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Article ; Online: Anisometropic amblyopia: A review of functional and structural changes and treatment.

Meng, Can / Zhang, Yan / Wang, Shurong

2022 Volume 33, Issue 4, Page(s) 1529–1535

Abstract: Amblyopia is the decreased best-corrected visual acuity (BCVA) in one or both eyes caused by the abnormal processing of visual input during development. One common cause of amblyopia is anisometropia, which has attracted widespread attention. Many ... ...

Abstract	Amblyopia is the decreased best-corrected visual acuity (BCVA) in one or both eyes caused by the abnormal processing of visual input during development. One common cause of amblyopia is anisometropia, which has attracted widespread attention. Many structural changes occur in the primary and extrastriate visual areas of the cerebral cortex, as well as in the eyes, in patients with anisometropic amblyopia. Understanding these mechanisms has provided a favorable theoretical basis for treating anisometropic amblyopia. This article reviews the functional and anatomical changes and progress toward the treatment of anisometropic amblyopia.
MeSH term(s)	Humans ; Amblyopia/therapy ; Visual Acuity ; Eye ; Anisometropia/complications ; Anisometropia/therapy
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221143164
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Article ; Online: Changes in accommodation and convergence function after refractive surgery in myopic patients.

Meng, Can / Zhang, Yan / Wang, Shurong

European journal of ophthalmology

2022 , Page(s) 11206721221128993

Abstract: In recent years, with the gradual maturation of myopia correction surgery, the changes in binocular visual function after surgery have attracted widespread attention. The accommodation of facility, the amplitude of accommodation, relative accommodation, ... ...

Abstract	In recent years, with the gradual maturation of myopia correction surgery, the changes in binocular visual function after surgery have attracted widespread attention. The accommodation of facility, the amplitude of accommodation, relative accommodation, and accommodation convergence/accommodation assembly are essential parameters for assessing binocular visual function. The changes in these parameters are significant for guiding patients in the design of the preoperative surgical approach and alleviating postoperative visual fatigue. This paper aims to guide the preoperative assessment, design, and postoperative visual training of refractive surgery in myopic patients from the perspective of changes in binocular visual function before and after myopia and surgery, which can improve accommodation and convergence function in patients after refractive surgery.
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221128993
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Article: Socio- and Clinical Characteristics in Relation to Mammography Screening Compliance.

Lai, Sue M / Meng, Can

Journal of registry management

2019 Volume 45, Issue 1, Page(s) 136–142

Abstract: Use of mammography screening in the general population has been credited with improvements in the diagnosis of breast cancer. Yet, the proportion of women with invasive breast cancers who are diagnosed at later, distant stages has not been declining. Two ...

Abstract	Use of mammography screening in the general population has been credited with improvements in the diagnosis of breast cancer. Yet, the proportion of women with invasive breast cancers who are diagnosed at later, distant stages has not been declining. Two statewide data sources were linked to compare mammography screening compliance of female Medicare beneficiaries and stage of breast cancer at diagnosis at a population level. Breast cancer diagnoses were ascertained from the Kansas Cancer Registry. Mammogram use was identified using Medicare claims files and were classified as annual, biennial, less than biennial, or never use. The study included women aged ≥69 years at the time of their primary invasive breast cancer diagnosis between 2011 and 2012 who were continuously enrolled in Medicare parts A and B for at least 4 years prior to diagnosis. This approach enabled demographic comparisons to be made at the population level, providing novel and important insights about how sociocharacteristics of residency affect mammography compliance in an invasive breast cancer population. Of the 915 female Kansans who met the eligibility criteria, 73% (672) had received at least 1 mammography screening during the 4 years prior to their primary invasive breast cancer. The percentages of these women who received annual, biennial, less than biennial, and no screening were 25.8%, 27.5%, 20.1%, and 26.6%, respectively. Women aged ≥74 years, those living in counties with a median income below $42,000, and those living in counties with a higher percentage of individuals without a college degree at the time of diagnosis had higher odds of not having had an annual screening. Linkage of data from the statewide cancer registry with Medicare claims data on mammogram screening may help to identify subgroups of older women to be targeted for promoting breast cancer screening.
MeSH term(s)	Aged ; Breast Neoplasms ; Early Detection of Cancer ; Female ; Humans ; Mammography ; Medicare ; Patient Compliance ; Registries ; Socioeconomic Factors ; United States
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article
ISSN	1945-6123
ISSN	1945-6123
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Article: [Nutritional components of five main products of freshwater shrimp in Anhui Province].

