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Article ; Online: Editorial for "Deep Learning Whole-Gland and Zonal Prostate Segmentation on a Public MRI Dataset".

Mendichovszky, Iosif A

Journal of magnetic resonance imaging : JMRI

2021 Volume 54, Issue 2, Page(s) 460–461

MeSH term(s)	Deep Learning ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Prostate/diagnostic imaging ; Specimen Handling
Language	English
Publishing date	2021-05-30
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.27748
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

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Article: Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am.

Bulat, Flaviu / Hesse, Friederike / Attili, Bala / Solanki, Chandra / Mendichovszky, Iosif A / Aigbirhio, Franklin / Leeper, Finian J / Brindle, Kevin M / Neves, André A

Cancers

2023 Volume 15, Issue 5

Abstract: There is an unmet clinical need for imaging agents capable of detecting early evidence of tumor cell death, since the timing, extent, and distribution of cell death in tumors following treatment can give an indication of treatment outcome. We describe ... ...

Abstract	There is an unmet clinical need for imaging agents capable of detecting early evidence of tumor cell death, since the timing, extent, and distribution of cell death in tumors following treatment can give an indication of treatment outcome. We describe here
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15051564
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Article ; Online: Molecular Imaging of Pituitary Tumors.

Gillett, Daniel / MacFarlane, James / Bashari, Waiel / Crawford, Rosy / Harper, Ines / Mendichovszky, Iosif A / Aloj, Luigi / Cheow, Heok / Gurnell, Mark

Seminars in nuclear medicine

2023 Volume 53, Issue 4, Page(s) 530–538

Abstract: Tumors of the pituitary gland, although mostly benign adenomas, are a cause of significant morbidity and even excess mortality due to local compressive effects (eg visual loss, hypopituitarism) and unregulated hormone secretion (eg acromegaly or Cushing ... ...

Abstract	Tumors of the pituitary gland, although mostly benign adenomas, are a cause of significant morbidity and even excess mortality due to local compressive effects (eg visual loss, hypopituitarism) and unregulated hormone secretion (eg acromegaly or Cushing Disease). Surgery, radiotherapy, and medical management (sometimes in combination) may be needed to mitigate the effects of tumor expansion and endocrine dysfunction. Magnetic resonance imaging (MRI) plays a central role in treatment planning for most patients. However, it does not always reliably identify the site(s) of primary or recurrent disease, especially where post-treatment remodeling results in indeterminate anatomical appearances. In these contexts, molecular imaging is a potential game-changer, allowing precise localization of sites of active disease and enabling safe and effective targeted intervention when patients would otherwise be consigned to expensive life-long medication. For pituitary and parasellar imaging, PET is the preferred modality due to its superior spatial resolution and sensitivity compared with SPECT, and an array of PET radioligands have been studied in different pituitary adenoma (PA) subtypes. While
MeSH term(s)	Humans ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/radiotherapy ; Adenoma/metabolism ; Adenoma/pathology ; Adenoma/surgery ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging ; Molecular Imaging
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2023.02.005
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Zs.A 763: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Improvements in Between-Vendor MRI Harmonization of Renal T

Li, Hao / Daniel, Alexander J / Buchanan, Charlotte E / Nery, Fábio / Morris, David M / Li, Shaohang / Huang, Yuan / Sousa, João A / Sourbron, Steven / Mendichovszky, Iosif A / Thomas, David L / Priest, Andrew N / Francis, Susan T

Journal of magnetic resonance imaging : JMRI

2024

Abstract: Background: T: Purpose: To harmonize renal T: Study type: Prospective.: Subjects: 8 healthy "travelling" volunteers (37.5% female, 32 ± 6 years) imaged on four MRI systems across three vendors at four sites, 10 healthy volunteers (50% female, ... ...

