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Article: Associations of Homocysteine, Procalcitonin, and D-Dimer Levels with Severity and Prognosis of Patients with Multiple Trauma.

Tian, Wei / Meng, Wen

2022 Volume 68, Issue 3

Abstract: Background: The aim was to explore the associations of plasma D-dimers (D-D), homocysteine (HCY), and procalcitonin (PCT) levels with multiple trauma.: Methods: A total of 116 patients were divided into two groups with severe and mild diseases. After ...

Abstract	Background: The aim was to explore the associations of plasma D-dimers (D-D), homocysteine (HCY), and procalcitonin (PCT) levels with multiple trauma. Methods: A total of 116 patients were divided into two groups with severe and mild diseases. After 6 months of follow-up, the group with severe disease was divided into survivor and non-survivor groups. The correlations of APACHE II score and simplified acute physiology score II (SAPS II) with D-D, HCY, and PCT levels were subjected to Spearman's analysis. The influencing factors for prognosis were studied using logistic regression analysis, and the values of these levels for prognostic evaluation were explored by plotting receiver operating characteristic curves. Results: After treatment, the group with severe disease had higher levels of D-D, HCY, PCT, APACHE II score, and SAPS II than those of the group with mild disease (p < 0.05). The non-survivor group had significantly higher levels than those of the survivor group (p < 0.05). The levels of 116 patients with multiple trauma had positive correlations with APACHE II score and SAPS II (p < 0.001). The levels were independent risk factors affecting prognosis. Their combination had high diagnostic value for prognostic evaluation. Conclusions: The combination of plasma D-D, HCY, and PCT levels seems to be a useful index for the early evaluation of severity and prognostic evaluation of patients with multiple trauma.
MeSH term(s)	APACHE ; Fibrin Fibrinogen Degradation Products ; Homocysteine ; Humans ; Multiple Trauma ; Procalcitonin ; Prognosis ; ROC Curve ; Sepsis/diagnosis
Chemical Substances	Fibrin Fibrinogen Degradation Products ; Procalcitonin ; fibrin fragment D ; Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2022-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2021.210525
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Article ; Online: Alkylammonium Halides for Phase Regulation and Luminescence Modulation of Cesium Copper Iodide Nanocrystals for Light-Emitting Diodes.

Meng, Wen / Wang, Chuying / Xu, Guangyong / Luo, Guigen / Deng, Zhengtao

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 5

Abstract: All-inorganic cesium copper halide nanocrystals have attracted extensive attention due to their cost-effectiveness, low toxicity, and rich luminescence properties. However, controlling the synthesis of these nanocrystals to achieve a precise composition ... ...

Abstract	All-inorganic cesium copper halide nanocrystals have attracted extensive attention due to their cost-effectiveness, low toxicity, and rich luminescence properties. However, controlling the synthesis of these nanocrystals to achieve a precise composition and high luminous efficiency remains a challenge that limits their future application. Herein, we report the effect of oleylammonium iodide on the synthesis of copper halide nanocrystals to control the composition and phase and modulate their photoluminescence (PL) quantum yields (QYs). For CsCu
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29051162
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Article ; Online: Immunotherapy with Immune Checkpoint Inhibitors for Advanced Colorectal Cancer: A Promising Individualized Treatment Strategy.

Yang, Ying / Meng, Wen-Jian / Wang, Zi-Qiang

Frontiers in bioscience (Landmark edition)

2023 Volume 28, Issue 4, Page(s) 69

Abstract: Colorectal cancer (CRC) is one of the high incident and lethal malignant tumors, and most of the patients are diagnosed at an advanced stage. The treatment of CRC mainly includes surgery, chemotherapy, radiotherapy and molecular targeted therapy. Despite ...

Abstract	Colorectal cancer (CRC) is one of the high incident and lethal malignant tumors, and most of the patients are diagnosed at an advanced stage. The treatment of CRC mainly includes surgery, chemotherapy, radiotherapy and molecular targeted therapy. Despite these approaches have increased overall survival (OS) of CRC patients, the prognosis of advanced CRC remains poor. In recent years, remarkable breakthroughs have been made in tumor immunotherapy, especially immune checkpoint inhibitors (ICIs) therapy, bringing long-term survival benefits to tumor patients. With the increasing wealth of clinical data, ICIs have achieved significant efficacy in the treatment of high microsatellite instability/deficient mismatch repair (MSI-H/dMMR) advanced CRC, but the therapeutic effects of ICIs on microsatellite stable (MSS) advanced CRC patients is currently unsatisfactory. As increasing numbers of large clinical trials are performed globally, patients treated with ICIs therapy also have immunotherapy-related adverse events and treatment resistance. Therefore, a large number of clinical trials are still needed to evaluate the therapeutic effect and safety of ICIs therapy in advanced CRC. This article will focus on the current research status of ICIs in advanced CRC and discuss the current predicament of ICIs treatment.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Brain Neoplasms ; Molecular Targeted Therapy
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-05-01
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2804069
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Article ; Online: Neurological and imaging phenotypes of adults with untreated phenylketonuria: new cases and literature review.