Cui, Jie / Meng, Can / Liu, Bolin / Li, Weidong

Wei sheng yan jiu = Journal of hygiene research

2021 Volume 49, Issue 6, Page(s) 962–968

Abstract: Objective: To analyze and evaluate the nutritional composition of five main products of freshwater shrimp including crawfish, river prawn, macrobrachium, freshwater shrimp, exopalaemon modestus in Anhui Province.: Methods: Conventional and ... ...

Abstract	Objective: To analyze and evaluate the nutritional composition of five main products of freshwater shrimp including crawfish, river prawn, macrobrachium, freshwater shrimp, exopalaemon modestus in Anhui Province. Methods: Conventional and biochemical analytical method were used to detect the moisture, ash, crude protein, crude fat, amino acid, fatty acid, minerals and vitamin. Results: The contents of crude protein, crude fat, ash of the five freshwater shrimp were 13. 9-20. 8 g/100 g edible, 0. 6-2. 2 g/100 g edible, 1. 5-4. 1 g/100 g edible, respectively. A total of 18 amino acids were detected, the content of which were 11600-18600 mg/100 g edible. The amount of nine essential amino acid was measured to be 5336-9342 mg/100 g edible. The main restrictive amino acids in the five kinds of shrimps were methionine and cysteine, threonine and valine. The essential amino acid indexes in five kinds of shrimps(EAAI) were 39. 62 and 31. 81, 28. 65, 44. 85, and 33. 48, respectively. Fourteen types of fatty acid were detected. The total content of fatty acid was 287-1851 mg/100 g edible. The monounsaturated fatty acid(MUFA) and the polyunsaturated fatty acid(PUFA) were 12-234 mg/100 g edible, 164-377 mg/100 g edible, respectively. Nine minerals were detected which including five microelements and four microelements. The content of calcium in river prawn, macrobrachium and exopalaemon modestus was higher than that in crawfish and freshwater shrimp. The content of phosphorus, kalium, sodium, magnesium in five freshwater shrimp were 221-296 mg/100 g edible, 196-278 mg/100 g edible, 120. 7-202. 7 mg/100 g edible, 37-95 mg/100 g edible, respectively. The content of iron, manganese, cuprum in crawfish were higher than the others. The content of zinc in river prawn and exopalaemon modestus was high. Moreover, the vitamin B_2 and E were also detected in five freshwater shrimp. The content of vitamin B_2 and E were 0. 02-0. 07 mg/100 g edible and 1. 61-3. 30 mg/100 g edible. Conclusion: Five main products of freshwater shrimp in Anhui belong to super nutritional value food which contained high protein, variety of amino acid, low fat, a certain amount of vitamin B_2 and E, rich in minerals.
MeSH term(s)	Fatty Acids/analysis ; Fresh Water ; Minerals/analysis ; Nutritive Value ; Seafood/analysis
Chemical Substances	Fatty Acids ; Minerals
Language	Chinese
Publishing date	2021-01-07
Publishing country	China
Document type	Journal Article
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
DOI	10.19813/j.cnki.weishengyanjiu.2020.06.016
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Article: Development and validation of a novel survival model for acute myeloid leukemia based on autophagy-related genes.

Huang, Li / Lin, Lier / Fu, Xiangjun / Meng, Can

PeerJ

2021 Volume 9, Page(s) e11968

Abstract: Background: Acute myeloid leukemia (AML) is one of the most common blood cancers, and is characterized by impaired hematopoietic function and bone marrow (BM) failure. Under normal circumstances, autophagy may suppress tumorigenesis, however under the ... ...

