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  1. AU="Mengzhen, Zhang"
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  1. Artikel ; Online: Universal interference-based construction of Gaussian operations in hybrid quantum systems

    Mengzhen Zhang / Shoumik Chowdhury / Liang Jiang

    npj Quantum Information, Vol 8, Iss 1, Pp 1-

    2022  Band 10

    Abstract: Abstract Beam-splitter operations are an indispensable resource for processing quantum information encoded in bosonic modes. In hybrid quantum systems, however, it can be challenging to implement reliable beam-splitters between two distinct modes due to ... ...

    Abstract Abstract Beam-splitter operations are an indispensable resource for processing quantum information encoded in bosonic modes. In hybrid quantum systems, however, it can be challenging to implement reliable beam-splitters between two distinct modes due to various experimental imperfections. Without beam-splitters, realizing arbitrary Gaussian operations between bosonic modes can become highly non-trivial or even infeasible. In this work, we develop interference-based protocols for engineering Gaussian operations in multi-mode hybrid bosonic systems without requiring beam-splitters. Specifically, for a given generic multi-mode Gaussian unitary coupler, we demonstrate a universal scheme for constructing Gaussian operations on a desired subset of the modes, requiring only multiple uses of the given coupler interleaved with single-mode Gaussian unitaries. Our results provide efficient construction of operations crucial to quantum information science, and are derived from fundamental physical properties of bosonic systems. The proposed scheme is thus widely applicable to existing platforms and couplers, with the exception of certain edge cases. We introduce a systematic approach to identify and treat these edge cases by utilizing an intrinsically invariant structure associated with our interference-based construction.
    Schlagwörter Physics ; QC1-999 ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 535
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Integrated machine learning-driven disulfidptosis profiling: CYFIP1 and EMILIN1 as therapeutic nodes in neuroblastoma.

    Mengzhen, Zhang / Xinwei, Hou / Zeheng, Tan / Nan, Li / Yang, Yang / Huirong, Yang / Kaisi, Fan / Xiaoting, Ding / Liucheng, Yang / Kai, Wu

    Journal of cancer research and clinical oncology

    2024  Band 150, Heft 3, Seite(n) 109

    Abstract: Background: Neuroblastoma (NB), a prevalent pediatric solid tumor, presents formidable challenges due to its high malignancy and intricate pathogenesis. The role of disulfidptosis, a novel form of programmed cell death, remains poorly understood in the ... ...

    Abstract Background: Neuroblastoma (NB), a prevalent pediatric solid tumor, presents formidable challenges due to its high malignancy and intricate pathogenesis. The role of disulfidptosis, a novel form of programmed cell death, remains poorly understood in the context of NB.
    Methods: Gaussian mixture model (GMM)-identified disulfidptosis-related molecular subtypes in NB, differential gene analysis, survival analysis, and gene set variation analysis were conducted subsequently. Weighted gene co-expression network analysis (WGCNA) selected modular genes most relevant to the disulfidptosis core pathways. Integration of machine learning approaches revealed the combination of the Least absolute shrinkage and selection operator (LASSO) and Random Survival Forest (RSF) provided optimal dimensionality reduction of the modular genes. The resulting model was validated, and a nomogram assessed disulfidptosis characteristics in NB. Core genes were filtered and subjected to tumor phenotype and disulfidptosis-related experiments.
    Results: GMM clustering revealed three distinct subtypes with diverse prognoses, showing significant variations in glucose metabolism, cytoskeletal structure, and tumor-related pathways. WGCNA highlighted the red module of genes highly correlated with disulfide isomerase activity, cytoskeleton formation, and glucose metabolism. The LASSO and RSF combination yielded the most accurate and stable prognostic model, with a significantly worse prognosis for high-scoring patients. Cytological experiments targeting core genes (CYFIP1, EMILIN1) revealed decreased cell proliferation, migration, invasion abilities, and evident cytoskeletal deformation upon core gene knockdown.
    Conclusions: This study showcases the utility of disulfidptosis-related gene scores for predicting prognosis and molecular subtypes of NB. The identified core genes, CYFIP1 and EMILIN1, hold promise as potential therapeutic targets and diagnostic markers for NB.
    Mesh-Begriff(e) Child ; Humans ; Adaptor Proteins, Signal Transducing ; Apoptosis ; Cell Proliferation/genetics ; Glucose ; Machine Learning ; Neuroblastoma/genetics ; Prognosis
    Chemische Substanzen Adaptor Proteins, Signal Transducing ; CYFIP1 protein, human ; Glucose (IY9XDZ35W2) ; elastin microfibril interface located protein
    Sprache Englisch
    Erscheinungsdatum 2024-03-01
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-024-05630-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.

