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Article ; Online: Co-circulation of vaccinia and monkeypox viruses in rural areas of Brazil: Importance of differential molecular diagnosis.

Luques, Matheus Nobrega / Oliveira, Régis Linhares / Hir, Samuel / Nunes, Desiree Dos Santos / Higa, Luiza M / Mendonça, Ana Flávia / Pereira, Luiz Augusto / Sousa, Fabrício / Castiñeiras, Terezinha Marta Pereira Pinto / Tanuri, Amilcar / Damaso, Clarissa R

Travel medicine and infectious disease

2023 Volume 53, Page(s) 102578

MeSH term(s)	Humans ; Vaccinia/diagnosis ; Vaccinia/epidemiology ; Monkeypox virus/genetics ; Brazil/epidemiology ; Vaccinia virus/genetics ; Diagnosis, Differential
Language	English
Publishing date	2023-04-22
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2023.102578
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Article ; Online: A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil.

Giovanetti, Marta / Pereira, Luiz Augusto / Adelino, Talita Émile Ribeiro / Fonseca, Vagner / Xavier, Joilson / de Araújo Fabri, Allison / Slavov, Svetoslav Nanev / da Silva Lemos, Poliana / de Almeida Marques, William / Kashima, Simone / Lourenço, José / de Oliveira, Tulio / Campelo de Albuquerque, Carlos Frederico / Freitas, Carla / Peterka, Cassio Roberto Leonel / da Cunha, Rivaldo Venancio / Mendonça, Ana Flávia / Lemes da Silva, Vinícius / Alcantara, Luiz Carlos Junior

Microbiology spectrum

2022 Volume 10, Issue 2, Page(s) e0015522

Abstract: Since the introduction of the Zika virus (ZIKV) into Brazil in 2015, its transmission dynamics have been intensively studied in many parts of the country, although much is still unknown about its circulation in the midwestern states. Here, using nanopore ...

Abstract	Since the introduction of the Zika virus (ZIKV) into Brazil in 2015, its transmission dynamics have been intensively studied in many parts of the country, although much is still unknown about its circulation in the midwestern states. Here, using nanopore technology, we obtained 23 novel partial and near-complete ZIKV genomes from the state of Goiás, located in the Midwest of Brazil. Genomic, phylogenetic, and epidemiological approaches were used to retrospectively explore the spatiotemporal evolution of the ZIKV-Asian genotype in this region. As a likely consequence of a gradual accumulation of herd immunity, epidemiological data revealed a decline in the number of reported cases over 2018 to 2021. Phylogenetic reconstructions revealed that multiple independent introductions of the Asian lineage have occurred in Goiás over time and revealed a complex transmission dynamic between epidemic seasons. Together, our results highlight the utility of genomic, epidemiological, and evolutionary methods to understand mosquito-borne epidemics.
MeSH term(s)	Animals ; Brazil/epidemiology ; Phylogeny ; Retrospective Studies ; Zika Virus/genetics ; Zika Virus Infection/epidemiology
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00155-22
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Article ; Online: Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype, Brazil.

Giovanetti, Marta / Pereira, Luiz Augusto / Santiago, Gilberto A / Fonseca, Vagner / Mendoza, Maria Paquita García / de Oliveira, Carla / de Moraes, Laise / Xavier, Joilson / Tosta, Stephane / Fristch, Hegger / de Castro Barbosa, Emerson / Rodrigues, Evandra Strazza / Figueroa-Romero, Dana / Padilla-Rojas, Carlos / Cáceres-Rey, Omar / Mendonça, Ana Flávia / de Bruycker Nogueira, Fernanda / Venancio da Cunha, Rivaldo / de Filippis, Ana Maria Bispo /

Freitas, Carla / Peterka, Cassio Roberto Leonel / de Albuquerque, Carlos Frederico Campelo / Franco, Leticia / Méndez Rico, Jairo Andrés / Muñoz-Jordán, Jorge L / Lemes da Silva, Vinícius / Alcantara, Luiz Carlos Junior

Emerging infectious diseases

2022 Volume 28, Issue 8, Page(s) 1725–1727

Abstract: We used nanopore sequencing and phylogenetic analyses to identify a cosmopolitan genotype of dengue virus serotype 2 that was isolated from a 56-year-old male patient from the state of Goiás in Brazil. The emergence of a cosmopolitan genotype in Brazil ... ...