Abstract	Background: T Purpose: To harmonize renal T Study type: Prospective. Subjects: 8 healthy "travelling" volunteers (37.5% female, 32 ± 6 years) imaged on four MRI systems across three vendors at four sites, 10 healthy volunteers (50% female, 32 ± 8 years) scanned multiple times on a given MR scanner for repeatability evaluation. ISMRM/NIST system phantom scanned for evaluation of T Field strength/sequence: 3T, multiecho spin-echo sequence. Assessment: T Statistical tests: Coefficient of variation (CV), linear mixed-effects model, analysis of variance, student's t-tests, Bland-Altman plots, P-value <0.05 considered statistically significant. Results: In the ISMRM/NIST phantom, "StimFit" reduced the MAPE from 4.9%, 9.1%, 24.4%, and 18.1% for the four sites (three vendors) to 3.3%, 3.0%, 6.6%, and 4.1%, respectively. In vivo, there was a significant difference in kidney T Data conclusion: Stimulated-echo correction reduces renal T Level of evidence: 2 TECHNICAL EFFICACY: Stage 1.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29282
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Article ; Online: Fast and High-Resolution T

Li, Hao / Priest, Andrew N / Horvat-Menih, Ines / Huang, Yuan / Li, Shaohang / Stewart, Grant D / Mendichovszky, Iosif A / Francis, Susan T / Gallagher, Ferdia A

Magnetic resonance in medicine

2024

Abstract: Purpose: To develop a highly accelerated multi-echo spin-echo method, TEMPURA, for reducing the acquisition time and/or increasing spatial resolution for kidney T: Methods: TEMPURA merges several adjacent echoes into one k-space by either combining ... ...

Abstract	Purpose: To develop a highly accelerated multi-echo spin-echo method, TEMPURA, for reducing the acquisition time and/or increasing spatial resolution for kidney T Methods: TEMPURA merges several adjacent echoes into one k-space by either combining independent echoes or sharing one echo between k-spaces. The combined k-space is reconstructed based on compressed sensing theory. Reduced flip angles are used for the refocusing pulses, and the extended phase graph algorithm is used to correct the effects of indirect echoes. Two sequences were developed: a fast breath-hold sequence; and a high-resolution sequence. The performance was evaluated prospectively on a phantom, 16 healthy subjects, and two patients with different types of renal tumors. Results: The fast TEMPURA method reduced the acquisition time from 3-5 min to one breath-hold (18 s). Phantom measurements showed that fast TEMPURA had a mean absolute percentage error (MAPE) of 8.2%, which was comparable to a standardized respiratory-triggered sequence (7.4%), but much lower than a sequence accelerated by purely k-t undersampling (21.8%). High-resolution TEMPURA reduced the in-plane voxel size from 3 × 3 to 1 × 1 mm Conclusion: TEMPURA provides fast and high-resolution renal T
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.30115
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Zs.A 1959: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: 3D printing

Gillett, Daniel / Marsden, Daniel / Ballout, Safia / Attili, Bala / Bird, Nick / Heard, Sarah / Gurnell, Mark / Mendichovszky, Iosif A / Aloj, Luigi

EJNMMI physics

2021 Volume 8, Issue 1, Page(s) 38

Abstract: Purpose: Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by creating phantoms which replicate human ...

Abstract	Purpose: Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by creating phantoms which replicate human anatomy which can be filled with radioactive material. The problem with these is that small objects suffer to a greater extent than larger objects from the effects of inactive walls, and therefore, phantoms without these are desirable. The purpose of this study was to explore the feasibility of creating resin-based 3D-printed phantoms using Methods: Radioactive resin was created using an emulsion of printer resin and Results: Creating radioactive resin was simple and effective. The radioactive concentration was uniform among identical objects; the CoV of the signal was 0.7% using a gamma counter. The printed cylinders and spheres were found to be within 4% of the model dimensions. A double helix was successfully printed as a test for the printer and appeared as expected on the PET scanner. The amount of radioactivity leached into the water was measurable (0.72%) but not visible above background on the imaging. Conclusions: Creating an
Language	English
Publishing date	2021-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-021-00383-6
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Article ; Online: Reproducibility of CT-based radiomic features against image resampling and perturbations for tumour and healthy kidney in renal cancer patients.

Mottola, Margherita / Ursprung, Stephan / Rundo, Leonardo / Sanchez, Lorena Escudero / Klatte, Tobias / Mendichovszky, Iosif / Stewart, Grant D / Sala, Evis / Bevilacqua, Alessandro

Scientific reports

2021 Volume 11, Issue 1, Page(s) 11542

Abstract: Computed Tomography (CT) is widely used in oncology for morphological evaluation and diagnosis, commonly through visual assessments, often exploiting semi-automatic tools as well. Well-established automatic methods for quantitative imaging offer the ... ...