Wang, Meng-Wen / Wu, Chu-Jun / Zhang, Zai-Qiang

Journal of neurology

2023 Volume 270, Issue 8, Page(s) 4060–4079

Abstract: Objectives: Phenylketonuria (PKU) is the most prevalent congenital disease of amino acid metabolism. Neurological manifestations usually complicate PKU in untreated adult patients. This study describes neurological and imaging phenotypes of adult ... ...

Abstract	Objectives: Phenylketonuria (PKU) is the most prevalent congenital disease of amino acid metabolism. Neurological manifestations usually complicate PKU in untreated adult patients. This study describes neurological and imaging phenotypes of adult patients with untreated PKU. Methods: We investigated a cohort of 320 unrelated adult patients with suspected genetic leukoencephalopathies using whole-exome sequencing (WES). We analyzed the phenotypic features of adult PKU patients in our cohort and summarized cases reported in the literature. Results: We identified 10 patients in our cohort and 12 patients in the literature, who presented with neurological manifestations and were diagnosed with PKU in adulthood. Approximately 60% of these patients had onset of clinical features in adulthood. The most common neurological symptoms of patients presenting in adulthood were cognitive disturbance and spastic paralysis, followed by vision loss, cerebellar ataxia, weakness of limbs, and seizure. This differed from that of patients presenting with PKU features in childhood, who consistently had mental retardation with various neurological complications emerging during a broad age range. Imaging findings were similar between patients presenting with clinical features in childhood compared with adulthood, comprising symmetric periventricular white matter hyperintense on T2-weighted imaging and diffusion-weighted imaging predominantly in the parietal and occipital lobes. Also, normal brain imaging and diffuse leukoencephalopathies were observed in both patient groups. Conclusion: PKU with clinical features presenting in adulthood is an atypical subtype and should be considered during diagnosis of adults with neurological symptoms and leukoencephalopathy. DWI seems to be most helpful to distinguish patients with PKU. Additionally, we demonstrate that PKU constitutes a part (3.1%) of adult genetic leukoencephalopathies.
MeSH term(s)	Humans ; Phenylketonurias/complications ; Phenylketonurias/diagnostic imaging ; Brain/diagnostic imaging ; Leukoencephalopathies/complications ; Seizures ; Phenotype
Language	English
Publishing date	2023-05-10
Publishing country	Germany
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-11760-9
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Article ; Online: Neoadjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma: Expecting Its Application in Temporal Bone Squamous Cell Carcinoma.

Shi, Meng-Wen / Huang, Jing / Sun, Yu

Current medical science

2023 Volume 43, Issue 2, Page(s) 213–222

Abstract: Temporal bone malignant tumors are characterized by atypical clinical symptoms, and easy recurrence and metastasis. They account for 0.2% of head and neck tumors, and the most common pathological type is squamous cell carcinoma. Patients with squamous ... ...

Abstract	Temporal bone malignant tumors are characterized by atypical clinical symptoms, and easy recurrence and metastasis. They account for 0.2% of head and neck tumors, and the most common pathological type is squamous cell carcinoma. Patients with squamous cell carcinoma of the temporal bone are often at advanced stages when diagnosed, and lose the chance for surgery. Neoadjuvant immunotherapy has recently been approved as the first-line treatment for refractory recurrent/metastatic squamous cell carcinoma of the head and neck. However, it remains to be determined whether neoadjuvant immunotherapy can be used as the first-line treatment for temporal bone squamous cell carcinoma to reduce the tumor stage before surgery, or as a palliative treatment for patients with unresectable advanced stage carcinoma. The present study reviews the development of immunotherapy and its clinical application in head and neck squamous cell carcinoma, summarizes the treatment of temporal bone squamous cell carcinoma, and prospects the neoadjuvant immunotherapy as the first-line treatment for temporal bone squamous cell carcinoma.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/therapy ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local/pathology ; Carcinoma, Squamous Cell/drug therapy ; Head and Neck Neoplasms/drug therapy ; Immunotherapy ; Temporal Bone/pathology
Language	English
Publishing date	2023-03-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-023-2700-2
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Article ; Online: Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor protein.