Abstract	We used nanopore sequencing and phylogenetic analyses to identify a cosmopolitan genotype of dengue virus serotype 2 that was isolated from a 56-year-old male patient from the state of Goiás in Brazil. The emergence of a cosmopolitan genotype in Brazil will require risk assessment and surveillance to reduce epidemic potential.
MeSH term(s)	Brazil/epidemiology ; Dengue/epidemiology ; Dengue Virus ; Genotype ; Humans ; Male ; Middle Aged ; Phylogeny ; Serogroup
Language	English
Publishing date	2022-07-25
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2808.220550
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Article ; Online: Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil.

Silva, Thaísa C / Treméa, Carolina M / Zara, Ana Laura S A / Mendonça, Ana Flávia / Godoy, Cássia S M / Costa, Carolina R / Souza, Lúcia K H / Silva, Maria R R

Mycoses

2017 Volume 60, Issue 1, Page(s) 59–65

Abstract: Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross-sectional and retrospective study with a secondary data analysis of medical records from 2000 to ... ...

Abstract	Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross-sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory-confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non-survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non-survivor patients (<.05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.
MeSH term(s)	Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/mortality ; Adolescent ; Adult ; Aged ; Antifungal Agents/therapeutic use ; Brazil/epidemiology ; CD4 Lymphocyte Count ; Child ; Cohort Studies ; Cross-Sectional Studies ; Female ; Hemoglobins/analysis ; Histoplasmosis/drug therapy ; Histoplasmosis/epidemiology ; Histoplasmosis/mortality ; Humans ; Male ; Medical Records ; Middle Aged ; Opportunistic Infections/drug therapy ; Opportunistic Infections/epidemiology ; Opportunistic Infections/mortality ; Platelet Count ; Prevalence ; Retrospective Studies ; Tertiary Care Centers/statistics & numerical data ; Urea/analysis ; Young Adult
Chemical Substances	Antifungal Agents ; Hemoglobins ; Urea (8W8T17847W)
Language	English
Publishing date	2017-01
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.12551
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Article: Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil.

Xavier, Joilson / Alcantara, Luiz / Fonseca, Vagner / Lima, Mauricio / Castro, Emerson / Fritsch, Hegger / Oliveira, Carla / Guimarães, Natalia / Adelino, Talita / Evaristo, Mariane / Rodrigues, Evandra S / Santos, Elaine Vieira / de La-Roque, Debora / de Moraes, Laise / Tosta, Stephane / Neto, Adelino / Rosewell, Alexander / Mendonça, Ana Flavia / Leite, Anderson /

Vasconcelos, Andreza / Silva de Mello, Arabela L / Vasconcelos, Bergson / Montalbano, Camila A / Zanluca, Camila / Freitas, Carla / de Albuquerque, Carlos F C / Duarte Dos Santos, Claudia Nunes / Santos, Cleiton S / Dos Santos, Cliomar Alves / Maymone Gonçalves, Crhistinne C / Teixeira, Dalane / Neto, Daniel F L / Cabral, Diego / de Oliveira, Elaine C / Noia Maciel, Ethel L / Pereira, Felicidade Mota / Iani, Felipe / de Carvalho, Fernanda P / Andrade, Gabriela / Bezerra, Gabriela / de Castro Lichs, Gislene G / Pereira, Glauco Carvalho / Barroso, Haline / Ferreira Franz, Helena Cristina / Ferreira, Hivylla / Gomes, Iago / Riediger, Irina N / Rodrigues, Isabela / de Siqueira, Isadora C / Silva, Jacilane / Rico, Jairo Mendez / Lima, Jaqueline / Abrantes, Jayra / do Nascimento, Jean Phellipe M / Wasserheit, Judith N / Pastor, Julia / de Magalhães, Jurandy J F / Luz, Kleber Giovanni / Lima Neto, Lidio G / Frutuoso, Livia C V / da Silva, Luana Barbosa / Sena, Ludmila / de Sousa, Luis Arthur F / Pereira, Luiz Augusto / Demarchi, Luiz / Câmara, Magaly C B / Astete, Marcela G / Almiron, Maria / Lima, Maricelia / Umaki Zardin, Marina C S / Presibella, Mayra M / Falcão, Melissa B / Gale, Michael / Freire, Naishe / Marques, Nelson / de Moura, Noely F O / Almeida Da Silva, Pedro E / Rabinowitz, Peter / da Cunha, Rivaldo V / Trinta, Karen S / do Carmo Said, Rodrigo F / Kato, Rodrigo / Stabeli, Rodrigo / de Jesus, Ronaldo / Santos, Roselene Hans / Haddad, Simone K / Slavov, Svetoslav N / Andrade, Tamires / Rocha, Themis / Carneiro, Thiago / Nardy, Vanessa / da Silva, Vinicius / Carvalho, Walterlene G / Van Voorhis, Wesley C / Araujo, Wildo N / de Filippis, Ana M B / Giovanetti, Marta

