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  1. Book ; Thesis: Regulation von Transportern für organische Kationen durch Glukose

    Menne, Johannes

    2018  

    Author's details vorgelegt von Menne, Johannes aus Paderborn
    Language German
    Size 84, V Blätter, Illustrationen, Diagramme
    Publishing place Münster
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Westfälische Wilhelms-Universität Münster, 2018
    HBZ-ID HT019933994
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 E 37 order for loan Magazin

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  2. Article ; Online: Regulation of Transporters for Organic Cations by High Glucose.

    Steinbüchel, Martin / Menne, Johannes / Schröter, Rita / Neugebauer, Ute / Schlatter, Eberhard / Ciarimboli, Giuliano

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Endogenous positively charged organic substances, including neurotransmitters and cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic medication metformin, serve as substrates for organic cation transporters (OCTs) and ... ...

    Abstract Endogenous positively charged organic substances, including neurotransmitters and cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic medication metformin, serve as substrates for organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs). These proteins facilitate their transport across cell membranes. Vectorial transport through the OCT/MATE axis mediates the hepatic and renal excretion of organic cations, regulating their systemic and local concentrations. Organic cation transporters are part of the remote sensing and signaling system, whose activity can be regulated to cope with changes in the composition of extra- and intracellular fluids. Glucose, as a source of energy, can also function as a crucial signaling molecule, regulating gene expression in various organs and tissues. Its concentration in the blood may fluctuate in specific physiological and pathophysiological conditions. In this work, the regulation of the activity of organic cation transporters was measured by incubating human embryonic kidney cells stably expressing human OCT1 (hOCT1), hOCT2, or hMATE1 with high glucose concentrations (16.7 mM). Incubation with this high glucose concentration for 48 h significantly stimulated the activity of hOCT1, hOCT2, and hMATE1 by increasing their maximal velocity (V
    MeSH term(s) Humans ; Organic Cation Transport Proteins/metabolism ; Organic Cation Transporter 2/genetics ; Metformin/pharmacology ; Metformin/metabolism ; Cations/metabolism ; RNA, Messenger
    Chemical Substances Organic Cation Transport Proteins ; Organic Cation Transporter 2 ; Metformin (9100L32L2N) ; Cations ; RNA, Messenger
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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