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  1. Article ; Online: Recent progress in drug development for fibrodysplasia ossificans progressiva.

    Meng, Xinmiao / Wang, Haotian / Hao, Jijun

    Molecular and cellular biochemistry

    2022  Volume 477, Issue 10, Page(s) 2327–2334

    Abstract: Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease caused by heterozygous missense mutations in Activin A receptor type I which is also known as Activin-like kinase 2 (ALK2), a type I receptor of Bone Morphogenetic Proteins(BMP). ... ...

    Abstract Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease caused by heterozygous missense mutations in Activin A receptor type I which is also known as Activin-like kinase 2 (ALK2), a type I receptor of Bone Morphogenetic Proteins(BMP). Patients with FOP usually undergo episodic flare-ups and the heterotopic ossification in soft and connective tissues. Molecular mechanism study indicates that Activin A, the ligand which normally transduces Transforming Growth Factor Beta signaling, abnormally activates BMP signaling through ALK2 mutants in FOP, leading to heterotopic bone formation. To date, effective therapies to FOP are unavailable. However, significant advances have recently been made in the development of FOP drugs. In this article, we review the recent advances in understanding the FOP mechanism and drug development, with a focus on the small-molecular and antibody drugs currently in the clinical trials for FOP treatment.
    MeSH term(s) Activins/genetics ; Activins/metabolism ; Bone Morphogenetic Proteins/metabolism ; Drug Development ; Humans ; Ligands ; Mutation ; Myositis Ossificans/drug therapy ; Myositis Ossificans/genetics ; Myositis Ossificans/metabolism ; Ossification, Heterotopic/genetics ; Ossification, Heterotopic/metabolism ; Transforming Growth Factor beta/genetics
    Chemical Substances Bone Morphogenetic Proteins ; Ligands ; Transforming Growth Factor beta ; Activins (104625-48-1)
    Language English
    Publishing date 2022-05-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-022-04446-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 892: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Shear performance of a novel non-metallic cross-laminated timber wall-to-wall connection using double-dovetail mortise-tenon joint

    Gao, Ying / Xuan, Shiqing / Xu, Feiyang / Diao, Yue / Meng, Xinmiao

    Wood Material Science & Engineering. 2023 May 04, v. 18, no. 3 p.1003-1013

    2023  

    Abstract: Wood structure is becoming more prevalent than ever for the sustainability of civil engineering due to its green and renewable characteristics. The mortise-tenon joint is a traditional wooden connection but emerges with prominent advantages over that ... ...

    Abstract Wood structure is becoming more prevalent than ever for the sustainability of civil engineering due to its green and renewable characteristics. The mortise-tenon joint is a traditional wooden connection but emerges with prominent advantages over that using metal connectors in the recycling process. This paper proposed a novel double-dovetail mortise-tenon joint, made of laminated veneer lumber, to connect cross-laminated timber (CLT) wall panels. The out-of-plane shear performance was investigated by monotonic and cyclic loading tests with a total of nine specimens in three groups. The failure modes, stiffness, strength and stiffness degradations, ductility and equivalent viscous damping ratios were discussed and analyzed. It was found that the dominant damage would transfer from the double-dovetail tenons to the CLT panels, when the ratio of the tenon head width to the panel thickness increased. In particular, the stiffness, maximum load and ductility of the joints decreased firstly and then showed an increase when the ratio increased from 0.6 to 0.67 and 0.75, respectively. The strength and stiffness degradations generally decreased when the ratio increased. In addition, the equivalent viscous damping ratio showed a transient fluctuation at the beginning, and increased with the damage accumulation, indicating more energy dissipation under seismic conditions.
    Keywords cross laminated timber ; energy ; geophysics ; head ; joints (wood) ; laminated veneer lumber ; wood ; wood anatomy ; Shear performance ; mortise-tenon joint ; CLT ; wall-to-wall connections ; failure mode
    Language English
    Dates of publication 2023-0504
    Size p. 1003-1013.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1748-0280
    DOI 10.1080/17480272.2022.2101382
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Sex-specific competitive social feedback amplifies the role of early life contingency in male mice.