Abstract	Background: Acute myeloid leukemia (AML) is one of the most common blood cancers, and is characterized by impaired hematopoietic function and bone marrow (BM) failure. Under normal circumstances, autophagy may suppress tumorigenesis, however under the stressful conditions of late stage tumor growth autophagy actually protects tumor cells, so inhibiting autophagy in these cases also inhibits tumor growth and promotes tumor cell death. Methods: AML gene expression profile data and corresponding clinical data were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, from which prognostic-related genes were screened to construct a risk score model through LASSO and univariate and multivariate Cox analyses. Then the model was verified in the TCGA cohort and GEO cohorts. In addition, we also analyzed the relationship between autophagy genes and immune infiltrating cells and therapeutic drugs. Results: We built a model containing 10 autophagy-related genes to predict the survival of AML patients by dividing them into high- or low-risk subgroups. The high-risk subgroup was prone to a poorer prognosis in both the training TCGA-LAML cohort and the validation GSE37642 cohort. Univariate and multivariate Cox analysis revealed that the risk score of the autophagy model can be used as an independent prognostic factor. The high-risk subgroup had not only higher fractions of CD4 naïve T cell, NK cell activated, and resting mast cells but also higher expression of immune checkpoint genes Conclusion: The risk score model based on 10 autophagy-related genes can serve as an effective prognostic predictor for AML patients and may guide for patient stratification for immunotherapies and drugs.
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.11968
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Article ; Online: RAB27B inhibits proliferation and promotes apoptosis of leukemic cells via 3-Hydroxy butyrate dehydrogenase 2 (BDH2).

Meng, Can / Huang, Li / Fu, Xiangjun / Wu, Bin / Lin, Lie

Bioengineered

2022 Volume 13, Issue 3, Page(s) 5103–5112

Abstract: RAB27B is a member of Ras-like small GTPases that plays a role in endocytosis, exocytosis, and vesicle trafficking. We made an attempt to study the impacts of RAB27B on the proliferation and apoptosis of acute myeloid leukemia (AML) cells. The silencing ... ...

Abstract	RAB27B is a member of Ras-like small GTPases that plays a role in endocytosis, exocytosis, and vesicle trafficking. We made an attempt to study the impacts of RAB27B on the proliferation and apoptosis of acute myeloid leukemia (AML) cells. The silencing of RAB27B was induced by siRNA for the detection of proliferation, cell cycle, and apoptosis, respectively by Cell Counting Kit-8 (CCK8), flow cytometry, and TUNEL. Related markers were also evaluated by Western blot analysis. The interaction between RAB27B and BDH2 was predicted by bioinformatics analysis and determined by immunoprecipitation. The gain of function of BDH2 was also detected by these functional assays. RAB27B exhibited high levels in AML cells, and RAB27B silencing led to reduced proliferation, increased cell cycle arrest and apoptosis levels. Then, the interaction between RAB27B and BDH2 was confirmed. Moreover, the effects of RAB27B inhibition on the proliferation, cell cycle arrest, and cell apoptosis were abolished after BDH2 overexpression. RAB27B inhibits proliferation and promotes apoptosis of leukemic cells by interacting with BDH2. Targeting RAB27B might be an effective method for the treatment of AML.
MeSH term(s)	Apoptosis/genetics ; Butyrates ; Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Hydroxybutyrate Dehydrogenase/genetics ; Hydroxybutyrate Dehydrogenase/metabolism ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Oxidoreductases/metabolism ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
Chemical Substances	Butyrates ; Oxidoreductases (EC 1.-) ; BDH2 protein, human (EC 1.1.1.30) ; Hydroxybutyrate Dehydrogenase (EC 1.1.1.30) ; Rab27B protein, human (EC 3.6.1.-.) ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2022.2036903
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Article ; Online: Design and analysis of partially randomized preference trials with propensity score stratification.

Wang, Yumin / Li, Fan / Blaha, Ondrej / Meng, Can / Esserman, Denise

Statistical methods in medical research

2022 Volume 31, Issue 8, Page(s) 1515–1537

Abstract: While the two-stage randomized design allows us to unbiasedly evaluate the impact of patients' treatment preference on the outcome of interest, it may not always be practical to implement in clinical practice; patients with a strong preference may not be ...

