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  1. Buch ; Online: HealthCare I

    Orlando, Valentina / Colonna, Roberto / Coscioni, Enrico / di Gennaro, Massimo / Giordana, Roberta / Guarino, Ilaria / Menditto, Enrica / Mucherino, Sara / Postiglione, Antonio / Riegler, Salvatore / Scafa, Luca / Stefanelli, Roberta / Trama, Ugo

    2022  

    Schlagwörter Medicine ; Chronic conditions, Comorbidity, RWE, Multimorbidity clusters
    Umfang 1 electronic resource (255 pages)
    Verlag FedOA - Federico II University Press
    Erscheinungsort Napoli
    Dokumenttyp Buch ; Online
    Anmerkung Italian ; Open Access
    HBZ-ID HT021291019
    ISBN 978-88-6887-125-3 ; 88-6887-125-4
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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    Fernleihe an ZB MED

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  2. Buch ; Online: Farmaci oppioidi e Cannabis nella terapia del dolore

    Colonna, Roberto / Guerriero, Francesca / Orlando, Valentina / Menditto, Enrica / Miro, Agnese / Cuomo, Arturo / Novellino, Ettore / Iadevaia, Vincenzo

    2018  

    Abstract: Opioid and Cannabis in Pain Control is the result of studies performed by the Pharmacy Department and the "Centro Interdipartimentale di Ricerca in Farmacoeconomia e Farmacoutilizzazione" (CIRFF) of the University of Naples, "Federico II". This book is ... ...

    Abstract Opioid and Cannabis in Pain Control is the result of studies performed by the Pharmacy Department and the "Centro Interdipartimentale di Ricerca in Farmacoeconomia e Farmacoutilizzazione" (CIRFF) of the University of Naples, "Federico II". This book is aimed to those who work in a pharmacy and who, scholars, teachers or students, are interested in delve into the issue. The text analyzes different topics with an interdisciplinary approach. A large part is devoted to the chemical and pharmacological aspects related to this topic. Subsequently, the text focuses the theme, still very debated, of using opioids and Cannabis in therapy through an exhaustive analysis of the entire existing legislation: from the first laws promulgated by the Kingdom of Italy until the last ministerial circulars by Italian republic. Finally yet importantly, an important part of the book focuses on medical and therapeutic interpretation with regard to the effects on pain control, where opioids and Cannabis are not only a fruitful frontier of research, but also a consolidated and effective tool to counteract some types of pain
    Schlagwörter Therapeutics. Pharmacology
    Umfang 1 electronic resource (224 p.)
    Verlag FedOA - Federico II University Press
    Dokumenttyp Buch ; Online
    Anmerkung Italian ; Open Access
    HBZ-ID HT020098583
    ISBN 9788868870256 ; 8868870258
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Buch ; Online: PharmaCare 2018

    Riegler, Salvatore / D'Amato, Daniele / Guida, Antonella / Trama, Ugo / Orlando, Valentina / Menditto, Enrica / Piscitelli, Antonella / Monetti, Valeria Marina / Colonna, Roberto / Mucherino, Sara / Postiglione, Antonio / Russo, Veronica / Coscioni, Enrico / Guerriero, Francesca / Guarino, Ilaria / Novellino, Ettore

    2020  

    Umfang 1 electronic resource (221 pages)
    Verlag FedOA - Federico II University Press
    Dokumenttyp Buch ; Online
    Anmerkung Open Access
    HBZ-ID HT021026460
    ISBN 9788868870898 ; 8868870894
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  4. Buch ; Online: Pharmacare 2019

    Orlando, Valentina / Cittadini, Antonio / Colonna, Roberto / Coscioni, Enrico / di Gennaro, Massimo / Giordana, Roberta / Guarino, Ilaria / Limongelli, Giuseppe / Marina Monetti, Valeria / Mucherino, Sara / Novellino, Ettore / Pandico, Fulvio / Perrella, Alessandro / Postiglione, Antonio / Riegler, Salvatore / Stefanelli, Roberta / Trama, Ugo / Menditto, Enrica / Filippelli, Amelia

    2021  

    Schlagwörter xxxx
    Umfang 1 electronic resource (221 pages)
    Verlag FedOA - Federico II University Press
    Erscheinungsort Napoli
    Dokumenttyp Buch ; Online
    Anmerkung Italian ; Open Access
    HBZ-ID HT021232126
    ISBN 978-88-6887-093-5 ; 88-6887-093-2
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  5. Buch ; Online: Il farmaco : ricerca, sviluppo e applicazione in terapia

