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Book ; Online ; Thesis: Morphometrische Progressionserkennung bei der Glaukomerkrankung mittels Optischer Kohärenztomographie

Menghesha, Leonie / Enders, Philip / Hörster, Robert

2023

Institution	Universitätsklinikum Köln / Klinik und Poliklinik für Allgemeine Augenheilkunde
Author's details	vorgelegt von Leonie Menghesha, geb. Marzinek ; 1. Gutachter: Privatdozent Dr. med. P. Enders, 2. Gutachter: Privatdozent Dr. med. R. Hörster ; aus dem Zentrum für Augenheilkunde der Universität zu Köln, Klinik und Poliklinik für Allgemeine Augenheilkunde
Subject code	610
Language	German
Size	1 Online-Ressource (79 Seiten), Illustrationen, Diagramme
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität zu Köln, 2023
Note	Open Access
HBZ-ID	HT030055037
Database	Repository for Life Sciences

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Article ; Online: Bilaterale Skotome bei COVID-19.

Menghesha, Leonie / Grajewski, Rafael S / Krohne, Tim U

Klinische Monatsblatter fur Augenheilkunde

2023

Title translation	Bilateral Scotomata in COVID-19.
Language	German
Publishing date	2023-08-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80175-6
ISSN	1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
ISSN (online)	1439-3999
ISSN	0344-6360 ; 0344-6387 ; 0023-2165
DOI	10.1055/a-2120-7665
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Outcomes of short- versus long-acting gas tamponades in vitrectomy for rhegmatogenous retinal detachment.

Schöneberger, Verena / Li, Jeany Q / Menghesha, Leonie / Holz, Frank G / Schaub, Friederike / Krohne, Tim U

International journal of retina and vitreous

2024 Volume 10, Issue 1, Page(s) 16

Abstract: Background: In vitrectomy for rhegmatogenous retinal detachment, long-acting gas tamponades (LGT) such as C3F8 or C2F6 may improve surgical success rate due to their prolonged effect compared to a short-acting gas tamponade (SGT) with SF6. On the other ... ...

Abstract	Background: In vitrectomy for rhegmatogenous retinal detachment, long-acting gas tamponades (LGT) such as C3F8 or C2F6 may improve surgical success rate due to their prolonged effect compared to a short-acting gas tamponade (SGT) with SF6. On the other hand, SGT allow a significantly faster visual rehabilitation after surgery and may reduce the risk of gas-related complications. As comparative data in retinal detachment surgery is limited, we assessed the outcomes of vitrectomies using either LGT or SGT. Methods: We retrospectively analyzed 533 eyes of 524 consecutive patients diagnosed with primary rhegmatogenous retinal detachment not complicated by proliferative vitreoretinopathy (PVR) and treated by vitrectomy at two clinical sites. Depending on the site the patients presented at, they received either preferentially LGT (study site 1) or SGT (study site 2). Retinal re-detachment rates during a period of 6 months following surgery were analyzed. Results: At study site 1, 254 of 278 eyes (91.4%) were treated by LGT (C3F8 72.3%; C2F6 19.1%), whereas at study site 2, 246 of 255 eyes (96.5%) received SGT (SF6). Rates of retinal re-detachment in the LGT- and SGT-treated groups were similar with 23 of 254 eyes (9.1%) and 24 of 246 eyes (9.8%), respectively (p = 0.9). Median time to re-detachment was 5.7 weeks in the LGT-treated group and 4.4 weeks in the SGT-treated group (p = 0.4). Conclusion: In rhegmatogenous retinal detachment repair by vitrectomy, the use of SGT results in comparable rates of successful retinal re-attachment as LGT. Given the faster visual rehabilitation with SGT, these results suggest SGT as a sensible alternative to LGT in surgery of retinal detachment without PVR.
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2836254-8
ISSN	2056-9920
ISSN	2056-9920
DOI	10.1186/s40942-024-00530-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Morphometrische Progressionserkennung bei der Glaukomerkrankung mittels Optischer Kohärenztomographie

Menghesha, Leonie [Verfasser] / Enders, Philip [Gutachter] / Hörster, Robert [Gutachter]

2023

Author's details	Leonie Menghesha ; Gutachter: Philip Enders, Robert Hörster
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Deutsche Zentralbibliothek für Medizin
Publishing place	Köln
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Bilaterale Skotome bei COVID-19

Menghesha, Leonie / Grajewski, Rafael S. / Krohne, Tim U.

Klinische Monatsblätter für Augenheilkunde

2023

Language	German
Publishing date	2023-08-29
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80175-6
ISSN	1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
ISSN (online)	1439-3999
ISSN	0023-2165 ; 0344-6360 ; 0344-6387
DOI	10.1055/a-2120-7665
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

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Article ; Online: Relevance of Laser Flare Photometry in Retinal Pathologies.

