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Article ; Online: Biotransformation approach to produce rare ginsenosides F1, compound Mc1, and Rd2 from major ginsenosides.

Diao, Mengxue / Chen, Yanchi / Meng, Lijun / Li, Jianxiu / Xie, Nengzhong

2024 Volume 206, Issue 4, Page(s) 176

Abstract: The stems and leaves of Panax notoginseng contain high saponins, but they are often discarded as agricultural waste. In this study, the predominant ginsenosides Rg1, Rc, and Rb2, presented in the stems and leaves of ginseng plants, were biotransformed ... ...

Abstract	The stems and leaves of Panax notoginseng contain high saponins, but they are often discarded as agricultural waste. In this study, the predominant ginsenosides Rg1, Rc, and Rb2, presented in the stems and leaves of ginseng plants, were biotransformed into value-added rare ginsenosides F1, compound Mc1 (C-Mc1), and Rd2, respectively. A fungal strain YMS6 (Penicillium sp.) was screened from the soil as a biocatalyst with high selectivity for the deglycosylation of major ginsenosides. Under the optimal fermentation conditions, the yields of F1, C-Mc1, and Rd2 were 97.95, 68.64, and 79.58%, respectively. This study provides a new microbial resource for the selective conversion of protopanaxadiol-type and protopanaxatriol-type major saponins into rare ginsenosides via the whole-cell biotransformation and offers a solution for the better utilization of P. notoginseng waste.
MeSH term(s)	Ginsenosides ; Saponins ; Agriculture ; Biotransformation
Chemical Substances	ginsenoside F1 (53963-43-2) ; Ginsenosides ; Saponins
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-024-03893-w
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Article ; Online: Genome-wide identification of the N

Su, Huan / Meng, Lijun / Qu, Zechao / Zhang, Wei / Liu, Nan / Cao, Peijian / Jin, Jingjing

BMC plant biology

2024 Volume 24, Issue 1, Page(s) 134

Abstract: Background: N: Results: In this study, we identified 52 candidate m: Conclusions: This study provides useful information for better understanding the evolution of ... ...

Abstract	Background: N Results: In this study, we identified 52 candidate m Conclusions: This study provides useful information for better understanding the evolution of m
MeSH term(s)	Nicotiana/genetics ; Drought Resistance ; Genes, Regulator ; RNA ; Gene Expression Regulation, Plant ; Stress, Physiological/genetics ; Phylogeny ; Adenosine/analogs & derivatives
Chemical Substances	N-methyladenosine (CLE6G00625) ; RNA (63231-63-0) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-024-04813-2
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Article ; Online: Biotransformation of Sclareol by a Fungal Endophyte of Salvia sclarea.

Diao, Mengxue / Li, Chi / Lu, Jian / Meng, Lijun / Xie, Nengzhong

Chemistry & biodiversity

2023 Volume 20, Issue 12, Page(s) e202301363

Abstract: Microbial endophytes are known as versatile producers of useful metabolites, which have extensive applications in pharmacy, fragrance, agriculture and food. This study aims to screen sclareol-biotransforming microorganisms from Salvia sclarea, an ... ...

Abstract	Microbial endophytes are known as versatile producers of useful metabolites, which have extensive applications in pharmacy, fragrance, agriculture and food. This study aims to screen sclareol-biotransforming microorganisms from Salvia sclarea, an untapped source of diverse endophytes. In this study, 50 culturable endophytes were isolated from S. sclarea grown in Xinjiang using sclareol as the sole carbon source and screened for their potential to transform sclareol into analogues. A fungal endophyte, identified as the generally recognized as safe (GRAS) strain Aspergillus tubingensis, can produce labd-14-ene-3β,8α,13β-triol and 8α,13β-dihydroxylabd-14-en-3-one from sclareol, involving hydroxylation and carbonylation at the C3 site. Structures of the two metabolites were elucidated by HR-ESI-MS and NMR analysis. S. sclarea was proven to be a good source of endophytes that are prospective producers of secondary metabolites with valuable chemical and biological properties. This study is the first report regarding the isolation of endophytes from S. sclarea.
MeSH term(s)	Endophytes ; Salvia/chemistry ; Prospective Studies ; Biotransformation
Chemical Substances	sclareol (B607NP0Q8Y)
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301363
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Article: Sparse Phenotyping and Haplotype-Based Models for Genomic Prediction in Rice.

He, Sang / Liang, Shanshan / Meng, Lijun / Cao, Liyong / Ye, Guoyou

Rice (New York, N.Y.)

2023 Volume 16, Issue 1, Page(s) 27

Abstract: The multi-environment genomic selection enables plant breeders to select varieties resilient to diverse environments or particularly adapted to specific environments, which holds a great potential to be used in rice breeding. To realize the multi- ... ...