medRxiv : the preprint server for health sciences

2023

Abstract: The emergence and reemergence of mosquito-borne diseases in Brazil such as Yellow Fever, Zika, Chikungunya, and Dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus (CHIKV) ... ...

Abstract	The emergence and reemergence of mosquito-borne diseases in Brazil such as Yellow Fever, Zika, Chikungunya, and Dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus (CHIKV) across the country since its first detection in 2014 in Northeast Brazil. Faced with this scenario, on-site training activities in genomic surveillance carried out in partnership with the National Network of Public Health Laboratories have led to the generation of 422 CHIKV genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These new genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersion dynamics of the CHIKV East-Central-South-African (ECSA) lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C>T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving CHIKV ECSA lineage genetic diversity in Brazil.
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.28.23287733
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Article ; Online: Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.

Xavier, Joilson / Alcantara, Luiz Carlos Junior / Fonseca, Vagner / Lima, Mauricio / Castro, Emerson / Fritsch, Hegger / Oliveira, Carla / Guimarães, Natalia / Adelino, Talita / Evaristo, Mariane / Rodrigues, Evandra S / Santos, Elaine Vieira / de La-Roque, Debora / de Moraes, Laise / Tosta, Stephane / Neto, Adelino / Rosewell, Alexander / Mendonça, Ana Flavia / Leite, Anderson /

Vasconcelos, Andreza / Silva de Mello, Arabela L / Vasconcelos, Bergson / Montalbano, Camila A / Zanluca, Camila / Freitas, Carla / de Albuquerque, Carlos F C / Duarte Dos Santos, Claudia Nunes / Santos, Cleiton S / Dos Santos, Cliomar Alves / Gonçalves, Crhistinne C Maymone / Teixeira, Dalane / Neto, Daniel F L / Cabral, Diego / de Oliveira, Elaine C / Noia Maciel, Ethel L / Pereira, Felicidade Mota / Iani, Felipe / de Carvalho, Fernanda P / Andrade, Gabriela / Bezerra, Gabriela / de Castro Lichs, Gislene G / Pereira, Glauco Carvalho / Barroso, Haline / Franz, Helena Cristina Ferreira / Ferreira, Hivylla / Gomes, Iago / Riediger, Irina N / Rodrigues, Isabela / de Siqueira, Isadora C / Silva, Jacilane / Rico, Jairo Mendez / Lima, Jaqueline / Abrantes, Jayra / do Nascimento, Jean Phellipe M / Wasserheit, Judith N / Pastor, Julia / de Magalhães, Jurandy J F / Luz, Kleber Giovanni / Lima Neto, Lidio G / Frutuoso, Livia C V / da Silva, Luana Barbosa / Sena, Ludmila / de Sousa, Luis Arthur F / Pereira, Luiz Augusto / Demarchi, Luiz / Câmara, Magaly C B / Astete, Marcela G / Almiron, Maria / Lima, Maricelia / Umaki Zardin, Marina C S / Presibella, Mayra M / Falcão, Melissa B / Gale, Michael / Freire, Naishe / Marques, Nelson / de Moura, Noely F O / Almeida Da Silva, Pedro E / Rabinowitz, Peter / da Cunha, Rivaldo V / Trinta, Karen S / do Carmo Said, Rodrigo F / Kato, Rodrigo / Stabeli, Rodrigo / de Jesus, Ronaldo / Hans Santos, Roselene / Kashima, Simone / Slavov, Svetoslav N / Andrade, Tamires / Rocha, Themis / Carneiro, Thiago / Nardy, Vanessa / da Silva, Vinicius / Carvalho, Walterlene G / Van Voorhis, Wesley C / Araujo, Wildo N / de Filippis, Ana M B / Giovanetti, Marta

Nature communications

2023 Volume 14, Issue 1, Page(s) 4413

Abstract: The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the ...