Schöneberger, Verena / Menghesha, Leonie / Feltgen, Nicolas / Fuchsluger, Thomas Armin / Cursiefen, Claus / Schaub, Friederike

Klinische Monatsblatter fur Augenheilkunde

2023 Volume 240, Issue 5, Page(s) 669–676

Abstract: Laser flare photometry provides a non-invasive and objective measurement of the Tyndall effect in the anterior chamber. The laser flare value (measured in photon number per millisecond [pc/ms]) thus quantifies the extent of disruption to the blood- ... ...

Title translation	Relevanz der Laser-Flare-Photometrie bei retinalen Pathologien.
Abstract	Laser flare photometry provides a non-invasive and objective measurement of the Tyndall effect in the anterior chamber. The laser flare value (measured in photon number per millisecond [pc/ms]) thus quantifies the extent of disruption to the blood-aqueous barrier and can be used in clinical applications to monitor uveitis therapy or to measure the postoperative degree of inflammation. Standardised performance must be observed during measurement. Publications of the last 35 years on laser flare photometry deal not only with the measurement procedure but also with its use in clinical practice for different ophthalmological pathologies. Likewise, various influencing factors have already been investigated and described that must be considered when measuring and evaluating laser flare values. The focus of this article is the relevance of laser flare photometry in retinal pathologies. In recently published studies, the level of objective tyndallometry in primary rhegmatogenous retinal detachment is shown to depend on lens status, symptom duration, and extent of retinal detachment. The greater is the area of the retina affected, the greater the disruption of the blood-aqueous barrier appears to be. Elevated laser flare values have also been considered as a predictor for the development of proliferative vitreoretinopathy (PVR). However, based on current knowledge, this assumption must be put into perspective. According to current data, objective tyndallometry can be used to monitor the progression of intraocular inflammation and to quantify the blood-aqueous barrier, and the values correlate with the extent and anatomical features, as well as the symptom duration in retinal detachment. Many influencing factors have already been identified. But further evaluation is desirable and needed. It is still unclear whether laser flare values can be used in the future as a predictor for sequelae such as PVR development.
MeSH term(s)	Humans ; Retinal Detachment/surgery ; Aqueous Humor ; Uveitis/diagnosis ; Uveitis/complications ; Inflammation ; Retina ; Vitreoretinopathy, Proliferative ; Photometry/methods ; Lasers
Language	German
Publishing date	2023-04-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80175-6
ISSN	1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
ISSN (online)	1439-3999
ISSN	0344-6360 ; 0344-6387 ; 0023-2165
DOI	10.1055/a-1974-4722
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Retinal Detachment Rates After Uncomplicated DMEK Versus Cataract Surgery Combined (Triple-)DMEK.

Schöneberger, Verena / Tahmaz, Volkan / Menghesha, Leonie / Lüke, Jan Niklas / Cursiefen, Claus / Schaub, Friederike / Bachmann, Björn O

Cornea

2024

Abstract: Purpose: To evaluate the rate of and risk factors for rhegmatogenous retinal detachment (RRD) after Descemet membrane endothelial keratoplasty (DMEK) either alone or in combination with cataract surgery.: Design: Retrospective analysis of prospective ...

Abstract	Purpose: To evaluate the rate of and risk factors for rhegmatogenous retinal detachment (RRD) after Descemet membrane endothelial keratoplasty (DMEK) either alone or in combination with cataract surgery. Design: Retrospective analysis of prospective database. Methods: Consecutive eyes with Fuchs endothelial corneal dystrophy (FECD) that received DMEK surgery with a minimum follow-up of 1 year between July 2011 and January 2021 at the Department of Ophthalmology at the University of Cologne were analyzed. Exclusion criteria were complicated history including repeat DMEK within 1-year, previous retinal or glaucoma surgery, complicated phacoemulsification, congenital cataract, history of trauma. Results: From 3858 consecutive DMEKs, 1961 patients were identified suitable for analysis. 846 (43.1%) were pseudophakic DMEK, 91 (4.6%) phakic DMEK and 1,024 (52.2%) combined with cataract surgery. RRD occurred in 13 eyes (12 patients). Within two years after DMEK RRD occurred in 0.49% and 0.47% after DMEK and DMEK with cataract surgery, respectively. Mean age of 59.24 ± 8.42 years with subsequent RRD was significantly lower than overall 68.81 ± 9.89 years (t-test two-tailed; p < 0.001). The spherical equivalent was -4.69 ± 3.98 D (range -9.00 to 0.5) in RRD after pseudophakic DMEK compared to -2.79 ± 3.54 D (range -7.5 to 0.75) in combined procedures. Re-bubbling had no influence on RRD rate. Conclusions: DMEK alone or in combination with cataract surgery showed similar postoperative RRD rates in the first two years, generally in the range of pseudophakic RRDs. Risk factors such as myopia and younger age could be identified. Re-bubbling has no influence on RRD rates.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003554
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lens status and degree of lens opacity influence laser flare photometry (objective tyndallometry).