Abstract	The multi-environment genomic selection enables plant breeders to select varieties resilient to diverse environments or particularly adapted to specific environments, which holds a great potential to be used in rice breeding. To realize the multi-environment genomic selection, a robust training set with multi-environment phenotypic data is of necessity. Considering the huge potential of genomic prediction enhanced sparse phenotyping on the cost saving of multi-environment trials (MET), the establishment of a multi-environment training set could also benefit from it. Optimizing the genomic prediction methods is also crucial to enhance the multi-environment genomic selection. Using haplotype-based genomic prediction models is able to capture local epistatic effects which could be conserved and accumulated across generations much like additive effects thereby benefitting breeding. However, previous studies often used fixed length haplotypes composed by a few adjacent molecular markers disregarding the linkage disequilibrium (LD) which is of essential role in determining the haplotype length. In our study, based on three rice populations with different sizes and compositions, we investigated the usefulness and effectiveness of multi-environment training sets with varying phenotyping intensities and different haplotype-based genomic prediction models based on LD-derived haplotype blocks for two agronomic traits, i.e., days to heading (DTH) and plant height (PH). Results showed that phenotyping merely 30% records in multi-environment training set is able to provide a comparable prediction accuracy to high phenotyping intensities; the local epistatic effects are much likely existent in DTH; dividing the LD-derived haplotype blocks into small segments with two or three single nucleotide polymorphisms (SNPs) helps to maintain the predictive ability of haplotype-based models in large populations; modelling the covariances between environments improves genomic prediction accuracy. Our study provides means to improve the efficiency of multi-environment genomic selection in rice.
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2457103-9
ISSN	1939-8433 ; 1939-8425
ISSN (online)	1939-8433
ISSN	1939-8425
DOI	10.1186/s12284-023-00643-2
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Article ; Online: Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation.

Meng, Lijun / Gu, Tijun / Wang, Jinhai / Zhang, He / Nan, Chao

Allergologia et immunopathologia

2023 Volume 51, Issue 5, Page(s) 41–47

Abstract: Objective: To investigate the regulatory mechanism of pleckstrin homology-like domain, family A, member 1 (PHLDA1) in sepsis-induced acute lung injury (ALI).: Method: Mice model of sepsis were established by cecal ligation and puncture (CLP). The ... ...

Abstract	Objective: To investigate the regulatory mechanism of pleckstrin homology-like domain, family A, member 1 (PHLDA1) in sepsis-induced acute lung injury (ALI). Method: Mice model of sepsis were established by cecal ligation and puncture (CLP). The expression of PHLDA1 was reduced by injecting short hairpin RNA (shRNA)-PHLDA1 into the tail vein. The levels of PHLDA1, pro-inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), IL-1β, IL-18, super-oxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH), molecular mechanism related to pyroptosis, such as caspase 1, adaptor apoptosis-associated speck-like protein containing a CARD (ASC), and gasdermin D (GSDMD)-N, and nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) were tested by Western blot analysis, quantitative real-time polymerase chain reaction, and enzyme-linked-immunosorbent serologic assay. Pathological changes in lung tissues were examined by hematoxylin and eosin staining. Wet-dry weight ratio of lung tissues was observed. Results: The expression of PHLDA1 was up-regulated in lung tissues from CLP-induced septic mice. Knockdown of PHLDA1 could reduce lung injury and wet-dry weight ratio in mice with sepsis-induced ALI. Moreover, silencing of PHLDA1 decreased the expressions of IL-1β, TNF-α, IL-18, IL-6, and MDA but increased SOD and GSH expressions in CLP-induced septic mice. The expressions of NLRP3, GSDMD-N, ASC, and caspase 1 were decreased by PHLDA1 silencing. Conclusion: Knockdown of PHLDA1 inhibited lung inflammation and pyroptosis in mice with sepsis-induced ALI by down-regulating NLRP3.
MeSH term(s)	Animals ; Mice ; Acute Lung Injury/genetics ; Caspase 1 ; Inflammasomes ; Interleukin-18 ; Interleukin-6 ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Sepsis/complications ; Sepsis/genetics ; Tumor Necrosis Factor-alpha ; Transcription Factors
Chemical Substances	Caspase 1 (EC 3.4.22.36) ; Inflammasomes ; Interleukin-18 ; Interleukin-6 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Tumor Necrosis Factor-alpha ; Phlda1 protein, mouse ; Transcription Factors
Language	English
Publishing date	2023-09-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v51i5.940
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Article ; Online: Single nucleobase identification for transversally-confined ssDNA using longitudinal ionic currents.

Meng, Lijun / Huang, Jianxiang / He, Zhi / Zhou, Ruhong

Nanoscale

2022 Volume 14, Issue 18, Page(s) 6922–6929

Abstract: High-fidelity DNA sequencing using solid-state nanopores remains a big challenge, partly due to difficulties related to efficient molecular capture and subsequent control of the dwell time. To help address these issues, here we propose a sequencing ... ...