    Zipple, Matthew N / Kuo, Daniel Chang / Meng, Xinmiao / Reichard, Tess M / Guess, Kwynn / Vogt, Caleb C / Moeller, Andrew H / Sheehan, Michael J

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Contingency (or 'luck') in early life plays an important role in shaping individuals' development. When individuals live within larger societies, social experiences may cause the importance of early contingencies to be magnified or dampened. Here we test ...

    Abstract Contingency (or 'luck') in early life plays an important role in shaping individuals' development. When individuals live within larger societies, social experiences may cause the importance of early contingencies to be magnified or dampened. Here we test the hypothesis that competition magnifies the importance of early contingency in a sex-specific manner by comparing the developmental trajectories of genetically identical, free-living mice who either experienced high levels of territorial competition (males) or did not (females). We show that male territoriality results in a competitive feedback loop that magnifies the importance of early contingency and pushes individuals onto divergent, self-reinforcing life trajectories, while the same process appears absent in females. Our results indicate that the strength of sexual selection may be self-limiting, as within-sex competition increases the importance of early life contingency, thereby reducing the ability of selection to lead to evolution. They also demonstrate the potential for contingency to lead to dramatic differences in life outcomes, even in the absence of any underlying differences in ability ('merit').
    Language English
    Publishing date 2024-04-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.19.590322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Physical and Mechanical Properties of Novel Porous Ecological Concrete Based on Magnesium Phosphate Cement.

    Zhao, Shuaiyu / Zhang, Dongpo / Li, Yaqiang / Gao, Hang / Meng, Xinmiao

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 21

    Abstract: Ecological concrete could reduce the environment impacts of the tremendous construction of infrastructures due to its favorability to plant growth. Nonetheless, the alkalinity of the ecological concrete is usually too high when using ordinary Portland ... ...

    Abstract Ecological concrete could reduce the environment impacts of the tremendous construction of infrastructures due to its favorability to plant growth. Nonetheless, the alkalinity of the ecological concrete is usually too high when using ordinary Portland cement (OPC). To solve this problem, the magnesium ammonium phosphate cement (MPC) was used to prepare a novel porous ecological concrete instead of OPC. The pH value and compressive strength of MPC were analyzed and the pore structure was evaluated. The chemical composition and morphology were investigated by an X-ray diffraction test and scanning electron microscope observation. In addition, the void ratio, compressive strength and planting-growing characteristic of MPC-based porous ecological concrete were also studied. The pH value of the MPC suspension ranged from 6.8 to 8.5, which was much lower than that of OPC. The pH value of MPC gradually increased with the increment of phosphorus/magnesium molar ratio (P/M) and the compressive strength reached a maximum value of 49.2 MPa when the P/M value was 1/4. Fly ash (FA) and ground blast furnace slag (GBFS) could improve the pore structure and compressive strength; however, the pH value was slightly increased. As the paste-to-aggregate ratio increased, the void ratio of concrete gradually decreased, while the compressive strength gradually increased. The meadow grass was planted in the MPC-based ecological concrete, and the seeds germinated in one week and showed a better growth status than those planted in the OPC-based ecological concrete.
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15217521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bearing Capacity and Mechanical Behavior of an Innovative Bamboo Fiber-Reinforced Polymer Tendon with U-Head.

    Li, Xiang / Zhao, Shuaiyu / Meng, Xinmiao / Ji, Xiaodong

    Polymers

    2021  Volume 13, Issue 22

    Abstract: The development of steel in engineering structures or components faces the problems of high cost and high carbon emission, which demands new materials used as reinforcement to be proposed and applied. Bamboo is a green and renewable natural material, and ...

    Abstract The development of steel in engineering structures or components faces the problems of high cost and high carbon emission, which demands new materials used as reinforcement to be proposed and applied. Bamboo is a green and renewable natural material, and has higher tensile strength parallel to grain compared to wood. Based on the excellent mechanical properties in the parallel-to-grain direction of bamboo fiber, this paper proposed an innovative bamboo fiber-reinforced polymer tendon with U-head (BFRP tendon). To analyze the tension capacity and mechanical behavior of the BFRP tendon, the thin-shell model and thick-shell model have been proposed in succession. Both models were compared with the results of tensile test and good agreement was achieved in the stress distribution and the ultimate load. The tension capacity of the BFRP tendon has been proved to be reliable, which can give full play to the advantages of bamboo fiber.
    Language English
    Publishing date 2021-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13223976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effects of Decay on the Mechanical Properties of Nailed Joints in Light Wood Frame Structure