    Capone, Giacomo / Tomasi, Francesco De / Fuccella, Luciano Maria / Orlando, Valentina / Menditto, Enrica / Putignano, Daria / Bocchi, Ilenia / Piscitelli, Antonella / Barone, Domenico / Bonato, Stefano / Colonna, Roberto / Iadevaia, Vincenzo / Russo, Veronica / Romano, Silvia / Vinci, Paolo / Cammarata, Silvia / Guerriero, Francesca / Calderazzo, Valentina / Novellino, Ettore

    2019  

    Schlagwörter xxxx
    Umfang 1 electronic resource (266 pages)
    Verlag FedOA - Federico II University Press
    Dokumenttyp Buch ; Online
    Anmerkung Italian ; Open Access
    HBZ-ID HT021047014
    ISBN 9788868870652 ; 8868870657
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  6. Artikel: Cost-Effectiveness of Treatment Optimisation with Biomarkers for Immunotherapy in Solid Tumours: A Systematic Review.

    Mucherino, Sara / Lorenzoni, Valentina / Triulzi, Isotta / Del Re, Marzia / Orlando, Valentina / Capuano, Annalisa / Danesi, Romano / Turchetti, Giuseppe / Menditto, Enrica

    Cancers

    2024  Band 16, Heft 5

    Abstract: This study investigated the health economic evaluations of predictive biomarker testing in solid tumours treated with immune checkpoint inhibitors (ICIs). Searching PubMed, EMBASE, and Web of Science from June 2010 to February 2022, 58 relevant articles ... ...

    Abstract This study investigated the health economic evaluations of predictive biomarker testing in solid tumours treated with immune checkpoint inhibitors (ICIs). Searching PubMed, EMBASE, and Web of Science from June 2010 to February 2022, 58 relevant articles were reviewed out of the 730 screened. The focus was predominantly on non-small cell lung cancer (NSCLC) (65%) and other solid tumours (40%). Among the NSCLC studies, 21 out of 35 demonstrated cost-effectiveness, notably for pembrolizumab as first-line treatment when preceded by PD-L1 assessment, cost-effective at a threshold of $100,000/QALY compared to the standard of care. However, for bladder, cervical, and triple-negative breast cancers (TNBCs), no economic evaluations met the affordability threshold of $100,000/QALY. Overall, the review highlights a certain degree of uncertainty about the cost-effectiveness of ICI. In particular, we found PD-L1 expression associated with ICI treatment to be a cost-effective strategy, particularly in NSCLC, urothelial, and renal cell carcinoma. The findings suggest the potential value of predictive biomarker testing, specifically with pembrolizumab in NSCLC, while indicating challenges in achieving cost-effectiveness for certain other solid tumours.
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050995
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Longitudinal Trajectory Modeling to Assess Adherence to Sacubitril/Valsartan among Patients with Heart Failure.

    Mucherino, Sara / Dima, Alexandra Lelia / Coscioni, Enrico / Vassallo, Maria Giovanna / Orlando, Valentina / Menditto, Enrica

    Pharmaceutics

    2023  Band 15, Heft 11

    Abstract: Medication adherence in chronic conditions is a long-term process. Modeling longitudinal trajectories using routinely collected prescription data is a promising method for describing adherence patterns and identifying at-risk groups. The study aimed to ... ...

    Abstract Medication adherence in chronic conditions is a long-term process. Modeling longitudinal trajectories using routinely collected prescription data is a promising method for describing adherence patterns and identifying at-risk groups. The study aimed to characterize distinct long-term sacubitril/valsartan adherence trajectories and factors associated with them in patients with heart failure (HF). Subjects with incident HF starting sac/val in 2017-2018 were identified from the Campania Regional Database for Medication Consumption. We estimated patients' continuous medication availability (CMA9; R package AdhereR) during a 12-month period. We selected groups with similar CMA9 trajectories (Calinski-Harabasz criterion; R package kml). We performed multinomial regression analysis, assessing the relationship between demographic and clinical factors and adherence trajectory groups. The cohort included 4455 subjects, 70% male. Group-based trajectory modeling identified four distinct adherence trajectories: high adherence (42.6% of subjects; CMA mean 0.91 ± 0.08), partial drop-off (19.6%; CMA 0.63 ± 0.13), moderate adherence (19.3%; CMA 0.54 ± 0.11), and low adherence (18.4%; CMA 0.17 ± 0.12). Polypharmacy was associated with partial drop-off adherence (OR 1.194, 95%CI 1.175-1.214), while the occurrence of ≥1 HF hospitalization (OR 1.165, 95%CI 1.151-1.179) or other hospitalizations (OR 1.481, 95%CI 1.459-1.503) were associated with low adherence. This study found that tailoring patient education, providing support, and ongoing monitoring can boost adherence within different groups, potentially improving health outcomes.
    Sprache Englisch
    Erscheinungsdatum 2023-11-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15112568
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Prescription Appropriateness of Drugs for Peptic Ulcer and Gastro-Esophageal Reflux Disease: Baseline Assessment in the LAPTOP-PPI Cluster Randomized Trial.

