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Article: The efficacy of a transdiagnostic group cognitive behavioral intervention for Chinese elderly with emotional disorders: A one-year follow-up randomized clinical trial.

Yan, Zijun / Meng, Fanqiang / He, Meiling / Li, Zhanjiang

2022 Volume 13, Page(s) 1027994

Abstract: Background: With the global aging, geriatric emotional disorders have received more and more attention. Psychotherapy is an effective approach for alleviating the symptoms associated with emotional disorder, but the number of experienced therapists is ... ...

Abstract	Background: With the global aging, geriatric emotional disorders have received more and more attention. Psychotherapy is an effective approach for alleviating the symptoms associated with emotional disorder, but the number of experienced therapists is low. Studies should be conducted to explore a low-cost and efficient treatment method. Previous findings indicate that transdiagnostic cognitive behavior therapy is an effective approach for treatment of emotional disorders. Group therapy is appropriate for the elderly as they are characterized by high levels of loneliness. In this study, we compared and explored the effects of a transdiagnostic group cognitive behavioral intervention (TD-GCBT), a transdiagnostic individual cognitive behavioral intervention (TD-CBT), and treatment as usual (TAU) on treatment of emotional disorders among the elderly. Method: A total of 120 elderly patients diagnosed with emotional disorders were randomly assigned to the TD-GCBT group (40), TD-CBT group (40), and TAU group (40). Changes in symptoms were assessed using HAMD, PHQ-9, HAMA, and GAD-7 scales at baseline, post-treatment (three months), six-month and twelve-months follow-up. The efficacies of the three intervention strategies were compared using linear mixed-effects models. Results: The HAMD, PHQ-9, HAMA, and GAD-7 scores revealed a significant effect from baseline to 12 months for time ( Conclusion: The findings indicate that TD-GCBT method is effective for treatment of emotional disorders among the elderly. TD-GCBT is effective for alleviating depression and anxiety symptoms up to at least nine months after treatment. The results indicate that TD-GCBT is a cost-effective and resource-effective strategy and can be used an alternative therapy for treatment of mental disorders. Clinical trial registration: [https://www.chictr.org.cn], identifier [ChiCTR1900021806].
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.1027994
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Review on Functional Testing Scenario Library Generation for Connected and Automated Vehicles.

Zhu, Yu / Wang, Jian / Meng, Fanqiang / Liu, Tongtao

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 20

Abstract: The advancement of autonomous driving technology has had a significant impact on both transportation networks and people's lives. Connected and automated vehicles as well as the surrounding driving environment are increasingly exchanging information. The ...

Abstract	The advancement of autonomous driving technology has had a significant impact on both transportation networks and people's lives. Connected and automated vehicles as well as the surrounding driving environment are increasingly exchanging information. The traditional open road test or closed field test, which has large costs, lengthy durations, and few diverse test scenarios, cannot satisfy the autonomous driving system's need for reliable and safe testing. Functional testing is the emphasis of the test since features such as frontal collision and traffic sign warning influence driving safety. As a result, simulation testing will undoubtedly emerge as a new technique for unmanned vehicle testing. A crucial aspect of simulation testing is the creation of test scenarios. With an emphasis on the map generating method and the dynamic scenario production method in the test scenarios, this article explains many scenarios and scenario construction techniques utilized in the process of self-driving car testing. A thorough analysis of the state of relevant research is conducted, and approaches for creating common scenarios as well as brand-new methods based on machine learning are emphasized.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Safety ; Autonomous Vehicles ; Automobile Driving ; Computer Simulation
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22207735
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Article ; Online: The LuxS/AI-2 system regulates the probiotic activities of lactic acid bacteria

Meng, Fanqiang / Zhao, Mingwen / Lu, Zhaoxin

Trends in Food Science & Technology. 2022 Sept., v. 127 p.272-279

2022

Abstract: The LuxS/AI-2 quorum sensing system mediates interspecies and intraspecies signaling in bacteria and is associated with biofilm formation, pathogenicity, and resistance to harsh conditions. The regulatory mechanisms of the LuxS/AI-2 system in Vibrio ... ...