    Gao, Ying / Mei, Shiyi / Ma, Xingxia / Meng, Xinmiao

    Forest products journal. 2021, v. 71, no. 1

    2021  

    Abstract: For this study, spruce–pine–fir (Picea–Pinus–Abies [SPF]) specification material, oriented strand board (OSB), and domestic twisted nails that were driven vertically and perpendicular-to-grain were selected. Referring to GB/T 13942.1-2009, nailed joints ... ...

    Abstract For this study, spruce–pine–fir (Picea–Pinus–Abies [SPF]) specification material, oriented strand board (OSB), and domestic twisted nails that were driven vertically and perpendicular-to-grain were selected. Referring to GB/T 13942.1-2009, nailed joints specimens were exposed both to white rot fungus and brown rot fungus for 1 month to 6 months. The monotonous loading test was applied to the specimens based on ASTM D1761-88. The holding power of the nails and weight loss of both OSB and SPF were investigated. Theoretical maximum load of the nailed joints was calculated according to Eurocode5. Results illustrated that the load, stiffness, and energy consumption of the nailed joints showed significant linear decline with the decay time. A linear decline of the ductility coefficient was not obvious, and there was no obvious difference between white rot fungus and brown rot fungus. Effect of decay on the OSB was much greater than the impact on the SPF. The decay grade of the nailed joints was established according to the linear relationship between weight loss and maximum load. Based on Eurocode5, the study calculated the maximum load of the nailed joints and introduced the correction coefficient γ to better predict the maximum load.
    Keywords brown-rot fungi ; energy ; forests ; weight loss ; white-rot fungi ; wood
    Language English
    Size p. 46-57.
    Publishing place [Forest Products Society, etc.]
    Document type Article
    Note NAL-AP-2-clean ; missing affliations
    ZDB-ID 240509-x
    ISSN 0015-7473
    ISSN 0015-7473
    DOI 10.13073/FPJ-D-20-00054
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3029: Show issues

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  7. Article: Research and prospects of bamboo bolts in China: state of the art [Erratum: October 2022, v.80(5); p.1039]

    Li, Xiang / Zhou, Jinyi / Meng, Xinmiao / Yan, Liting / Zhao, Shuaiyu / Ji, Xiaodong

    European journal of wood and wood products. 2022 Oct., v. 80, no. 5

    2022  

    Abstract: Bamboo has been used as a structural material for thousands of years. Due to its advantages in carbon absorption, mechanical properties, material supply and growth rate, etc., many bamboo products, especially engineered bamboo, were proposed and applied ... ...

    Abstract Bamboo has been used as a structural material for thousands of years. Due to its advantages in carbon absorption, mechanical properties, material supply and growth rate, etc., many bamboo products, especially engineered bamboo, were proposed and applied in buildings and structures. In this process, more than 40 years have passed since bamboo bolts were first applied. However, the shortage of strength and durability rendered the stagnated development of bamboo bolts, leading to the risk of being completely displaced. To arouse this environmental-friendly and high-specific-strength material in the application of ground anchorage, this paper summarised and further discussed the achievements of bamboo bolts and related products in China, including their classification, mechanical properties, anchorage performance, etc. According to the results, bamboo bolts still have vitality as a means of reinforcement if the shortcomings can be overcome. Therefore, a self-anchored bamboo bolt with a U-anchor head has been proposed in the following, which can give full play to the parallel-to-fibre tensile strength of bamboo strips and thus realise the efficient transformation from material properties to anchorage performance.
    Keywords absorption ; bamboos ; carbon ; durability ; head ; risk ; tensile strength ; wood ; China
    Language English
    Dates of publication 2022-10
    Size p. 1015-1038.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 2485250-8
    ISSN 1436-736X ; 0018-3768
    ISSN (online) 1436-736X
    ISSN 0018-3768
    DOI 10.1007/s00107-022-01834-2
    Database NAL-Catalogue (AGRICOLA)

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