    Nan, Li / Kaisi, Fan / Mengzhen, Zhang / Yang, Yang / Jiaming, Yang / Huirong, Yang / Xinwei, Hou / Chen, Wang / Liucheng, Yang / Kai, Wu

    Pediatric surgery international

    2024  Band 40, Heft 1, Seite(n) 63

    Abstract: Purpose: Necrotizing enterocolitis (NEC) is a significant contributor to neonatal mortality. This study aimed to investigate the role of high levels of miR-375-3p in breast milk in the development of NEC and elucidate its mechanism.: Methods: ... ...

    Abstract Purpose: Necrotizing enterocolitis (NEC) is a significant contributor to neonatal mortality. This study aimed to investigate the role of high levels of miR-375-3p in breast milk in the development of NEC and elucidate its mechanism.
    Methods: Differential expression of miR-375-3p in the intestines of breast-fed and formula-fed mice was confirmed using real-time polymerase chain reaction (RT-PCR). NEC mice models were established, and intestinal injury was assessed using HE staining. RT-PCR and Western blot were conducted to examine the expression of miR-375-3p, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein β (YWHAB), as well as the inflammatory in IEC-6 cells, and intestinal tissues obtained from NEC mice and patients. Flow cytometry and cell counting kit-8 (CCK-8) were employed to elucidate the impact of miR-375-3p and YWHAB on cell apoptosis and proliferation.
    Results: Breastfeeding increases miR-375-3p expression in the intestines. The expression of miR-375-3p in NEC intestinal tissues exhibited a significant decrease compared to the healthy group. Additionally, the expression of interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) was higher in the NEC group compared to the control group. Down-regulation of miR-375-3p inhibited IEC-6 cell proliferation, increased apoptosis, and elevated secretion of inflammatory factors. Bioinformatics revealed that YWHAB may be a target of miR-375-3p. RT-PCR and Western blot indicated a down-regulation of YWHAB expression in intestines of NEC patients and mice. Furthermore, YWHAB was found to be positively connected with miR-375-3p. Knockdown miR-375-3p down-regulated YWHAB expression in cells. Inhibition of YWHAB exhibited similar effects to miR-375-3p in IEC-6 cells. YWHAB plasmid partially reverse cellular functional impairment induced by miR-375-3p knockdown.
    Conclusions: Breastfeeding elevated miR-375-3p expression in intestines in neonatal mice. MiR-375-3p leads to a decrease in apoptosis of intestinal epithelial cells, an increase in cell proliferation, and a concomitant reduction in the expression of inflammatory factors partly through targeting YWHAB.
    Mesh-Begriff(e) Animals ; Female ; Humans ; Infant, Newborn ; Mice ; 14-3-3 Proteins/metabolism ; Abdominal Injuries ; Enterocolitis, Necrotizing/metabolism ; Fetal Diseases ; Infant, Newborn, Diseases ; MicroRNAs/genetics
    Chemische Substanzen 14-3-3 Proteins ; MicroRNAs ; MIRN375 microRNA, human ; YWHAB protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-03-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-024-05653-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2138: Hefte anzeigen Standort:
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  4. Artikel ; Online: Achieving the Heisenberg limit in quantum metrology using quantum error correction

    Sisi Zhou / Mengzhen Zhang / John Preskill / Liang Jiang

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 11

    Abstract: The possibility to reach Heisenberg-limited quantum measurements in the presence of noise is a long-standing problem. Here, the authors derive a necessary and sufficient condition on the noise acting on any finite-dimensional probe to establish whether ... ...