Abstract	The LuxS/AI-2 quorum sensing system mediates interspecies and intraspecies signaling in bacteria and is associated with biofilm formation, pathogenicity, and resistance to harsh conditions. The regulatory mechanisms of the LuxS/AI-2 system in Vibrio harveyi, Escherichia coli, and Salmonella have been fully elucidated and have been termed lux operon and lsr operon. Furthermore, AI-2 is essential for the probiotic activities of lactic acid bacteria (LAB), including the gastrointestinal tract tolerance, adhesion, and colonization. However, there is limited information on the LuxS/AI-2 system in LAB. The health benefits of LAB regulated by AI-2 are emerging as a new research area in the field of probiotics, although the number of reports is limited. In this review, the different aspects of AI-2, including AI-2 synthesis and its roles in the resistance to harsh environmental conditions, biofilm formation, adhesion and colonization, bacteriocin synthesis, and competition in LAB, are summarized. AI-2 regulates the communication among LAB and their populations, thus influencing the probiotic activities of LAB. This review provides novel insights for the design of new, efficient, and specific probiotic products. However, the uncovering of the AI-2 regulatory pathways in LAB remains a critical challenge in the absence of AI-2 homologous proteins from of V. harveyi or E. coli.
Keywords	Escherichia coli ; Salmonella ; Vibrio harveyi ; adhesion ; bacteriocins ; biofilm ; digestive tract ; food science ; lactic acid ; operon ; pathogenicity ; probiotics ; technology ; Lactic acid bacteria ; AI-2 ; Quorum sensing ; Biofilm formation ; Gastrointestinal environment
Language	English
Dates of publication	2022-09
Size	p. 272-279.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1049246-x
ISSN	1879-3053 ; 0924-2244
ISSN (online)	1879-3053
ISSN	0924-2244
DOI	10.1016/j.tifs.2022.05.014
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Probiotic Yogurt Alleviates High-Fat Diet-Induced Lipid Accumulation and Insulin Resistance in Mice via the Adiponectin Pathway.

Tang, Chao / Zhao, Hongyuan / Kong, Liangyu / Meng, Fanqiang / Zhou, Libang / Lu, Zhaoxin / Lu, Yingjian

Journal of agricultural and food chemistry

2023 Volume 71, Issue 3, Page(s) 1464–1476

Abstract: A high-fat diet (HFD) easily contributes to the pathogenesis of obesity and insulin resistance. Obesity and insulin resistance have been clinical and public health challenges all over the world. Probiotic-fermented yogurt is one type of popular and ... ...

Abstract	A high-fat diet (HFD) easily contributes to the pathogenesis of obesity and insulin resistance. Obesity and insulin resistance have been clinical and public health challenges all over the world. Probiotic-fermented yogurt is one type of popular and functional beverage in people's daily lives. This study mainly explored the lipid- and glucose-lowering effects of
MeSH term(s)	Mice ; Animals ; Insulin Resistance ; Diet, High-Fat/adverse effects ; Adiponectin/metabolism ; Yogurt ; Obesity/drug therapy ; Obesity/etiology ; Lipid Metabolism ; Insulin/metabolism ; Lipids ; Probiotics ; Mice, Inbred C57BL ; Adaptor Proteins, Signal Transducing/metabolism
Chemical Substances	Adiponectin ; Insulin ; Lipids ; Appl1 protein, mouse ; Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c05670
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Zs.A 1172: Show issues

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Article ; Online: Clinical outcomes in dynamic intraligamentary stabilization technique for anterior cruciate ligament tear: A meta-analysis.

Meng, Jiahao / Xie, Dongxing / Meng, Fanqiang / Liu, Weijie / Xiao, Yifan / Tang, Hang / Gao, Shuguang

Medicine

2023 Volume 102, Issue 10, Page(s) e33091

Abstract: Background: To compare the clinical outcome between dynamic intraligamentary stabilization (DIS) and anterior cruciate ligament (ACL) reconstruction in ACL tears.: Methods: PubMed, the Cochrane Library, and Embase databases were searched to identify ... ...

Abstract	Background: To compare the clinical outcome between dynamic intraligamentary stabilization (DIS) and anterior cruciate ligament (ACL) reconstruction in ACL tears. Methods: PubMed, the Cochrane Library, and Embase databases were searched to identify published articles on clinical studies comparing DIS versus ACL reconstruction. The results of the eligible studies were analyzed in terms of anteroposterior knee laxity translation (ΔATT) between the injured and contralateral knees, and subjective International Knee Documentation Committee (IKDC), Lysholm score, Tegner score, and ipsilateral ACL failure, implant removal, and ACL revision. Results: Five clinical studies including 429 patients with ACL tears met the inclusion criteria. DIS showed statistically comparable outcomes of ΔATT (P = .12), IKDC (P = .38), Tegner (P = .82), ACL failure (P = .50), ACL revision (P = .29) with ACL reconstruction. A significantly higher rate of implant removal (odds ratio for DIS vs ACL reconstruction, 7.73; 95% confidence interval [CI], 2.72-22.00; P = .0001) but statistically higher Lysholm score (mean difference between DIS and ACL reconstruction, 1.59; 95% CI, 0.24-2.93; P = .02) were found in DIS group. Conclusion: Five clinical studies including 429 patients with ACL tears met the inclusion criteria. DIS showed statistically comparable outcomes of ΔATT (P = .12), IKDC (P = .38), Tegner (P = .82), ACL failure (P = .50), ACL revision (P = .29) with ACL reconstruction. A significantly higher rate of implant removal (odds ratio for DIS vs ACL reconstruction, 7.73; 95% CI, 2.72-22.00; P = .0001) but statistically higher Lysholm score (mean difference between DIS and ACL reconstruction, 1.59; 95% CI, 0.24-2.93; P = .02) were found in DIS group.
MeSH term(s)	Humans ; Anterior Cruciate Ligament Injuries/surgery ; Knee Joint/surgery ; Anterior Cruciate Ligament Reconstruction/methods ; Treatment Outcome
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033091
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Article: The Effect of Ru on the Evolution of the γ' Phase in Ni-Al-Ru Alloys.