Abstract	While the two-stage randomized design allows us to unbiasedly evaluate the impact of patients' treatment preference on the outcome of interest, it may not always be practical to implement in clinical practice; patients with a strong preference may not be willing to be randomized. The more pragmatic, partially randomized preference design (PRPD) allows patients who are unwilling to be randomized, but willing to state their preference, to receive their preferred treatment in lieu of the first-stage randomization in the two-stage design, at the cost of potentially introducing bias in estimating the effects of interest. In this article, we consider the application of propensity score stratification (PSS) in a PRPD to recreate a conditional first-stage randomization based on observed covariates, enabling the estimation and inference of the overall treatment, selection and preference effects with minimum bias. We additionally derive a set of closed-form sample size formulas for detecting all three effects of interest in a PSS-PRPD. Simulation studies demonstrate the bias reduction properties of the PSS-PRPD, and validate the accuracy of the proposed sample size formulas. Our results show that 5 to 10 propensity score strata may be needed to correct for biases in effect estimates, and the exact number of strata needed to achieve the best match between the empirical power and formula prediction may depend on the degree of effect heterogeneity. Finally, we demonstrate our proposed formulas by estimating the required sample sizes to detect treatment, selection and preference effects in the context of the Harapan Study.
MeSH term(s)	Bias ; Computer Simulation ; Humans ; Patient Preference ; Propensity Score ; Randomized Controlled Trials as Topic ; Research Design ; Sample Size
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/09622802221095673
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Article ; Online: ORTH.Ord: An R package for analyzing correlated ordinal outcomes using alternating logistic regressions with orthogonalized residuals.

Meng, Can / Ryan, Mary / Rathouz, Paul J / Turner, Elizabeth L / Preisser, John S / Li, Fan

Computer methods and programs in biomedicine

2023 Volume 237, Page(s) 107567

Abstract: Background and objectives: Marginal models with generalized estimating equations (GEE) are usually recommended for analyzing correlated ordinal outcomes which are commonly seen in a longitudinal study or clustered randomized trial (CRT). Within-cluster ... ...

Abstract	Background and objectives: Marginal models with generalized estimating equations (GEE) are usually recommended for analyzing correlated ordinal outcomes which are commonly seen in a longitudinal study or clustered randomized trial (CRT). Within-cluster association is often of interest in longitudinal studies or CRTs, and can be estimated with paired estimating equations. However, the estimators for within-cluster association parameters and variances may be subject to finite-sample biases when the number of clusters is small. The objective of this article is to introduce a newly developed R package ORTH.Ord for analyzing correlated ordinal outcomes using GEE models with finite-sample bias corrections. Methods: The R package ORTH.Ord implements a modified version of alternating logistic regressions with estimation based on orthogonalized residuals (ORTH), which use paired estimating equations to jointly estimate parameters in marginal mean and association models. The within-cluster association between ordinal responses is modeled by global pairwise odds ratios (POR). The R package also provides a finite-sample bias correction to POR parameter estimates based on matrix multiplicative adjusted orthogonalized residuals (MMORTH) for correcting estimating equations, and bias-corrected sandwich estimators with different options for covariance estimation. Results: A simulation study shows that MMORTH provides less biased global POR estimates and coverage of their 95% confidence intervals closer to the nominal level than uncorrected ORTH. An analysis of patient-reported outcomes from an orthognathic surgery clinical trial illustrates features of ORTH.Ord. Conclusions: This article provides an overview of the ORTH method with bias-correction on both estimating equations and sandwich estimators for analyzing correlated ordinal data, describes the features of the ORTH.Ord R package, evaluates the performance of the package using a simulation study, and finally illustrates its application in an analysis of a clinical trial.
MeSH term(s)	Humans ; Logistic Models ; Longitudinal Studies ; Cluster Analysis ; Computer Simulation ; Bias ; Models, Statistical
Language	English
Publishing date	2023-04-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107567
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Article: Fire-resistant iron-based phosphates/phosphorus-doped carbon composites derived from phytic acid-treated metal organic frameworks as high-efficiency microwave absorbers

Liu, Jue / Meng, Can / Liu, Qingwei / Li, Nailin / Yu, Ronghai / Zeng, Min

Carbon. 2022 Aug. 08,

2022

Abstract: Considering the electromagnetic pollution in harsh environments, it is vital to prepare multifunctional microwave absorbers to broaden their application fields. Herein, fire-resistant iron-based phosphates/phosphorus-doped carbon composites were annealed ...