Abstract	The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil.
MeSH term(s)	Animals ; Humans ; Chikungunya virus/genetics ; Brazil/epidemiology ; Chikungunya Fever/epidemiology ; Yellow Fever ; Zika Virus ; Nucleotides ; Zika Virus Infection
Chemical Substances	Nucleotides
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40099-y
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Article ; Online: Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil.

Giovanetti, Marta / Pinotti, Francesco / Zanluca, Camila / Fonseca, Vagner / Nakase, Taishi / Koishi, Andrea C / Tscha, Marcel / Soares, Guilherme / Dorl, Gisiane Gruber / Marques, Antônio Ernesto M L / Sousa, Renato / Adelino, Talita Emile Ribeiro / Xavier, Joilson / de Oliveira, Carla / Patroca, Sandro / Guimaraes, Natalia Rocha / Fritsch, Hegger / Mares-Guia, Maria Angélica / Levy, Flavia /

Passos, Pedro Henrique / da Silva, Vinicius Leme / Pereira, Luiz Augusto / Mendonça, Ana Flávia / de Macêdo, Isabel Luana / Ribeiro de Sousa, Davi Emanuel / Rodrigues de Toledo Costa, Gabriela / Botelho de Castro, Marcio / de Souza Andrade, Miguel / de Abreu, Filipe Vieira Santos / Campos, Fabrício Souza / Iani, Felipe Campos de Melo / Pereira, Maira Alves / Cavalcante, Karina Ribeiro Leite Jardim / de Freitas, Andre Ricardo Ribas / Campelo de Albuquerque, Carlos Frederico / Macário, Eduardo Marques / Dos Anjos, Marlei Pickler Debiasi / Ramos, Rosane Campanher / Campos, Aline Alves Scarpellini / Pinter, Adriano / Chame, Marcia / Abdalla, Livia / Riediger, Irina Nastassja / Ribeiro, Sérvio Pontes / Bento, Ana I / de Oliveira, Tulio / Freitas, Carla / Oliveira de Moura, Noely Fabiana / Fabri, Allison / Dos Santos Rodrigues, Cintia Damasceno / Dos Santos, Carolina Cardoso / Barreto de Almeida, Marco Antonio / Dos Santos, Edmilson / Cardoso, Jader / Augusto, Douglas Adriano / Krempser, Eduardo / Mucci, Luís Filipe / Gatti, Renata Rispoli / Cardoso, Sabrina Fernandes / Fuck, João Augusto Brancher / Lopes, Maria Goretti David / Belmonte, Ivana Lucia / Mayoral Pedroso da Silva, Gabriela / Soares, Maiane Regina Ferreira / de Castilhos, Marilia de Melo Santos / de Souza E Silva, Joseana Cardoso / Bisetto Junior, Alceu / Pouzato, Emanuelle Gemin / Tanabe, Laurina Setsuko / Arita, Daniele Akemi / Matsuo, Ricardo / Dos Santos Raymundo, Josiane / Silva, Paula Cristina Linder / Santana Araújo Ferreira Silva, Ana / Samila, Sandra / Carvalho, Glauco / Stabeli, Rodrigo / Navegantes, Wildo / Moreira, Luciano Andrade / Ferreira, Alvaro Gil A / Pinheiro, Guilherme Garcia / Nunes, Bruno Tardelli Diniz / de Almeida Medeiros, Daniele Barbosa / Cruz, Ana Cecília Ribeiro / Venâncio da Cunha, Rivaldo / Van Voorhis, Wes / Bispo de Filippis, Ana Maria / Almiron, Maria / Holmes, Edward C / Ramos, Daniel Garkauskas / Romano, Alessandro / Lourenço, José / Alcantara, Luiz Carlos Junior / Duarte Dos Santos, Claudia Nunes

Science advances

2023 Volume 9, Issue 35, Page(s) eadg9204

Abstract: Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, ... ...