    Abstract The possibility to reach Heisenberg-limited quantum measurements in the presence of noise is a long-standing problem. Here, the authors derive a necessary and sufficient condition on the noise acting on any finite-dimensional probe to establish whether the Heisenberg limit is reachable using quantum error correction.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: Achieving the Heisenberg limit in quantum metrology using quantum error correction

    Sisi Zhou / Mengzhen Zhang / John Preskill / Liang Jiang

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 11

    Abstract: The possibility to reach Heisenberg-limited quantum measurements in the presence of noise is a long-standing problem. Here, the authors derive a necessary and sufficient condition on the noise acting on any finite-dimensional probe to establish whether ... ...

    Abstract The possibility to reach Heisenberg-limited quantum measurements in the presence of noise is a long-standing problem. Here, the authors derive a necessary and sufficient condition on the noise acting on any finite-dimensional probe to establish whether the Heisenberg limit is reachable using quantum error correction.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Nature Publishing Group
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  6. Artikel ; Online: Hexafluoropropylene oxide tetramer acid (HFPO-TeA)-induced developmental toxicities in chicken embryo

    Qixuan Dong / Yajie Guo / Junhua Yuan / Shuping Zhong / Hao Ni / Jingyi Liu / Mengzhen Zhang / Jiaqi Sun / Shuqi Yuan / Huan Yu / Yuxu Zhong / Qixiao Jiang

    Ecotoxicology and Environmental Safety, Vol 253, Iss , Pp 114671- (2023)

    Peroxisome proliferator-activated receptor Alpha (PPARα) is involved

    2023  

    Abstract: Hexafluoropropylene oxide tetramer acid (HFPO-TeA) is an emerging environmental contaminant, with environmental presence but limited toxicological information. To investigate its potential developmental toxicities, various doses of HFPO-TeA exposure were ...

    Abstract Hexafluoropropylene oxide tetramer acid (HFPO-TeA) is an emerging environmental contaminant, with environmental presence but limited toxicological information. To investigate its potential developmental toxicities, various doses of HFPO-TeA exposure were achieved in chicken embryos via air cell injection, and the exposed embryos were incubated until hatch. Within 24 h of hatch, the hatchling chickens were assessed with electrocardiography and histopathology for toxicological evaluation. For mechanistic investigation, in ovo silencing of PPARα was achieved via lentivirus microinjection, then the morphological/functional endpoints along with protein expression levels of PPARα-regulated genes were assessed. HFPO-TeA exposure in chicken embryo resulted in developmental cardiotoxicity and hepatotoxicity. Specifically, decreased right ventricular wall thickness, increased heart rate and hepatic steatosis were observed, whereas silencing of PPARα resulted in alleviation of observed toxicities. Western blotting for EHHADH and FABPs suggested that developmental exposure to HFPO-TeA effectively increased the expression levels of both targets in hatchling chicken heart and liver tissue samples, while PPARα silencing prevented such changes, suggesting that PPARα and its downstream genes are playing critical roles in HFPO-TeA induced developmental toxicities.
    Schlagwörter Hexafluoropropylene oxide tetramer acid ; Peroxisome proliferator-activated receptor Alpha ; Developmental toxicities ; Chicken embryo ; In ovo silencing ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: Involvement of plasminogen activator inhibitor-1 in p300/p53-mediated age-related atrial fibrosis

    Yingyu Lai / Jintao He / Xiaoyan Gao / Dewei Peng / Huishan Zhou / Yuwen Xu / Xueshan Luo / Hui Yang / Mengzhen Zhang / Chunyu Deng / Shulin Wu / Yumei Xue / Feng Zhou / Fang Rao

    PeerJ, Vol 11, p e

    2023  Band 16545

    Abstract: Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is also intimately involved in the fibrosis. Although PAI-1 may be involved in the occurrence of atrial fibrillation (AF) and thrombosis in the elderly, but whether it ...