Wang, Shaoyang / Meng, Fanqiang / Wang, Lu / Yu, Hongying / Sun, Dongbai

Materials (Basel, Switzerland)

2022 Volume 15, Issue 9

Abstract: With the development and wide application of nickel-based single-crystal superalloys, the effect of Ru on the microstructure stability and high-temperature properties of superalloys is becoming increasingly important. In this study, the effect of Ru on ... ...

Abstract	With the development and wide application of nickel-based single-crystal superalloys, the effect of Ru on the microstructure stability and high-temperature properties of superalloys is becoming increasingly important. In this study, the effect of Ru on the evolution of the γ' phase in Ni-Al-Ru ternary alloys during aging treatment was analyzed, using a scanning electron microscope and transmission electron microscope, combined with energy-dispersive spectroscopy. The relationship between chemical partition behavior and γ/γ' lattice misfit was investigated in detail. During the aging process, Ru addition suppressed the growth rate and rafting process of γ' precipitates, while the effect of Ru on hindering γ' phase growth was reduced when the Ru content was over 3 at%. Ru preferentially partitioned to the γ phase, and its partitioning ratio to the γ phase increased with a variation in Ru content from 1 at% to 3 at% and decreased for the NiAl6Ru alloy. Additionally, the lattice misfit of all alloys was positive and reduced with the increase in Ru content, which hindered the Ru atoms to diffuse into the γ phase and promoted the shape of γ' precipitates to change from cubic to spherical.
Language	English
Publishing date	2022-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15093344
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Article ; Online: Biochemical and molecular regulatory mechanism of the pgpH gene on biofilm formation in Listeria monocytogenes.

Zhang, Xinyi / Zheng, Liping / Lu, Zhaoxin / Zhou, Libang / Meng, Fanqiang / Shi, Changzheng / Bie, Xiaomei

Journal of applied microbiology

2023 Volume 134, Issue 2

Abstract: Aims: PgpH gene has an important regulatory role on bacterial physiological activity, but studies on its regulation mechanism on biofilm formation of Listeria monocytogenes are lacking. Our aim was to investigate the effect of pgpH gene deletion on ... ...

Abstract	Aims: PgpH gene has an important regulatory role on bacterial physiological activity, but studies on its regulation mechanism on biofilm formation of Listeria monocytogenes are lacking. Our aim was to investigate the effect of pgpH gene deletion on biofilm formation in L. monocytogenes. Methods and results: The ΔpgpH deletion strain of L. monocytogenes LMB 33 426 was constructed by homologous recombination. Deletion of the pgpH gene resulted in a significant reduction in biofilm formation. The swimming ability of the ΔpgpH strain on semisolid plates was unchanged compared to the wild-type strain (WT), and the auto-aggregation capacity of L. monocytogenes was decreased. RNA-seq showed that ΔpgpH resulted in the differential expression of 2357 genes compared to WT. pgpH inactivation resulted in the significant downregulation of the cell wall formation-related genes dltC, dltD, walK, and walR and the flagellar assembly related genes fliG and motB. Conclusions: This study shows that the deletion of pgpH gene regulates biofilm formation and auto-aggregation ability of L. monocytogenes by affecting the expression of flagellar assembly and cell wall related genes. pgpH has a global regulatory effect on biofilm formation in L. monocytogenes.
MeSH term(s)	Biofilms ; Listeria monocytogenes/physiology ; Gene Deletion ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
Chemical Substances	Bacterial Proteins
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1093/jambio/lxac086
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Article ; Online: Prevention of high-fat-diet-induced obesity in mice by soluble dietary fiber from fermented and unfermented millet bran.

Yang, Duo / Shen, Juan / Tang, Chao / Lu, Zhaoxin / Lu, Fengxia / Bie, Xiaomei / Meng, Fanqiang / Zhao, Haizhen

Food research international (Ottawa, Ont.)