Abstract	Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated
MeSH term(s)	Humans ; Yellow fever virus/genetics ; Phylogeny ; Brazil/epidemiology ; Yellow Fever/epidemiology ; Disease Outbreaks ; Genomics
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adg9204
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Article ; Online: Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil.

Adelino, Talita Émile Ribeiro / Giovanetti, Marta / Fonseca, Vagner / Xavier, Joilson / de Abreu, Álvaro Salgado / do Nascimento, Valdinete Alves / Demarchi, Luiz Henrique Ferraz / Oliveira, Marluce Aparecida Assunção / da Silva, Vinícius Lemes / de Mello, Arabela Leal E Silva / Cunha, Gabriel Muricy / Santos, Roselene Hans / de Oliveira, Elaine Cristina / Júnior, Jorge Antônio Chamon / de Melo Iani, Felipe Campos / de Filippis, Ana Maria Bispo / de Abreu, André Luiz / de Jesus, Ronaldo / de Albuquerque, Carlos Frederico Campelo /

Rico, Jairo Mendez / do Carmo Said, Rodrigo Fabiano / Silva, Joscélio Aguiar / de Moura, Noely Fabiana Oliveira / Leite, Priscila / Frutuoso, Lívia Carla Vinhal / Haddad, Simone Kashima / Martínez, Alexander / Barreto, Fernanda Khouri / Vazquez, Cynthia Carolina / da Cunha, Rivaldo Venâncio / Araújo, Emerson Luiz Lima / de Oliveira Tosta, Stephane Fraga / de Araújo Fabri, Allison / Chalhoub, Flávia Löwen Levy / da Silva Lemos, Poliana / de Bruycker-Nogueira, Fernanda / de Castro Lichs, Gislene Garcia / Zardin, Marina Castilhos Souza Umaki / Segovia, Fátima María Cardozo / Gonçalves, Crhistinne Cavalheiro Maymone / Grillo, Zoraida Del Carmen Fernandez / Slavov, Svetoslav Nanev / Pereira, Luiz Augusto / Mendonça, Ana Flávia / Pereira, Felicidade Mota / de Magalhães, Jurandy Júnior Ferraz / Dos Santos Júnior, Agenor de Castro Moreira / de Lima, Maricélia Maia / Nogueira, Rita Maria Ribeiro / Góes-Neto, Aristóteles / de Carvalho Azevedo, Vasco Ariston / Ramalho, Dario Brock / Oliveira, Wanderson Kleber / Macario, Eduardo Marques / de Medeiros, Arnaldo Correia / Pimentel, Victor / Holmes, Edward C / de Oliveira, Tulio / Lourenço, José / Alcantara, Luiz Carlos Junior

Nature communications

2021 Volume 12, Issue 1, Page(s) 2296

Abstract: Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV ...

Abstract	Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases. Using both phylogenetic and epidemiological models we retrospectively reconstructed the recent transmission history of DENV1-2. Phylogenetic analysis revealed complex patterns of transmission, with both lineage co-circulation and replacement. We identified two lineages within the DENV2 BR-4 clade, for which we estimated the effective reproduction number and pattern of seasonality. Overall, the surveillance outputs and training initiative described here serve as a proof-of-concept for the utility of real-time portable sequencing for research and local capacity building in the genomic surveillance of emerging viruses.
MeSH term(s)	Brazil/epidemiology ; Dengue/epidemiology ; Dengue/prevention & control ; Dengue/transmission ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Epidemics/prevention & control ; Epidemiological Monitoring ; Feasibility Studies ; Genetic Variation ; Genome, Viral/genetics ; Humans ; Mobile Health Units ; Molecular Epidemiology ; Molecular Typing ; Phylogeny ; Proof of Concept Study ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Whole Genome Sequencing
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-04-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-22607-0
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Article ; Online: Co-circulation of vaccinia and monkeypox viruses in rural areas of Brazil: Importance of differential molecular diagnosis.

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Article ; Online: A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil.

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Article ; Online: Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype, Brazil.

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Article ; Online: Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil.

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Article: Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil.

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Article ; Online: Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.

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Article ; Online: Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil.

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Article ; Online: Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil.

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