Treatment Outcome ; Urinary Incontinence, Stress ; Urinary Retention ; Uterine Prolapse/complications ; Uterine Prolapse/surgery
Chemical Substances	Polypropylenes
Language	Spanish
Publishing date	2019-04-05
Publishing country	Spain
Document type	Journal Article ; Observational Study
ISSN	2173-5786
ISSN (online)	2173-5786
DOI	10.1016/j.acuro.2018.12.002
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