Schoeneberger, Verena / Menghesha, Leonie / Gerlach, Stefanie / Gietzelt, Caroline / Eberhardt, Somaie / Cursiefen, Claus / Schaub, Friederike

European journal of ophthalmology

2022 , Page(s) 11206721221137169

Abstract: Purpose: Objective tyndallometry using laser flare photometry can be utilized e.g., in management of uveitis. Previous studies showed a significant difference in flare values between pseudophakic and phakic eyes. We investigate a potential association ... ...

Abstract	Purpose: Objective tyndallometry using laser flare photometry can be utilized e.g., in management of uveitis. Previous studies showed a significant difference in flare values between pseudophakic and phakic eyes. We investigate a potential association between the degree of lens opacification and flare value in a large cohort phakic eyes. Methods: Retrospective, non-interventional single center study. Laser flare values of 460 healthy fellow eyes from two large cohorts (primary rhegmatogenous retinal detachment (RRD), macular holes (MH)) were correlated with lens status, degree of lens opacity, and age. Results: Out of 460 patients (mean age 64.6 ± 11.2, 57% male) 30.4% were pseudophakic (70.2 ± 10.9) and 69.6% phakic, of which 47.8% showed a clear lens (57.3 ± 9.1), 43.2% an mild cataract (65.2 ± 9.0) and 9.0% a moderate cataract (73.5 ± 9.0).In pseudophakia, flare (8.14 ± 4.6 pc/ms) was significantly higher compared to phakia (6.4 ± 3.9 pc/ms; p < 0.001). In phakic eyes, flare values increased significantly with increasing lens opacity (clear lens 5.3 ± 2.8 pc/ms; mild cataract 7.0 ± 4.0 pc/ms; moderate cataract 9.5 ± 6.1 pc/ms; p < 0.001). In clear lenses and mild cataract, age correlated significantly with flare (two-sided, p < 0.001, clear lenses R = 0.3; mild cataract R = 0.4). In clear lenses, flare values increased with age by 0.09 per year, in mild cataract by 0.17 (regression coefficients). No significant correlation was found between age and flare value in moderate cataract and pseudophakic eyes. Conclusion: The level of objective tyndallometry seems to be dependent on lens status, degree of lens opacity and age. These factors should therefore be taken into account when interpreting laser flare values in the future.
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221137169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between blood-aqueous barrier disruption and extent of retinal detachment.

Schoeneberger, Verena / Eberhardt, Somaie / Menghesha, Leonie / Enders, Philip / Cursiefen, Claus / Schaub, Friederike

European journal of ophthalmology

2022 , Page(s) 11206721221099251

Abstract: Purpose: To investigate the association between anatomical features of rhegmatogenous retinal detachment (RRD) and the extent of blood-aqueous barrier disorder measured by non-invasiv laser flare photometry.: Methods: Retrospective evaluation of ... ...

Abstract	Purpose: To investigate the association between anatomical features of rhegmatogenous retinal detachment (RRD) and the extent of blood-aqueous barrier disorder measured by non-invasiv laser flare photometry. Methods: Retrospective evaluation of consecutive patients with RRD that underwent surgery between November 2016 and October 2018. Descriptive evaluation of pre- and postoperative parameters and correlation to preoperative laser flare value, extent of retinal detachment and re-detachment rate were performed. Results: 266 patients (mean age 62.73 ± 10.40 years, 62.8% male) were included. Mean preoperative flare value was 11.0 ± 11.9 pc/ms. In pseudophakia flare values were higher than in phakia (12.7 ± 10.4 pc/ms versus 9.8 ± 12.9 pc/ms; Conclusion: The level of objective tyndallometry in RRD seems to be influenced by lens status and extent of retinal detachment. Thus, the greater the affected retinal area is, the more blood-aqueous barrier disruption seems to be present.
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221099251
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Relevanz der Laser-Flare-Photometrie bei retinalen Pathologien

Schöneberger, Verena / Menghesha, Leonie / Feltgen, Nicolas / Fuchsluger, Thomas Armin / Cursiefen, Claus / Schaub, Friederike

Klinische Monatsblätter für Augenheilkunde

2023 Volume 240, Issue 05, Page(s) 669–676

Abstract: Mithilfe der Laser-Flare-Photometrie kann eine nicht invasive und objektive Messung des Tyndall-Effekts in der Vorderkammer erfolgen. Der Laser-Flare-Wert (Tyndallometrie; gemessen in Photonenzahl pro Millisekunde [pc/ms]) quantifiziert somit ... ...