Meng, Wen / Gao, Shou-Jiang

Cell death & disease

2021 Volume 12, Issue 1, Page(s) 29

Abstract: Nucleocytoplasmic transport of signaling modulators is essential for regulating cellular responses to extracellular stimulation and stress, as well as pathogen infection. Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), mediates nuclear ...

Abstract	Nucleocytoplasmic transport of signaling modulators is essential for regulating cellular responses to extracellular stimulation and stress, as well as pathogen infection. Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), mediates nuclear export of proteins, rRNAs, snRNAs, and some mRNAs. In this study, we have identified an essential role of XPO1 in regulating Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication during primary infection of primary human umbilical vein endothelial cells. Treatment with an XPO1 inhibitor KPT-8602 and short hairpin RNA (shRNA)-mediated knockdown of XPO1 reduced KSHV lytic replication but had no effect on KSHV entry and trafficking. XPO1 inhibition induced retention of autophagy adaptor protein p62 (SQSTM1) in the nucleus, which enhanced activation of TBK1 and IRF3. As a result, nuclear accumulation of p62 increased expression of innate immune-related genes including IRF7, ISG15, IFIT1, IFIT2, and IFIT3, leading to a reduction of KSHV lytic replication. These results illustrate a novel mechanism by which XPO1 mediates innate immune response and KSHV replication, and identify XPO1 as a potential therapeutic target and KPT-8602 as a promising therapeutic agent for KSHV infection.
MeSH term(s)	Active Transport, Cell Nucleus ; Autophagy ; Gene Expression Regulation, Viral ; Herpesvirus 8, Human/physiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Karyopherins/physiology ; Receptors, Cytoplasmic and Nuclear/physiology ; Sarcoma, Kaposi/immunology ; Sarcoma, Kaposi/virology ; Sequestosome-1 Protein/immunology ; Virus Latency ; Virus Replication ; Exportin 1 Protein
Chemical Substances	Karyopherins ; Receptors, Cytoplasmic and Nuclear ; SQSTM1 protein, human ; Sequestosome-1 Protein
Language	English
Publishing date	2021-01-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-020-03303-1
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Article: Binder-Free Three-Dimensional Porous Graphene Cathodes via Self-Assembly for High-Capacity Lithium-Oxygen Batteries.

Liu, Yanna / Meng, Wen / Gao, Yuying / Zhao, Menglong / Li, Ming / Xiao, Liang

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 9

Abstract: The porous architectures of oxygen cathodes are highly desired for high-capacity lithium-oxygen batteries (LOBs) to support cathodic catalysts and provide accommodation for discharge products. However, controllable porosity is still a challenge for ... ...

Abstract	The porous architectures of oxygen cathodes are highly desired for high-capacity lithium-oxygen batteries (LOBs) to support cathodic catalysts and provide accommodation for discharge products. However, controllable porosity is still a challenge for laminated cathodes with cathode materials and binders, since polymer binders usually shield the active sites of catalysts and block the pores of cathodes. In addition, polymer binders such as poly(vinylidene fluoride) (PVDF) are not stable under the nucleophilic attack of intermediate product superoxide radicals in the oxygen electrochemical environment. The parasitic reactions and blocking effect of binders deteriorate and then quickly shut down the operation of LOBs. Herein, the present work proposes a binder-free three-dimensional (3D) porous graphene (PG) cathode for LOBs, which is prepared by the self-assembly and the chemical reduction of GO with triblock copolymer soft templates (Pluronic F127). The interconnected mesoporous architecture of resultant 3D PG cathodes achieved an ultrahigh capacity of 10,300 mAh g
Language	English
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14090754
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Article: Regional transarterial chemoembolization combined with chemoradiotherapy for locally advanced rectal cancer: a retrospective study of a new combination.

Meng, Wen-Jun / Liu, Chun-Hua / Zheng, Ru-Jun / Li, Chun-Xue

Frontiers in oncology

2023 Volume 13, Page(s) 1201544

Abstract: Objectives: Locally advanced rectal cancer (LARC) has a high risk of distant metastasis (DM). Currently, many treatment courses of LARC have arisen, but patients' DM status has not significantly improved. This study was designed to compare the effect ... ...