Abstract	Computed Tomography (CT) is widely used in oncology for morphological evaluation and diagnosis, commonly through visual assessments, often exploiting semi-automatic tools as well. Well-established automatic methods for quantitative imaging offer the opportunity to enrich the radiologist interpretation with a large number of radiomic features, which need to be highly reproducible to be used reliably in clinical practice. This study investigates feature reproducibility against noise, varying resolutions and segmentations (achieved by perturbing the regions of interest), in a CT dataset with heterogeneous voxel size of 98 renal cell carcinomas (RCCs) and 93 contralateral normal kidneys (CK). In particular, first order (FO) and second order texture features based on both 2D and 3D grey level co-occurrence matrices (GLCMs) were considered. Moreover, this study carries out a comparative analysis of three of the most commonly used interpolation methods, which need to be selected before any resampling procedure. Results showed that the Lanczos interpolation is the most effective at preserving original information in resampling, where the median slice resolution coupled with the native slice spacing allows the best reproducibility, with 94.6% and 87.7% of features, in RCC and CK, respectively. GLCMs show their maximum reproducibility when used at short distances.
MeSH term(s)	Algorithms ; Carcinoma, Renal Cell/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Kidney/diagnostic imaging ; Kidney Neoplasms/diagnostic imaging ; Reproducibility of Results ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2021-06-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-90985-y
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Article ; Online: Bias, Repeatability and Reproducibility of Liver T<sub>1</sub> Mapping With Variable Flip Angles.

Tadimalla, Sirisha / Wilson, Daniel J / Shelley, David / Bainbridge, Gavin / Saysell, Margaret / Mendichovszky, Iosif A / Graves, Martin J / Guthrie, J Ashley / Waterton, John C / Parker, Geoffrey J M / Sourbron, Steven P

Journal of magnetic resonance imaging : JMRI

2022 Volume 56, Issue 4, Page(s) 1042–1052

Abstract: Background: Three-dimensional variable flip angle (VFA) methods are commonly used for T ... 1 ... mapping of the liver, but there is no data on the accuracy, repeatability, and reproducibility of this technique in this organ in a multivendor setting.!# ...

Abstract	Background: Three-dimensional variable flip angle (VFA) methods are commonly used for T<sub>1</sub> mapping of the liver, but there is no data on the accuracy, repeatability, and reproducibility of this technique in this organ in a multivendor setting. Purpose: To measure bias, repeatability, and reproducibility of VFA T<sub>1</sub> mapping in the liver. Study type: Prospective observational. Population: Eight healthy volunteers, four women, with no known liver disease. Field strength/sequence: 1.5-T and 3.0-T; three-dimensional steady-state spoiled gradient echo with VFAs; Look-Locker. Assessment: Traveling volunteers were scanned twice each (30 minutes to 3 months apart) on six MRI scanners from three vendors (GE Healthcare, Philips Medical Systems, and Siemens Healthineers) at two field strengths. The maximum period between the first and last scans among all volunteers was 9 months. Volunteers were instructed to abstain from alcohol intake for at least 72 hours prior to each scan and avoid high cholesterol foods on the day of the scan. Statistical tests: Repeated measures ANOVA, Student t-test, Levene's test of variances, and 95% significance level. The percent error relative to literature liver T<sub>1</sub> in healthy volunteers was used to assess bias. The relative error (RE) due to intrascanner and interscanner variation in T<sub>1</sub> measurements was used to assess repeatability and reproducibility. Results: The 95% confidence interval (CI) on the mean bias and mean repeatability RE of VFA T<sub>1</sub> in the healthy liver was 34 ± 6% and 10 ± 3%, respectively. The 95% CI on the mean reproducibility RE at 1.5 T and 3.0 T was 29 ± 7% and 25 ± 4%, respectively. Data conclusion: Bias, repeatability, and reproducibility of VFA T<sub>1</sub> mapping in the liver in a multivendor setting are similar to those reported for breast, prostate, and brain. Level of evidence: 1 TECHNICAL EFFICACY STAGE: 1.
MeSH term(s)	Brain/diagnostic imaging ; Female ; Humans ; Liver/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Male ; Phantoms, Imaging ; Prostate ; Reproducibility of Results
Language	English
Publishing date	2022-02-27
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28127
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Article ; Online: Heparin-induced thrombocytopaenia presenting as acute aortic mural thrombosis.