Abstract	Considering the electromagnetic pollution in harsh environments, it is vital to prepare multifunctional microwave absorbers to broaden their application fields. Herein, fire-resistant iron-based phosphates/phosphorus-doped carbon composites were annealed from phytic acid-treated metal organic frameworks. Through tailoring the dosage of phytic acid used in the preparation process, composites with diverse morphologies, crystal structures, electric and microwave absorption properties are obtained. When the dosage of phytic acid used reaches 4 mL, the obtained composite, Fe₂P₄O₁₂/phosphorus-doped carbon, possesses the best microwave absorption performance with a minimum reflection loss of −67.6 dB (2.0 mm) and an effective absorption bandwidth of 5.76 GHz (2.1 mm, 12.24–18 GHz). The microwave attenuation could be mainly attributed to the high conductivity brought by phosphorus-doped carbon, and polarization relaxations triggered by dipoles, functional groups, and unbalanced charges at interfaces. Specifically, the charge density distribution, obtained with density functional theory (DFT), suggests the occurrence of intense charge transfer and formation of internal electric field at P-carbon, O-carbon, and iron-based phosphates/phosphorus-doped carbon interfaces. Meanwhile, the as-prepared iron-based phosphates/phosphorus-doped carbon composites possess good fire-resistant property. The work provides a novel idea to construct multifunctional materials with high-efficient microwave absorption to broaden their application fields.
Keywords	absorption ; carbon ; density functional theory ; electric field ; fire resistance ; phytic acid ; pollution
Language	English
Dates of publication	2022-0808
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ISSN	0008-6223
DOI	10.1016/j.carbon.2022.08.037
Database	NAL-Catalogue (AGRICOLA)

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Article: Secondary peripheral T-cell lymphoma and acute myeloid leukemia after Burkitt lymphoma treatment: A case report.

Huang, Li / Meng, Can / Liu, Dan / Fu, Xiang-Jun

World journal of clinical cases

2021 Volume 9, Issue 24, Page(s) 7237–7244

Abstract: Background: Multiple primary cancer refers to more than one synchronous or sequential cancer in the same individual. Multiple primary cancer always presents as solid cancer or acute myeloid leukemia (AML) secondary to lymphoma. Here, we report a rare ... ...

Abstract	Background: Multiple primary cancer refers to more than one synchronous or sequential cancer in the same individual. Multiple primary cancer always presents as solid cancer or acute myeloid leukemia (AML) secondary to lymphoma. Here, we report a rare case of secondary peripheral T-cell lymphoma and AML after Burkitt lymphoma treatment. Case summary: A 54-year-old female patient was admitted to our hospital complaining of edema on her left lower limb. Physical examination revealed multiple superficial lymphadenectasis on her neck and pelvis. Color ultrasonography examination showed multiple uterine fibroids and a solid mass at the lower left side of the abdomen. Pathological biopsy revealed Burkitt lymphoma. After three hyper-CVAD (A + B) regimens, she achieved complete remission. Two years later, lymphadenectasis reoccurred. A relevant biopsy confirmed the diagnosis of peripheral T-cell lymphoma, which was accompanied by gastrointestinal invasion and hemocytopenia. Meanwhile, bone marrow examination revealed AML. On the second day of scheduled treatment, she developed gastrointestinal bleeding, peptic ulcers, and hemorrhagic shock and was critically ill. She was then discharged from the hospital due to financial concerns. Conclusion: This is the first report of secondary peripheral T-cell lymphoma and AML after Burkitt lymphoma treatment with heterochronous and synchronal multiple primary cancers.
Language	English
Publishing date	2021-09-14
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i24.7237
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