Abstract	Objectives: Locally advanced rectal cancer (LARC) has a high risk of distant metastasis (DM). Currently, many treatment courses of LARC have arisen, but patients' DM status has not significantly improved. This study was designed to compare the effect between preoperative regional transarterial chemoembolization combined with neoadjuvant chemoradiotherapy and standard neoadjuvant therapy on preventing DM in patients with LARC. Methods: A total of 81 LARC patients between July 2013 and May 2018 were enrolled in this retrospective study. Among them, 44 patients received preoperative regional transarterial chemoembolization combined with concurrent chemoradiotherapy (the interventional group), and 37 patients received only neoadjuvant chemoradiotherapy (the control group). The baseline data; preoperative toxicities; postoperative DM rate within 1, 2, and 3 years; and postoperative complications were compared between the two groups. Results: All patients successfully completed their treatments. There were no significant differences between the two groups in age, gender, tumor size, distance between the tumor and anal verge, CEA level, lymphovascular invasion, or tumor stage before treatment. The pathological T staging post-treatment in the interventional group was significantly reduced compared to that of the control group ( Conclusion: Preoperative regional transarterial chemoembolization combined with concurrent chemoradiotherapy may play an important role in reducing postoperative DM in LARC.
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1201544
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Article: The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer.

Yang, Ying / Meng, Wen-Jian / Wang, Zi-Qiang

Frontiers in oncology

2022 Volume 12, Page(s) 960539

Abstract: Gastric cancer (GC) is one of the most prevalent malignancies and the most common causes of cancer-related mortality worldwide. Furthermore, the prognosis of advanced GC remains poor even after surgery combined with chemoradiotherapy. As a small group of ...

Abstract	Gastric cancer (GC) is one of the most prevalent malignancies and the most common causes of cancer-related mortality worldwide. Furthermore, the prognosis of advanced GC remains poor even after surgery combined with chemoradiotherapy. As a small group of cells with unlimited differentiation and self-renewal ability in GC, accumulating evidence shows that GC stem cells (GCSCs) are closely associated with the refractory characteristics of GC, such as drug resistance, recurrence, and metastasis. With the extensive development of research on GCSCs, GCSCs seem to be promising therapeutic targets for GC. However, the relationship between GCSCs and GC is profound and intricate, and its mechanism of action is still under exploration. In this review, we elaborate on the source and key concepts of GCSCs, systematically summarize the role of GCSCs in GC and their underlying mechanisms. Finally, we review the latest information available on the treatment of GC by targeting GCSCs. Thus, this article may provide a theoretical basis for the future development of the novel targets based on GCSCs for the treatment of GC.
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.960539
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Article ; Online: Antitumor activity and molecular mechanism of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition.

Sun, Huimin / Meng, Wen / Zhu, Jie / Wang, Lu

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 395, Issue 6, Page(s) 643–658

Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proprotein convertase family of proteins that activate other proteins in cells. Functionally, PCSK9 binds to the receptor of low-density lipoprotein particles (LDL) to regulate ... ...

Abstract	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proprotein convertase family of proteins that activate other proteins in cells. Functionally, PCSK9 binds to the receptor of low-density lipoprotein particles (LDL) to regulate cholesterol metabolism and lipoprotein homeostasis in human body. PCSK9 inhibition is a novel pharmacological strategy to control hypercholesterolemia and cardiovascular diseases. Recently accumulating evidence realizes that PCSK9 possesses other roles in cells, such as regulation of tissue inflammatory response, intratumoral immune cell infiltration, and tumor progression. This review discussed the advancement of PCSK9 research on its role and underlying mechanisms in tumor development and progression. For example, PCSK9 inhibition could attenuate progression of breast cancer, glioma, colon tumor, hepatocellular cancer, prostate cancer, and lung adenocarcinoma and promote apoptosis of glioma, prostate cancer, and hepatocellular cancer cells. PCSK9 deficiency could reduce liver metastasis of B16F1 melanoma cells by lowering the circulating cholesterol levels. PCSK9 gene knockdown substantially attenuated mouse tumor growth in vivo by activation of cytotoxic T cells, although PCSK9 knockdown had no effect on morphology and growth rate of different mouse cancer cell lines in vitro. PCSK9 inhibition thus can be used to control human cancers. Future preclinical and clinical studies are warranted to define anti-tumor activity of PCSK9 inhibition.
MeSH term(s)	Animals ; Cholesterol ; Glioma ; Humans ; Liver Neoplasms/drug therapy ; Male ; Mice ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; Prostatic Neoplasms/drug therapy ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Subtilisins
Chemical Substances	Receptors, LDL ; Cholesterol (97C5T2UQ7J) ; PCSK9 protein, human (EC 3.4.21.-) ; Pcsk9 protein, mouse (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-)
Language	English
Publishing date	2022-03-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-022-02200-y
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