    Ardoino, Ilaria / Casula, Manuela / Molari, Giulia / Mucherino, Sara / Orlando, Valentina / Menditto, Enrica / Franchi, Carlotta

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 803809

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2022-03-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.803809
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Drug Utilization and Measurement of Medication Adherence: A Real World Study of Psoriasis in Italy.

    Mucherino, Sara / Rafaniello, Concetta / Serino, Marianna / Zinzi, Alessia / Trama, Ugo / Capuano, Annalisa / Menditto, Enrica / Orlando, Valentina

    Pharmaceutics

    2023  Band 15, Heft 12

    Abstract: Exceptional advances have been made with systemic treatment for psoriasis (PSO). However, that disease still represents a heavy burden in terms of impact on healthcare systems worldwide. This study comprehensively assesses medication adherence in a real ... ...

    Abstract Exceptional advances have been made with systemic treatment for psoriasis (PSO). However, that disease still represents a heavy burden in terms of impact on healthcare systems worldwide. This study comprehensively assesses medication adherence in a real world setting in Italy across all phases-initiation, implementation, and persistence-of PSO therapies. By distinguishing between switches and swaps, it provides unique insights into the patient's own approach to prescribed therapy as well as clinical decision-making processes, enhancing our understanding of medication adherence and discontinuation in a real world daily setting. The study's refined methodology for assessing persistence, considering variations in refill gaps and complex dosing regimens, shows that anti-interleukin (IL) therapies are associated with longer periods of adherence compared with other available therapeutic strategies. Among the selected drugs, ixekizumab and secukinumab were the ones with higher rate of treatment adherence at the expense of anti-TNF-α and anti-PDE4 agents. Notably, patients who opt for swaps are approximately 2.8 times more likely to discontinue their PSO therapy within one year. These findings carry practical implications for optimizing medication adherence, including tailored patient counseling, monitoring, and therapeutic adjustments, highlighting the need for a comprehensive and patient-centered approach to managing these conditions.
    Sprache Englisch
    Erscheinungsdatum 2023-11-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122647
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Pre-Exposure Prophylaxis with Hydroxychloroquine Does Not Prevent COVID-19 nor Virus Related Venous Thromboembolism

    Perrella, Alessandro / Orlando, Valentina / Trama, Ugo / Bernardi, Francesca F. / Menditto, Enrica / Coscioni, Enrico

    Viruses. 2021 Oct. 13, v. 13, no. 10

    2021  

    Abstract: Different and several public health strategies have been planned to reduce transmission of pandemic due to SARS-CoV-2 since it started. None drugs have been confirmed as able to prevent viral transmission. Hydroxychloroquine with its immunomodulatory ... ...

    Abstract Different and several public health strategies have been planned to reduce transmission of pandemic due to SARS-CoV-2 since it started. None drugs have been confirmed as able to prevent viral transmission. Hydroxychloroquine with its immunomodulatory properties has been proposed as potential anti-viral drug in particular for prevention once viral exposure has been happen or in first phases of infection. Furthermore, in several immunological systemic disease hydroxychloroquine was able to reduce the number of thrombotic complications. So, because COVID-19 was associated to immunological imbalance and to thrombotic complications, we retrospectively analyzed the rate of infection in those patients being under treatment with this drug during COVID-19 epidemic outbreak from 8 March until 28 April in particular comparing those with pre-exposure to this treatment and those that were not taking this medication before SARS-CoV-2 viral infections.
    Schlagwörter COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antiviral agents ; disease prevention ; drug therapy ; pandemic ; public health ; virus transmission ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2021-1013
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13102052
    Datenquelle NAL Katalog (AGRICOLA)

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