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  1. Article ; Online: Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review.

    Menezes, Catarina Ester Gomes / Santos, Débora Lopes Dos / Nery, Erick Santos / Serpa, Evelin Duarte / Morais, Lécio Aragão Souza / Dutra, Lucas Santana / Portela Filho, Marcos Baruch / Goes, Julieta Sobreira

    Arquivos de neuro-psiquiatria

    2023  Volume 81, Issue 4, Page(s) 392–398

    Abstract: Background: Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some ... ...

    Title translation Everolimo como opção terapêutica na epilepsia refratária em crianças com esclerose tuberosa: uma revisão sistemática.
    Abstract Background: Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some evidence suggests that its use benefits the treatment of refractory epilepsy in these patients.
    Objective: To evaluate the efficacy of everolimus in controlling refractory epilepsy in children with TS.
    Methods: A literature review was conducted in the Pubmed, BVS, and Medline databases, using the descriptors
    Results: Our search screened 246 articles from electronic databases, 6 of which were chosen for review. Despite the methodological variations between the studies, most patients benefited from the use of everolimus to control refractory epilepsy, with response rates ranging from 28.6 to 100%. Adverse effects were present in all studies leading to dropouts of some patients; however, the majority were of low severity.
    Conclusion: The selected studies suggest a beneficial effect of everolimus in the treatment of refractory epilepsy in children with TS, despite the adverse effects observed. Further studies involving a larger sample in double-blind controlled clinical trials should be performed to provide more information and statistical credibility.
    MeSH term(s) Humans ; Child ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/etiology ; Everolimus/therapeutic use ; Prospective Studies ; Tuberous Sclerosis/complications ; Tuberous Sclerosis/drug therapy ; Combined Modality Therapy ; Drug-Related Side Effects and Adverse Reactions ; Randomized Controlled Trials as Topic
    Chemical Substances Everolimus (9HW64Q8G6G)
    Language English
    Publishing date 2023-03-02
    Publishing country Germany
    Document type Systematic Review ; Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0042-1758442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.239: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Geographical Inequalities in Access to Bellwether Procedures in Brazil.

    Faleiro, Matheus Daniel / Fernandez, Miguel Godeiro / Santos, Jéssica Moreira / Menezes, Catarina Ester Gomes / Lima, João Vitor Sabadine / Haddad, Júlia Oliveira Dabien / Viana, Sofia Wagemaker / Alonso, Nivaldo

    World journal of surgery

    2022  Volume 47, Issue 3, Page(s) 593–599

    Abstract: Background: Brazil is a middle-income country that aims to provide universal health coverage, but its surgical system's efficiency has rarely been analyzed. In an effort to strengthen surgical national systems, the Lancet Commission on Global Surgery ... ...

    Abstract Background: Brazil is a middle-income country that aims to provide universal health coverage, but its surgical system's efficiency has rarely been analyzed. In an effort to strengthen surgical national systems, the Lancet Commission on Global Surgery proposed bellwether procedures as quality indicators of surgical workforces. This study aims to evaluate regional inequalities in access to bellwether procedures and their associated mortality across the five Brazilian geographical regions.
    Methods: Using DATASUS, Brazil's national healthcare database, data were collected on the total amount of performed bellwether procedures-cesarean section, laparotomy, and open fracture management-and their associated mortality, by geographical region. We evaluated the years 2018-2020, both in emergent and elective conditions. Statistical analysis was performed by one-way ANOVA test and Tukey's multiple comparisons test.
    Results: During this period, DATASUS registered 2,687,179 cesarean sections, 1,036,841 laparotomies, and 648,961 open fracture treatments. The access and associated mortality related to these procedures were homogeneous between the regions in elective care. There were significant geographical inequalities in access and associated mortality in emergency care (p < 0.05, 95% CI) for all bellwether procedures. The Southeast, the most economically developed region of the country, was the region with the lowest amount of bellwether procedures per 100,000 inhabitants.
    Conclusion: Brazil's public surgical system is competent at promoting elective surgical care, but more effort is needed to fortify emergency care services. Public policies should encourage equity in the geographic allocation of the surgical workforce.
    MeSH term(s) Humans ; Female ; Pregnancy ; Fractures, Open/surgery ; Health Services Accessibility ; Brazil ; Cesarean Section ; Laparotomy
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06855-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review

    Menezes, Catarina Ester Gomes / Santos, Débora Lopes dos / Nery, Erick Santos / Serpa, Evelin Duarte / Morais, Lécio Aragão Souza / Dutra, Lucas Santana / Portela Filho, Marcos Baruch / Goes, Julieta Sobreira

    Arquivos de Neuro-Psiquiatria

    2023  Volume 81, Issue 04, Page(s) 392–398

    Abstract: Background: Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some ... ...

    Abstract Background: Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some evidence suggests that its use benefits the treatment of refractory epilepsy in these patients.
    Objective: To evaluate the efficacy of everolimus in controlling refractory epilepsy in children with TS.
    Methods: A literature review was conducted in the Pubmed, BVS, and Medline databases, using the descriptors Tuberous sclerosis Children Epilepsy, and Everolimus. Original clinical trials and prospective studies published in Portuguese or English in the last decade that evaluated the use of everolimus as an adjuvant therapy in the control of refractory epilepsy in pediatric patients with TS were included.
    Results: Our search screened 246 articles from electronic databases, 6 of which were chosen for review. Despite the methodological variations between the studies, most patients benefited from the use of everolimus to control refractory epilepsy, with response rates ranging from 28.6 to 100%. Adverse effects were present in all studies leading to dropouts of some patients; however, the majority were of low severity.
    Conclusion: The selected studies suggest a beneficial effect of everolimus in the treatment of refractory epilepsy in children with TS, despite the adverse effects observed. Further studies involving a larger sample in double-blind controlled clinical trials should be performed to provide more information and statistical credibility.
    Keywords Tuberous Sclerosis ; Epilepsy ; Everolimus ; TOR Serine-Threonine Kinases ; Child ; Esclerose Tuberosa ; Epilepsia ; Everolimo ; Serina-Treonina Quinases TOR ; Criança
    Language English
    Publishing date 2023-03-02
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0042-1758442
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.239: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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