2024 Volume 179, Page(s) 113974

Abstract: Obesity-related diabetes, cardiovascular disease, and hypertension pose many risks to human health. Thus, mice on a high-fat diet were gavaged with millet bran (unfermented/fermented) soluble dietary fiber (RSDF/FSDF, 500 mg· ... ...

Abstract	Obesity-related diabetes, cardiovascular disease, and hypertension pose many risks to human health. Thus, mice on a high-fat diet were gavaged with millet bran (unfermented/fermented) soluble dietary fiber (RSDF/FSDF, 500 mg·kg
MeSH term(s)	Mice ; Humans ; Animals ; Diet, High-Fat/adverse effects ; Millets ; Obesity ; Cholesterol ; Dietary Fiber
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Dietary Fiber
Language	English
Publishing date	2024-01-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.113974
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Article ; Online: Effects of monolauroyl-galactosylglycerol on membrane fatty acids and properties of Bacillus cereus.

Wang, Ying / Shen, Juan / Meng, Fanqiang / Lu, Zhaoxin / Lv, Fengxia / Zhou, Libang / Zhao, Haizhen

Applied microbiology and biotechnology

2023 Volume 107, Issue 13, Page(s) 4381–4393

Abstract: The purpose of this study was to provide new ideas for the antibacterial mechanism of monolauroyl-galactosylglycerol (MLGG) from the perspective of cell membranes. The changes in cell membrane properties of Bacillus cereus (B. cereus) CMCC 66,301 exposed ...

Abstract	The purpose of this study was to provide new ideas for the antibacterial mechanism of monolauroyl-galactosylglycerol (MLGG) from the perspective of cell membranes. The changes in cell membrane properties of Bacillus cereus (B. cereus) CMCC 66,301 exposed to different concentrations (1 × MIC (minimum inhibitory concentration), 2 × MIC, 1 × MBC (minimum bacterial concentration)) of MLGG were evaluated. It was found that the lag phase of B. cereus cells was prolonged at low concentration MLGG (1 × MIC and 2 × MIC), while about 2 log CFU/mL reduction in B. cereus populations were observed when exposed to high concentration MLGG (1 × MBC). MLGG treated B. cereus displayed obvious membrane depolarization, while membrane permeability had no change using PI (propidium iodide) staining. Significant increase in the membrane fluidity in response to MLGG exposure occurred, which was consistent with the modification of membrane fatty acids compositions, where the relative content of straight-chain fatty acids (SCFAs) and unsaturated fatty acids (UFAs) increased, while branched-chain fatty acids (BCFAs) decreased significantly. The decreased transition T
MeSH term(s)	Fatty Acids/metabolism ; Bacillus cereus ; Fatty Acids, Unsaturated/metabolism ; Cell Membrane ; Membrane Fluidity
Chemical Substances	Fatty Acids ; Fatty Acids, Unsaturated
Language	English
Publishing date	2023-05-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-023-12567-4
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Article ; Online: Establishment of real-time fluorescence and visual LAMP for rapid detection of Escherichia coli O157:H7 and kits construction.

Wang, Zuwei / Cui, Xinping / Hu, Antuo / Lu, Zhaoxin / Meng, Fanqiang / Zhou, Libang / Bie, Xiaomei

Letters in applied microbiology

2023 Volume 76, Issue 11

Abstract: Escherichia coli O157:H7 is a common pathogenic bacterium in food and water that can pose a threat to human health. The aim of this study was to develop loop-mediated isothermal amplification (LAMP) method for the detection of E. coli O157:H7 in food ... ...

Abstract	Escherichia coli O157:H7 is a common pathogenic bacterium in food and water that can pose a threat to human health. The aim of this study was to develop loop-mediated isothermal amplification (LAMP) method for the detection of E. coli O157:H7 in food based on the specific gene Ecs_2840 and to construct rapid detection kits based on the established methods. Specifically, we established two methods of real-time fluorescent LAMP (RT-LAMP) and visual LAMP with calcein as an indicator. In pure bacterial culture, the cell sensitivity and genomic sensitivity of the RT-LAMP kit were 8.8 × 100 CFU ml-1 and 4.61 fg µl-1, respectively. The sensitivity of the visual LAMP kit was 2.35 × 100 CFU ml-1 and 4.61 fg µl-1. Both kits had excellent specificity and anti-interference performance. In addition, milk inoculated with 2.26 × 100 CFU ml-1E. coli O157:H7 could be detected within the reaction time after enrichment for 3 h. The results showed that the LAMP kits were rapid, sensitive, and specific for the detection of E. coli O157:H7 in food and had good application prospects in food safety surveillance.
MeSH term(s)	Humans ; Escherichia coli O157/genetics ; Sensitivity and Specificity ; Food Microbiology
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1093/lambio/ovad122
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