    Abstract Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is also intimately involved in the fibrosis. Although PAI-1 may be involved in the occurrence of atrial fibrillation (AF) and thrombosis in the elderly, but whether it participated in aging-related atrial fibrosis and the detailed mechanism is still unclear. We compared the transcriptomics data of young (passage 4) versus senescent (passage 14) human atrial fibroblasts and found that PAI-1 was closely related to aging-related fibrosis. Aged mice and senescent human and mouse atrial fibroblasts underwent electrophysiological and biochemical studies. We found that p300, p53, and PAI-1 protein expressions were increased in the atrial tissue of aged mice and senescent human and mouse atrial fibroblasts. Curcumin or C646 (p300 inhibitor), or p300 knockdown inhibited the expression of PAI-1 contributing to reduced atrial fibroblasts senescence, atrial fibrosis, and the AF inducibility. Furthermore, p53 knockdown decreased the protein expression of PAI-1 and p21 in senescent human and mouse atrial fibroblasts. Our results suggest that p300/p53/PAI-1 signaling pathway participates in the mechanism of atrial fibrosis induced by aging, which provides new sights into the treatment of elderly AF.
    Schlagwörter Plasminogen activator inhibitor-1 ; p300 ; p53 ; Bioinformatics analysis ; Age-related atrial fibrosis ; Atrial fibrillation ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Enhanced Photocatalytic Hydrogen Production of the Polyoxoniobate Modified with RGO and PPy

    Shiliang Heng / Lei Li / Weiwei Li / Haiyan Li / Jingyu Pang / Mengzhen Zhang / Yan Bai / Dongbin Dang

    Nanomaterials, Vol 10, Iss 2449, p

    2020  Band 2449

    Abstract: The development of high-efficiency, recyclable, and inexpensive photocatalysts for water splitting for hydrogen production is of great significance to the application of solar energy. Herein, a series of graphene-decorated polyoxoniobate photocatalysts ... ...

    Abstract The development of high-efficiency, recyclable, and inexpensive photocatalysts for water splitting for hydrogen production is of great significance to the application of solar energy. Herein, a series of graphene-decorated polyoxoniobate photocatalysts Nb 6 /PPy-RGO (Nb 6 = K 7 Nb 6 O 19 , RGO = reduced graphene oxide, PPy = polypyrrole), with the bridging effect of polypyrrole were prepared through a simple one-step solvothermal method, which is the first example of polyoxoniobate-graphene-based nanocomposites. The as-fabricated photocatalyst showed a photocatalytic H 2 evolution activity without any co-catalyst. The rate of 1038 µmol g −1 in 5 h under optimal condition is almost 43 times higher than that of pure K 7 HNb 6 O 19 ×13H 2 O. The influencing factors for photocatalysts in photocatalytic hydrogen production under simulated sunlight were studied in detail and the feasible mechanism is presented in this paper. These results demonstrate that Nb 6 O 19 acts as the main catalyst and electron donor, RGO provides active sites, and PPy acted as an electronic bridge to extend the lifetime of photo-generated carriers, which are crucial factors for photocatalytic H 2 production.
    Schlagwörter polyoxoniobate ; Nb 6 /PPy-RGO composites ; electronic bridge ; H 2 production ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 290
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag MDPI AG
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  9. Artikel ; Online: Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells

    Liping Mai / Guodong He / Jing Chen / Jiening Zhu / Shaoxian Chen / Xinghua Hou / Hui Yang / Mengzhen Zhang / Yueheng Wu / Qiuxiong Lin / Min Yang / Xiaohong Li

    Stem Cells International, Vol

    2021  Band 2021

    Abstract: Background and Aim. The senescence of human bone marrow mesenchymal stem cells (hBMSCs) can be induced by oxidative stress, but the mechanism by which it occurs is not yet clear. Here, we performed an investigation on the pathogenesis of hypoxia-induced ... ...