Abstract	High-fidelity DNA sequencing using solid-state nanopores remains a big challenge, partly due to difficulties related to efficient molecular capture and subsequent control of the dwell time. To help address these issues, here we propose a sequencing platform consisting of stacked two-dimensional materials with tailored structures containing a funnel-shaped step defect and a nanopore drilled inside the nanochannel. Our all-atom molecular dynamics (MD) simulations showed that, assisted by the step defect, single-stranded DNA (ssDNA) can be transported to the nanopore in a deterministic way by pulsed transversal electric fields. Furthermore, different types of DNA bases can reside in the pore for a sufficiently long time which can be successfully differentiated by longitudinal ionic currents. By using the decoupled driving forces for ssDNA transport and ionic current measurements, this approach holds potential for high-fidelity DNA sequencing.
MeSH term(s)	DNA/chemistry ; DNA, Single-Stranded ; Ion Transport ; Molecular Dynamics Simulation ; Nanopores ; Sequence Analysis, DNA/methods
Chemical Substances	DNA, Single-Stranded ; DNA (9007-49-2)
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d1nr07116e
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Article ; Online: Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss.

Wang, Huaibin / Liu, Zhao / Meng, Lijun / Zhang, Xiujun

Human fertility (Cambridge, England)

2022 Volume 26, Issue 5, Page(s) 1015–1022

Abstract: Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics ... ...

Abstract	Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE165004 from the Gene Expression Omnibus (GEO). Gene ontology (GO) analysis and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analyses were performed on selected genes by using the R Programming Language. A protein-protein interaction (PPI) network was constructed with the Retrieval of Interacting Genes (STRING). Our analysis revealed that 1,869 genes were differentially expressed in RPL and control groups. GO analysis revealed that the interferon type 1 and the glycoprotein-related biological processes played irreplaceable roles, meanwhile KEGG enrichment analysis also revealed that the cAMP signalling pathway and the prolactin signalling pathway played important roles. In the following study, we found that there were many DEGs in the RPL group that were closely related to endometrial decidualization, such as IL17RD, IL16, SOX4, CREBBP, and POFUT1 as well as Notch1 and RBPJ in the Notch signalling pathway family were down-regulated in the RPL group. The results provided valuable information on the pathogenesis of RPL.
MeSH term(s)	Female ; Pregnancy ; Humans ; Gene Expression Profiling/methods ; Computational Biology/methods ; SOXC Transcription Factors
Chemical Substances	SOX4 protein, human ; SOXC Transcription Factors
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2086960-5
ISSN	1742-8149 ; 1464-7273
ISSN (online)	1742-8149
ISSN	1464-7273
DOI	10.1080/14647273.2022.2045636
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Article ; Online: The lagged effect and attributable risk of apparent temperature on hand, foot, and mouth disease in Changsha, China: a distributed lag non-linear model

Meng, Lijun / Zhou, Chunliang / Xu, Yiqing / Liu, Fuqiang / Zhou, Cui / Yao, Meng / Li, Xingli

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 5 p.11504-11515

2023

Abstract: Hand, foot, and mouth disease (HFMD) is the leading Category C infectious disease affecting millions of children in China every year. In the context of global climate change, the understanding and quantification of the impact of weather factors on human ... ...

Abstract	Hand, foot, and mouth disease (HFMD) is the leading Category C infectious disease affecting millions of children in China every year. In the context of global climate change, the understanding and quantification of the impact of weather factors on human health are particularly critical to the development and implementation of climate change adaptation and mitigation strategies. The aim of this study was to quantify the attributable burden of a combined bioclimatic indicator (apparent temperature) on HFMD and to identify temperature-specific sensitive populations. A total of 123,622 HFMD cases were included in the study. The non-linear relationship between apparent temperature and the incidence of HFMD was approximately M-shaped, with hot weather being more likely to be attributable than cold conditions, of which moderately hot accounting for the majority of cases (21,441, 17.34%). Taking the median apparent temperature (19.2 °C) as reference, the cold effect showed a short acute effect with the highest risk on the day of lag 0 (RR = 1.086, 95% CI: 1.024 ~ 1.152), whereas the hot effect lasted longer with the greatest risk at a lag of 7 days (RR = 1.081, 95% CI: 1.059 ~ 1.104). Subgroup analysis revealed that males, children under 3 years old, and scattered children tended to be more vulnerable to HFMD in hot weather, while females, those aged 3 ~ 5 years, and nursery children were sensitive to cold conditions. This study suggests that high temperatures have a greater impact on HFMD than low temperatures as well as lasting longer, of particular concern being moderately high temperatures rather than extreme temperatures. Early intervention takes on greater importance during cold days, while the duration of HFMD intervention must be longer during hot days.
Keywords	acute effects ; bioclimatic indexes ; climate change ; cold ; human health ; infectious diseases ; mouth ; nonlinear models ; risk ; temperature ; weather ; China
Language	English
Dates of publication	2023-01
Size	p. 11504-11515.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22875-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Janus membranes at the water-energy nexus: A critical review.