Bienz, Maya Joanne / Obrocki, Pawel / Russell, James / Jena, Rajesh / Mendichovszky, Iosif Alexandru

BJR case reports

2018 Volume 5, Issue 1, Page(s) 20180025

Abstract: Heparin-induced thrombocytopaenia (HIT) is a life and limb-threatening acquired autoimmune complication of heparin-based treatment, characterised by thrombocytopaenia and thrombosis. We present a case of a 77-year-old female with concomitant metastatic ... ...

Abstract	Heparin-induced thrombocytopaenia (HIT) is a life and limb-threatening acquired autoimmune complication of heparin-based treatment, characterised by thrombocytopaenia and thrombosis. We present a case of a 77-year-old female with concomitant metastatic ovarian and breast cancer who presented to our institution with worsening shortness of breath. She had been diagnosed with acute pulmonary embolism 1 month earlier that was treated with therapeutic low molecular weight heparin (LMWH). In view of her worsening symptoms, CT imaging was performed. This demonstrated significant progression of the bilateral pulmonary emboli and new mural thrombosis of the thoracic aorta, despite being compliant with therapeutic anticoagulation. She had also developed thrombocytopaenia since commencing LMWH, which raised the clinical suspicion of HIT syndrome. The HIT pre-test probability score was intermediate and LMWH was immediately discontinued pending further investigation. She was commenced on rivaroxaban, a direct oral anticoagulant, and her platelet count soon recovered. Laboratory testing was strongly positive on both immunological and functional assays, thus confirming a diagnosis of HIT syndrome. A repeat CT scan 3 weeks later showed a reduction in the overall thrombus load. Whilst venous thrombosis is observed in as many as half of patients with HIT, arterial thrombosis is a far less common event. Furthermore, arterial involvement usually affects the distal vessels with significant atherosclerotic burden and typically presents as acute limb ischaemia or ischaemic stroke. Aortic thrombosis, as in this case, is a rare complication of HIT syndrome.
Language	English
Publishing date	2018-10-05
Publishing country	England
Document type	Journal Article
ISSN	2055-7159
ISSN (online)	2055-7159
DOI	10.1259/bjrcr.20180025
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Article: Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors.

EJNMMI physics

2023 Volume 10, Issue 1, Page(s) 34

Abstract: Background: Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this presents a particular challenge ... ...

Abstract	Background: Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this presents a particular challenge when imaging endocrine glands to detect small (often subcentimeter) tumors. To address this, we developed a novel phantom for optimization of positron emission tomography (PET) imaging of the human pituitary gland. Using radioactive 3D printing, phantoms were created which mimicked the distribution of Results: The phantom enabled us to replicate pituitary glands harboring tumors of varying sizes (2, 4 and 6 mm diameters) and differing radioactive concentrations (2 ×, 5 × and 8 × the normal gland). The anatomical phantom successfully approximated the attenuation properties of surrounding bone and soft tissue. Two iterative reconstruction algorithms [ordered subset expectation maximization (OSEM); Bayesian penalized likelihood (BPL)] with a range of reconstruction parameters (e.g., 3, 5, 7 and 9 OSEM iterations with 24 subsets; BPL regularization parameter (β) from 50 to 1000) were tested. Images were analyzed quantitatively and qualitatively by eight expert readers. Quantitatively, signal was the highest using BPL with β = 50; noise was the lowest using BPL with β = 1000; contrast was the highest using BPL with β = 100. The qualitative review found that accuracy and confidence were the highest when using BPL with β = 400. Conclusions: The development of a bespoke phantom has allowed the identification of optimal parameters for molecular pituitary imaging: BPL reconstruction with TOF, PSF correction and a β value of 400; in addition, for small (< 4 mm) tumors with low contrast (2:1 or 5:1), sensitivity may be improved using a β value of 100. Together, these findings should increase tumor detection and confidence in reporting scans.
Language	English
Publishing date	2023-06-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00552-9
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