Abstract	Mithilfe der Laser-Flare-Photometrie kann eine nicht invasive und objektive Messung des Tyndall-Effekts in der Vorderkammer erfolgen. Der Laser-Flare-Wert (Tyndallometrie; gemessen in Photonenzahl pro Millisekunde [pc/ms]) quantifiziert somit das Ausmaß einer Störung der Blut-Kammerwasser-Schranke und kann dadurch in der klinischen Anwendung zur Überwachung einer Uveitistherapie oder zum Messen eines postoperativen Entzündungsgrades verwendet werden. Bei der Messung ist eine standardisierte Durchführung zu beachten. Publikationen der letzten 35 Jahre zur Laser-Flare-Photometrie beschäftigen sich neben dem Messverfahren mit dessen Einsatz in der klinischen Praxis bei unterschiedlichen ophthalmologischen Erkrankungen. Ebenso wurden bereits verschiedene Einflussfaktoren untersucht und beschrieben, die bei der Messung und Auswertung von Laser-Flare-Werten zu beachten sind. Fokus dieses Beitrags ist die Relevanz der Laser-Flare-Photometrie in der Retinologie. In kürzlich veröffentlichten Studien zeigt sich die Höhe der objektiven Tyndallometrie bei einer primären rhegmatogenen Amotio abhängig vom Linsenstatus, der Symptomdauer und dem Ausmaß der Netzhautablösung. Je mehr Fläche der Netzhaut betroffen ist, desto größer scheint die Störung der Blut-Kammerwasser-Schranke. Erhöhte Laser-Flare-Werte galten zudem bislang als Prädiktor für die Entwicklung einer proliferativen Vitreoretinopathie (PVR), jedoch muss diese Annahme nach aktuellem Kenntnisstand relativiert werden. Die objektive Tyndallometrie kann nach derzeitiger Datenlage zur Verlaufskontrolle bei intraokularen Entzündungen und zur Quantifizierung der Blut-Kammerwasser-Schranke genutzt werden. Die Werte korrelieren mit dem Ausmaß und anatomischen Gegebenheiten sowie der Symptomdauer bei Netzhautablösung. Es gibt viele bereits identifizierte Einflussfaktoren, eine weitere Evaluation ist jedoch wünschenswert und erforderlich. Ob der Laser-Flare-Wert zukünftig als Prädiktor für Folgeerkrankungen wie bspw. die PVR-Entwicklung genutzt werden kann, ist derzeit noch unklar. Laser flare photometry provides a non-invasive and objective measurement of the Tyndall effect in the anterior chamber. The laser flare value (measured in photon number per millisecond [pc/ms]) thus quantifies the extent of disruption to the blood-aqueous barrier and can be used in clinical applications to monitor uveitis therapy or to measure the postoperative degree of inflammation. Standardised performance must be observed during measurement. Publications of the last 35 years on laser flare photometry deal not only with the measurement procedure but also with its use in clinical practice for different ophthalmological pathologies. Likewise, various influencing factors have already been investigated and described that must be considered when measuring and evaluating laser flare values. The focus of this article is the relevance of laser flare photometry in retinal pathologies. In recently published studies, the level of objective tyndallometry in primary rhegmatogenous retinal detachment is shown to depend on lens status, symptom duration, and extent of retinal detachment. The greater is the area of the retina affected, the greater the disruption of the blood-aqueous barrier appears to be. Elevated laser flare values have also been considered as a predictor for the development of proliferative vitreoretinopathy (PVR). However, based on current knowledge, this assumption must be put into perspective. According to current data, objective tyndallometry can be used to monitor the progression of intraocular inflammation and to quantify the blood-aqueous barrier, and the values correlate with the extent and anatomical features, as well as the symptom duration in retinal detachment. Many influencing factors have already been identified. But further evaluation is desirable and needed. It is still unclear whether laser flare values can be used in the future as a predictor for sequelae such as PVR development.
Keywords	Laser-Flare-Photometrie ; Tyndall-Effekt ; Entzündung ; proliferative Vitreoretinopathie ; Netzhautablösung ; laser flare photometry ; Tyndall effect ; inflammation ; proliferative vitreoretinopathy ; retinal detachment
Language	German
Publishing date	2023-04-04
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80175-6
ISSN	1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
ISSN (online)	1439-3999
ISSN	0023-2165 ; 0344-6360 ; 0344-6387
DOI	10.1055/a-1974-4722
Database	Thieme publisher's database

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