Meng, Lijun / Shi, Wei / Li, Yang / Li, Xuesong / Tong, Xin / Wang, Zhiwei

Advances in colloid and interface science

2023 Volume 318, Page(s) 102937

Abstract: Membrane technology has emerged as a highly efficient strategy for alleviating water and energy scarcity globally. As the key component, the membrane plays a fatal role in different membrane systems; however, traditional membranes still suffer from ... ...

Abstract	Membrane technology has emerged as a highly efficient strategy for alleviating water and energy scarcity globally. As the key component, the membrane plays a fatal role in different membrane systems; however, traditional membranes still suffer from shortcomings including low permeability, low selectivity, and high fouling tendency. Janus membranes are promising to overcome those shortcomings and appealing for applications in the realm of water-energy nexus, due to their special transport behaviors and separation properties as a result of their unique asymmetric wetting or surface charge properties. Recently, numerous research studies have been conducted on the design, fabrication, and application of Janus membranes. In this review, we aim to provide a state-of-the-art summary and a critical discussion on the research advances of Janus membranes at the water-energy nexus. The innovative design strategies of different types of Janus membranes are summarized and elucidated in detail. The fundamental working principles of various Janus membranes and their applications in oil/water separation, membrane distillation, solar evaporation, electrodialysis, nanofiltration, and forward osmosis are discussed systematically. The mechanisms of directional transport properties, switchable permeability, and superior separation properties of Janus membranes in those different applications are elucidated. Lastly, future research directions and challenges are highlighted in improving Janus membrane performance for various membrane systems.
Language	English
Publishing date	2023-06-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	210507-x
ISSN	1873-3727 ; 0001-8686
ISSN (online)	1873-3727
ISSN	0001-8686
DOI	10.1016/j.cis.2023.102937
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Zs.A 2716: Show issues

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Article ; Online: A moderated mediation analysis of depression and age on the relationship between resilience and frailty among HIV-positive adults.

Meng, Lijun / Chen, Dan / Hu, Peiwu / Yao, Meng / Zhou, Cui / Li, Xingli

Frontiers in public health

2023 Volume 11, Page(s) 1128309

Abstract: Background: Given the continuing challenges frailty poses among people living with human immunodeficiency virus (HIV) (PLHIV), accumulating evidence suggests that frailty is linked to psychological factors. However, the mutual influences of resilience, ... ...

Abstract	Background: Given the continuing challenges frailty poses among people living with human immunodeficiency virus (HIV) (PLHIV), accumulating evidence suggests that frailty is linked to psychological factors. However, the mutual influences of resilience, depression, and frailty have not yet been clarified. This study aimed to identify the potential mechanistic pathway through which psychological factors mitigate frailty. Methods: Data were collected from June to August 2019 by trained investigators through face-to-face interviews with 375 HIV-positive Chinese adults. Each participant completed structured questionnaires to collect data in respect of their socio-demographic characteristics, and levels of frailty, depression, and resilience. These assessment measures included a self-designed questionnaire, the Tilburg Frailty Indicator (TFI), the 10-item Center for Epidemiological Studies Depression Scale (CES-D-10), and the 10-item Connor-Davidson Resilience Scale (CD-RISC-10). SPSS PROCESS macro was used to analyze the mediation and moderated mediation models. Results: The overall prevalence of frailty was 26.4%, and the prevalence of frailty among older and younger adults living with HIV was 22 and 31.4%, respectively. Mediation analysis showed that an association between resilience and frailty was mediated by depression, whereas resilience did not mediate the relationship between depression and frailty. Compared to physical frailty, depression was a stronger mediator of resilience to psychological frailty. We further found that age moderated the indirect effect of resilience on psychological frailty, with resilience being a stronger negative predictor of depression and depression being a stronger positive predictor of psychological frailty for older PLHIV than for younger PLHIV. Conclusion: Lower levels of resilience and greater levels of depression may be significant risk factors for frailty among PLHIV. Levels of resilience influenced frailty directly and frailty was indirectly affected by depression. Therefore, it is recommended that PLHIV, especially older patients, should be encouraged to establish positive psychological coping strategies to slow the progression of frailty.
MeSH term(s)	Humans ; Adult ; Frailty/epidemiology ; Resilience, Psychological ; Mediation Analysis ; Depression/epidemiology ; Depression/psychology ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/psychology
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1128309
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