    Abstract Background and Aim. The senescence of human bone marrow mesenchymal stem cells (hBMSCs) can be induced by oxidative stress, but the mechanism by which it occurs is not yet clear. Here, we performed an investigation on the pathogenesis of hypoxia-induced senescence through proteomic analyses and aimed to explore the mechanisms of stem cell senescence. Methods. Hypoxia in hBMSCs was induced for 0, 4, and 12 hours, and cellular senescence was evaluated by senescence-associated β-galactosidase (SA-β-gal) staining. Tandem mass tag (TMT) labeling was combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for differential proteomic analysis of hypoxia in hBMSCs. Parallel reaction monitoring (PRM) analysis was used to validate the candidate proteins. Verifications of signaling pathways were evaluated by western blotting. Cell apoptosis was evaluated using Annexin V/7-AAD staining by flow cytometry. The production of reactive oxygen species (ROS) was detected by the fluorescent probe 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA). Results. Cell senescence detected by SA-β-gal activity was higher in the 12-hour hypoxia-induced group. TMT analysis of 12-hour hypoxia-induced cells identified over 6000 proteins, including 686 differentially expressed proteins. Based on biological pathway analysis, we found that the senescence-associated proteins were predominantly enriched in the cancer pathways, PI3K-Akt pathway, and cellular senescence signaling pathways. CDK1, CDK2, and CCND1 were important nodes in PPI analyses. Moreover, the CCND1, UQCRH, and COX7C expressions were verified by PRM. Hypoxia induction for 12 hours in hBMSCs reduced CCND1 expression but promoted ROS production and cell apoptosis. Such effects were markedly reduced by the PI3K agonist, 740 Y-P, and attenuated by LY294002. Conclusions. Hypoxia of hBMSCs inhibited CCND1 expression but promoted ROS production and cell apoptosis through activating the PI3K-dependent signaling pathway. These findings provided a detailed characterization of ...
    Schlagwörter Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
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  10. Artikel: An islanding partition method of active distribution networks based on chance-constrained programming

    Zhao, Jinli / Mengzhen Zhang / Hao Yu / Haoran Ji / Guanyu Song / Peng Li / Chengshan Wang / Jianzhong Wu

    Applied energy. 2019 May 15, v. 242

    2019  

    Abstract: With the high integration of uncontrollable distributed generators (NDGs) comprising photovoltaic arrays (PVs) and wind turbines (WTs), many technical issues have become increasingly prominent in the islanding operation of active distribution networks ( ... ...

    Abstract With the high integration of uncontrollable distributed generators (NDGs) comprising photovoltaic arrays (PVs) and wind turbines (WTs), many technical issues have become increasingly prominent in the islanding operation of active distribution networks (ADNs). Such problems including branch overloading and voltage violations threaten the secure operation of distribution systems and a continuous power supply. To address the uncertainties of NDG outputs when implementing islanding partition strategies, this paper proposes a new method of the islanding partition of ADNs based on chance-constrained programming. First, power generation scenarios and probability distributions for these scenarios are generated according to historical data considering the time series characteristics and uncertainties of NDGs. Then, the chance-constrained description of islanding operation is expanded to consider the effect of uncertainties related to NDGs. Moreover, an islanding partition model of ADNs based on chance-constrained programming is established. By applying convex relaxation and introducing auxiliary variables, the model is converted to a mixed-integer quadratically constrained programming model that can be effectively solved. Finally, case studies involving the modified IEEE 33-node system, IEEE 123-node system and an actual distribution system are conducted to verify the effectiveness and scalability of the proposed method.
    Schlagwörter case studies ; electric potential difference ; models ; power generation ; probability distribution ; time series analysis ; uncertainty ; wind turbines
    Sprache Englisch
    Erscheinungsverlauf 2019-0515
    Umfang p. 78-91.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 2000772-3
    ISSN 0306-2619
    ISSN 0306-2619
    DOI 10.1016/j.apenergy.2019.03.118
    Datenquelle NAL Katalog (AGRICOLA)

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